This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for SSH2 Gene

Aliases for SSH2 Gene

  • Slingshot Protein Phosphatase 2 2 3 5
  • Protein Phosphatase Slingshot Homolog 2 3 4
  • SSH-Like Protein 2 3 4
  • KIAA1725 2 4
  • SSH-2L 3 4
  • Slingshot Homolog 2 (Drosophila) 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • HSSH-2L 4
  • SSH-2 3
  • SSH2L 4
  • SSH2 5

External Ids for SSH2 Gene

Previous GeneCards Identifiers for SSH2 Gene

  • GC17M027612
  • GC17M029853
  • GC17M027804
  • GC17M028098
  • GC17M024977
  • GC17M027952
  • GC17M024162

Summaries for SSH2 Gene

Entrez Gene Summary for SSH2 Gene

  • This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SSH2 Gene

SSH2 (Slingshot Protein Phosphatase 2) is a Protein Coding gene. Diseases associated with SSH2 include Familial Renal Oncocytoma. Among its related pathways are Axon guidance and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot Summary for SSH2 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSH2 Gene

Genomics for SSH2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SSH2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSH2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSH2

Top Transcription factor binding sites by QIAGEN in the SSH2 gene promoter:
  • AP-1
  • c-Fos
  • Egr-2
  • ER-alpha
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-1
  • HNF-1A
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SSH2 Gene

Genomic Locations for SSH2 Gene
chr17:29,625,938-29,930,276
(GRCh38/hg38)
Size:
304,339 bases
Orientation:
Minus strand
chr17:27,952,956-28,257,294
(GRCh37/hg19)
Size:
304,339 bases
Orientation:
Minus strand

Genomic View for SSH2 Gene

Genes around SSH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH2 Gene

Proteins for SSH2 Gene

  • Protein details for SSH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76I76-SSH2_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 2
    Protein Accession:
    Q76I76
    Secondary Accessions:
    • Q8TDB5
    • Q8WYL1
    • Q8WYL2
    • Q96F40
    • Q96H36
    • Q9C0D8

    Protein attributes for SSH2 Gene

    Size:
    1423 amino acids
    Molecular mass:
    158216 Da
    Quaternary structure:
    • Interacts with filamentous actin.
    SequenceCaution:
    • Sequence=AAH11636.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL92027.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Three dimensional structures from OCA and Proteopedia for SSH2 Gene

    Alternative splice isoforms for SSH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH2 Gene

Post-translational modifications for SSH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH2 Gene

Domains & Families for SSH2 Gene

Gene Families for SSH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SSH2 Gene

Suggested Antigen Peptide Sequences for SSH2 Gene

GenScript: Design optimal peptide antigens:
  • SSH-like protein 2 (SSH2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q76I76

UniProtKB/Swiss-Prot:

SSH2_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH2: view

Function for SSH2 Gene

Molecular function for SSH2 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU10044};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.

Enzyme Numbers (IUBMB) for SSH2 Gene

Phenotypes From GWAS Catalog for SSH2 Gene

Gene Ontology (GO) - Molecular Function for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA,IDA 11832213
GO:0004721 phosphoprotein phosphatase activity IBA,IDA 11832213
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SSH2: view
genes like me logo Genes that share phenotypes with SSH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSH2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSH2 Gene

Localization for SSH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSH2 gene
Compartment Confidence
cytoskeleton 5
extracellular 4
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1
endosome 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SSH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSH2 Gene

Pathways & Interactions for SSH2 Gene

genes like me logo Genes that share pathways with SSH2: view

Pathways by source for SSH2 Gene

1 Sino Biological pathway for SSH2 Gene
1 BioSystems pathway for SSH2 Gene
2 KEGG pathways for SSH2 Gene

SIGNOR curated interactions for SSH2 Gene

Activates:

Gene Ontology (GO) - Biological Process for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 11832213
GO:0016311 dephosphorylation IEA --
GO:0030036 actin cytoskeleton organization IMP 11832213
GO:0030335 positive regulation of cell migration IEA --
GO:0030837 negative regulation of actin filament polymerization IBA 21873635
genes like me logo Genes that share ontologies with SSH2: view

Drugs & Compounds for SSH2 Gene

(2) Drugs for SSH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for SSH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with SSH2: view

Transcripts for SSH2 Gene

mRNA/cDNA for SSH2 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSH2

Alternative Splicing Database (ASD) splice patterns (SP) for SSH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for SSH2 Gene

GeneLoc Exon Structure for
SSH2

Expression for SSH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSH2 Gene

This gene is overexpressed in Whole Blood (x12.5) and Muscle - Skeletal (x7.8).

Protein differential expression in normal tissues from HIPED for SSH2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.1), Pancreatic juice (14.1), Blymphocyte (7.1), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSH2 Gene



Protein tissue co-expression partners for SSH2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSH2

SOURCE GeneReport for Unigene cluster for SSH2 Gene:

Hs.654754

Evidence on tissue expression from TISSUES for SSH2 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Liver(4.2)
  • Muscle(2.6)
  • Blood(2)
genes like me logo Genes that share expression patterns with SSH2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSH2 Gene

Orthologs for SSH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SSH2 30 31
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SSH2 30 31
  • 88.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SSH2 30 31
  • 86.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ssh2 30 17 31
  • 85.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ssh2 30
  • 84.73 (n)
Oppossum
(Monodelphis domestica)
Mammalia SSH2 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SSH2 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SSH2 30 31
  • 66.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SSH2 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ssh2 30
  • 62.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii ssh2a 31
  • 48 (a)
OneToMany
ssh2b 31
  • 46 (a)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta ssh 31
  • 29 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for SSH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SSH2 Gene

ENSEMBL:
Gene Tree for SSH2 (if available)
TreeFam:
Gene Tree for SSH2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSH2: view image

Paralogs for SSH2 Gene

(7) SIMAP similar genes for SSH2 Gene using alignment to 8 proteins:

  • SSH2_HUMAN
  • F5H527_HUMAN
  • J3KSP5_HUMAN
  • J3KSQ9_HUMAN
  • K7EKN7_HUMAN
  • K7EP00_HUMAN
  • K7EQZ0_HUMAN
  • L8E929_HUMAN
genes like me logo Genes that share paralogs with SSH2: view

Variants for SSH2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSH2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
768866 Benign: not provided 29,672,000(-) A/G SYNONYMOUS_VARIANT
778686 Benign: not provided 29,631,772(-) G/C MISSENSE_VARIANT
781361 Benign: not provided 29,630,850(-) A/G SYNONYMOUS_VARIANT
781362 Benign: not provided 29,631,179(-) C/T MISSENSE_VARIANT
rs2289629 - p.Ser743Leu

Additional dbSNP identifiers (rs#s) for SSH2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SSH2 Gene

Variant ID Type Subtype PubMed ID
dgv410e201 CNV deletion 23290073
esv2666488 CNV deletion 23128226
esv2715798 CNV deletion 23290073
esv2715800 CNV deletion 23290073
esv2715802 CNV deletion 23290073
esv2715803 CNV deletion 23290073
esv2715804 CNV deletion 23290073
esv3332072 CNV insertion 20981092
esv3554301 CNV deletion 23714750
esv3640329 CNV loss 21293372
esv9716 CNV gain 19470904
nsv1109064 CNV deletion 24896259
nsv1109065 CNV deletion 24896259
nsv1123121 CNV deletion 24896259
nsv112489 CNV deletion 16902084
nsv1152451 CNV deletion 26484159
nsv442415 CNV loss 18776908
nsv507838 OTHER sequence alteration 20534489
nsv514833 CNV loss 21397061
nsv833409 CNV gain 17160897
nsv833410 CNV loss 17160897
nsv953875 CNV duplication 24416366
nsv962302 CNV duplication 23825009
nsv978403 CNV duplication 23825009

Variation tolerance for SSH2 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSH2 Gene

Human Gene Mutation Database (HGMD)
SSH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSH2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH2 Gene

Disorders for SSH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSH2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial renal oncocytoma
- elite association - COSMIC cancer census association via MalaCards
Search SSH2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SSH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSH2 Gene

Publications for SSH2 Gene

  1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R … Uemura T (Cell 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  3. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PMID: 20477815) Song SY … Lee SH (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010) 3 41
  4. Crystal structure of human slingshot phosphatase 2. (PMID: 17427953) Jung SK … Kim SJ (Proteins 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SSH2 Gene

Sources for SSH2 Gene