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Aliases for SSR3 Gene

Aliases for SSR3 Gene

  • Signal Sequence Receptor Subunit 3 2 3 5
  • Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma) 2 3
  • Signal Sequence Receptor Subunit Gamma 3 4
  • TRAP-Gamma 3 4
  • TRAPG 3 4
  • Translocon-Associated Protein Gamma Subunit 3
  • Translocon-Associated Protein Subunit Gamma 3
  • Translocon-Associated Protein Gamma 2
  • TRAP-Complex Gamma Subunit 3
  • SSR Gamma 3
  • SSR-Gamma 4

External Ids for SSR3 Gene

Previous GeneCards Identifiers for SSR3 Gene

  • GC03M153272
  • GC03M157205
  • GC03M157539
  • GC03M157579
  • GC03M157741
  • GC03M156257
  • GC03M153653

Summaries for SSR3 Gene

Entrez Gene Summary for SSR3 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

GeneCards Summary for SSR3 Gene

SSR3 (Signal Sequence Receptor Subunit 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation.

UniProtKB/Swiss-Prot for SSR3 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Additional gene information for SSR3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR3 Gene

Genomics for SSR3 Gene

GeneHancer (GH) Regulatory Elements for SSR3 Gene

Promoters and enhancers for SSR3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I156549 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557 +2.2 2242 6.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SSR3 GMPS CCNL1 ENSG00000272990 KCNAB1 GC03P156555 GC03M156535
GH03I156673 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -125.3 -125327 14.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 TIPARP CCNL1 LINC00886 LEKR1 SSR3 TIPARP-AS1 PIR33904 METTL15P1
GH03I157085 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -533.5 -533509 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 LINC00881 CCNL1 TIPARP-AS1 TIPARP ENSG00000241770 KRT18P34 SSR3 KCNAB1-AS1 LINC02029 LINC00880
GH03I157124 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -576.3 -576264 13.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 ZNF2 GC03M157131 KRT18P34 CCNL1 LEKR1 LINC00880 ENSG00000241770 TIPARP SSR3 TIPARP-AS1
GH03I156482 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +71.2 71160 2.9 HDGF PKNOX1 ATF1 TAF9B ZBTB40 BATF IRF4 TCF12 EGR1 ARID2 KCNAB1-AS1 SSR3 KCNAB1 TIPARP LEKR1 GC03P156486 GC03M156457
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSR3 gene promoter:

Genomic Locations for SSR3 Gene

Genomic Locations for SSR3 Gene
15,045 bases
Minus strand

Genomic View for SSR3 Gene

Genes around SSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR3 Gene

Proteins for SSR3 Gene

  • Protein details for SSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translocon-associated protein subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B2R7D0
    • B4E2P2
    • D3DNK5
    • Q549M4

    Protein attributes for SSR3 Gene

    185 amino acids
    Molecular mass:
    21080 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

    Alternative splice isoforms for SSR3 Gene


neXtProt entry for SSR3 Gene

Post-translational modifications for SSR3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SSR3 Gene

Domains & Families for SSR3 Gene

Gene Families for SSR3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SSR3 Gene


Suggested Antigen Peptide Sequences for SSR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAP-gamma family.
  • Belongs to the TRAP-gamma family.
genes like me logo Genes that share domains with SSR3: view

Function for SSR3 Gene

Molecular function for SSR3 Gene

UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Phenotypes From GWAS Catalog for SSR3 Gene

genes like me logo Genes that share phenotypes with SSR3: view

Animal Models for SSR3 Gene

MGI Knock Outs for SSR3:

Animal Model Products

CRISPR Products

miRNA for SSR3 Gene

miRTarBase miRNAs that target SSR3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSR3 Gene

Localization for SSR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSR3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

Pathways & Interactions for SSR3 Gene

genes like me logo Genes that share pathways with SSR3: view

Pathways by source for SSR3 Gene

Gene Ontology (GO) - Biological Process for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

No data available for SIGNOR curated interactions for SSR3 Gene

Drugs & Compounds for SSR3 Gene

(1) Drugs for SSR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SSR3: view

Transcripts for SSR3 Gene

Unigene Clusters for SSR3 Gene

Signal sequence receptor, gamma (translocon-associated protein gamma):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR3 Gene

No ASD Table

Relevant External Links for SSR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR3 Gene

This gene is overexpressed in Pancreas (7.2), Bone (7.0), Tlymphocyte (6.4), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSR3 Gene

Protein tissue co-expression partners for SSR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSR3 Gene:


SOURCE GeneReport for Unigene cluster for SSR3 Gene:


Evidence on tissue expression from TISSUES for SSR3 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Liver(4.4)
  • Kidney(2.7)
  • Heart(2)
genes like me logo Genes that share expression patterns with SSR3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSR3 Gene

Orthologs for SSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SSR3 33 34
  • 99.28 (n)
(Monodelphis domestica)
Mammalia SSR3 34
  • 97 (a)
(Bos Taurus)
Mammalia SSR3 33 34
  • 93.69 (n)
(Rattus norvegicus)
Mammalia Ssr3 33
  • 92.25 (n)
(Mus musculus)
Mammalia Ssr3 33 16 34
  • 91.89 (n)
(Canis familiaris)
Mammalia SSR3 33 34
  • 91.35 (n)
(Ornithorhynchus anatinus)
Mammalia SSR3 34
  • 65 (a)
(Gallus gallus)
Aves SSR3 33 34
  • 82.7 (n)
(Anolis carolinensis)
Reptilia SSR3 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr3 33
  • 79.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64286 33
(Danio rerio)
Actinopterygii ssr3 34 34
  • 94 (a)
LOC100535344 33
  • 80.54 (n)
wufb01d07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9105 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008761 33
  • 64.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK01296 35
  • 62 (a)
CG5885 33 34
  • 61.82 (n)
(Caenorhabditis elegans)
Secernentea trap-3 33 34
  • 51.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2581 34
  • 51 (a)
Species where no ortholog for SSR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR3 Gene

Gene Tree for SSR3 (if available)
Gene Tree for SSR3 (if available)

Paralogs for SSR3 Gene Pseudogenes for SSR3 Gene

genes like me logo Genes that share paralogs with SSR3: view

No data available for Paralogs for SSR3 Gene

Variants for SSR3 Gene

Sequence variations from dbSNP and Humsavar for SSR3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000170005 -- 156,545,606(-) G/A intron_variant
rs1000201899 -- 156,556,720(-) G/A upstream_transcript_variant
rs1000254328 -- 156,556,912(-) C/T upstream_transcript_variant
rs1000389941 -- 156,544,507(-) G/T intron_variant
rs1000457369 -- 156,550,969(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSR3 Gene

Variant ID Type Subtype PubMed ID
nsv829764 CNV gain 17160897

Variation tolerance for SSR3 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR3 Gene

Disorders for SSR3 Gene

Additional Disease Information for SSR3

No disorders were found for SSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSR3 Gene

Publications for SSR3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for SSR3 Gene

Sources for SSR3 Gene

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