The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SS... See more...

Aliases for SSX5 Gene

Aliases for SSX5 Gene

  • SSX Family Member 5 2 3 5
  • Synovial Sarcoma, X Breakpoint 5 2 3
  • Protein SSX5 3 4
  • SSX5 5

External Ids for SSX5 Gene

Previous GeneCards Identifiers for SSX5 Gene

  • GC0XM046848
  • GC0XM046306
  • GC0XM047091
  • GC0XM047801
  • GC0XM047930
  • GC0XM048045
  • GC0XM045758

Summaries for SSX5 Gene

Entrez Gene Summary for SSX5 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX5 Gene

SSX5 (SSX Family Member 5) is a Protein Coding gene. Diseases associated with SSX5 include Sarcoma and Synovium Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.

UniProtKB/Swiss-Prot Summary for SSX5 Gene

Gene Wiki entry for SSX5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSX5 Gene

Genomics for SSX5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SSX5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ048189 Enhancer 0.3 Ensembl 0.4 +6.6 6597 1.2 JUN ENSG00000204620 SSX5 S100A11P5 lnc-SSX5-1 SPACA5B MG828730-072
GH0XJ048214 Enhancer 0.2 Ensembl 0.4 -17.5 -17503 1.4 ENSG00000204368 SSX1 lnc-SSX5-2 SSX5 MG828730-072
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSX5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSX5

Top Transcription factor binding sites by QIAGEN in the SSX5 gene promoter:
  • ATF-2
  • C/EBPalpha
  • CUTL1
  • En-1
  • FOXF2
  • HOXA9
  • HOXA9B
  • Meis-1
  • NCX
  • Sox9

Genomic Locations for SSX5 Gene

Genomic Locations for SSX5 Gene
chrX:48,177,982-48,196,798
(GRCh38/hg38)
Size:
18,817 bases
Orientation:
Minus strand
chrX:48,045,656-48,056,199
(GRCh37/hg19)
Size:
10,544 bases
Orientation:
Minus strand

Genomic View for SSX5 Gene

Genes around SSX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX5 Gene

Proteins for SSX5 Gene

  • Protein details for SSX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60225-SSX5_HUMAN
    Recommended name:
    Protein SSX5
    Protein Accession:
    O60225
    Secondary Accessions:
    • Q5JQ59
    • Q5JQ60
    • Q96AW3

    Protein attributes for SSX5 Gene

    Size:
    188 amino acids
    Molecular mass:
    21660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX5 Gene

Post-translational modifications for SSX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX5 Gene

No data available for DME Specific Peptides for SSX5 Gene

Domains & Families for SSX5 Gene

Gene Families for SSX5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SSX5 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for SSX5 Gene

GenScript: Design optimal peptide antigens:
  • Synovial sarcoma, X breakpoint 5 (Q5JQ63_HUMAN)
  • Protein SSX5 (SSX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60225

UniProtKB/Swiss-Prot:

SSX5_HUMAN :
  • Belongs to the SSX family.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX5: view

Function for SSX5 Gene

Molecular function for SSX5 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.
GENATLAS Biochemistry:
protein SSX5 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma

Gene Ontology (GO) - Molecular Function for SSX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SSX5: view
genes like me logo Genes that share phenotypes with SSX5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSX5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX5 Gene

Localization for SSX5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX5 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with SSX5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX5 Gene

Pathways & Interactions for SSX5 Gene

PathCards logo

SuperPathways for SSX5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SSX5: view

No data available for Pathways by source and SIGNOR curated interactions for SSX5 Gene

Drugs & Compounds for SSX5 Gene

No Compound Related Data Available

Transcripts for SSX5 Gene

mRNA/cDNA for SSX5 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSX5

Alternative Splicing Database (ASD) splice patterns (SP) for SSX5 Gene

No ASD Table

Relevant External Links for SSX5 Gene

GeneLoc Exon Structure for
SSX5

Expression for SSX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSX5 Gene

mRNA differential expression in normal tissues according to GTEx for SSX5 Gene

This gene is overexpressed in Testis (x39.4).

Protein differential expression in normal tissues from HIPED for SSX5 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSX5 Gene



Protein tissue co-expression partners for SSX5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSX5

SOURCE GeneReport for Unigene cluster for SSX5 Gene:

Hs.166198

Evidence on tissue expression from TISSUES for SSX5 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with SSX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX5 Gene

Orthologs for SSX5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100608018 30
  • 93.01 (n)
-- 31
  • 69 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 44 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm21876 31
  • 43 (a)
ManyToMany
Ssxa1 31
  • 43 (a)
ManyToMany
Gm5751 31
  • 34 (a)
ManyToMany
Ssxb5 31
  • 33 (a)
ManyToMany
Ssxb8 31
  • 32 (a)
ManyToMany
Ssxb10 31
  • 32 (a)
ManyToMany
Ssxb9 31
  • 31 (a)
ManyToMany
Ssxb1 31
  • 31 (a)
ManyToMany
Ssxb3 31
  • 31 (a)
ManyToMany
Gm14459 31
  • 31 (a)
ManyToMany
Gm6592 31
  • 30 (a)
ManyToMany
Ssx9 31
  • 29 (a)
ManyToMany
Ssxb6 31
  • 28 (a)
ManyToMany
Ssxb2 31
  • 28 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia SSX5 31
  • 28 (a)
OneToMany
Species where no ortholog for SSX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SSX5 Gene

ENSEMBL:
Gene Tree for SSX5 (if available)
TreeFam:
Gene Tree for SSX5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSX5: view image

Paralogs for SSX5 Gene

Paralogs for SSX5 Gene

(17) SIMAP similar genes for SSX5 Gene using alignment to 2 proteins:

  • SSX5_HUMAN
  • Q5JQ63_HUMAN
genes like me logo Genes that share paralogs with SSX5: view

Variants for SSX5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSX5 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs4824675 - p.Glu19Gln

Additional dbSNP identifiers (rs#s) for SSX5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SSX5 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
esv25781 CNV gain 19812545
esv2671998 CNV deletion 23128226
esv2740145 CNV deletion 23290073
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
nsv1133119 OTHER inversion 24896259
nsv471601 CNV gain 15918152
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680

Variation tolerance for SSX5 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSX5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX5 Gene

Disorders for SSX5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SSX5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
synovium cancer
  • malignant tumor of synovium
sarcoma, synovial
  • synovial sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search SSX5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SSX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX5 Gene

Publications for SSX5 Gene

  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure AO … Chen YT (International journal of cancer 1997) 3 4 23
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2002) 3 23
  5. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PMID: 10749136) dos Santos NR … van Kessel AG (Cancer research 2000) 3 23

Products for SSX5 Gene

  • Signalway Proteins for SSX5

Sources for SSX5 Gene