Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSH1 Gene

Aliases for SSH1 Gene

  • Slingshot Protein Phosphatase 1 2 3 5
  • SSH-Like Protein 1 3 4
  • HSSH-1L 3 4
  • SSH1L 3 4
  • Protein Phosphatase Slingshot Homolog 1 3
  • Slingshot Homolog 1 (Drosophila) 2
  • Slingshot Homolog 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1298 4
  • SSH-1L 4

External Ids for SSH1 Gene

Previous GeneCards Identifiers for SSH1 Gene

  • GC12M108286
  • GC12M109057
  • GC12M109111
  • GC12M107681
  • GC12M107683
  • GC12M107705
  • GC12M109180
  • GC12M106241
  • GC12M108779
  • GC12M108780
  • GC12M108781
  • GC12M108782
  • GC12M108783
  • GC12M108784
  • GC12M108785
  • GC12M108786

Summaries for SSH1 Gene

Entrez Gene Summary for SSH1 Gene

  • The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SSH1 Gene

SSH1 (Slingshot Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with SSH1 include Porokeratosis and Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease. Among its related pathways are Cytoskeletal Signaling and FGF signaling pathway. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH2.

UniProtKB/Swiss-Prot for SSH1 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH1 Gene

Additional gene information for SSH1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH1 Gene

Genomics for SSH1 Gene

GeneHancer (GH) Regulatory Elements for SSH1 Gene

Promoters and enhancers for SSH1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108849 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.9 +3.2 3211 9.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZBTB7B IRF4 ZNF766 ZNF213 CORO1C SSH1 SART3 ALKBH2 UBE3B ENSG00000257221 SELPLG DAO MIR619
GH12J108820 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +25.9 25879 23.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 ZNF766 SART3 UBE3B SSH1 CORO1C LINC01486 LOC644746 RNU4-32P SELPLG ALKBH2 ACACB
GH12J108726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +126.5 126485 9.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC CORO1C LOC101929162 RNU4-32P RNU7-169P SSH1 SART3 SELPLG UBE3B PRDM4 ENSG00000257221
GH12J108663 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +191.6 191573 5.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 CORO1C SELPLG SSH1 SART3 ISCU ENSG00000257221 MVK ACACB GC12P108669 RNU7-169P
GH12J108797 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.6 +54.7 54662 10 HDGF FOXA2 ARNT ARID4B SIN3A ZNF2 IRF4 ARID2 ZNF143 FOS LOC101929204 CORO1C SSH1 MIR619 SELPLG RNU7-169P TMEM119 ACACB ENSG00000257221 ENSG00000274598
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSH1 gene promoter:
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Egr-4

Genomic Locations for SSH1 Gene

Genomic Locations for SSH1 Gene
chr12:108,778,192-108,857,590
(GRCh38/hg38)
Size:
79,399 bases
Orientation:
Minus strand
chr12:109,176,466-109,251,366
(GRCh37/hg19)
Size:
74,901 bases
Orientation:
Minus strand

Genomic View for SSH1 Gene

Genes around SSH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH1 Gene

Proteins for SSH1 Gene

  • Protein details for SSH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYL5-SSH1_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 1
    Protein Accession:
    Q8WYL5
    Secondary Accessions:
    • Q6P6C0
    • Q8N9A7
    • Q8WYL3
    • Q8WYL4
    • Q9P2P8

    Protein attributes for SSH1 Gene

    Size:
    1049 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.
    SequenceCaution:
    • Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH1 Gene

Post-translational modifications for SSH1 Gene

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH1 Gene

Domains & Families for SSH1 Gene

Gene Families for SSH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYL5

UniProtKB/Swiss-Prot:

SSH1_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH1: view

Function for SSH1 Gene

Molecular function for SSH1 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for SSH1 Gene

Phenotypes From GWAS Catalog for SSH1 Gene

Gene Ontology (GO) - Molecular Function for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IDA 11832213
GO:0004721 phosphoprotein phosphatase activity IMP 19000834
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15159416
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with SSH1: view
genes like me logo Genes that share phenotypes with SSH1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH1

miRNA for SSH1 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSH1 Gene

Localization for SSH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH1 Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSH1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 14645219
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 14645219
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SSH1: view

Pathways & Interactions for SSH1 Gene

genes like me logo Genes that share pathways with SSH1: view

Pathways by source for SSH1 Gene

1 Cell Signaling Technology pathway for SSH1 Gene

SIGNOR curated interactions for SSH1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IMP 14645219
GO:0006470 protein dephosphorylation IMP 11832213
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with SSH1: view

Drugs & Compounds for SSH1 Gene

(2) Drugs for SSH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for SSH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with SSH1: view

Transcripts for SSH1 Gene

Unigene Clusters for SSH1 Gene

Slingshot protein phosphatase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SSH1 Gene

GeneLoc Exon Structure for
SSH1
ECgene alternative splicing isoforms for
SSH1

Expression for SSH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSH1 Gene

This gene is overexpressed in Spinal cord (35.4), Peripheral blood mononuclear cells (10.1), and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSH1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SSH1 Gene:

SSH1

SOURCE GeneReport for Unigene cluster for SSH1 Gene:

Hs.199763

Evidence on tissue expression from TISSUES for SSH1 Gene

  • Nervous system(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(2)
genes like me logo Genes that share expression patterns with SSH1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSH1 Gene

Orthologs for SSH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH1 33
  • 97.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SSH1 34 33
  • 86.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SSH1 34 33
  • 83.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh1 16 34 33
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Ssh1 33
  • 81.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSH1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSH1 34 33
  • 71.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh1 33
  • 63.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia SSH 33
zebrafish
(Danio rerio)
Actinopterygii LOC101885659 33
  • 65.29 (n)
ssh1b 34
  • 53 (a)
OneToMany
ssh1a 34
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ssh 34 35
  • 27 (a)
OneToMany
Species where no ortholog for SSH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH1 Gene

ENSEMBL:
Gene Tree for SSH1 (if available)
TreeFam:
Gene Tree for SSH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSH1: view image

Paralogs for SSH1 Gene

Paralogs for SSH1 Gene

(7) SIMAP similar genes for SSH1 Gene using alignment to 4 proteins:

  • SSH1_HUMAN
  • F8VS18_HUMAN
  • F8W1D9_HUMAN
  • H0YHR3_HUMAN
genes like me logo Genes that share paralogs with SSH1: view

Variants for SSH1 Gene

Sequence variations from dbSNP and Humsavar for SSH1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000031909 -- 108,814,119(-) G/A intron_variant
rs1000047329 -- 108,811,840(-) T/C intron_variant
rs1000077143 -- 108,853,453(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000107067 -- 108,813,611(-) G/C intron_variant
rs1000199344 -- 108,805,850(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSH1 Gene

Variant ID Type Subtype PubMed ID
dgv864n106 CNV deletion 24896259
dgv865n106 CNV deletion 24896259
esv24121 CNV loss 19812545
esv2422361 CNV duplication 17116639
esv2763002 CNV gain 21179565
esv3370337 CNV insertion 20981092
nsv1070125 CNV deletion 25765185
nsv1071053 CNV deletion 25765185
nsv1119430 CNV insertion 24896259
nsv1145620 CNV deletion 24896259
nsv952472 CNV deletion 24416366
nsv952473 CNV deletion 24416366
nsv976026 CNV duplication 23825009

Variation tolerance for SSH1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSH1 Gene

Human Gene Mutation Database (HGMD)
SSH1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSH1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH1 Gene

Disorders for SSH1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSH1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
porokeratosis
  • porokeratosis of mibelli
polycystic kidney disease 3 with or without polycystic liver disease
  • pkd3
- elite association - COSMIC cancer census association via MalaCards
Search SSH1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSH1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SSH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSH1 Gene

Publications for SSH1 Gene

  1. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PMID: 16230460) Nishita M … Mizuno K (The Journal of cell biology 2005) 3 4 22 58
  2. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PMID: 15671020) Wang Y … Mizuno K (The Journal of biological chemistry 2005) 3 4 22 58
  3. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PMID: 15660133) Soosairajah J … Bernard O (The EMBO journal 2005) 3 4 22 58
  4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PMID: 15159416) Nagata-Ohashi K … Mizuno K (The Journal of cell biology 2004) 3 4 22 58
  5. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PMID: 12807904) Kaji N … Mizuno K (The Journal of biological chemistry 2003) 3 4 22 58

Products for SSH1 Gene

Sources for SSH1 Gene

Content
Loading form....