Aliases for SSBP4 Gene

Aliases for SSBP4 Gene

  • Single Stranded DNA Binding Protein 4 2 3 5
  • Single-Stranded DNA-Binding Protein 4 3 4

External Ids for SSBP4 Gene

Previous GeneCards Identifiers for SSBP4 Gene

  • GC19P019023
  • GC19P018922
  • GC19P018375
  • GC19P018391
  • GC19P018531
  • GC19P018093
  • GC19P018644

Summaries for SSBP4 Gene

GeneCards Summary for SSBP4 Gene

SSBP4 (Single Stranded DNA Binding Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP3.

Additional gene information for SSBP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSBP4 Gene

Genomics for SSBP4 Gene

GeneHancer (GH) Regulatory Elements for SSBP4 Gene

Promoters and enhancers for SSBP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSBP4 gene promoter:
  • AP-4
  • Egr-4
  • FOXO1
  • FOXO1a
  • HOXA5
  • Olf-1
  • p300
  • RFX1
  • Sp1
  • STAT3

Genomic Locations for SSBP4 Gene

Genomic Locations for SSBP4 Gene
chr19:18,418,661-18,434,562
(GRCh38/hg38)
Size:
15,902 bases
Orientation:
Plus strand
chr19:18,529,674-18,545,372
(GRCh37/hg19)
Size:
15,699 bases
Orientation:
Plus strand

Genomic View for SSBP4 Gene

Genes around SSBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP4 Gene

Proteins for SSBP4 Gene

  • Protein details for SSBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWG4-SSBP4_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 4
    Protein Accession:
    Q9BWG4
    Secondary Accessions:
    • Q9BWW5

    Protein attributes for SSBP4 Gene

    Size:
    385 amino acids
    Molecular mass:
    39388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP4 Gene

Post-translational modifications for SSBP4 Gene

  • Glycosylation at Asn327
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SSBP4_HUMAN (2076)

No data available for DME Specific Peptides for SSBP4 Gene

Domains & Families for SSBP4 Gene

Gene Families for SSBP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSBP4 Gene

GenScript: Design optimal peptide antigens:
  • Single-stranded DNA-binding protein 4 (SSBP4_HUMAN)
genes like me logo Genes that share domains with SSBP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SSBP4 Gene

Function for SSBP4 Gene

Phenotypes From GWAS Catalog for SSBP4 Gene

Gene Ontology (GO) - Molecular Function for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SSBP4: view
genes like me logo Genes that share phenotypes with SSBP4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP4 Gene

Localization for SSBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP4 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSBP4 Gene

Pathways & Interactions for SSBP4 Gene

PathCards logo

SuperPathways for SSBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with SSBP4: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP4 Gene

Drugs & Compounds for SSBP4 Gene

No Compound Related Data Available

Transcripts for SSBP4 Gene

mRNA/cDNA for SSBP4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^
SP1: - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - - -
SP11: - -
SP12: - - - - -
SP13:
SP14:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SSBP4 Gene

GeneLoc Exon Structure for
SSBP4
ECgene alternative splicing isoforms for
SSBP4

Expression for SSBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSBP4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSBP4 Gene



Protein tissue co-expression partners for SSBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSBP4 Gene:

SSBP4

SOURCE GeneReport for Unigene cluster for SSBP4 Gene:

Hs.515259

Evidence on tissue expression from TISSUES for SSBP4 Gene

  • Eye(4.2)
  • Nervous system(3.2)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with SSBP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP4 Gene

Orthologs for SSBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSBP4 33 32
  • 98.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SSBP4 33 32
  • 91.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SSBP4 33 32
  • 90.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp4 17 33 32
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Ssbp4 32
  • 85.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP4 33
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSBP4 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488961 32
  • 72.33 (n)
zebrafish
(Danio rerio)
Actinopterygii SSBP4 (2 of 2) 33
  • 74 (a)
OneToMany
ssbp4 33 32
  • 73.09 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 33
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 33
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 33
  • 54 (a)
OneToMany
Species where no ortholog for SSBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP4 Gene

ENSEMBL:
Gene Tree for SSBP4 (if available)
TreeFam:
Gene Tree for SSBP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSBP4: view image

Paralogs for SSBP4 Gene

Paralogs for SSBP4 Gene

(3) SIMAP similar genes for SSBP4 Gene using alignment to 8 proteins:

  • SSBP4_HUMAN
  • M0R338_HUMAN
  • U3KPY3_HUMAN
  • U3KQ46_HUMAN
  • U3KQ98_HUMAN
  • U3KQN6_HUMAN
  • U3KQP2_HUMAN
  • V9GYB2_HUMAN
genes like me logo Genes that share paralogs with SSBP4: view

Variants for SSBP4 Gene

Sequence variations from dbSNP and Humsavar for SSBP4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000114419 -- 18,427,552(+) G/A intron_variant
rs1000183561 -- 18,424,730(+) G/A/C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000188673 -- 18,426,364(+) G/A intron_variant
rs1000197673 -- 18,421,901(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000212910 -- 18,424,888(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP4 Gene

Variant ID Type Subtype PubMed ID
esv2677302 CNV deletion 23128226
nsv1072337 CNV deletion 25765185
nsv1144870 CNV deletion 24896259
nsv952420 CNV deletion 24416366

Variation tolerance for SSBP4 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP4 Gene

Disorders for SSBP4 Gene

Additional Disease Information for SSBP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP4 Gene

Publications for SSBP4 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P … Nagarajan L (Genomics 2002) 2 3 4 56
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for SSBP4 Gene

Sources for SSBP4 Gene