Aliases for SSTR2 Gene
External Ids for SSTR2 Gene
Previous GeneCards Identifiers for SSTR2 Gene
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
GeneCards Summary for SSTR2 Gene
SSTR2 (Somatostatin Receptor 2) is a Protein Coding gene. Diseases associated with SSTR2 include Neuroendocrine Tumor and Growth Hormone Secreting Pituitary Adenoma. Among its related pathways are Signaling by GPCR and Salivary secretion. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide binding. An important paralog of this gene is SSTR5.
UniProtKB/Swiss-Prot Summary for SSTR2 Gene
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.