Aliases for SSH3 Gene
External Ids for SSH3 Gene
Previous GeneCards Identifiers for SSH3 Gene
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SSH3 Gene
SSH3 (Slingshot Protein Phosphatase 3) is a Protein Coding gene. Diseases associated with SSH3 include Laurence-Moon Syndrome and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are Cytoskeletal Signaling and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot Summary for SSH3 Gene
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).