Aliases for SSH1 Gene
External Ids for SSH1 Gene
Previous GeneCards Identifiers for SSH1 Gene
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for SSH1 Gene
SSH1 (Slingshot Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with SSH1 include Porokeratosis and Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease. Among its related pathways are Axon guidance and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH2.
UniProtKB/Swiss-Prot Summary for SSH1 Gene
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.