Aliases for SSH2 Gene
External Ids for SSH2 Gene
Previous GeneCards Identifiers for SSH2 Gene
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for SSH2 Gene
SSH2 (Slingshot Protein Phosphatase 2) is a Protein Coding gene. Diseases associated with SSH2 include Familial Renal Oncocytoma. Among its related pathways are Axon guidance and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot Summary for SSH2 Gene
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.