This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] See more...

Aliases for SRSF8 Gene

Aliases for SRSF8 Gene

  • Serine And Arginine Rich Splicing Factor 8 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 2B 2 3 4
  • Serine/Arginine-Rich Splicing Factor 8 2 3 4
  • SRP46 2 3 4
  • Pre-MRNA-Splicing Factor SRP46 3 4
  • SR Splicing Factor 8 2 3
  • SFRS2B 3 4
  • Splicing Factor, Arginine/Serine-Rich, 46kD 3
  • Splicing Factor SRp46 4
  • DSM-1 3
  • SRSF8 5

External Ids for SRSF8 Gene

Previous HGNC Symbols for SRSF8 Gene

  • SFRS2B

Previous GeneCards Identifiers for SRSF8 Gene

  • GC11P094801
  • GC11P090864

Summaries for SRSF8 Gene

Entrez Gene Summary for SRSF8 Gene

  • This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for SRSF8 Gene

SRSF8 (Serine And Arginine Rich Splicing Factor 8) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF2.

UniProtKB/Swiss-Prot Summary for SRSF8 Gene

Additional gene information for SRSF8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF8 Gene

Genomics for SRSF8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRSF8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRSF8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF8

Genomic Locations for SRSF8 Gene

Genomic Locations for SRSF8 Gene
chr11:95,066,877-95,071,227
(GRCh38/hg38)
Size:
4,351 bases
Orientation:
Plus strand
chr11:94,800,056-94,804,388
(GRCh37/hg19)
Size:
4,333 bases
Orientation:
Plus strand

Genomic View for SRSF8 Gene

Genes around SRSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF8 Gene

Proteins for SRSF8 Gene

  • Protein details for SRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRL6-SRSF8_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 8
    Protein Accession:
    Q9BRL6
    Secondary Accessions:
    • B2R6B8
    • Q6PF01
    • Q96TA3

    Protein attributes for SRSF8 Gene

    Size:
    282 amino acids
    Molecular mass:
    32288 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRSF8 Gene

    Alternative splice isoforms for SRSF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF8 Gene

Post-translational modifications for SRSF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF8 Gene

Domains & Families for SRSF8 Gene

Gene Families for SRSF8 Gene

Protein Domains for SRSF8 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for SRSF8 Gene

GenScript: Design optimal peptide antigens:
  • Splicing factor, arginine/serine-rich 2B (SRSF8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRL6

UniProtKB/Swiss-Prot:

SRSF8_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF8: view

Function for SRSF8 Gene

Molecular function for SRSF8 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA alternative splicing.

Phenotypes From GWAS Catalog for SRSF8 Gene

Gene Ontology (GO) - Molecular Function for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with SRSF8: view
genes like me logo Genes that share phenotypes with SRSF8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SRSF8 Gene

Localization for SRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF8 gene
Compartment Confidence
nucleus 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IBA,IDA --
genes like me logo Genes that share ontologies with SRSF8: view

Pathways & Interactions for SRSF8 Gene

PathCards logo

SuperPathways for SRSF8 Gene

genes like me logo Genes that share pathways with SRSF8: view

Pathways by source for SRSF8 Gene

2 KEGG pathways for SRSF8 Gene

Gene Ontology (GO) - Biological Process for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA 21873635
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045292 mRNA cis splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with SRSF8: view

No data available for SIGNOR curated interactions for SRSF8 Gene

Drugs & Compounds for SRSF8 Gene

No Compound Related Data Available

Transcripts for SRSF8 Gene

mRNA/cDNA for SRSF8 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF8

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF8 Gene

No ASD Table

Relevant External Links for SRSF8 Gene

GeneLoc Exon Structure for
SRSF8

Expression for SRSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF8 Gene

Protein differential expression in normal tissues from HIPED for SRSF8 Gene

This gene is overexpressed in Heart (24.2), Blymphocyte (16.4), CD8 Tcells (8.4), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF8 Gene



Protein tissue co-expression partners for SRSF8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF8

SOURCE GeneReport for Unigene cluster for SRSF8 Gene:

Hs.476680

mRNA Expression by UniProt/SwissProt for SRSF8 Gene:

Q9BRL6-SRSF8_HUMAN
Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus.

Evidence on tissue expression from TISSUES for SRSF8 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SRSF8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF8 Gene

Orthologs for SRSF8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SRSF8 30
  • 99.65 (n)
Species where no ortholog for SRSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SRSF8 Gene

ENSEMBL:
Gene Tree for SRSF8 (if available)
TreeFam:
Gene Tree for SRSF8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRSF8: view image

Paralogs for SRSF8 Gene

Paralogs for SRSF8 Gene

(7) SIMAP similar genes for SRSF8 Gene using alignment to 1 proteins:

  • SRSF8_HUMAN

Pseudogenes.org Pseudogenes for SRSF8 Gene

genes like me logo Genes that share paralogs with SRSF8: view

Variants for SRSF8 Gene

Additional dbSNP identifiers (rs#s) for SRSF8 Gene

Additional Variant Information for SRSF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SRSF8 Gene

Disorders for SRSF8 Gene

No disorders were found for SRSF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF8 Gene

Publications for SRSF8 Gene

  1. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PMID: 9671500) Soret J … Perbal B (Molecular and cellular biology 1998) 2 3 4 23
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for SRSF8 Gene

Sources for SRSF8 Gene