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This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009] See more...
Aliases for SSX2IP Gene
Aliases for SSX2IP Gene
External Ids for SSX2IP Gene
- HGNC: 16509
- Entrez Gene: 117178
- Ensembl: ENSG00000117155
- OMIM: 608690
- UniProtKB: Q9Y2D8
Previous GeneCards Identifiers for SSX2IP Gene
- GC00U991126
- GC01M084247
- GC01M084397
- GC01M084531
- GC01M084532
- GC01M084821
- GC01M084881
- GC01M085109
- GC01M083219
Summaries for SSX2IP Gene
-
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]
GeneCards Summary for SSX2IP Gene
SSX2IP (SSX Family Member 2 Interacting Protein) is a Protein Coding gene. Among its related pathways are PAK Pathway and Adherens junction. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.
UniProtKB/Swiss-Prot Summary for SSX2IP Gene
-
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).
Additional gene information for SSX2IP Gene
- HGNC(16509)
- Entrez Gene(117178)
- Ensembl(ENSG00000117155)
- OMIM(608690)
- UniProtKB(Q9Y2D8)
- Open Targets Platform(ENSG00000117155)
- Search for SSX2IP at DataMed
- Search for SSX2IP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSX2IP Gene
Genomics for SSX2IP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SSX2IP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SSX2IP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSX2IP
- Top Transcription factor binding sites by QIAGEN in the SSX2IP gene promoter:
-
- ATF-2
- Bach2
- CBF(2)
- Evi-1
- GATA-2
- GATA-3
- NF-Y
- POU3F2
- POU3F2 (N-Oct-5a)
- S8
Genomic Locations for SSX2IP Gene
Genomic Locations for SSX2IP Gene
- chr1:84,643,706-84,690,803
- (GRCh38/hg38)
- Size:
- 47,098 bases
- Orientation:
- Minus strand
- chr1:85,109,390-85,156,486
- (GRCh37/hg19)
- Size:
- 47,097 bases
- Orientation:
- Minus strand
Genomic View for SSX2IP Gene
Genes around SSX2IP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by HGNC
- 1p22.3 by Entrez Gene
- 1p22.3 by Ensembl
SSX2IP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SSX2IP Gene
Proteins for SSX2IP Gene
-
Protein details for SSX2IP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2D8-ADIP_HUMAN
- Recommended name:
- Afadin- and alpha-actinin-binding protein
- Protein Accession:
- Q9Y2D8
- A8K8W0
- B4DFE3
- D3DT13
- J3KR02
- Q6P2P8
- Q6ULS1
- Q7L168
- Q9UIX0
Protein attributes for SSX2IP Gene
- Size:
- 614 amino acids
- Molecular mass:
- 71236 Da
- Quaternary structure:
-
- Interacts with afadin and alpha-actinin (By similarity). Interacts with VAV2 (By similarity). Interacts with SSX2 and SSX3. Does not interact with SSX1 and SSX4 (PubMed:12007189). Interacts with PCM1 (By similarity). Interacts with WRAP73 (PubMed:26545777).
- SequenceCaution:
-
- Sequence=BAA76767.2; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy target for leukemia (PubMed:17686061, PubMed:19179477).
Protein Expression for SSX2IP Gene
Post-translational modifications for SSX2IP Gene
Other Protein References for SSX2IP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SSX2IP Antibody
- Novus Biologicals Antibodies for SSX2IP
-
Abcam antibodies for SSX2IP
- Invitrogen Antibodies for SSX2IP (AFLGC-SSX2IP)
Protein Products
-
OriGene Purified Proteins for SSX2IP
- Search Origene for MassSpec and Protein Over-expression Lysates for SSX2IP
- Origene Custom Protein Services for SSX2IP
- antibodies-online: Show 5 available SSX2IP Proteins ranked by validation data
- Compare Top SSX2IP Proteins
-
Quality Products:
-
Signalway Proteins for SSX2IP
-
Abcam proteins for SSX2IP
Assay Products
- antibodies-online: Show 6 available SSX2IP Elisa Kits ranked by validation data
- Compare Top SSX2IP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SSX2IP Gene
Domains & Families for SSX2IP Gene
Gene Families for SSX2IP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SSX2IP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SSX2IP Gene
- GenScript: Design optimal peptide antigens:
-
- SSX2-interacting protein (ADIP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y2D8UniProtKB/Swiss-Prot:
ADIP_HUMAN :- Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2.
- Belongs to the ADIP family.
- Domain:
-
- Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2.
- Family:
-
- Belongs to the ADIP family.
Function for SSX2IP Gene
Molecular function for SSX2IP Gene
- UniProtKB/Swiss-Prot Function:
- Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).
Phenotypes From GWAS Catalog for SSX2IP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12007189 |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for SSX2IP Gene
- MGI mutant phenotypes for SSX2IP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SSX2IP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SSX2IP - Select products 50% OFF >
- * SSX2IP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SSX2IP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SSX2IP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSX2IP
miRNA for SSX2IP Gene
- miRTarBase miRNAs that target SSX2IP
-
- hsa-miR-193b-3p (MIRT016383)
- hsa-miR-155-5p (MIRT020713)
- hsa-miR-339-5p (MIRT042758)
- hsa-miR-92a-3p (MIRT049125)
- hsa-miR-222-3p (MIRT053144)
- hsa-miR-221-3p (MIRT053145)
- hsa-miR-338-3p (MIRT053532)
- hsa-miR-374a-5p (MIRT148608)
- hsa-miR-26a-5p (MIRT346489)
- hsa-miR-26b-5p (MIRT346490)
- hsa-miR-106b-5p (MIRT439534)
- hsa-miR-20a-5p (MIRT439535)
- mmu-miR-126a-5p (MIRT594780)
- hsa-miR-6864-3p (MIRT718023)
- hsa-miR-3672 (MIRT718024)
- hsa-miR-5189-3p (MIRT718025)
- hsa-miR-4524a-3p (MIRT718026)
- hsa-miR-181d-5p (MIRT726438)
- hsa-miR-181c-5p (MIRT726439)
- hsa-miR-181b-5p (MIRT726440)
- hsa-miR-181a-5p (MIRT726441)
- hsa-miR-93-5p (MIRT726442)
- hsa-miR-519d-3p (MIRT726443)
- hsa-miR-20b-5p (MIRT726444)
- hsa-miR-17-5p (MIRT726445)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SSX2IP
- Browse OriGene Inhibitory RNA Products For SSX2IP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSX2IP
Clone Products
- Applied Biological Materials (abm): Clones for SSX2IP - Select products 50% OFF >
- * SSX2IP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209435
- MR209435
- MR209435L3
- MR209435L4
- MR230683
- MR230684
- MR230685
- RC207526
- RC207526L1
- RC207526L2
- RC207526L3
- RC207526L4
- RC230315
- RC230315L3
- RC230315L4
- RC230316
- RC230316L3
- RC230316L4
- RC230350
- RC230350L3
- RC230350L4
- RC230351
- RC230351L3
- RC230351L4
- RG207526
- RG230315
- RG230316
- RG230350
- RG230351
- RR205065
- RR205065L3
- RR205065L4
- MR209435L3V
- MR209435L4V
- RC207526L1V
- RC207526L2V
- RC207526L3V
- RC207526L4V
- RC230315L3V
- RC230315L4V
- RC230316L3V
- RC230316L4V
- RC230350L3V
- RC230350L4V
- RC230351L3V
- RC230351L4V
- RR205065L3V
- RR205065L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SSX2IP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SSX2IP
Cell Line Products
-
Horizon Cell Lines for SSX2IP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX2IP Gene
Localization for SSX2IP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SSX2IP Gene
- Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Not found at cell-matrix AJs. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005912 | adherens junction | IEA | -- |
Pathways & Interactions for SSX2IP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adherens junction | ||
| 2 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
Pathways by source for SSX2IP Gene
1 KEGG pathway for SSX2IP Gene
1 Qiagen pathway for SSX2IP Gene
- Epithelial Adherens Junctions
Interacting Proteins for SSX2IP Gene
Selected Interacting proteins:
Q9Y2D8-ADIP_HUMAN
ENSP00000340279
for SSX2IP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SSX2IP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007098 | centrosome cycle | IMP | 23816619 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0030030 | cell projection organization | IEA | -- |
| GO:0035020 | regulation of Rac protein signal transduction | IEA | -- |
| GO:0035735 | intraciliary transport involved in cilium assembly | IMP | 24356449 |
No data available for SIGNOR curated interactions for SSX2IP Gene
Transcripts for SSX2IP Gene
mRNA/cDNA for SSX2IP Gene
- 5 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342203 5835 nts (view in UCSC)
- ENST00000422026 759 nts (view in UCSC)
- ENST00000437941 5843 nts (view in UCSC)
- ENST00000459708 453 nts (view in UCSC)
- ENST00000460500 2116 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SSX2IP - Select products 50% OFF >
- * SSX2IP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SSX2IP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SSX2IP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSX2IP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SSX2IP
- Browse OriGene Inhibitory RNA Products For SSX2IP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSX2IP
Clone Products
- Applied Biological Materials (abm): Clones for SSX2IP - Select products 50% OFF >
- * SSX2IP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209435
- MR209435
- MR209435L3
- MR209435L4
- MR230683
- MR230684
- MR230685
- RC207526
- RC207526L1
- RC207526L2
- RC207526L3
- RC207526L4
- RC230315
- RC230315L3
- RC230315L4
- RC230316
- RC230316L3
- RC230316L4
- RC230350
- RC230350L3
- RC230350L4
- RC230351
- RC230351L3
- RC230351L4
- RG207526
- RG230315
- RG230316
- RG230350
- RG230351
- RR205065
- RR205065L3
- RR205065L4
- MR209435L3V
- MR209435L4V
- RC207526L1V
- RC207526L2V
- RC207526L3V
- RC207526L4V
- RC230315L3V
- RC230315L4V
- RC230316L3V
- RC230316L4V
- RC230350L3V
- RC230350L4V
- RC230351L3V
- RC230351L4V
- RR205065L3V
- RR205065L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SSX2IP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SSX2IP
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for SSX2IP Gene
- GeneLoc Exon Structure for
- SSX2IP
Expression for SSX2IP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Seminiferous Tubules
- Testis Interstitium
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for SSX2IP Gene
This gene is overexpressed in Testis (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).
This gene is overexpressed in Liver (41.9) and Testis (20.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSX2IP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSX2IP
SOURCE GeneReport for Unigene cluster for SSX2IP Gene:
Hs.22587mRNA Expression by UniProt/SwissProt for SSX2IP Gene:
Q9Y2D8-ADIP_HUMAN
Tissue specificity:
Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
Evidence on tissue expression from TISSUES for SSX2IP Gene
- Nervous system(4.9)
- Eye(4.3)
- Kidney(2.2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for SSX2IP
-
OriGene qPCR primer pairs and template standards for SSX2IP
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX2IP Gene
Orthologs for SSX2IP Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SSX2IP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SSX2IP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SSX2IP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ssx2ip 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ssx2ip 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SSX2IP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SSX2IP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SSX2IP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SSX2IP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ssx2ip 30 |
|
||
| Str.8904 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100534665 30 |
|
||
| SSX2IP (2 of 3) 31 |
|
OneToMany | |||
| ssx2ip 31 |
|
OneToMany | |||
| SSX2IP (3 of 3) 31 |
|
OneToMany | |||
| zgc73314 30 |
|
||||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G18876 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0242900 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for SSX2IP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SSX2IP Gene
- ENSEMBL:
- Gene Tree for SSX2IP (if available)
- TreeFam:
- Gene Tree for SSX2IP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SSX2IP: view image
Paralogs for SSX2IP Gene
Pseudogenes.org Pseudogenes for SSX2IP Gene
No data available for Paralogs for SSX2IP Gene
Variants for SSX2IP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSX2IP Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057746 | - | p.Cys578Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3893779 | CNV | gain | 25118596 |
Residual Variation Intolerance Score:
32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SSX2IP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SSX2IP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX2IP Gene
Disorders for SSX2IP Gene
Additional Disease Information for SSX2IP
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for SSX2IP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSX2IP Gene
Publications for SSX2IP Gene
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2002) 3 4 23
- The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. (PMID: 26545777) Hori A … Toda T (Biochemical and biophysical research communications 2015) 3 4
- The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone. (PMID: 24356449) Klinger M … Gruss OJ (Molecular biology of the cell 2014) 3 4
- The centriolar satellite protein SSX2IP promotes centrosome maturation. (PMID: 23816619) Bärenz F … Gruss OJ (The Journal of cell biology 2013) 3 4
- Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements. (PMID: 19179477) Guinn B … Mills KI (Blood 2009) 3 4
ExternalLinks
Products for SSX2IP Gene
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Sources for SSX2IP Gene
- (1) GeneCards
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