SSBP3 Gene (Protein Coding)

Single Stranded DNA Binding Protein 3

GC01M054225
GIFtS:
38
See more...

Aliases for SSBP3 Gene

Aliases for SSBP3 Gene

  • Single Stranded DNA Binding Protein 3 2 3 5
  • Single-Stranded DNA-Binding Protein 3 2 3 4
  • SSDP1 2 3 4
  • SSDP 2 3 4
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 3 4
  • CSDP 2 3
  • FLJ10355 2
  • SSBP3 5

External Ids for SSBP3 Gene

Previous GeneCards Identifiers for SSBP3 Gene

  • GC01M054521
  • GC01M053580
  • GC01M054049
  • GC01M054062
  • GC01M054404
  • GC01M054464
  • GC01M054692
  • GC01M052807

Summaries for SSBP3 Gene

GeneCards Summary for SSBP3 Gene

SSBP3 (Single Stranded DNA Binding Protein 3) is a Protein Coding gene. Diseases associated with SSBP3 include Prostate Carcinoma In Situ and Panhypopituitarism, X-Linked. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot Summary for SSBP3 Gene

  • May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Wiki entry for SSBP3 Gene

Additional gene information for SSBP3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSBP3 Gene

Genomics for SSBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SSBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSBP3

Top Transcription factor binding sites by QIAGEN in the SSBP3 gene promoter:
  • E2F-1
  • E2F-2
  • GATA-1

Genomic Locations for SSBP3 Gene

Latest Assembly
chr1:54,225,432-54,413,479
(GRCh38/hg38)
Size:
188,048 bases
Orientation:
Minus strand

Previous Assembly
chr1:54,691,105-54,872,067
(GRCh37/hg19 by Entrez Gene)
Size:
180,963 bases
Orientation:
Minus strand

chr1:54,691,105-54,879,152
(GRCh37/hg19 by Ensembl)
Size:
188,048 bases
Orientation:
Minus strand

Genomic View for SSBP3 Gene

Genes around SSBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SSBP3 Gene

Proteins for SSBP3 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SSBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW4-SSBP3_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 3
    Protein Accession:
    Q9BWW4
    Secondary Accessions:
    • A8K0A9
    • Q5T860
    • Q5T861
    • Q9BTM0
    • Q9BWW3

    Protein attributes for SSBP3 Gene

    Size:
    388 amino acids
    Molecular mass:
    40421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP3 Gene

Protein Expression for SSBP3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SSBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSBP3 Gene

Domains & Families for SSBP3 Gene

Gene Families for SSBP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SSBP3 Gene

InterPro:
Blocks:
  • Lissencephaly type-1-like homology motif
  • Single-stranded DNA-binding protein, SSDP

Suggested Antigen Peptide Sequences for SSBP3 Gene

GenScript: Design optimal peptide antigens:
  • Single stranded DNA binding protein 3 (Q5T862_HUMAN)
  • Single stranded DNA binding protein 3 (Q5T863_HUMAN)
  • Single stranded DNA binding protein 3 (Q5T864_HUMAN)
  • Single stranded DNA binding protein 3 (Q5T865_HUMAN)
  • SSBP3 protein (Q9BT57_HUMAN)
genes like me logo Genes that share domains with SSBP3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SSBP3 Gene

Function for SSBP3 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for SSBP3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Phenotypes From GWAS Catalog for SSBP3 Gene

Gene Ontology (GO) - Molecular Function for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IEA,IPI 18330356
genes like me logo Genes that share ontologies with SSBP3: view
genes like me logo Genes that share phenotypes with SSBP3: view

Animal Models for research

miRNA for SSBP3 Gene

miRTarBase miRNAs that target SSBP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSBP3

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP3 Gene

Localization for SSBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP3 gene
Compartment Confidence
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005667 transcription factor complex IEA --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with SSBP3: view

Pathways & Interactions for SSBP3 Gene

PathCards logo

SuperPathways for SSBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0021501 prechordal plate formation IEA --
GO:0021547 midbrain-hindbrain boundary initiation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP3 Gene

Drugs & Compounds for SSBP3 Gene

Products:

  1. Drug products for research

(13) Drugs for SSBP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SSBP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SSBP3: view

Transcripts for SSBP3 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for SSBP3 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSBP3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:

Relevant External Links for SSBP3 Gene

GeneLoc Exon Structure for
SSBP3

Expression for SSBP3 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSBP3 Gene

mRNA expression in normal human tissues for SSBP3 Gene
mRNA expression by BioGPS for SSBP3 GenemRNA expression by GTEx for SSBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP3 Gene

This gene is overexpressed in NK cells (13.2), Uterus (10.9), Tlymphocyte (10.3), Ovary (10.1), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSBP3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSBP3

SOURCE GeneReport for Unigene cluster for SSBP3 Gene:

Hs.658676

mRNA Expression by UniProt/SwissProt for SSBP3 Gene:

Q9BWW4-SSBP3_HUMAN
Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Evidence on tissue expression from TISSUES for SSBP3 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Eye(4.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with SSBP3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP3 Gene

Orthologs for SSBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia SSBP3 29 30
  • 96.39 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ssbp3 29 16 30
  • 95.36 (n)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia SSBP3 29 30
  • 94.85 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ssbp3 29
  • 94.83 (n)
Dog
(Canis familiaris)
 Mammalia SSBP3 29 30
  • 94.57 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SSBP3 30
  • 77 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SSBP3 29 30
  • 85.69 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SSBP3 30
  • 95 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ssbp3 29
  • 80.68 (n)
MGC75859 29
African clawed frog
(Xenopus laevis)
 Amphibia ssbp3-prov 29
Zebrafish
(Danio rerio)
 Actinopterygii ssbp3b 30
  • 81 (a)
 OneToMany
ssbp3a 29 30
  • 76.75 (n)
 OneToMany
Dr.28337 29
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP010909 29
  • 62.99 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Ssdp 29 30
  • 55.92 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea sam-10 30
  • 22 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.102 30
  • 60 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.4608 29
Species where no ortholog for SSBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SSBP3 Gene

ENSEMBL:
Gene Tree for SSBP3 (if available)
TreeFam:
Gene Tree for SSBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSBP3: view image
Alliance of Genome Resources:
Additional Orthologs for SSBP3

Paralogs for SSBP3 Gene

Paralogs for SSBP3 Gene

(3) SIMAP similar genes for SSBP3 Gene using alignment to 5 proteins:

  • SSBP3_HUMAN
  • E9PK49_HUMAN
  • Q5T863_HUMAN
  • Q9BT57_HUMAN
  • Q9NW25_HUMAN

Pseudogenes.org Pseudogenes for SSBP3 Gene

genes like me logo Genes that share paralogs with SSBP3: view

Variants for SSBP3 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SSBP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SSBP3 Gene

Variant ID Type Subtype PubMed ID
esv2748308 CNV deletion 23290073
esv3423065 CNV duplication 20981092
esv3586088 CNV loss 21293372
nsv1078412 CNV deletion 25765185
nsv1078417 CNV deletion 25765185
nsv1112532 CNV deletion 24896259
nsv1112533 CNV deletion 24896259
nsv1118119 CNV deletion 24896259
nsv1122346 CNV deletion 24896259
nsv461550 CNV loss 19166990
nsv461561 CNV gain 19166990
nsv470713 CNV loss 18288195
nsv472617 CNV novel sequence insertion 20440878
nsv509291 CNV insertion 20534489
nsv546266 CNV gain 21841781
nsv822631 CNV gain 20364138
nsv829893 CNV loss 17160897

Variation tolerance for SSBP3 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP3
Leiden Open Variation Database (LOVD)
SSBP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSBP3 Gene

Disorders for SSBP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SSBP3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
prostate carcinoma in situ
  • carcinoma in situ of prostate
panhypopituitarism, x-linked
  • phpx
ring dermoid of cornea
  • rdc
xeroderma pigmentosum group e
  • xeroderma pigmentosum v
cockayne syndrome
  • cockayne's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SSBP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSBP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SSBP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSBP3 Gene

Publications for SSBP3 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P … Nagarajan L (Genomics 2002) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PMID: 10524251) Raval-Fernandes S … Rome LH (Gene 1999) 3 22

ExternalLinks

View latest publications for SSBP3 gene in Mastermind

Products for SSBP3 Gene

Sources for SSBP3 Gene