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Aliases for SRSF8 Gene

Aliases for SRSF8 Gene

  • Serine And Arginine Rich Splicing Factor 8 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 2B 2 3 4
  • Serine/Arginine-Rich Splicing Factor 8 2 3
  • Pre-MRNA-Splicing Factor SRP46 3 4
  • SR Splicing Factor 8 2 3
  • SFRS2B 3 4
  • SRP46 3 4
  • Splicing Factor, Arginine/Serine-Rich, 46kD 3
  • Splicing Factor SRp46 4
  • DSM-1 3

External Ids for SRSF8 Gene

Previous HGNC Symbols for SRSF8 Gene

  • SFRS2B

Previous GeneCards Identifiers for SRSF8 Gene

  • GC11P094801
  • GC11P090864

Summaries for SRSF8 Gene

Entrez Gene Summary for SRSF8 Gene

  • This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for SRSF8 Gene

SRSF8 (Serine And Arginine Rich Splicing Factor 8) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Influenza A. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF2.

UniProtKB/Swiss-Prot for SRSF8 Gene

  • Involved in pre-mRNA alternative splicing.

Additional gene information for SRSF8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF8 Gene

Genomics for SRSF8 Gene

GeneHancer (GH) Regulatory Elements for SRSF8 Gene

Promoters and enhancers for SRSF8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I095066 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 +1.2 1235 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SRSF8 GC11M095066 GC11P095067 ENDOD1 LOC101929295 KDM4E CWC15 KDM4D MTMR2 GC11P095083
GH11I095088 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 17.1 +23.0 22992 2.9 HDGF ATF1 ARID4B SIN3A ZNF48 YY1 ZNF207 ZNF143 ATF7 RUNX3 ENDOD1 GC11P095088 SRSF8 LOC101929295 KDM4E GC11P095093 GC11M095076
GH11I095146 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +83.7 83652 7.8 HDGF PKNOX1 ARNT ARID4B SIN3A IRF4 YY1 ZNF766 CBX5 ZNF143 LOC101929295 CEP57 FAM76B FGFR3P2 SESN3 ANKRD49 MRE11 SRSF8 ENDOD1 LOC105369435
GH11I095074 Enhancer 1 Ensembl ENCODE dbSUPER 14.4 +8.1 8128 1 USF1 SMARCC1 ZNF189 USF2 NR2F2 ZNF507 OSR2 MITF ZFHX2 NFIC SRSF8 LOC101929295 ENDOD1 GC11P095067 GC11P095083
GH11I095084 Enhancer 0.7 dbSUPER 17.6 +18.3 18315 1.3 BACH1 JUNB CEBPG MNT BATF ZFHX2 ATF4 JUND EGR1 BCL6B GC11P095083 SRSF8 ENDOD1 GC11P095088 GC11M095076
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRSF8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRSF8 Gene

Genomic Locations for SRSF8 Gene
4,351 bases
Plus strand

Genomic View for SRSF8 Gene

Genes around SRSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF8 Gene

Proteins for SRSF8 Gene

  • Protein details for SRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/arginine-rich splicing factor 8
    Protein Accession:
    Secondary Accessions:
    • B2R6B8
    • Q6PF01
    • Q96TA3

    Protein attributes for SRSF8 Gene

    282 amino acids
    Molecular mass:
    32288 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRSF8 Gene

    Alternative splice isoforms for SRSF8 Gene


neXtProt entry for SRSF8 Gene

Post-translational modifications for SRSF8 Gene

No Post-translational modifications

Other Protein References for SRSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF8 Gene

Domains & Families for SRSF8 Gene

Gene Families for SRSF8 Gene

Protein Domains for SRSF8 Gene

Suggested Antigen Peptide Sequences for SRSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the splicing factor SR family.
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF8: view

Function for SRSF8 Gene

Molecular function for SRSF8 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA alternative splicing.

Phenotypes From GWAS Catalog for SRSF8 Gene

Gene Ontology (GO) - Molecular Function for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with SRSF8: view
genes like me logo Genes that share phenotypes with SRSF8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SRSF8 Gene

Localization for SRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF8 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with SRSF8: view

No data available for Subcellular locations from COMPARTMENTS for SRSF8 Gene

Pathways & Interactions for SRSF8 Gene

genes like me logo Genes that share pathways with SRSF8: view

Pathways by source for SRSF8 Gene

2 KEGG pathways for SRSF8 Gene

Interacting Proteins for SRSF8 Gene

Gene Ontology (GO) - Biological Process for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRSF8: view

No data available for SIGNOR curated interactions for SRSF8 Gene

Drugs & Compounds for SRSF8 Gene

No Compound Related Data Available

Transcripts for SRSF8 Gene

mRNA/cDNA for SRSF8 Gene

Unigene Clusters for SRSF8 Gene

Serine/arginine-rich splicing factor 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF8 Gene

No ASD Table

Relevant External Links for SRSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF8 Gene

Protein differential expression in normal tissues from HIPED for SRSF8 Gene

This gene is overexpressed in Heart (24.2), Blymphocyte (16.4), CD8 Tcells (8.4), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF8 Gene

Protein tissue co-expression partners for SRSF8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRSF8 Gene:


SOURCE GeneReport for Unigene cluster for SRSF8 Gene:


mRNA Expression by UniProt/SwissProt for SRSF8 Gene:

Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus.
genes like me logo Genes that share expression patterns with SRSF8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF8 Gene

Orthologs for SRSF8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRSF8 33
  • 99.65 (n)
Species where no ortholog for SRSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRSF8 Gene

Gene Tree for SRSF8 (if available)
Gene Tree for SRSF8 (if available)

Paralogs for SRSF8 Gene

Paralogs for SRSF8 Gene

(7) SIMAP similar genes for SRSF8 Gene using alignment to 1 proteins: Pseudogenes for SRSF8 Gene

genes like me logo Genes that share paralogs with SRSF8: view

Variants for SRSF8 Gene

Sequence variations from dbSNP and Humsavar for SRSF8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000083272 -- 95,070,262(+) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1002448043 -- 95,065,282(+) T/A upstream_transcript_variant
rs1004931293 -- 95,067,753(+) G/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1005344586 -- 95,071,609(+) T/C downstream_transcript_variant
rs1006201696 -- 95,066,090(+) G/T upstream_transcript_variant

Additional Variant Information for SRSF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SRSF8 Gene

Disorders for SRSF8 Gene

Additional Disease Information for SRSF8

No disorders were found for SRSF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF8 Gene

Publications for SRSF8 Gene

  1. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PMID: 9671500) Soret J … Perbal B (Molecular and cellular biology 1998) 2 3 4 22 58
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SRSF8 Gene

Sources for SRSF8 Gene

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