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Aliases for SS18L2 Gene

Aliases for SS18L2 Gene

  • SS18 Like 2 2 3 5
  • SYT Homolog 2 2 3 4
  • Synovial Sarcoma Translocation Gene On Chromosome 18-Like 2 2 3
  • SS18-Like Protein 2 3
  • KIAA-Iso 3

External Ids for SS18L2 Gene

Previous GeneCards Identifiers for SS18L2 Gene

  • GC03P041937
  • GC03P041812
  • GC03P042442
  • GC03P042592
  • GC03P042569

Summaries for SS18L2 Gene

Entrez Gene Summary for SS18L2 Gene

  • Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]

GeneCards Summary for SS18L2 Gene

SS18L2 (SS18 Like 2) is a Protein Coding gene. An important paralog of this gene is SS18L1.

Additional gene information for SS18L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SS18L2 Gene

Genomics for SS18L2 Gene

GeneHancer (GH) Regulatory Elements for SS18L2 Gene

Promoters and enhancers for SS18L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I042580 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 252 2.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SEC22C SS18L2 NKTR SNRK-AS1 ENSG00000271941
GH03I042589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +9.1 9126 2.5 HDGF PKNOX1 ATF1 IRF4 BRCA1 YY1 GTF3C2 POLR2B GLIS2 ZNF207 SS18L2 SEC22C NKTR CCDC13-AS1 CCDC13
GH03I042501 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -74.8 -74831 10.5 PKNOX1 ATF1 SIN3A FOS SP3 RXRA NFYC REST SMARCA4 PBX2 VIPR1 NKTR SEC22C VIPR1-AS1 SNRK-AS1 SS18L2 ZNF662 CCDC13-AS1
GH03I042650 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +72.0 71988 6.4 HDGF PKNOX1 ARNT ZFP64 SIN3A DMAP1 POLR2B CBX5 FOS SP3 LOC101928323 ZBTB47 NKTR SEC22C SNRK-AS1 SS18L2 HHATL FAM198A
GH03I042544 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 -36.7 -36681 1.3 ELF3 CTCF SOX13 GATAD2A FOXA2 NFIA RXRA FOXA3 REST NR2F2 SEC22C NKTR SS18L2 VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SS18L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SS18L2 gene promoter:

Genomic Locations for SS18L2 Gene

Genomic Locations for SS18L2 Gene
13,275 bases
Plus strand

Genomic View for SS18L2 Gene

Genes around SS18L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SS18L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SS18L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SS18L2 Gene

Proteins for SS18L2 Gene

  • Protein details for SS18L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SS18-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R5L1

    Protein attributes for SS18L2 Gene

    77 amino acids
    Molecular mass:
    8835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SS18L2 Gene

Post-translational modifications for SS18L2 Gene

No Post-translational modifications

Other Protein References for SS18L2 Gene

No data available for DME Specific Peptides for SS18L2 Gene

Domains & Families for SS18L2 Gene

Gene Families for SS18L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SS18L2 Gene


Suggested Antigen Peptide Sequences for SS18L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SS18 family.
  • Belongs to the SS18 family.
genes like me logo Genes that share domains with SS18L2: view

Function for SS18L2 Gene

Gene Ontology (GO) - Molecular Function for SS18L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with SS18L2: view
genes like me logo Genes that share phenotypes with SS18L2: view

miRNA for SS18L2 Gene

miRTarBase miRNAs that target SS18L2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SS18L2 Gene

Localization for SS18L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SS18L2 gene
Compartment Confidence
extracellular 3
nucleus 3
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SS18L2 Gene

Pathways & Interactions for SS18L2 Gene

SuperPathways for SS18L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SS18L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903506 regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with SS18L2: view

No data available for Pathways by source and SIGNOR curated interactions for SS18L2 Gene

Drugs & Compounds for SS18L2 Gene

No Compound Related Data Available

Transcripts for SS18L2 Gene

mRNA/cDNA for SS18L2 Gene

Unigene Clusters for SS18L2 Gene

Synovial sarcoma translocation gene on chromosome 18-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SS18L2 Gene

No ASD Table

Relevant External Links for SS18L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SS18L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SS18L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SS18L2 Gene

This gene is overexpressed in Lung (55.0) and CD8 Tcells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SS18L2 Gene

Protein tissue co-expression partners for SS18L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SS18L2 Gene:


SOURCE GeneReport for Unigene cluster for SS18L2 Gene:


Evidence on tissue expression from TISSUES for SS18L2 Gene

  • Lymph node(4.3)
  • Spleen(4.2)
  • Blood(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SS18L2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SS18L2 Gene

Orthologs for SS18L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SS18L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SS18L2 33
  • 91.34 (n)
(Canis familiaris)
Mammalia SS18L2 33 34
  • 90.91 (n)
(Pan troglodytes)
Mammalia SS18L2 34
  • 90 (a)
(Mus musculus)
Mammalia Deb1 34 33
  • 83.98 (n)
Ss18l2 16
(Rattus norvegicus)
Mammalia LOC687029 33
  • 83.55 (n)
(Ornithorhynchus anatinus)
Mammalia SS18L2 34
  • 69 (a)
(Monodelphis domestica)
Mammalia SS18L2 34
  • 34 (a)
(Gallus gallus)
Aves SS18L2 33 34
  • 79.22 (n)
(Anolis carolinensis)
Reptilia SS18L2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ss18l2 33
  • 70.37 (n)
Str.7278 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13215 33
(Danio rerio)
Actinopterygii ss18l2 34 33
  • 69.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10555 34
  • 1 (a)
Species where no ortholog for SS18L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SS18L2 Gene

Gene Tree for SS18L2 (if available)
Gene Tree for SS18L2 (if available)

Paralogs for SS18L2 Gene

Paralogs for SS18L2 Gene

(5) SIMAP similar genes for SS18L2 Gene using alignment to 1 proteins: Pseudogenes for SS18L2 Gene

genes like me logo Genes that share paralogs with SS18L2: view

Variants for SS18L2 Gene

Sequence variations from dbSNP and Humsavar for SS18L2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000031355 -- 42,587,536(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000047793 -- 42,594,248(+) G/C intron_variant
rs1000115352 -- 42,589,997(+) C/G 5_prime_UTR_variant, intron_variant
rs1000183047 -- 42,591,523(+) A/T splice_acceptor_variant
rs1000189937 -- 42,581,282(+) T/C upstream_transcript_variant

Variation tolerance for SS18L2 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SS18L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SS18L2 Gene

Disorders for SS18L2 Gene

Additional Disease Information for SS18L2

No disorders were found for SS18L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SS18L2 Gene

Publications for SS18L2 Gene

  1. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. (PMID: 11435705) de Bruijn DR … Geurts Van Kessel A (Cytogenetics and cell genetics 2001) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PMID: 16484776) de Bruijn DR … Geurts van Kessel A (Cytogenetic and genome research 2006) 22 58

Products for SS18L2 Gene

Sources for SS18L2 Gene

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