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Aliases for SSX2B Gene

Aliases for SSX2B Gene

  • SSX Family Member 2B 2 3 5
  • Cancer/Testis Antigen Family 5, Member 2b 2 3
  • Synovial Sarcoma, X Breakpoint 2B 2 3
  • Cancer/Testis Antigen 5.2 3 4
  • Tumor Antigen HOM-MEL-40 3 4
  • CT5.2 3 4
  • Synovial Sarcoma, X Breakpoint 2 4
  • Protein SSX2 3
  • HOM-MEL-40 3
  • SSX2 SSX2B 4
  • CT5.2b 3
  • SSX2A 4
  • SSX 3

External Ids for SSX2B Gene

Previous GeneCards Identifiers for SSX2B Gene

  • GC0XP052797

Summaries for SSX2B Gene

Entrez Gene Summary for SSX2B Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX2B Gene

SSX2B (SSX Family Member 2B) is a Protein Coding gene. Diseases associated with SSX2B include Sarcoma and Epithelioid Cell Synovial Sarcoma. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX2.

UniProtKB/Swiss-Prot for SSX2B Gene

  • Could act as a modulator of transcription.

Additional gene information for SSX2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX2B Gene

Genomics for SSX2B Gene

GeneHancer (GH) Regulatory Elements for SSX2B Gene

Promoters and enhancers for SSX2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI052751 Promoter 0.5 EPDnew 550.8 +0.1 101 0.1 LOC102723585 SSX2B ENSG00000269281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSX2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSX2B gene promoter:

Genomic Locations for SSX2B Gene

Genomic Locations for SSX2B Gene
39,174 bases
Plus strand

Genomic View for SSX2B Gene

Genes around SSX2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX2B Gene

Proteins for SSX2B Gene

  • Protein details for SSX2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SSX2
    Protein Accession:
    Secondary Accessions:
    • Q16404
    • Q5JS26
    • Q96IP7
    • Q9BU88

    Protein attributes for SSX2B Gene

    188 amino acids
    Molecular mass:
    21620 Da
    Quaternary structure:
    • Interacts via its N-terminal region with RAB3IP and SSX2IP.
    • Interacts via its N-terminal region with RAB3IP and SSX2IP.
    • Sequence=AAB35674.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX2B Gene


neXtProt entry for SSX2B Gene

Post-translational modifications for SSX2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX2B Gene

No data available for DME Specific Peptides for SSX2B Gene

Domains & Families for SSX2B Gene

Gene Families for SSX2B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for SSX2B Gene

Suggested Antigen Peptide Sequences for SSX2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SSX family.
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX2B: view

Function for SSX2B Gene

Molecular function for SSX2B Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 12007189
genes like me logo Genes that share ontologies with SSX2B: view

Phenotypes for SSX2B Gene

genes like me logo Genes that share phenotypes with SSX2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX2B Gene

Localization for SSX2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSX2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX2B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SSX2B: view

Pathways & Interactions for SSX2B Gene

genes like me logo Genes that share pathways with SSX2B: view

Pathways by source for SSX2B Gene

1 KEGG pathway for SSX2B Gene

Gene Ontology (GO) - Biological Process for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7539744
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX2B: view

No data available for SIGNOR curated interactions for SSX2B Gene

Drugs & Compounds for SSX2B Gene

No Compound Related Data Available

Transcripts for SSX2B Gene

mRNA/cDNA for SSX2B Gene

(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX2B Gene

No ASD Table

Relevant External Links for SSX2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSX2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSX2B Gene

mRNA differential expression in normal tissues according to GTEx for SSX2B Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for SSX2B Gene

This gene is overexpressed in Testis (48.3) and Ovary (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSX2B Gene

Protein tissue co-expression partners for SSX2B Gene

NURSA nuclear receptor signaling pathways regulating expression of SSX2B Gene:


mRNA Expression by UniProt/SwissProt for SSX2B Gene:

Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.

Evidence on tissue expression from TISSUES for SSX2B Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with SSX2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX2B Gene

Orthologs for SSX2B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SSX2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100609340 33
  • 98.94 (n)
Species where no ortholog for SSX2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX2B Gene

Gene Tree for SSX2B (if available)
Gene Tree for SSX2B (if available)

Paralogs for SSX2B Gene

Paralogs for SSX2B Gene

(14) SIMAP similar genes for SSX2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSX2B: view

Variants for SSX2B Gene

Sequence variations from dbSNP and Humsavar for SSX2B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111728628 -- 52,759,783(+) C/A intron_variant
rs112024130 -- 52,751,209(+) G/C 5_prime_UTR_variant
rs112365460 -- 52,749,490(+) C/T upstream_transcript_variant
rs199749187 -- 52,759,554(+) A/G coding_sequence_variant, intron_variant, missense_variant
rs201422418 -- 52,760,479(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSX2B Gene

Variant ID Type Subtype PubMed ID
esv21492 CNV gain 19812545
esv2740170 CNV deletion 23290073
nsv1119340 CNV duplication 24896259
nsv7446 OTHER inversion 18451855

Additional Variant Information for SSX2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX2B Gene

Disorders for SSX2B Gene

MalaCards: The human disease database

(11) MalaCards diseases for SSX2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • connective and soft tissue neoplasm
epithelioid cell synovial sarcoma
  • epithelioid synovial sarcoma
synovium cancer
  • malignant tumor of synovium
kidney hemangiopericytoma
  • hemangiopericytoma of kidney
extraskeletal mesenchymal chondrosarcoma
  • mesenchymal extraosseous chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search SSX2B in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). {ECO:0000269 PubMed:7539744, ECO:0000269 PubMed:7951320}.

Additional Disease Information for SSX2B

genes like me logo Genes that share disorders with SSX2B: view

No data available for Genatlas for SSX2B Gene

Publications for SSX2B Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2002) 3 4 58
  4. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PMID: 7495284) Fligman I … Ladanyi M (The American journal of pathology 1995) 3 4 58
  5. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PMID: 7539744) Crew AJ … Cooper CS (The EMBO journal 1995) 3 4 58

Products for SSX2B Gene

Sources for SSX2B Gene

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