The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different ... See more...

Aliases for SRSF5 Gene

Aliases for SRSF5 Gene

  • Serine And Arginine Rich Splicing Factor 5 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 5 2 3 4
  • Serine/Arginine-Rich Splicing Factor 5 2 3 4
  • Pre-MRNA-Splicing Factor SRP40 3 4
  • Delayed-Early Protein HRS 3 4
  • SR Splicing Factor 5 2 3
  • SFRS5 3 4
  • SRP40 3 4
  • HRS 3 4

External Ids for SRSF5 Gene

Previous HGNC Symbols for SRSF5 Gene

  • SFRS5

Previous GeneCards Identifiers for SRSF5 Gene

  • GC14P070234
  • GC14P050402

Summaries for SRSF5 Gene

Entrez Gene Summary for SRSF5 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SRSF5 Gene

SRSF5 (Serine And Arginine Rich Splicing Factor 5) is a Protein Coding gene. Diseases associated with SRSF5 include Endometrial Stromal Tumor and Endometrial Stromal Sarcoma. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF6.

UniProtKB/Swiss-Prot Summary for SRSF5 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Gene Wiki entry for SRSF5 Gene

Additional gene information for SRSF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF5 Gene

Genomics for SRSF5 Gene

GeneHancer (GH) Regulatory Elements for SRSF5 Gene

Promoters and enhancers for SRSF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J069765 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.4 +40.9 40881 3.8 HNRNPK ZBTB40 ZNF217 EP300 TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 SRSF5 HQ292181 LOC100289511 NONHSAG015336.2 piR-44940-001 piR-39245 ADAM20P1 ERH SLC10A1
GH14J069726 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.3 250 1.2 ZNF217 CTCF NRF1 ZFX GABPA TARDBP REST RAD21 CTBP1 TRIM22 SRSF5 HSALNG0102188
GH14J069724 Enhancer 0.3 dbSUPER 500.7 -1.6 -1626 1 NFIC SRSF5 piR-33294
GH14J070358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 63.3 +632.3 632300 2.8 FOXK2 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A TCF12 USF1 POLR2G SP1 COX16 RF00004-043 RNU2-51P SRSF5 MED6 ADAM20P1 SUSD6 ERH PTTG4P RPL7AP6
GH14J068778 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 46.5 -938.7 -938679 20.4 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 ZFP36L1 SRSF5 DCAF5 ZFYVE26 DDX18P1 SUSD6 RNU6-921P MG828526 lnc-RAD51B-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRSF5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF5

Genomic Locations for SRSF5 Gene

Genomic Locations for SRSF5 Gene
chr14:69,726,900-69,772,005
(GRCh38/hg38)
Size:
45,106 bases
Orientation:
Plus strand
chr14:70,193,617-70,238,722
(GRCh37/hg19)
Size:
45,106 bases
Orientation:
Plus strand

Genomic View for SRSF5 Gene

Genes around SRSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF5 Gene

Proteins for SRSF5 Gene

  • Protein details for SRSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13243-SRSF5_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Protein Accession:
    Q13243
    Secondary Accessions:
    • O14797
    • Q16662
    • Q49AD6
    • Q6FGE0

    Protein attributes for SRSF5 Gene

    Size:
    272 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
    Miscellaneous:
    • [Isoform SRP40-2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAC39543.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for SRSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF5 Gene

Post-translational modifications for SRSF5 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRSF5 Gene

Domains & Families for SRSF5 Gene

Gene Families for SRSF5 Gene

Protein Domains for SRSF5 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRSF5 Gene

GenScript: Design optimal peptide antigens:
  • Splicing factor arginine/serine-rich 5 (B5BUD8_HUMAN)
  • cDNA, FLJ92066, Homo sapiens splicing factor, arginine/serine-rich 5 (SFRS5), mRNA (Q6FGE0_HUMAN)
  • Splicing factor, arginine/serine-rich 5, isoform CRA_c (Q86U32_HUMAN)
  • Splicing factor, arginine/serine-rich 5 (SRSF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13243

UniProtKB/Swiss-Prot:

SRSF5_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF5: view

Function for SRSF5 Gene

Molecular function for SRSF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Phenotypes From GWAS Catalog for SRSF5 Gene

Gene Ontology (GO) - Molecular Function for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,IEA 21873635
GO:0005515 protein binding IPI 12762840
GO:0043422 protein kinase B binding IEA --
genes like me logo Genes that share ontologies with SRSF5: view
genes like me logo Genes that share phenotypes with SRSF5: view

Animal Model Products

CRISPR Products

miRNA for SRSF5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF5 Gene

Localization for SRSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF5 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck IBA,ISS --
genes like me logo Genes that share ontologies with SRSF5: view

Pathways & Interactions for SRSF5 Gene

genes like me logo Genes that share pathways with SRSF5: view

Pathways by source for SRSF5 Gene

Gene Ontology (GO) - Biological Process for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA 21873635
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001889 liver development IEA --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
genes like me logo Genes that share ontologies with SRSF5: view

No data available for SIGNOR curated interactions for SRSF5 Gene

Drugs & Compounds for SRSF5 Gene

(2) Drugs for SRSF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SRSF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRSF5: view

Transcripts for SRSF5 Gene

mRNA/cDNA for SRSF5 Gene

3 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - -
SP19: - - - -
SP20: - - -
SP21:
SP22: - - -
SP23: -
SP24:
SP25:

ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for SRSF5 Gene

GeneLoc Exon Structure for
SRSF5

Expression for SRSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF5 Gene

This gene is overexpressed in Adrenal (15.1), Peripheral blood mononuclear cells (8.4), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF5 Gene



Protein tissue co-expression partners for SRSF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF5

SOURCE GeneReport for Unigene cluster for SRSF5 Gene:

Hs.632326

Evidence on tissue expression from TISSUES for SRSF5 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Skin(4.7)
  • Intestine(4.5)
  • Eye(3.1)
  • Lung(2.9)
  • Pancreas(2.9)
  • Bone marrow(2.5)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Blood(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Heart(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SRSF5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF5 Gene

Orthologs for SRSF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF5 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS5 31
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF5 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF5 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf5 31
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF5 31
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF5 31 30
  • 81.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF5 31
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5499 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8018 30
zebrafish
(Danio rerio)
Actinopterygii srsf5b 31
  • 70 (a)
OneToOne
Dr.11695 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8311 30
fruit fly
(Drosophila melanogaster)
Insecta B52 31
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-5 31
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 31
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToMany
CSA.9965 31
  • 53 (a)
OneToMany
Species where no ortholog for SRSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF5 Gene

ENSEMBL:
Gene Tree for SRSF5 (if available)
TreeFam:
Gene Tree for SRSF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRSF5: view image

Paralogs for SRSF5 Gene

Paralogs for SRSF5 Gene

(33) SIMAP similar genes for SRSF5 Gene using alignment to 5 proteins:

  • SRSF5_HUMAN
  • B4DJK0_HUMAN
  • B4DUA4_HUMAN
  • G3V5K8_HUMAN
  • L8E9M6_HUMAN
genes like me logo Genes that share paralogs with SRSF5: view

Variants for SRSF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1057683 - p.Ala160Ser

Additional dbSNP identifiers (rs#s) for SRSF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRSF5 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781

Variation tolerance for SRSF5 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF5 Gene

Disorders for SRSF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRSF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrial stromal tumor
  • endometrial stromal neoplasm
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards
Search SRSF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRSF5

genes like me logo Genes that share disorders with SRSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF5 Gene

Publications for SRSF5 Gene

  1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PMID: 9434190) Du K … Taub R (Gene 1997) 3 4 23 54
  2. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton GR … Krainer AR (The EMBO journal 1995) 3 4 23 54
  3. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. (PMID: 19843576) Chandradas S … Bogdanov VY (Journal of leukocyte biology 2010) 3 23 54
  4. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 54
  5. Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. (PMID: 19004959) Jablonski JA … Caputi M (Journal of virology 2009) 3 23 54

Products for SRSF5 Gene