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Aliases for SSBP3 Gene

Aliases for SSBP3 Gene

  • Single Stranded DNA Binding Protein 3 2 3 5
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 3 4
  • Single-Stranded DNA-Binding Protein 3 2 3
  • SSDP1 3 4
  • SSDP 3 4
  • CSDP 3

External Ids for SSBP3 Gene

Previous GeneCards Identifiers for SSBP3 Gene

  • GC01M054521
  • GC01M053580
  • GC01M054049
  • GC01M054062
  • GC01M054404
  • GC01M054464
  • GC01M054692
  • GC01M052807

Summaries for SSBP3 Gene

GeneCards Summary for SSBP3 Gene

SSBP3 (Single Stranded DNA Binding Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot for SSBP3 Gene

  • May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Wiki entry for SSBP3 Gene

Additional gene information for SSBP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP3 Gene

Genomics for SSBP3 Gene

GeneHancer (GH) Regulatory Elements for SSBP3 Gene

Promoters and enhancers for SSBP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I054403 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 551.9 +6.6 6573 7.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 SSBP3 PIR46432 ENSG00000225632 SSBP3-AS1 TCEANC2 TMEM59 ENSG00000230728 GC01M054384
GH01I054411 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +1.6 1641 0.9 HDGF PKNOX1 ATF1 ZNF384 E4F1 POLR2A ATF7 SMARCE1 ZNF639 SOX6 SSBP3 PIR46432
GH01I054413 Enhancer 1 Ensembl ENCODE dbSUPER 550.8 -0.1 -86 1.1 USF1 TFE3 ZNF449 KLF17 MAX NR2F2 GABPA ZBTB48 PRDM10 SSBP3 ENSG00000232245
GH01I054271 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +136.9 136944 10.6 HDGF FOXA2 PKNOX1 ARNT FEZF1 ZNF2 YY1 CBX5 ZNF213 E2F8 SSBP3-AS1 ENSG00000256407 SSBP3 TMEM59 HSPB11 CYB5RL NDC1 TCEANC2 ENSG00000237453 TTC22
GH01I054486 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -75.3 -75337 4.8 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF213 ZNF207 SSBP3 TTC22 ENSG00000237453 TCEANC2 LOC105378735 ENSG00000232245
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSBP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSBP3 gene promoter:

Genomic Locations for SSBP3 Gene

Genomic Locations for SSBP3 Gene
188,055 bases
Minus strand

Genomic View for SSBP3 Gene

Genes around SSBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP3 Gene

Proteins for SSBP3 Gene

  • Protein details for SSBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-stranded DNA-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K0A9
    • Q5T860
    • Q5T861
    • Q9BTM0
    • Q9BWW3

    Protein attributes for SSBP3 Gene

    388 amino acids
    Molecular mass:
    40421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP3 Gene


neXtProt entry for SSBP3 Gene

Post-translational modifications for SSBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP3 Gene

Domains & Families for SSBP3 Gene

Gene Families for SSBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSBP3: view

No data available for UniProtKB/Swiss-Prot for SSBP3 Gene

Function for SSBP3 Gene

Molecular function for SSBP3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Phenotypes From GWAS Catalog for SSBP3 Gene

Gene Ontology (GO) - Molecular Function for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 18330356
genes like me logo Genes that share ontologies with SSBP3: view
genes like me logo Genes that share phenotypes with SSBP3: view

Animal Model Products

CRISPR Products

miRNA for SSBP3 Gene

miRTarBase miRNAs that target SSBP3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP3 Gene

Localization for SSBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSBP3 Gene

Pathways & Interactions for SSBP3 Gene

SuperPathways for SSBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP3 Gene

Drugs & Compounds for SSBP3 Gene

(13) Drugs for SSBP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SSBP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SSBP3: view

Transcripts for SSBP3 Gene

mRNA/cDNA for SSBP3 Gene

(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSBP3 Gene

Single stranded DNA binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -

Relevant External Links for SSBP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP3 Gene

This gene is overexpressed in NK cells (13.2), Uterus (10.9), Tlymphocyte (10.3), Ovary (10.1), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSBP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSBP3 Gene:


SOURCE GeneReport for Unigene cluster for SSBP3 Gene:


mRNA Expression by UniProt/SwissProt for SSBP3 Gene:

Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Evidence on tissue expression from TISSUES for SSBP3 Gene

  • Nervous system(4.5)
  • Eye(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SSBP3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP3 Gene

Orthologs for SSBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SSBP3 33 34
  • 96.39 (n)
(Mus musculus)
Mammalia Ssbp3 33 16 34
  • 95.36 (n)
(Pan troglodytes)
Mammalia SSBP3 33 34
  • 94.85 (n)
(Rattus norvegicus)
Mammalia Ssbp3 33
  • 94.83 (n)
(Canis familiaris)
Mammalia SSBP3 33 34
  • 94.57 (n)
(Ornithorhynchus anatinus)
Mammalia SSBP3 34
  • 77 (a)
(Gallus gallus)
Aves SSBP3 33 34
  • 85.69 (n)
(Anolis carolinensis)
Reptilia SSBP3 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp3 33
  • 80.68 (n)
MGC75859 33
African clawed frog
(Xenopus laevis)
Amphibia ssbp3-prov 33
(Danio rerio)
Actinopterygii ssbp3b 34
  • 81 (a)
ssbp3a 33 34
  • 76.75 (n)
Dr.28337 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010909 33
  • 62.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 33 34
  • 55.92 (n)
(Caenorhabditis elegans)
Secernentea sam-10 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 34
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4608 33
Species where no ortholog for SSBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP3 Gene

Gene Tree for SSBP3 (if available)
Gene Tree for SSBP3 (if available)

Paralogs for SSBP3 Gene

Paralogs for SSBP3 Gene

(3) SIMAP similar genes for SSBP3 Gene using alignment to 5 proteins: Pseudogenes for SSBP3 Gene

genes like me logo Genes that share paralogs with SSBP3: view

Variants for SSBP3 Gene

Sequence variations from dbSNP and Humsavar for SSBP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016002 -- 54,394,954(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000024669 -- 54,240,177(-) G/A intron_variant
rs1000032209 -- 54,283,237(-) C/T intron_variant
rs1000038275 -- 54,245,596(-) A/T intron_variant
rs1000044496 -- 54,349,253(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP3 Gene

Variant ID Type Subtype PubMed ID
esv2748308 CNV deletion 23290073
esv3423065 CNV duplication 20981092
esv3586088 CNV loss 21293372
nsv1078412 CNV deletion 25765185
nsv1078417 CNV deletion 25765185
nsv1112532 CNV deletion 24896259
nsv1112533 CNV deletion 24896259
nsv1118119 CNV deletion 24896259
nsv1122346 CNV deletion 24896259
nsv461550 CNV loss 19166990
nsv461561 CNV gain 19166990
nsv470713 CNV loss 18288195
nsv472617 CNV novel sequence insertion 20440878
nsv509291 CNV insertion 20534489
nsv546266 CNV gain 21841781
nsv822631 CNV gain 20364138
nsv829893 CNV loss 17160897

Variation tolerance for SSBP3 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP3 Gene

Disorders for SSBP3 Gene

Additional Disease Information for SSBP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP3 Gene

Publications for SSBP3 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P … Nagarajan L (Genomics 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PMID: 10524251) Raval-Fernandes S … Rome LH (Gene 1999) 3 22 58

Products for SSBP3 Gene

Sources for SSBP3 Gene

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