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Aliases for SRSF5 Gene

Aliases for SRSF5 Gene

  • Serine And Arginine Rich Splicing Factor 5 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 5 2 3 4
  • Serine/Arginine-Rich Splicing Factor 5 2 3
  • Pre-MRNA-Splicing Factor SRP40 3 4
  • Delayed-Early Protein HRS 3 4
  • SR Splicing Factor 5 2 3
  • SFRS5 3 4
  • SRP40 3 4
  • HRS 3 4

External Ids for SRSF5 Gene

Previous HGNC Symbols for SRSF5 Gene

  • SFRS5

Previous GeneCards Identifiers for SRSF5 Gene

  • GC14P070234
  • GC14P050402

Summaries for SRSF5 Gene

Entrez Gene Summary for SRSF5 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SRSF5 Gene

SRSF5 (Serine And Arginine Rich Splicing Factor 5) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and RNA Polymerase II Transcription Termination. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF6.

UniProtKB/Swiss-Prot for SRSF5 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Gene Wiki entry for SRSF5 Gene

Additional gene information for SRSF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF5 Gene

Genomics for SRSF5 Gene

GeneHancer (GH) Regulatory Elements for SRSF5 Gene

Promoters and enhancers for SRSF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069765 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.4 +40.7 40695 3.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 SRSF5 LOC100289511 PIR62290 MED6 ADAM20P1 SLC10A1
GH14I069726 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 550.8 +0.3 250 1.2 ARID4B ZNF48 GLIS2 ARID2 ZNF207 ZNF143 ATF7 RUNX3 DEK NCOA1 SRSF5 LOC100289511
GH14I070358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 113.4 +632.5 632500 2 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 COX16 GC14P070361 RNU2-51P SRSF5 MED6 SUSD6 RPL7AP6 ADAM20P1 PTTG4P ERH
GH14I069724 Enhancer 0.3 dbSUPER 550.8 -1.6 -1626 1 NFIC SRSF5 PIR54293
GH14I069396 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.7 -328.0 -327969 4.5 PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ERH SLC39A9 SRSF5 DDX18P1 DCAF5 RPL7AP6 GALNT16 PLEKHD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRSF5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRSF5 Gene

Genomic Locations for SRSF5 Gene
chr14:69,726,900-69,772,005
(GRCh38/hg38)
Size:
45,106 bases
Orientation:
Plus strand
chr14:70,193,617-70,238,722
(GRCh37/hg19)

Genomic View for SRSF5 Gene

Genes around SRSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF5 Gene

Proteins for SRSF5 Gene

  • Protein details for SRSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13243-SRSF5_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Protein Accession:
    Q13243
    Secondary Accessions:
    • O14797
    • Q16662
    • Q49AD6
    • Q6FGE0

    Protein attributes for SRSF5 Gene

    Size:
    272 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
    SequenceCaution:
    • Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140; Evidence={ECO:0000305};

    Alternative splice isoforms for SRSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF5 Gene

Post-translational modifications for SRSF5 Gene

No data available for DME Specific Peptides for SRSF5 Gene

Domains & Families for SRSF5 Gene

Gene Families for SRSF5 Gene

Protein Domains for SRSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13243

UniProtKB/Swiss-Prot:

SRSF5_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF5: view

Function for SRSF5 Gene

Molecular function for SRSF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Phenotypes From GWAS Catalog for SRSF5 Gene

Gene Ontology (GO) - Molecular Function for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 12762840
GO:0043422 protein kinase B binding IEA --
genes like me logo Genes that share ontologies with SRSF5: view

Phenotypes for SRSF5 Gene

genes like me logo Genes that share phenotypes with SRSF5: view

Animal Model Products

miRNA for SRSF5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF5 Gene

Localization for SRSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF5 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck ISS --
genes like me logo Genes that share ontologies with SRSF5: view

Pathways & Interactions for SRSF5 Gene

genes like me logo Genes that share pathways with SRSF5: view

Pathways by source for SRSF5 Gene

Gene Ontology (GO) - Biological Process for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001889 liver development IEA --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
genes like me logo Genes that share ontologies with SRSF5: view

No data available for SIGNOR curated interactions for SRSF5 Gene

Drugs & Compounds for SRSF5 Gene

(2) Drugs for SRSF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SRSF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRSF5: view

Transcripts for SRSF5 Gene

Unigene Clusters for SRSF5 Gene

Serine/arginine-rich splicing factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - -
SP19: - - - -
SP20: - - -
SP21:
SP22: - - -
SP23: -
SP24:
SP25:

ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for SRSF5 Gene

GeneLoc Exon Structure for
SRSF5
ECgene alternative splicing isoforms for
SRSF5

Expression for SRSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF5 Gene

This gene is overexpressed in Adrenal (15.1), Peripheral blood mononuclear cells (8.4), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF5 Gene



Protein tissue co-expression partners for SRSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF5 Gene:

SRSF5

SOURCE GeneReport for Unigene cluster for SRSF5 Gene:

Hs.632326

Evidence on tissue expression from TISSUES for SRSF5 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Skin(4.7)
  • Intestine(4.5)
  • Eye(3.1)
  • Lung(2.9)
  • Pancreas(2.9)
  • Bone marrow(2.5)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Blood(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Heart(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SRSF5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF5 Gene

Orthologs for SRSF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF5 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia SFRS5 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF5 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF5 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf5 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF5 34
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF5 33 34
  • 81.46 (n)
lizard
(Anolis carolinensis)
Reptilia SRSF5 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8018 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5499 33
zebrafish
(Danio rerio)
Actinopterygii srsf5b 34
  • 70 (a)
OneToOne
Dr.11695 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8311 33
fruit fly
(Drosophila melanogaster)
Insecta B52 34
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-5 34
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
CSA.9965 34
  • 53 (a)
OneToMany
Species where no ortholog for SRSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF5 Gene

ENSEMBL:
Gene Tree for SRSF5 (if available)
TreeFam:
Gene Tree for SRSF5 (if available)

Paralogs for SRSF5 Gene

Variants for SRSF5 Gene

Sequence variations from dbSNP and Humsavar for SRSF5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000041250 -- 69,771,646(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000320344 -- 69,767,144(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000487319 -- 69,770,275(+) A/G intron_variant, non_coding_transcript_variant
rs1001042489 -- 69,770,590(+) C/T intron_variant
rs1001300670 -- 69,767,733(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF5 Gene

Variant ID Type Subtype PubMed ID
nsv565007 CNV gain 21841781
nsv456336 CNV gain 19166990

Variation tolerance for SRSF5 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF5 Gene

Disorders for SRSF5 Gene

Additional Disease Information for SRSF5

No disorders were found for SRSF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF5 Gene

Publications for SRSF5 Gene

  1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PMID: 9434190) Du K … Taub R (Gene 1997) 3 4 22 58
  2. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton GR … Krainer AR (The EMBO journal 1995) 3 4 22 58
  3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 58
  4. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. (PMID: 19843576) Chandradas S … Bogdanov VY (Journal of leukocyte biology 2010) 3 22 58
  5. Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. (PMID: 19004959) Jablonski JA … Caputi M (Journal of virology 2009) 3 22 58

Products for SRSF5 Gene

Sources for SRSF5 Gene

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