Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somato... See more...

Aliases for SSTR1 Gene

Aliases for SSTR1 Gene

  • Somatostatin Receptor 1 2 3 5
  • Somatostatin Receptor Type 1 3 4
  • SRIF-2 3 4
  • SS-1-R 3 4
  • SS1-R 3 4
  • SS1R 3 4
  • SSTR1 5

External Ids for SSTR1 Gene

Previous GeneCards Identifiers for SSTR1 Gene

  • GC14P036059
  • GC14P032534
  • GC14P036668
  • GC14P036667
  • GC14P037746
  • GC14P038677
  • GC14P018792

Summaries for SSTR1 Gene

Entrez Gene Summary for SSTR1 Gene

  • Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

GeneCards Summary for SSTR1 Gene

SSTR1 (Somatostatin Receptor 1) is a Protein Coding gene. Diseases associated with SSTR1 include Intracranial Hypertension, Idiopathic and Acromegaly. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR4.

UniProtKB/Swiss-Prot Summary for SSTR1 Gene

  • Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Tocris Summary for SSTR1 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSTR1 Gene

Genomics for SSTR1 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around SSTR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSTR1

Top Transcription factor binding sites by QIAGEN in the SSTR1 gene promoter:
  • AREB6
  • Arnt
  • ARP-1
  • c-Ets-1
  • C/EBPalpha
  • GATA-1
  • Nkx2-5
  • POU3F2
  • Roaz
  • STAT5B

Genomic Locations for SSTR1 Gene

Latest Assembly
chr14:38,207,904-38,213,067
(GRCh38/hg38)
Size:
5,164 bases
Orientation:
Plus strand

Previous Assembly
chr14:38,677,109-38,682,272
(GRCh37/hg19 by Entrez Gene)
Size:
5,164 bases
Orientation:
Plus strand

chr14:38,677,204-38,682,272
(GRCh37/hg19 by Ensembl)
Size:
5,069 bases
Orientation:
Plus strand

Genomic View for SSTR1 Gene

Genes around SSTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR1 Gene

Proteins for SSTR1 Gene

  • Protein details for SSTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30872-SSR1_HUMAN
    Recommended name:
    Somatostatin receptor type 1
    Protein Accession:
    P30872

    Protein attributes for SSTR1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42686 Da
    Quaternary structure:
    • Interacts with SKB1.

neXtProt entry for SSTR1 Gene

Post-translational modifications for SSTR1 Gene

  • Glycosylation at Asn4, Asn44, and Asn48
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR1 Gene

Domains & Families for SSTR1 Gene

Gene Families for SSTR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for SSTR1 Gene

InterPro:
Blocks:
  • Somatostatin receptor signature
  • Somatostatin receptor type 1 signature

Suggested Antigen Peptide Sequences for SSTR1 Gene

GenScript: Design optimal peptide antigens:
  • SRIF-2 (SSR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30872

UniProtKB/Swiss-Prot:

SSR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR1: view

Function for SSTR1 Gene

Molecular function for SSTR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
GENATLAS Biochemistry:
somatostatin receptor gene 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for SSTR1 Gene

Gene Ontology (GO) - Molecular Function for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004994 somatostatin receptor activity TAS,IDA 1346068
GO:0042277 peptide binding IBA 21873635
GO:0042923 neuropeptide binding IBA 21873635
genes like me logo Genes that share ontologies with SSTR1: view
genes like me logo Genes that share phenotypes with SSTR1: view

Animal Models for SSTR1 Gene

MGI Knock Outs for SSTR1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSTR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR1 Gene

Localization for SSTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSTR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSTR1: view

Pathways & Interactions for SSTR1 Gene

genes like me logo Genes that share pathways with SSTR1: view

SIGNOR curated interactions for SSTR1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007215 glutamate receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA,IBA 21873635
genes like me logo Genes that share ontologies with SSTR1: view

Drugs & Compounds for SSTR1 Gene

(50) Drugs for SSTR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pasireotide Approved Pharma Target, inhibitor, agonist 78
Octreotide Approved, Investigational Pharma binder sst2, sst3 and sst5 agonist 256
Somatostatin Approved, Investigational Pharma Target, agonist Influences growth hormone release 264
lanreotide Approved Pharma 102
Edotreotide gallium Ga-68 Approved Pharma Target, ligand 0

(8) Additional Compounds for SSTR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SOM-230
Agonist, Full agonist

(5) Tocris Compounds for SSTR1 Gene

Compound Action Cas Number
Cortistatin 14 Endogenous neuropeptide; binds sst1 - sst5 and ghrelin receptor 193829-96-8
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1

(12) ApexBio Compounds for SSTR1 Gene

Compound Action Cas Number
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1
BIM 23056 Somatostatin receptor ligand 150155-61-6
CH 275 174688-78-9
Cortistatin 14 193829-96-8
Cyclosomatostatin somatostatin receptor antagonist 84211-54-1
L-803,087 trifluoroacetate 217480-26-7
L-817,818 217480-27-8
Octreotide acetate octapeptide congener of native somatostatin 83150-76-9
Pasireotide 396091-73-9
Seglitide 81377-02-8
Somatostatin 1-28 74315-46-1
TT 232 147159-51-1
genes like me logo Genes that share compounds with SSTR1: view

Drug products for research

Transcripts for SSTR1 Gene

mRNA/cDNA for SSTR1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSTR1

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR1 Gene

No ASD Table

Relevant External Links for SSTR1 Gene

GeneLoc Exon Structure for
SSTR1

Expression for SSTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSTR1 Gene

mRNA differential expression in normal tissues according to GTEx for SSTR1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Hypothalamus (x4.9), Stomach (x4.5), and Brain - Frontal Cortex (BA9) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSTR1

SOURCE GeneReport for Unigene cluster for SSTR1 Gene:

Hs.248160

mRNA Expression by UniProt/SwissProt for SSTR1 Gene:

P30872-SSR1_HUMAN
Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Evidence on tissue expression from TISSUES for SSTR1 Gene

  • Nervous system(4.6)
  • Stomach(2.3)
  • Pancreas(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SSTR1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSTR1 Gene

Orthologs for SSTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SSTR1 29 30
  • 99.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SSTR1 29 30
  • 92.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SSTR1 29 30
  • 92.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SSTR1 30
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sstr1 29
  • 89.68 (n)
Mouse
(Mus musculus)
Mammalia Sstr1 29 16 30
  • 89.26 (n)
OneToOne
Chicken
(Gallus gallus)
Aves SS1R 30
  • 85 (a)
OneToOne
SSTR1 29
  • 83.66 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sstr1 29
  • 69.38 (n)
Zebrafish
(Danio rerio)
Actinopterygii sstr1a 29 30
  • 74.49 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6499 29
Fruit Fly
(Drosophila melanogaster)
Insecta AlCR2 31
  • 39 (a)
Drostar1 31
  • 37 (a)
Species where no ortholog for SSTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SSTR1 Gene

ENSEMBL:
Gene Tree for SSTR1 (if available)
TreeFam:
Gene Tree for SSTR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSTR1: view image
Alliance of Genome Resources:
Additional Orthologs for SSTR1

Paralogs for SSTR1 Gene

genes like me logo Genes that share paralogs with SSTR1: view

Variants for SSTR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSTR1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10130808 Benign: not provided 38,209,797(+) G/A
NM_001049.3(SSTR1):c.408G>A (p.Val136=)
SYNONYMOUS
rs146928458 Likely Benign: not provided 38,209,632(+) C/T
NM_001049.3(SSTR1):c.243C>T (p.Tyr81=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SSTR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SSTR1 Gene

Variant ID Type Subtype PubMed ID
esv3584282 CNV gain 25503493
nsv832773 CNV loss 17160897
nsv952830 CNV deletion 24416366

Variation tolerance for SSTR1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSTR1 Gene

Human Gene Mutation Database (HGMD)
SSTR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSTR1
Leiden Open Variation Database (LOVD)
SSTR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR1 Gene

Disorders for SSTR1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for SSTR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
intracranial hypertension, idiopathic
  • pseudotumor cerebri
acromegaly
  • growth hormone excess
pituitary adenoma, prolactin-secreting
  • prolactinoma, familial
primary pigmented nodular adrenocortical disease
  • ppnad
gastrinoma
  • gastrin cell tumour
- elite association - COSMIC cancer census association via MalaCards
Search SSTR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSTR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SSTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR1 Gene

Publications for SSTR1 Gene

  1. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PMID: 10734105) Schwärzler A … Richter D (The Journal of biological chemistry 2000) 3 4 22
  2. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y … Bell GI (Genomics 1993) 2 3 22
  3. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y … Seino S (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 40
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 40

Products for SSTR1 Gene

Sources for SSTR1 Gene