This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effec... See more...

Aliases for SSTR3 Gene

Aliases for SSTR3 Gene

  • Somatostatin Receptor 3 2 3 5
  • Somatostatin Receptor Type 3 3 4
  • SS-3-R 3 4
  • SSR-28 3 4
  • SS3-R 3 4
  • SS3R 3 4

External Ids for SSTR3 Gene

Previous GeneCards Identifiers for SSTR3 Gene

  • GC22M034217
  • GC22M035845
  • GC22M035926
  • GC22M037600
  • GC22M020567

Summaries for SSTR3 Gene

Entrez Gene Summary for SSTR3 Gene

  • This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSTR3 Gene

SSTR3 (Somatostatin Receptor 3) is a Protein Coding gene. Diseases associated with SSTR3 include Vipoma and Pituitary Adenoma, Prolactin-Secreting. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR5.

UniProtKB/Swiss-Prot Summary for SSTR3 Gene

  • Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Tocris Summary for SSTR3 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR3 Gene

Additional gene information for SSTR3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSTR3 Gene

Genomics for SSTR3 Gene

GeneHancer (GH) Regulatory Elements for SSTR3 Gene

Promoters and enhancers for SSTR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSTR3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSTR3

Top Transcription factor binding sites by QIAGEN in the SSTR3 gene promoter:
  • AhR
  • AREB6
  • E47
  • GATA-2
  • HEN1
  • NF-1
  • NF-1/L
  • p53
  • Tal-1
  • Zic3

Genomic Locations for SSTR3 Gene

Genomic Locations for SSTR3 Gene
chr22:37,204,237-37,220,447
(GRCh38/hg38)
Size:
16,211 bases
Orientation:
Minus strand
chr22:37,600,278-37,608,362
(GRCh37/hg19)
Size:
8,085 bases
Orientation:
Minus strand

Genomic View for SSTR3 Gene

Genes around SSTR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR3 Gene

Proteins for SSTR3 Gene

  • Protein details for SSTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32745-SSR3_HUMAN
    Recommended name:
    Somatostatin receptor type 3
    Protein Accession:
    P32745
    Secondary Accessions:
    • A8K550
    • Q53ZR7

    Protein attributes for SSTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    45847 Da
    Quaternary structure:
    • Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).

neXtProt entry for SSTR3 Gene

Post-translational modifications for SSTR3 Gene

  • Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).
  • Glycosylation at Asn17 and Asn30
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR3 Gene

No data available for DME Specific Peptides for SSTR3 Gene

Domains & Families for SSTR3 Gene

Gene Families for SSTR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for SSTR3 Gene

Blocks:
  • Somatostatin receptor signature
  • Somatostatin receptor type 3 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSTR3 Gene

GenScript: Design optimal peptide antigens:
  • SSR-28 (SSR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32745

UniProtKB/Swiss-Prot:

SSR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR3: view

Function for SSTR3 Gene

Molecular function for SSTR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
GENATLAS Biochemistry:
somatostatin receptor gene 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for SSTR3 Gene

Gene Ontology (GO) - Molecular Function for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004994 somatostatin receptor activity IEA,TAS --
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 19071123
GO:0042277 peptide binding IBA 21873635
genes like me logo Genes that share ontologies with SSTR3: view
genes like me logo Genes that share phenotypes with SSTR3: view

Animal Models for SSTR3 Gene

MGI Knock Outs for SSTR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SSTR3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSTR3

Clone Products

  • Addgene plasmids for SSTR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR3 Gene

Localization for SSTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR3 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSTR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SSTR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSTR3 Gene

Pathways & Interactions for SSTR3 Gene

genes like me logo Genes that share pathways with SSTR3: view

SIGNOR curated interactions for SSTR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007218 neuropeptide signaling pathway IBA 21873635
GO:0007267 cell-cell signaling TAS 1337145
genes like me logo Genes that share ontologies with SSTR3: view

Drugs & Compounds for SSTR3 Gene

(61) Drugs for SSTR3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist, binder sst2, sst3 and sst5 agonist 271
Pasireotide Approved Pharma Target, inhibitor, agonist 76
lanreotide Approved Pharma Full agonist, Agonist 98
Somatostatin Approved, Investigational Pharma Target, agonist Influences growth hormone release 295
Edotreotide gallium Ga-68 Approved Pharma Target, ligand 0

(2) Additional Compounds for SSTR3 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MK-678
Full agonist, Agonist
SOM-230
Full agonist, Agonist

(5) Tocris Compounds for SSTR3 Gene

Compound Action Cas Number
Cortistatin 14 Endogenous neuropeptide; binds sst1 - sst5 and ghrelin receptor 193829-96-8
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1

(12) ApexBio Compounds for SSTR3 Gene

Compound Action Cas Number
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1
BIM 23056 Somatostatin receptor ligand 150155-61-6
CH 275 174688-78-9
Cortistatin 14 193829-96-8
Cyclosomatostatin somatostatin receptor antagonist 84211-54-1
CYN 154806 183658-72-2
L-803,087 trifluoroacetate 217480-26-7
L-817,818 217480-27-8
Octreotide acetate octapeptide congener of native somatostatin 83150-76-9
Pasireotide 396091-73-9
Seglitide 81377-02-8
Somatostatin 1-28 74315-46-1
genes like me logo Genes that share compounds with SSTR3: view

Drug Products

Transcripts for SSTR3 Gene

mRNA/cDNA for SSTR3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSTR3

Clone Products

  • Addgene plasmids for SSTR3

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR3 Gene

No ASD Table

Relevant External Links for SSTR3 Gene

GeneLoc Exon Structure for
SSTR3

Expression for SSTR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR3 Gene

This gene is overexpressed in Brain - Cortex (x6.2), Testis (x6.1), and Brain - Frontal Cortex (BA9) (x5.7).

Protein differential expression in normal tissues from HIPED for SSTR3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSTR3 Gene



Protein tissue co-expression partners for SSTR3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSTR3

SOURCE GeneReport for Unigene cluster for SSTR3 Gene:

Hs.225995

mRNA Expression by UniProt/SwissProt for SSTR3 Gene:

P32745-SSR3_HUMAN
Tissue specificity: Brain, pituitary and pancreas.

Evidence on tissue expression from TISSUES for SSTR3 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with SSTR3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SSTR3 Gene

Orthologs for SSTR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR3 30
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia SSTR3 30
  • 89.93 (n)
cow
(Bos Taurus)
Mammalia SSTR3 30
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Sstr3 17 30
  • 83.46 (n)
rat
(Rattus norvegicus)
Mammalia Sstr3 30
  • 82.72 (n)
chicken
(Gallus gallus)
Aves SSTR3 30
  • 72.15 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr3 30
  • 58.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334518 30
  • 62.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta Drostar1 32
  • 40 (a)
AlCR2 32
  • 38 (a)
Species where no ortholog for SSTR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR3 Gene

ENSEMBL:
Gene Tree for SSTR3 (if available)
TreeFam:
Gene Tree for SSTR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSTR3: view image

Paralogs for SSTR3 Gene

(29) SIMAP similar genes for SSTR3 Gene using alignment to 1 proteins:

  • SSR3_HUMAN
genes like me logo Genes that share paralogs with SSTR3: view

Variants for SSTR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSTR3 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs229568 - p.Ser411Thr
rs34943557 - p.Pro37Leu
rs4988466 - p.Ala33Val
rs4988469 - p.Arg336Cys
rs4988471 - p.Arg414His

Additional dbSNP identifiers (rs#s) for SSTR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SSTR3 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV loss 20364138
nsv834188 CNV loss 17160897

Variation tolerance for SSTR3 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSTR3 Gene

Human Gene Mutation Database (HGMD)
SSTR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSTR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR3 Gene

Disorders for SSTR3 Gene

MalaCards: The human disease database

(26) MalaCards diseases for SSTR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vipoma
  • malignant vasoactive intestinal peptide-secreting tumor
pituitary adenoma, prolactin-secreting
  • prolactinoma, familial
ovarian stromal hyperthecosis
pituitary adenoma
  • adenoma of the pituitary gland
pineal region meningioma
  • pineal meningioma
- elite association - COSMIC cancer census association via MalaCards
Search SSTR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSTR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SSTR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR3 Gene

Publications for SSTR3 Gene

  1. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y … Bell GI (Genomics 1993) 2 3 23 54
  2. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. (PMID: 8097479) Corness JD … Niznik HB (FEBS letters 1993) 3 4 23 54
  3. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (PMID: 1337145) Yamada Y … Seino S (Molecular endocrinology (Baltimore, Md.) 1992) 3 4 23 54
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 41 54

Products for SSTR3 Gene

Sources for SSTR3 Gene