This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016] See more...

Aliases for SSBP2 Gene

Aliases for SSBP2 Gene

  • Single Stranded DNA Binding Protein 2 2 3 5
  • Single-Stranded DNA-Binding Protein 2 2 3 4
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 2 3 4
  • Single-Stranded DNA Binding Protein 2 2
  • HSPC116 3
  • SOSS-B2 3
  • SSDP2 4

External Ids for SSBP2 Gene

Previous GeneCards Identifiers for SSBP2 Gene

  • GC05M079501
  • GC05M080954
  • GC05M080754
  • GC05M080799
  • GC05M080751
  • GC05M075924

Summaries for SSBP2 Gene

Entrez Gene Summary for SSBP2 Gene

  • This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for SSBP2 Gene

SSBP2 (Single Stranded DNA Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP3.

Gene Wiki entry for SSBP2 Gene

Additional gene information for SSBP2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSBP2 Gene

Genomics for SSBP2 Gene

GeneHancer (GH) Regulatory Elements for SSBP2 Gene

Promoters and enhancers for SSBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J081748 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.3 1258 4.5 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 SP1 GTF2E2 SSBP2 lnc-ATG10-7 lnc-SSBP2-5 ZCCHC9 RPS23 ENSG00000248794 ATG10 RF00994-844
GH05J081753 Enhancer 0.4 dbSUPER 500.7 -1.8 -1843 0.5 USF1 RELA EHMT2 MNT MAX SSBP2 lnc-SSBP2-5 HSALNG0043044
GH05J081849 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.5 -100.2 -100197 4.8 RXRA ZNF217 EP300 NRF1 TCF12 USF1 SP1 BCLAF1 GTF2E2 JUND ENSG00000249483 ZCCHC9 ATP6AP1L SSBP2 PPIAP11 piR-44878-006 RF00017-4771
GH05J081735 Enhancer 0.9 Ensembl 10.3 +15.6 15571 0.4 ZSCAN5C ZNF300 RBAK ZNF510 ZNF662 ZEB1 RBM25 OSR2 ZNF491 ZNF132 ENSG00000248794 ATP6AP1L CKMT2-AS1 ZCCHC9 ATG10 SSBP2 lnc-SSBP2-5 lnc-ATG10-7 RF00994-844
GH05J081638 Enhancer 0.6 Ensembl dbSUPER 12.5 +112.5 112496 1.4 ATF4 ATF2 ZBTB33 ATF3 SSBP2 RF00017-4770 RF00994-844 lnc-SSBP2-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSBP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSBP2

Top Transcription factor binding sites by QIAGEN in the SSBP2 gene promoter:
  • COMP1
  • ER-alpha
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GATA-1
  • LUN-1

Genomic Locations for SSBP2 Gene

Genomic Locations for SSBP2 Gene
chr5:81,413,021-81,751,797
(GRCh38/hg38)
Size:
338,777 bases
Orientation:
Minus strand
chr5:80,708,840-81,047,616
(GRCh37/hg19)
Size:
338,777 bases
Orientation:
Minus strand

Genomic View for SSBP2 Gene

Genes around SSBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP2 Gene

Proteins for SSBP2 Gene

  • Protein details for SSBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81877-SSBP2_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 2
    Protein Accession:
    P81877
    Secondary Accessions:
    • B2R5W1
    • B7Z1J2
    • B7Z2L9
    • B7Z665
    • D6RH18
    • E9PB74
    • E9PDA8
    • Q8N2Q2
    • Q9BWW6
    • Q9Y4T7

    Protein attributes for SSBP2 Gene

    Size:
    361 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SSBP2 Gene

    Alternative splice isoforms for SSBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP2 Gene

Post-translational modifications for SSBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP2 Gene

Domains & Families for SSBP2 Gene

Gene Families for SSBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SSBP2 Gene

Blocks:
  • Lissencephaly type-1-like homology motif
  • Single-stranded DNA-binding protein, SSDP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSBP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52881, highly similar to Single-stranded DNA-binding protein 2 (B7Z1J2_HUMAN)
  • Sequence-specific single-stranded-DNA-binding protein 2 (SSBP2_HUMAN)
genes like me logo Genes that share domains with SSBP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SSBP2 Gene

Function for SSBP2 Gene

Phenotypes From GWAS Catalog for SSBP2 Gene

Gene Ontology (GO) - Molecular Function for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding NAS,IEA 12079286
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SSBP2: view
genes like me logo Genes that share phenotypes with SSBP2: view

Animal Models for SSBP2 Gene

MGI Knock Outs for SSBP2:
  • Ssbp2 Ssbp2<tm1b(KOMP)Wtsi>
  • Ssbp2 Ssbp2<tm1Lana>

Animal Model Products

CRISPR Products

miRNA for SSBP2 Gene

miRTarBase miRNAs that target SSBP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSBP2

Clone Products

  • Addgene plasmids for SSBP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSBP2 Gene

Localization for SSBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP2 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SSBP2: view

Pathways & Interactions for SSBP2 Gene

PathCards logo

SuperPathways for SSBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 12079286
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with SSBP2: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP2 Gene

Drugs & Compounds for SSBP2 Gene

No Compound Related Data Available

Transcripts for SSBP2 Gene

mRNA/cDNA for SSBP2 Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSBP2

Clone Products

  • Addgene plasmids for SSBP2

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP2 Gene

No ASD Table

Relevant External Links for SSBP2 Gene

GeneLoc Exon Structure for
SSBP2

Expression for SSBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP2 Gene

This gene is overexpressed in CD4 Tcells (15.2), Fetal ovary (14.0), Blymphocyte (8.1), CD8 Tcells (7.5), and Fetal heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSBP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSBP2

SOURCE GeneReport for Unigene cluster for SSBP2 Gene:

Hs.102735

mRNA Expression by UniProt/SwissProt for SSBP2 Gene:

P81877-SSBP2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SSBP2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SSBP2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP2 Gene

Orthologs for SSBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SSBP2 31
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SSBP2 31 30
  • 97.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SSBP2 31 30
  • 97.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp2 17 31 30
  • 95.66 (n)
chimpanzee
(Pan troglodytes)
Mammalia SSBP2 31 30
  • 95.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp2 30
  • 92.18 (n)
chicken
(Gallus gallus)
Aves SSBP2 31 30
  • 91.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP2 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp2 30
  • 84.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia ssbp2-prov 30
zebrafish
(Danio rerio)
Actinopterygii SSBP2 (2 of 2) 31
  • 83 (a)
OneToMany
SSBP2 (1 of 2) 31
  • 81 (a)
OneToMany
LOC798086 30
  • 74.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7187 32
  • 91 (a)
Ssdp 31
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 31
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 31
  • 55 (a)
OneToMany
Species where no ortholog for SSBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP2 Gene

ENSEMBL:
Gene Tree for SSBP2 (if available)
TreeFam:
Gene Tree for SSBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSBP2: view image

Paralogs for SSBP2 Gene

Paralogs for SSBP2 Gene

(3) SIMAP similar genes for SSBP2 Gene using alignment to 4 proteins:

  • SSBP2_HUMAN
  • D6RAC5_HUMAN
  • H0Y9M5_HUMAN
  • H0Y9V4_HUMAN

Pseudogenes.org Pseudogenes for SSBP2 Gene

genes like me logo Genes that share paralogs with SSBP2: view

Variants for SSBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSBP2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1057518330 Uncertain Significance: not specified 81,636,601(-) G/GT FRAMESHIFT_VARIANT
rs193920757 Uncertain Significance: Malignant tumor of prostate 81,448,794(-) T/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SSBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SSBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1109e214 CNV loss 21293372
dgv3107n106 CNV deletion 24896259
esv1711772 CNV deletion 17803354
esv2034602 CNV deletion 18987734
esv2125406 CNV deletion 18987734
esv2524327 CNV deletion 19546169
esv2613325 CNV deletion 19546169
esv2668722 CNV deletion 23128226
esv2730382 CNV deletion 23290073
esv2730383 CNV deletion 23290073
esv2730385 CNV deletion 23290073
esv2730386 CNV deletion 23290073
esv2763467 CNV loss 21179565
esv3134 CNV loss 18987735
esv3566174 CNV deletion 23714750
esv3566175 CNV deletion 23714750
esv3605594 CNV gain 21293372
esv3605595 CNV gain 21293372
esv3605597 CNV gain 21293372
esv3605599 CNV gain 21293372
esv3605601 CNV loss 21293372
esv3605602 CNV gain 21293372
esv3605603 CNV loss 21293372
esv3605604 CNV loss 21293372
esv3890665 CNV loss 25118596
esv4616 CNV loss 18987735
esv993941 CNV deletion 20482838
nsv1028322 CNV gain 25217958
nsv1073900 CNV deletion 25765185
nsv1074849 CNV deletion 25765185
nsv1114697 CNV deletion 24896259
nsv1139842 CNV duplication 24896259
nsv1144112 CNV deletion 24896259
nsv1146271 CNV duplication 26484159
nsv1146766 CNV deletion 26484159
nsv1149956 CNV deletion 26484159
nsv327664 CNV deletion 16902084
nsv462221 CNV loss 19166990
nsv462222 CNV gain 19166990
nsv471018 CNV gain 18288195
nsv4900 CNV deletion 18451855
nsv519589 CNV gain+loss 19592680
nsv525225 CNV loss 19592680
nsv525437 CNV loss 19592680
nsv527374 CNV loss 19592680
nsv598751 CNV loss 21841781
nsv598752 CNV gain 21841781
nsv598753 CNV gain 21841781
nsv830361 CNV loss 17160897
nsv830362 CNV gain 17160897
nsv950097 CNV deletion 24416366
nsv956443 CNV deletion 24416366
nsv956479 CNV deletion 24416366

Variation tolerance for SSBP2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP2 Gene

Disorders for SSBP2 Gene

Additional Disease Information for SSBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP2 Gene

Publications for SSBP2 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
  2. SSBP2 variants are associated with survival in glioblastoma patients. (PMID: 22472174) Xiao Y … Wrensch MR (Clinical cancer research : an official journal of the American Association for Cancer Research 2012) 3 41 54
  3. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PMID: 21079607) Wang K … Price Foundation Collaborative Group (Molecular psychiatry 2011) 3 41 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. (PMID: 17311003) Fleisig HB … Nagarajan L (Oncogene 2007) 3 23 54

Products for SSBP2 Gene

Sources for SSBP2 Gene