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Aliases for SSTR1 Gene

Aliases for SSTR1 Gene

  • Somatostatin Receptor 1 2 3 5
  • SRIF-2 3 4
  • SS-1-R 3 4
  • SS1-R 3 4
  • SS1R 3 4
  • Somatostatin Receptor Type 1 3

External Ids for SSTR1 Gene

Previous GeneCards Identifiers for SSTR1 Gene

  • GC14P036059
  • GC14P032534
  • GC14P036668
  • GC14P036667
  • GC14P037746
  • GC14P038677
  • GC14P018792

Summaries for SSTR1 Gene

Entrez Gene Summary for SSTR1 Gene

  • Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

GeneCards Summary for SSTR1 Gene

SSTR1 (Somatostatin Receptor 1) is a Protein Coding gene. Diseases associated with SSTR1 include Intracranial Hypertension, Idiopathic and Small Intestine Neuroendocrine Neoplasm. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR4.

UniProtKB/Swiss-Prot for SSTR1 Gene

  • Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Tocris Summary for SSTR1 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR1 Gene

Additional gene information for SSTR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR1 Gene

Genomics for SSTR1 Gene

GeneHancer (GH) Regulatory Elements for SSTR1 Gene

Promoters and enhancers for SSTR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I038206 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +1.1 1120 4.5 ZNF133 ZNF48 RAD21 YY1 ZNF207 SMARCC2 FOS PAF1 ZNF202 SMARCC1 GC14P038209 SSTR1 PNN CLEC14A GC14M038195
GH14I038253 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.8 +47.9 47916 4.4 CTCF FOXA2 RXRA JUN CEBPB EP300 RAD21 NR2F2 MAFF JUND CLEC14A GC14M038256 PIR37390 SSTR1
GH14I038289 Enhancer 0.9 Ensembl ENCODE 11.1 +83.1 83112 2.6 FOXA2 JUN MAX RAD21 RFX5 RCOR1 FOS NFE2L2 CHD2 TCF7L2 ENSG00000259072 CLEC14A SSTR1 PIR41157
GH14I038187 Enhancer 0.7 dbSUPER 12.3 -20.4 -20407 0.5 NFIB JUN RFX5 CTBP1 GATA3 ARID3A RCOR1 FOS FOSL2 CHD2 SSTR1 ENSG00000258649 ENSG00000259048 LOC105370456
GH14I038042 Enhancer 0.7 Ensembl ENCODE 11 -165.5 -165455 0.5 JUND JUN SMC3 FOS EP300 RAD21 SSTR1 LOC105370456 ENSG00000258649 ENSG00000259048
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSTR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSTR1 gene promoter:

Genomic Locations for SSTR1 Gene

Genomic Locations for SSTR1 Gene
5,069 bases
Plus strand

Genomic View for SSTR1 Gene

Genes around SSTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR1 Gene

Proteins for SSTR1 Gene

  • Protein details for SSTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Somatostatin receptor type 1
    Protein Accession:

    Protein attributes for SSTR1 Gene

    391 amino acids
    Molecular mass:
    42686 Da
    Quaternary structure:
    • Interacts with SKB1.

neXtProt entry for SSTR1 Gene

Post-translational modifications for SSTR1 Gene

  • Glycosylation at isoforms=4, posLast=4444, and isoforms=48
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR1 Gene

Domains & Families for SSTR1 Gene

Gene Families for SSTR1 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SSTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR1: view

Function for SSTR1 Gene

Molecular function for SSTR1 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Phenotypes From GWAS Catalog for SSTR1 Gene

Gene Ontology (GO) - Molecular Function for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004994 somatostatin receptor activity TAS,IDA 1346068
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR1: view
genes like me logo Genes that share phenotypes with SSTR1: view

Animal Models for SSTR1 Gene

MGI Knock Outs for SSTR1:

Animal Model Products

Clone Products

  • Addgene plasmids for SSTR1
  • R&D Systems cDNA Clones for SSTR1 (Somatostatin R1/SSTR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR1 Gene

Localization for SSTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1346068
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSTR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSTR1 Gene

Pathways & Interactions for SSTR1 Gene

genes like me logo Genes that share pathways with SSTR1: view

Gene Ontology (GO) - Biological Process for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 1346068
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007215 glutamate receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SSTR1: view

No data available for SIGNOR curated interactions for SSTR1 Gene

Drugs & Compounds for SSTR1 Gene

(49) Drugs for SSTR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist, Target, binder sst2, sst3 and sst5 agonist 232
Pasireotide Approved Pharma Target, inhibitor, agonist 0
lanreotide Approved Pharma Full agonist, Agonist 88
Somatostatin Approved, Investigational Pharma Influences growth hormone release 249
TT-232 Investigational Pharma 0

(8) Additional Compounds for SSTR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Full agonist, Agonist

(5) Tocris Compounds for SSTR1 Gene

Compound Action Cas Number
Cortistatin 14 Endogenous neuropeptide; binds sst1 - sst5 and ghrelin receptor 193829-96-8
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1

(14) ApexBio Compounds for SSTR1 Gene

Compound Action Cas Number
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1
BIM 23052 sst5 receptor agonist 133073-82-2
BIM 23056 Somatostatin receptor ligand 150155-61-6
CH 275 174688-78-9
Cortistatin 14 193829-96-8
Cyclosomatostatin somatostatin receptor antagonist 84211-54-1
CYN 154806 183658-72-2
L-803,087 trifluoroacetate 217480-26-7
L-817,818 217480-27-8
Octreotide acetate octapeptide congener of native somatostatin 83150-76-9
Pasireotide 396091-73-9
Seglitide 81377-02-8
Somatostatin 1-28 74315-46-1
TT 232 147159-51-1
genes like me logo Genes that share compounds with SSTR1: view

Drug Products

Transcripts for SSTR1 Gene

mRNA/cDNA for SSTR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSTR1 Gene

Somatostatin receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for SSTR1
  • R&D Systems cDNA Clones for SSTR1 (Somatostatin R1/SSTR1)

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR1 Gene

No ASD Table

Relevant External Links for SSTR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSTR1 Gene

mRNA differential expression in normal tissues according to GTEx for SSTR1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Hypothalamus (x4.9), Stomach (x4.5), and Brain - Frontal Cortex (BA9) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of SSTR1 Gene:


SOURCE GeneReport for Unigene cluster for SSTR1 Gene:


mRNA Expression by UniProt/SwissProt for SSTR1 Gene:

Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Evidence on tissue expression from TISSUES for SSTR1 Gene

  • Nervous system(4.6)
  • Stomach(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SSTR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSTR1 Gene

Orthologs for SSTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SSTR1 34 33
  • 99.57 (n)
(Bos Taurus)
Mammalia SSTR1 34 33
  • 92.65 (n)
(Canis familiaris)
Mammalia SSTR1 34 33
  • 92.22 (n)
(Monodelphis domestica)
Mammalia SSTR1 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Sstr1 33
  • 89.68 (n)
(Mus musculus)
Mammalia Sstr1 16 34 33
  • 89.26 (n)
(Gallus gallus)
Aves SS1R 34
  • 85 (a)
SSTR1 33
  • 83.66 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr1 33
  • 69.38 (n)
(Danio rerio)
Actinopterygii sstr1a 34 33
  • 74.49 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6499 33
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 35
  • 39 (a)
Drostar1 35
  • 37 (a)
Species where no ortholog for SSTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR1 Gene

Gene Tree for SSTR1 (if available)
Gene Tree for SSTR1 (if available)

Paralogs for SSTR1 Gene

genes like me logo Genes that share paralogs with SSTR1: view

Variants for SSTR1 Gene

Sequence variations from dbSNP and Humsavar for SSTR1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000372493 -- 38,211,626(+) C/T 3_prime_UTR_variant
rs1000730866 -- 38,206,324(+) A/G upstream_transcript_variant
rs1001157299 -- 38,211,932(+) A/C 3_prime_UTR_variant
rs1001204367 -- 38,206,114(+) C/G upstream_transcript_variant
rs1001377547 -- 38,211,774(+) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SSTR1 Gene

Variant ID Type Subtype PubMed ID
esv3584282 CNV gain 25503493
nsv832773 CNV loss 17160897
nsv952830 CNV deletion 24416366

Variation tolerance for SSTR1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSTR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR1 Gene

Disorders for SSTR1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SSTR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
intracranial hypertension, idiopathic
  • pseudotumor cerebri
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
intracranial hypertension
  • raised intracranial pressure
primary pigmented nodular adrenocortical disease
  • pigmented nodular adrenocortical disease, primary, 2
oncogenic osteomalacia
  • oncogenic hypophosphatemic osteomalacia
- elite association - COSMIC cancer census association via MalaCards
Search SSTR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSTR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SSTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR1 Gene

Publications for SSTR1 Gene

  1. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PMID: 10734105) Schwärzler A … Richter D (The Journal of biological chemistry 2000) 3 4 22 58
  2. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y … Bell GI (Genomics 1993) 2 3 22 58
  3. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y … Seino S (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 58
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58

Products for SSTR1 Gene

  • Addgene plasmids for SSTR1

Sources for SSTR1 Gene

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