The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes ... See more...

Aliases for SSX7 Gene

Aliases for SSX7 Gene

  • SSX Family Member 7 2 3 5
  • Synovial Sarcoma, X Breakpoint 7 2 3
  • Protein SSX7 3 4

External Ids for SSX7 Gene

Previous GeneCards Identifiers for SSX7 Gene

  • GC0XU900002
  • GC0XM051324
  • GC0XM051639
  • GC0XM052556
  • GC0XM052689
  • GC0XM049800
  • GC0XM052674

Summaries for SSX7 Gene

Entrez Gene Summary for SSX7 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSX7 Gene

SSX7 (SSX Family Member 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.

UniProtKB/Swiss-Prot Summary for SSX7 Gene

Additional gene information for SSX7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSX7 Gene

Genomics for SSX7 Gene

GeneHancer (GH) Regulatory Elements for SSX7 Gene

Promoters and enhancers for SSX7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ053224 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 14.6 -569.5 -569501 4 FOXK2 ZNF785 SIN3A ZNF24 ZBTB40 ZBTB6 SMARCE1 POLR2A ATF1 CREB1 KDM5C lnc-KANTR-7 TSPYL2 GPR173 PHF8 FAM156B FAM120C RPSAP62 SSXP5 SSX7
GH0XJ053420 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 14.6 -767.3 -767300 3.2 FOXK2 SIN3A SP1 POLR2A HCFC1 ZNF133 ELF1 HLF RBM39 L3MBTL2 SMC1A RIBC1 piR-57135-150 FAM156B ACTG1P10 GPR173 ENSG00000233250 TSPYL2 PHF8 KDM5C
GH0XJ052933 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 14.6 -279.9 -279946 1.9 ZNF785 ZNF24 SP1 ZBTB40 CTCF ZBTB6 RBPJ POLR2A ATF1 CREB1 GPR173 IQSEC2 TSPYL2 SSXP5 SSX7 RPSAP62 XAGE1B XAGE1A KDM5C-IT1 SPANXN5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSX7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSX7 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • Cart-1
  • En-1
  • NCX
  • NF-1
  • POU2F1b
  • POU2F1c
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SSX7 Gene

Genomic Locations for SSX7 Gene
chrX:52,644,061-52,654,900
(GRCh38/hg38)
Size:
10,840 bases
Orientation:
Minus strand
chrX:52,673,111-52,683,950
(GRCh37/hg19)
Size:
10,840 bases
Orientation:
Minus strand

Genomic View for SSX7 Gene

Genes around SSX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX7 Gene

Proteins for SSX7 Gene

  • Protein details for SSX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTT5-SSX7_HUMAN
    Recommended name:
    Protein SSX7
    Protein Accession:
    Q7RTT5

    Protein attributes for SSX7 Gene

    Size:
    188 amino acids
    Molecular mass:
    21591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSX7 Gene

Post-translational modifications for SSX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSX7 Gene

Domains & Families for SSX7 Gene

Gene Families for SSX7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SSX7 Gene

Suggested Antigen Peptide Sequences for SSX7 Gene

GenScript: Design optimal peptide antigens:
  • Protein SSX7 (SSX7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7RTT5

UniProtKB/Swiss-Prot:

SSX7_HUMAN :
  • Belongs to the SSX family.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX7: view

Function for SSX7 Gene

Molecular function for SSX7 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SSX7: view
genes like me logo Genes that share phenotypes with SSX7: view

Animal Model Products

CRISPR Products

miRNA for SSX7 Gene

miRTarBase miRNAs that target SSX7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX7 Gene

Localization for SSX7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX7 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with SSX7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX7 Gene

Pathways & Interactions for SSX7 Gene

PathCards logo

SuperPathways for SSX7 Gene

No Data Available

Interacting Proteins for SSX7 Gene

Gene Ontology (GO) - Biological Process for SSX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SSX7: view

No data available for Pathways by source and SIGNOR curated interactions for SSX7 Gene

Drugs & Compounds for SSX7 Gene

No Compound Related Data Available

Transcripts for SSX7 Gene

mRNA/cDNA for SSX7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX7 Gene

No ASD Table

Relevant External Links for SSX7 Gene

GeneLoc Exon Structure for
SSX7
ECgene alternative splicing isoforms for
SSX7

Expression for SSX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSX7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSX7 Gene:

SSX7

SOURCE GeneReport for Unigene cluster for SSX7 Gene:

Hs.558712

mRNA Expression by UniProt/SwissProt for SSX7 Gene:

Q7RTT5-SSX7_HUMAN
Tissue specificity: Testis-specific. Expressed in a melanoma cell line.
genes like me logo Genes that share expression patterns with SSX7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX7 Gene

Orthologs for SSX7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSX7 33
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ssxa1 33
  • 43 (a)
ManyToMany
Gm21876 33
  • 40 (a)
ManyToMany
Ssxb8 33
  • 33 (a)
ManyToMany
Ssxb5 33
  • 33 (a)
ManyToMany
Gm5751 33
  • 33 (a)
ManyToMany
Ssxb10 33
  • 32 (a)
ManyToMany
Ssxb1 33
  • 32 (a)
ManyToMany
Ssxb3 33
  • 32 (a)
ManyToMany
Gm6592 33
  • 31 (a)
ManyToMany
Ssxb9 33
  • 31 (a)
ManyToMany
Ssx9 33
  • 31 (a)
ManyToMany
Ssxb2 33
  • 30 (a)
ManyToMany
Gm14459 33
  • 30 (a)
ManyToMany
Ssxb6 33
  • 27 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SSX5 33
  • 30 (a)
OneToMany
Species where no ortholog for SSX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX7 Gene

ENSEMBL:
Gene Tree for SSX7 (if available)
TreeFam:
Gene Tree for SSX7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSX7: view image

Paralogs for SSX7 Gene

Paralogs for SSX7 Gene

(14) SIMAP similar genes for SSX7 Gene using alignment to 1 proteins:

  • SSX7_HUMAN
genes like me logo Genes that share paralogs with SSX7: view

Variants for SSX7 Gene

Sequence variations from dbSNP and Humsavar for SSX7 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111730587 -- 52,655,665(-) TTT/TTTT/TTTTATTTT/TTTTATTTTATTTT/TTTTATTTTATTTTATTTT upstream_transcript_variant
rs112111558 -- 52,645,439(-) G/A 3_prime_UTR_variant
rs112211534 -- 52,649,420(-) A/G intron_variant
rs112382781 -- 52,645,464(-) G/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs112751012 -- 52,644,508(-) A/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SSX7 Gene

Variant ID Type Subtype PubMed ID
esv21492 CNV gain 19812545
esv2740170 CNV deletion 23290073

Variation tolerance for SSX7 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSX7 Gene

Human Gene Mutation Database (HGMD)
SSX7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSX7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX7 Gene

Disorders for SSX7 Gene

Additional Disease Information for SSX7

No disorders were found for SSX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSX7 Gene

Publications for SSX7 Gene

  1. The SSX gene family: characterization of 9 complete genes. (PMID: 12216073) Güre AO … Chen YT (International journal of cancer 2002) 2 3 4 23 56
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Expressions of cancer-testis antigens in human hepatocellular carcinomas. (PMID: 11179834) Chen CH … Sheu JC (Cancer letters 2001) 3 56

Products for SSX7 Gene

Sources for SSX7 Gene