Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSH3 Gene

Aliases for SSH3 Gene

  • Slingshot Protein Phosphatase 3 2 3 5
  • SSH-Like Protein 3 3 4
  • HSSH-3L 3 4
  • SSH-3L 3 4
  • SSH3L 3 4
  • Protein Phosphatase Slingshot Homolog 3 3
  • Slingshot Homolog 3 (Drosophila) 2
  • Slingshot Homolog 3 3
  • Slingshot 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for SSH3 Gene

Previous GeneCards Identifiers for SSH3 Gene

  • GC11P066847
  • GC11P066827
  • GC11P067071
  • GC11P063400

Summaries for SSH3 Gene

Entrez Gene Summary for SSH3 Gene

  • The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SSH3 Gene

SSH3 (Slingshot Protein Phosphatase 3) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for SSH3 Gene

  • Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).

Gene Wiki entry for SSH3 Gene

Additional gene information for SSH3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH3 Gene

Genomics for SSH3 Gene

GeneHancer (GH) Regulatory Elements for SSH3 Gene

Promoters and enhancers for SSH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J067301 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 666.6 -0.4 -360 3.8 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 GLIS2 SSH3 PTPRCAP ANKRD13D GC11M067291
GH11J067116 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 19.9 -183.7 -183745 5.7 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZNF207 SP3 KDM2A ENSG00000258297 RBM14 ENSG00000254461 LOC105369352 RBM4 RAD9A RCE1 ENSG00000245156 BBS1
GH11J067364 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +67.4 67409 12.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 E2F8 ZNF143 FOS CLCF1 POLD4 SSH3 ANKRD13D PTPRCAP RHOD RAD9A NDUFS8 CDK2AP2 PPP1CA
GH11J066478 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.7 -823.1 -823105 3.3 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 MRPL11 DPP3 LOC101928069 EIF1AD ACTN3 RBM14 RBM4 PCNX3 KDM2A ENSG00000258297
GH11J067265 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.9 -25.0 -24984 25.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MEF2D SSRP1 GRK2 ANKRD13D SSH3 KDM2A PTPRCAP RHOD CARNS1 C11orf80 PC RAD9A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSH3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSH3 gene promoter:
  • Nkx2-5
  • NF-1
  • c-Ets-1
  • AREB6
  • Arnt
  • Nkx5-1
  • E47
  • SRF (504 AA)
  • YY1
  • SRF

Genomic Locations for SSH3 Gene

Genomic Locations for SSH3 Gene
chr11:67,303,448-67,312,607
(GRCh38/hg38)
Size:
9,160 bases
Orientation:
Plus strand
chr11:67,070,919-67,080,078
(GRCh37/hg19)
Size:
9,160 bases
Orientation:
Plus strand

Genomic View for SSH3 Gene

Genes around SSH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH3 Gene

Proteins for SSH3 Gene

  • Protein details for SSH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE77-SSH3_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 3
    Protein Accession:
    Q8TE77
    Secondary Accessions:
    • Q6PK42
    • Q76I75
    • Q8N9L8
    • Q8WYL0
    • Q9NV45
    • Q9NWZ7

    Protein attributes for SSH3 Gene

    Size:
    659 amino acids
    Molecular mass:
    72996 Da
    Quaternary structure:
    • Does not bind to, or colocalize with, filamentous actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Alternative splice isoforms for SSH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH3 Gene

Post-translational modifications for SSH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH3 Gene

Domains & Families for SSH3 Gene

Gene Families for SSH3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE77

UniProtKB/Swiss-Prot:

SSH3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH3: view

Function for SSH3 Gene

Molecular function for SSH3 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for SSH3 Gene

Phenotypes From GWAS Catalog for SSH3 Gene

Gene Ontology (GO) - Molecular Function for SSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SSH3: view
genes like me logo Genes that share phenotypes with SSH3: view

Animal Models for SSH3 Gene

MGI Knock Outs for SSH3:
  • Ssh3 Ssh3<tm1Taue>

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSH3 Gene

Localization for SSH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH3 Gene

Cytoplasm, cytoskeleton. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSH3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SSH3: view

Pathways & Interactions for SSH3 Gene

genes like me logo Genes that share pathways with SSH3: view

Pathways by source for SSH3 Gene

1 BioSystems pathway for SSH3 Gene
2 KEGG pathways for SSH3 Gene
1 Cell Signaling Technology pathway for SSH3 Gene

Gene Ontology (GO) - Biological Process for SSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with SSH3: view

No data available for SIGNOR curated interactions for SSH3 Gene

Drugs & Compounds for SSH3 Gene

(2) Drugs for SSH3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with SSH3: view

Transcripts for SSH3 Gene

mRNA/cDNA for SSH3 Gene

Unigene Clusters for SSH3 Gene

Slingshot protein phosphatase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSH3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9: - - -
SP10:
SP11:

ExUns: 16b ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SSH3 Gene

GeneLoc Exon Structure for
SSH3
ECgene alternative splicing isoforms for
SSH3

Expression for SSH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSH3 Gene

This gene is overexpressed in Nasal epithelium (17.1), Esophagus (7.3), and Prostate (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSH3 Gene



Protein tissue co-expression partners for SSH3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSH3 Gene:

SSH3

SOURCE GeneReport for Unigene cluster for SSH3 Gene:

Hs.29173

Evidence on tissue expression from TISSUES for SSH3 Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SSH3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSH3 Gene

Orthologs for SSH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH3 34 33
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SSH3 34 33
  • 86.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SSH3 34 33
  • 85.47 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh3 16 34 33
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Ssh3 33
  • 82.11 (n)
oppossum
(Monodelphis domestica)
Mammalia SSH3 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSH3 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH3 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488263 33
  • 56.76 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886694 33
  • 59.67 (n)
CR847496.2 34
  • 42 (a)
OneToMany
SSH3 (2 of 2) 34
  • 27 (a)
OneToMany
Species where no ortholog for SSH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH3 Gene

ENSEMBL:
Gene Tree for SSH3 (if available)
TreeFam:
Gene Tree for SSH3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSH3: view image

Paralogs for SSH3 Gene

Paralogs for SSH3 Gene

(5) SIMAP similar genes for SSH3 Gene using alignment to 6 proteins:

  • SSH3_HUMAN
  • C9JUG3_HUMAN
  • E9PIT5_HUMAN
  • E9PJJ6_HUMAN
  • E9PMS1_HUMAN
  • L8EA09_HUMAN
genes like me logo Genes that share paralogs with SSH3: view

Variants for SSH3 Gene

Sequence variations from dbSNP and Humsavar for SSH3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000378333 -- 67,301,660(+) T/C upstream_transcript_variant
rs1000876377 -- 67,311,381(+) G/C intron_variant
rs1000892802 -- 67,305,895(+) C/T intron_variant
rs1001366629 -- 67,311,234(+) C/T intron_variant
rs1001398891 -- 67,307,714(+) G/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SSH3 Gene

Variant ID Type Subtype PubMed ID
nsv468603 CNV loss 19166990
nsv555253 CNV loss 21841781

Variation tolerance for SSH3 Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSH3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSH3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH3 Gene

Disorders for SSH3 Gene

Additional Disease Information for SSH3

No disorders were found for SSH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSH3 Gene

Publications for SSH3 Gene

  1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R … Uemura T (Cell 2002) 2 3 4 58
  2. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. (PMID: 18442045) Kousaka K … Uemura T (Genesis (New York, N.Y. : 2000) 2008) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. (PMID: 14531860) Ohta Y … Mizuno K (Genes to cells : devoted to molecular & cellular mechanisms 2003) 3 4 58

Products for SSH3 Gene

Sources for SSH3 Gene

Content
Loading form....