Aliases for SRXN1 Gene

Aliases for SRXN1 Gene

  • Sulfiredoxin 1 2 3 5
  • SRX1 2 3 4
  • Sulfiredoxin-1 3 4
  • C20orf139 3 4
  • Npn3 2 3
  • SRX 3 4
  • Sulfiredoxin 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 139 2
  • EC 1.8.98.2 4
  • DJ850E9.2 2
  • YKL086W 2
  • SRXN1 5

External Ids for SRXN1 Gene

Previous HGNC Symbols for SRXN1 Gene

  • C20orf139

Previous GeneCards Identifiers for SRXN1 Gene

  • GC20M000577
  • GC20M000630

Summaries for SRXN1 Gene

GeneCards Summary for SRXN1 Gene

SRXN1 (Sulfiredoxin 1) is a Protein Coding gene. Diseases associated with SRXN1 include Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency. Among its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors and sulfiredoxin activity.

UniProtKB/Swiss-Prot Summary for SRXN1 Gene

  • Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Gene Wiki entry for SRXN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRXN1 Gene

Genomics for SRXN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRXN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000651 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 275.3 +0.3 299 3 ZNF207 MYC NCOR1 SSRP1 JUND ZNF580 ZNF592 ZMYM3 CEBPA NFIC SRXN1 LOC107985423 NONHSAG031087.2 TBC1D20 RBCK1 ENSG00000229728 ACTG1P3 SDCBP2-AS1 HSALNG0128051-002 ENSG00000270299
GH20J000645 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 264.6 +7.0 6978 2.3 ZNF207 ZNF654 ZNF600 ZMYM3 CEBPA ATF3 CHD4 MXD4 CTCF REST SRXN1 TCF15 CSNK2A1 SCRT2 SLC52A3 HSALNG0128051-002 ENSG00000270299
GH20J000648 Promoter 0.4 EPDnew 250.4 +5.1 5066 0.1 MYRF SRXN1 HSALNG0128051-002 ENSG00000270299 TCF15
GH20J000647 Promoter 0.4 EPDnew 250.4 +5.8 5774 0.1 POLR2A SRXN1 HSALNG0128051-002 ENSG00000270299 TCF15
GH20J000649 Promoter 0.3 EPDnew 250.7 +4.3 4333 0.1 SRXN1 HSALNG0128051-002 ENSG00000270299 TCF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRXN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRXN1

Top Transcription factor binding sites by QIAGEN in the SRXN1 gene promoter:
  • AP-4
  • HEN1
  • p53
  • Pax-4a
  • Pbx1a
  • RFX1
  • RSRFC4
  • Sox5

Genomic Locations for SRXN1 Gene

Latest Assembly
chr20:646,615-653,200
(GRCh38/hg38)
Size:
6,586 bases
Orientation:
Minus strand

Previous Assembly
chr20:627,259-633,844
(GRCh37/hg19 by Entrez Gene)
Size:
6,586 bases
Orientation:
Minus strand

chr20:627,259-634,014
(GRCh37/hg19 by Ensembl)
Size:
6,756 bases
Orientation:
Minus strand

Genomic View for SRXN1 Gene

Genes around SRXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRXN1 Gene

Proteins for SRXN1 Gene

  • Protein details for SRXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN0-SRXN1_HUMAN
    Recommended name:
    Sulfiredoxin-1
    Protein Accession:
    Q9BYN0
    Secondary Accessions:
    • B2R543
    • Q8NDM3
    • Q96AK6

    Protein attributes for SRXN1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRXN1 Gene

neXtProt entry for SRXN1 Gene

Post-translational modifications for SRXN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRXN1 Gene

Domains & Families for SRXN1 Gene

Gene Families for SRXN1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SRXN1 Gene

Suggested Antigen Peptide Sequences for SRXN1 Gene

GenScript: Design optimal peptide antigens:
  • Sulfiredoxin-1 (SRXN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYN0

UniProtKB/Swiss-Prot:

SRXN1_HUMAN :
  • Belongs to the sulfiredoxin family.
Family:
  • Belongs to the sulfiredoxin family.
genes like me logo Genes that share domains with SRXN1: view

Function for SRXN1 Gene

Molecular function for SRXN1 Gene

UniProtKB/Swiss-Prot Function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP = [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate; Xref=Rhea:RHEA:17545, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, Rhea:RHEA-COMP:13681, Rhea:RHEA-COMP:14051, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:50058, ChEBI:CHEBI:61967, ChEBI:CHEBI:61973, ChEBI:CHEBI:456216; EC=1.8.98.2;.

Enzyme Numbers (IUBMB) for SRXN1 Gene

Phenotypes From GWAS Catalog for SRXN1 Gene

Gene Ontology (GO) - Molecular Function for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 18172504
GO:0005524 ATP binding IEA --
GO:0016209 antioxidant activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SRXN1: view
genes like me logo Genes that share phenotypes with SRXN1: view

Animal Models for SRXN1 Gene

MGI Knock Outs for SRXN1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRXN1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRXN1 Gene

Localization for SRXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRXN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRXN1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA 15448164
genes like me logo Genes that share ontologies with SRXN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRXN1 Gene

Pathways & Interactions for SRXN1 Gene

genes like me logo Genes that share pathways with SRXN1: view

Pathways by source for SRXN1 Gene

Gene Ontology (GO) - Biological Process for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 15448164
GO:0034599 cellular response to oxidative stress IBA 21873635
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with SRXN1: view

No data available for SIGNOR curated interactions for SRXN1 Gene

Drugs & Compounds for SRXN1 Gene

(1) Drugs for SRXN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with SRXN1: view

Transcripts for SRXN1 Gene

mRNA/cDNA for SRXN1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRXN1

Alternative Splicing Database (ASD) splice patterns (SP) for SRXN1 Gene

No ASD Table

Relevant External Links for SRXN1 Gene

GeneLoc Exon Structure for
SRXN1

Expression for SRXN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Dermis (Integumentary System)

Protein differential expression in normal tissues from HIPED for SRXN1 Gene

This gene is overexpressed in Bone (14.1) and Stomach (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRXN1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRXN1

SOURCE GeneReport for Unigene cluster for SRXN1 Gene:

Hs.516830

mRNA Expression by UniProt/SwissProt for SRXN1 Gene:

Q9BYN0-SRXN1_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, lung, spleen and thymus.

Evidence on tissue expression from TISSUES for SRXN1 Gene

  • Lung(4.7)
  • Nervous system(4.6)
  • Liver(4.5)
  • Kidney(4.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SRXN1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRXN1 Gene

Orthologs for SRXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRXN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SRXN1 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SRXN1 29 30
  • 90.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SRXN1 29 30
  • 86.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Srxn1 29 16 30
  • 86.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Srxn1 29
  • 84.8 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SRXN1 30
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SRXN1 30
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SRXN1 29
  • 69.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii srxn1 29 30
  • 59 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6762 29 30
  • 62.73 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRX1 30 32
  • 32 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 49 (a)
OneToOne
Species where no ortholog for SRXN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SRXN1 Gene

ENSEMBL:
Gene Tree for SRXN1 (if available)
TreeFam:
Gene Tree for SRXN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRXN1: view image
Alliance of Genome Resources:
Additional Orthologs for SRXN1

Paralogs for SRXN1 Gene

Pseudogenes.org Pseudogenes for SRXN1 Gene

genes like me logo Genes that share paralogs with SRXN1: view

No data available for Paralogs for SRXN1 Gene

Variants for SRXN1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRXN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRXN1 Gene

Variant ID Type Subtype PubMed ID
dgv7424n54 CNV loss 21841781
esv3644952 CNV gain 21293372
nsv522812 CNV loss 19592680
nsv585188 CNV gain 21841781

Variation tolerance for SRXN1 Gene

Gene Damage Index Score: 1.26; 25.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRXN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRXN1
Leiden Open Variation Database (LOVD)
SRXN1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRXN1 Gene

Disorders for SRXN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRXN1 Gene - From: COP

Disorder Aliases PubMed IDs
dystonia, dopa-responsive, due to sepiapterin reductase deficiency
  • sepiapterin reductase deficiency; srd
- elite association - COSMIC cancer census association via MalaCards
Search SRXN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRXN1

genes like me logo Genes that share disorders with SRXN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRXN1 Gene

Publications for SRXN1 Gene

  1. Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. (PMID: 15952770) Jönsson TJ … Lowther WT (Biochemistry 2005) 3 4 22
  2. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. (PMID: 19561357) Park JW … Chock PB (The Journal of biological chemistry 2009) 3 22
  3. Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. (PMID: 18172504) Jönsson TJ … Lowther WT (Nature 2008) 3 22
  4. Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. (PMID: 15590625) Woo HA … Rhee SG (The Journal of biological chemistry 2005) 3 4
  5. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. (PMID: 15448164) Chang TS … Rhee SG (The Journal of biological chemistry 2004) 3 4

Products for SRXN1 Gene

Sources for SRXN1 Gene