This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009] See more...

Aliases for SRSF4 Gene

Aliases for SRSF4 Gene

  • Serine And Arginine Rich Splicing Factor 4 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 4 2 3 4
  • Serine/Arginine-Rich Splicing Factor 4 2 3 4
  • Pre-MRNA-Splicing Factor SRP75 3 4
  • SR Splicing Factor 4 2 3
  • SRP001LB 3 4
  • SFRS4 3 4
  • SRP75 3 4

External Ids for SRSF4 Gene

Previous HGNC Symbols for SRSF4 Gene

  • SFRS4

Previous GeneCards Identifiers for SRSF4 Gene

  • GC01M029474
  • GC01M027727

Summaries for SRSF4 Gene

Entrez Gene Summary for SRSF4 Gene

  • This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

GeneCards Summary for SRSF4 Gene

SRSF4 (Serine And Arginine Rich Splicing Factor 4) is a Protein Coding gene. Diseases associated with SRSF4 include Frontotemporal Dementia. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF6.

UniProtKB/Swiss-Prot Summary for SRSF4 Gene

  • Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF4 Gene

Additional gene information for SRSF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF4 Gene

Genomics for SRSF4 Gene

GeneHancer (GH) Regulatory Elements for SRSF4 Gene

Promoters and enhancers for SRSF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRSF4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF4

Genomic Locations for SRSF4 Gene

Genomic Locations for SRSF4 Gene
chr1:29,147,738-29,182,125
(GRCh38/hg38)
Size:
34,388 bases
Orientation:
Minus strand
chr1:29,474,250-29,508,637
(GRCh37/hg19)
Size:
34,388 bases
Orientation:
Minus strand

Genomic View for SRSF4 Gene

Genes around SRSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF4 Gene

Proteins for SRSF4 Gene

  • Protein details for SRSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08170-SRSF4_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 4
    Protein Accession:
    Q08170
    Secondary Accessions:
    • Q5VXP1
    • Q9BUA4
    • Q9UEB5

    Protein attributes for SRSF4 Gene

    Size:
    494 amino acids
    Molecular mass:
    56678 Da
    Quaternary structure:
    • Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

neXtProt entry for SRSF4 Gene

Post-translational modifications for SRSF4 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF4 Gene

No data available for DME Specific Peptides for SRSF4 Gene

Domains & Families for SRSF4 Gene

Gene Families for SRSF4 Gene

Protein Domains for SRSF4 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRSF4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76859, highly similar to Homo sapiens splicing factor, arginine/serine-rich 4 (SFRS4), mRNA (A8K644_HUMAN)
  • Splicing factor, arginine/serine-rich 4 (SRSF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08170

UniProtKB/Swiss-Prot:

SRSF4_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF4: view

Function for SRSF4 Gene

Molecular function for SRSF4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Phenotypes From GWAS Catalog for SRSF4 Gene

Gene Ontology (GO) - Molecular Function for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0005515 protein binding IPI 22365833
GO:1990825 sequence-specific mRNA binding IEA --
genes like me logo Genes that share ontologies with SRSF4: view
genes like me logo Genes that share phenotypes with SRSF4: view

Animal Models for SRSF4 Gene

MGI Knock Outs for SRSF4:
  • Srsf4 Srsf4<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF4 Gene

Localization for SRSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF4 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF4 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA,IBA --
genes like me logo Genes that share ontologies with SRSF4: view

Pathways & Interactions for SRSF4 Gene

genes like me logo Genes that share pathways with SRSF4: view

Pathways by source for SRSF4 Gene

Gene Ontology (GO) - Biological Process for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 8321209
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA 21873635
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 8321209
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF4: view

No data available for SIGNOR curated interactions for SRSF4 Gene

Drugs & Compounds for SRSF4 Gene

(1) Drugs for SRSF4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 113
genes like me logo Genes that share compounds with SRSF4: view

Transcripts for SRSF4 Gene

mRNA/cDNA for SRSF4 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - -

Relevant External Links for SRSF4 Gene

GeneLoc Exon Structure for
SRSF4

Expression for SRSF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF4 Gene

This gene is overexpressed in Nasal epithelium (18.8) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF4 Gene



Protein tissue co-expression partners for SRSF4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF4

SOURCE GeneReport for Unigene cluster for SRSF4 Gene:

Hs.469970

Evidence on tissue expression from TISSUES for SRSF4 Gene

  • Liver(4.4)
  • Nervous system(3.8)
  • Lung(2.1)
  • Spleen(2.1)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SRSF4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF4 Gene

Orthologs for SRSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF4 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS4 31
  • 93 (a)
OneToOne
SRSF4 30
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF4 31
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF4 31 30
  • 88.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf4 30
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Srsf4 17 31 30
  • 83.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF4 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF4 31 30
  • 73.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii srsf4 31
  • 68 (a)
OneToOne
wufb37e02 30
worm
(Caenorhabditis elegans)
Secernentea rsp-2 31
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 31
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.9457 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9457 30
Species where no ortholog for SRSF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRSF4 Gene

ENSEMBL:
Gene Tree for SRSF4 (if available)
TreeFam:
Gene Tree for SRSF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRSF4: view image

Paralogs for SRSF4 Gene

Paralogs for SRSF4 Gene

(10) SIMAP similar genes for SRSF4 Gene using alignment to 3 proteins:

  • SRSF4_HUMAN
  • F6T1J1_HUMAN
  • S4R2X6_HUMAN
genes like me logo Genes that share paralogs with SRSF4: view

Variants for SRSF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1049928 - p.Gln438Glu
rs2230677 - p.Gly338Ala
rs2230678 - p.Gly356Ser
rs2230679 - p.Glu253Asp

Additional dbSNP identifiers (rs#s) for SRSF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRSF4 Gene

Variant ID Type Subtype PubMed ID
esv3585602 CNV gain 21293372
nsv509091 CNV insertion 20534489

Variation tolerance for SRSF4 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.22; 97.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF4 Gene

Disorders for SRSF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia
  • multiple system tauopathy with presenile dementia
- elite association - COSMIC cancer census association via MalaCards
Search SRSF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRSF4

genes like me logo Genes that share disorders with SRSF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF4 Gene

Publications for SRSF4 Gene

  1. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PMID: 14578391) Zimowska G … Sugrue SP (Investigative ophthalmology & visual science 2003) 3 4 23 54
  2. Human SR proteins and isolation of a cDNA encoding SRp75. (PMID: 8321209) Zahler AM … Roth MB (Molecular and cellular biology 1993) 2 3 4 54
  3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for SRSF4 Gene