The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein ... See more...

Aliases for SSB Gene

Aliases for SSB Gene

  • Small RNA Binding Exonuclease Protection Factor La 2 3 5
  • Lupus La Protein 2 3 4
  • La Autoantigen 2 3 4
  • La Ribonucleoprotein Domain Family, Member 3 2 3
  • Sjoegren Syndrome Type B Antigen 3 4
  • Sjogren Syndrome Antigen B 2 3
  • La/SSB 2 3
  • LARP3 2 3
  • SS-B 3 4
  • La 2 3
  • Sjogren Syndrome Antigen B (Autoantigen La) 2
  • La Ribonucleoprotein 4
  • Lupus La Antigen 3
  • SS-B/La Protein 3
  • Autoantigen La 3
  • SSB 5

External Ids for SSB Gene

Previous GeneCards Identifiers for SSB Gene

  • GC02P168707
  • GC02P169196
  • GC02P170619
  • GC02P170857
  • GC02P170480
  • GC02P170363
  • GC02P162543
  • GC02P170649

Summaries for SSB Gene

Entrez Gene Summary for SSB Gene

  • The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

GeneCards Summary for SSB Gene

SSB (Small RNA Binding Exonuclease Protection Factor La) is a Protein Coding gene. Diseases associated with SSB include Sjogren Syndrome and Lupus Erythematosus. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is LARP7.

UniProtKB/Swiss-Prot Summary for SSB Gene

  • Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Gene Wiki entry for SSB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SSB Gene

Genomics for SSB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SSB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SSB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SSB

Top Transcription factor binding sites by QIAGEN in the SSB gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • En-1
  • Meis-1b
  • p53
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for SSB Gene

Genomic Locations for SSB Gene
chr2:169,791,933-169,812,064
(GRCh38/hg38)
Size:
20,132 bases
Orientation:
Plus strand
chr2:170,648,443-170,668,575
(GRCh37/hg19)
Size:
20,133 bases
Orientation:
Plus strand

Genomic View for SSB Gene

Genes around SSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSB Gene

Proteins for SSB Gene

  • Protein details for SSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05455-LA_HUMAN
    Recommended name:
    Lupus La protein
    Protein Accession:
    P05455
    Secondary Accessions:
    • Q15367
    • Q53XJ4

    Protein attributes for SSB Gene

    Size:
    408 amino acids
    Molecular mass:
    46837 Da
    Quaternary structure:
    • Interacts with DDX15. May interact with RUFY1.
    Miscellaneous:
    • Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

    Three dimensional structures from OCA and Proteopedia for SSB Gene

neXtProt entry for SSB Gene

Post-translational modifications for SSB Gene

  • Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
  • The N-terminus is blocked.
  • Ubiquitination at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312, and Lys328
  • Modification sites at PhosphoSitePlus

Other Protein References for SSB Gene

Antibody Products

  • Abcam antibodies for SSB

No data available for DME Specific Peptides for SSB Gene

Domains & Families for SSB Gene

Gene Families for SSB Gene

Protein Domains for SSB Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Lupus La protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for SSB Gene

GenScript: Design optimal peptide antigens:
  • Autoantigen La (B5BUB5_HUMAN)
  • Sjoegren syndrome type B antigen (LA_HUMAN)
genes like me logo Genes that share domains with SSB: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SSB Gene

Function for SSB Gene

Molecular function for SSB Gene

UniProtKB/Swiss-Prot Function:
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Phenotypes From GWAS Catalog for SSB Gene

Gene Ontology (GO) - Molecular Function for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IMP 10983981
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IMP 3192525
GO:0003729 mRNA binding TAS 9154801
GO:0005515 protein binding IPI 23552417
genes like me logo Genes that share ontologies with SSB: view
genes like me logo Genes that share phenotypes with SSB: view

Animal Models for SSB Gene

MGI Knock Outs for SSB:
  • Ssb Ssb<tm1Rjma>
  • Ssb Ssb<tm2Rjma>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSB Gene

Localization for SSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSB gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0005634 nucleus IDA 17308035
GO:0005737 cytoplasm IDA 17308035
GO:1990904 ribonucleoprotein complex TAS,IEA --
genes like me logo Genes that share ontologies with SSB: view

Pathways & Interactions for SSB Gene

genes like me logo Genes that share pathways with SSB: view

SIGNOR curated interactions for SSB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001682 tRNA 5'-leader removal IGI 10983981
GO:0006396 RNA processing IEA --
GO:0006400 tRNA modification TAS 10983981
GO:0006409 tRNA export from nucleus IMP 17308035
GO:0008033 tRNA processing IMP 17308035
genes like me logo Genes that share ontologies with SSB: view

Drugs & Compounds for SSB Gene

(2) Drugs for SSB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TMP Experimental Pharma Target 0
genes like me logo Genes that share compounds with SSB: view

Transcripts for SSB Gene

mRNA/cDNA for SSB Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SSB

Alternative Splicing Database (ASD) splice patterns (SP) for SSB Gene

No ASD Table

Relevant External Links for SSB Gene

GeneLoc Exon Structure for
SSB

Expression for SSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSB Gene

Protein differential expression in normal tissues from HIPED for SSB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SSB Gene



Protein tissue co-expression partners for SSB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SSB

SOURCE GeneReport for Unigene cluster for SSB Gene:

Hs.632535

Evidence on tissue expression from TISSUES for SSB Gene

  • Liver(4.6)
  • Muscle(4.6)
  • Nervous system(4.2)
  • Heart(3.1)
  • Kidney(3.1)
  • Spleen(3)
  • Eye(2.9)
  • Lymph node(2.8)
  • Lung(2.8)
  • Bone marrow(2.8)
  • Thyroid gland(2.8)
  • Blood(2.7)
  • Skin(2.6)
  • Intestine(2.3)
  • Saliva(2.1)
  • Adrenal gland(2.1)
  • Pancreas(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SSB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSB Gene

Orthologs for SSB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SSB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SSB 30 31
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SSB 30 31
  • 92.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SSB 30 31
  • 92.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ssb 30 17 31
  • 85.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ssb 30
  • 85.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SSB 31
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 80 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SSB 30 31
  • 75.66 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SSB 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ssb 30
  • 67.08 (n)
Str.2099 30
African clawed frog
(Xenopus laevis)
Amphibia MGC52876 30
Zebrafish
(Danio rerio)
Actinopterygii ssb 30 31
  • 61.98 (n)
OneToOne
wufb17f11 30
Fruit Fly
(Drosophila melanogaster)
Insecta La 30 31 32
  • 47.97 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008952 30
  • 46.85 (n)
Worm
(Caenorhabditis elegans)
Secernentea C44E4.4 30 31 32
  • 47.08 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LHP1 31 33
  • 20 (a)
OneToMany
Species where no ortholog for SSB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SSB Gene

ENSEMBL:
Gene Tree for SSB (if available)
TreeFam:
Gene Tree for SSB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SSB: view image

Paralogs for SSB Gene

Paralogs for SSB Gene

(3) SIMAP similar genes for SSB Gene using alignment to 5 proteins:

  • LA_HUMAN
  • B5BUB5_HUMAN
  • E7ERC4_HUMAN
  • E9PFL9_HUMAN
  • E9PGX9_HUMAN
genes like me logo Genes that share paralogs with SSB: view

Variants for SSB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SSB Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
785015 Benign: not provided 169,800,972(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SSB Gene

Structural Variations from Database of Genomic Variants (DGV) for SSB Gene

Variant ID Type Subtype PubMed ID
nsv1011368 CNV loss 25217958
nsv10201 CNV loss 18304495
nsv3026 CNV deletion 18451855
nsv583606 CNV loss 21841781
nsv583607 CNV gain 21841781
nsv583608 CNV gain 21841781
nsv961527 CNV duplication 23825009

Variation tolerance for SSB Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSB Gene

Disorders for SSB Gene

MalaCards: The human disease database

(32) MalaCards diseases for SSB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sjogren syndrome
  • sicca syndrome
lupus erythematosus
  • systemic lupus erythematosus
systemic lupus erythematosus
  • sle
undifferentiated connective tissue disease
  • uctd
submandibular gland disease
  • submandibular gland diseases
- elite association - COSMIC cancer census association via MalaCards
Search SSB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSB Gene

Publications for SSB Gene

  1. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. (PMID: 1692037) Kohsaka H … Miyamoto T (The Journal of clinical investigation 1990) 2 3 23
  2. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PMID: 2468131) Chan EK … Tan EM (Nucleic acids research 1989) 2 3 4
  3. The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives. (PMID: 28782243) Maraia RJ … Conte MR (Wiley interdisciplinary reviews. RNA 2017) 2 3
  4. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PMID: 18547518) Kotik-Kogan O … Curry S (Structure (London, England : 1993) 2008) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for SSB Gene

Sources for SSB Gene