Aliases for SSRP1 Gene
- Structure Specific Recognition Protein 1 2 3 5
- Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit 3 4
- Facilitates Chromatin Transcription Complex 80 KDa Subunit 3 4
- Facilitates Chromatin Transcription Complex Subunit SSRP1 3 4
- Recombination Signal Sequence Recognition Protein 1 3 4
- Facilitates Chromatin Remodeling 80 KDa Subunit 2 3
- FACT Complex Subunit SSRP1 3 4
- FACT 80 KDa Subunit 3 4
External Ids for SSRP1 Gene
Previous GeneCards Identifiers for SSRP1 Gene
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for SSRP1 Gene
SSRP1 (Structure Specific Recognition Protein 1) is a Protein Coding gene. Diseases associated with SSRP1 include Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked and Systemic Lupus Erythematosus. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is UBTF.
UniProtKB/Swiss-Prot Summary for SSRP1 Gene
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.