Aliases for SSBP1 Gene
External Ids for SSBP1 Gene
Previous GeneCards Identifiers for SSBP1 Gene
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
GeneCards Summary for SSBP1 Gene
SSBP1 (Single Stranded DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with SSBP1 include Optic Atrophy 13 With Retinal And Foveal Abnormalities and Mitochondrial Dna Depletion Syndrome 7. Among its related pathways are Organelle biogenesis and maintenance and Mismatch repair. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding.
UniProtKB/Swiss-Prot Summary for SSBP1 Gene
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork (PubMed:21953457, PubMed:12975372, PubMed:26446790, PubMed:15167897). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:26446790, PubMed:21953457). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262).