The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different ... See more...

Aliases for SRSF3 Gene

Aliases for SRSF3 Gene

  • Serine And Arginine Rich Splicing Factor 3 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 3 2 3 4
  • Serine/Arginine-Rich Splicing Factor 3 2 3 4
  • Pre-MRNA-Splicing Factor SRP20 3 4
  • SFRS3 3 4
  • SRp20 2 3
  • Splicing Factor, Arginine/Serine-Rich, 20-KD 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Pre-MRNA Splicing Factor SRp20 3
  • SRSF3 5
  • SRP20 4

External Ids for SRSF3 Gene

Previous HGNC Symbols for SRSF3 Gene

  • SFRS3

Previous GeneCards Identifiers for SRSF3 Gene

  • GC06P036562
  • GC06P036280
  • GC06P036928
  • GC06P036964
  • GC06P042820
  • GC06P043160
  • GC06P043362
  • GC06P046053
  • GC06P037790
  • GC06P038413
  • GC06P039002
  • GC06P039591
  • GC06P040151
  • GC06P041229
  • GC06P041906
  • GC06P042550

Summaries for SRSF3 Gene

Entrez Gene Summary for SRSF3 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF3 Gene

SRSF3 (Serine And Arginine Rich Splicing Factor 3) is a Protein Coding gene. Diseases associated with SRSF3 include Ocular Hypertension and Paralytic Poliomyelitis. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF7.

UniProtKB/Swiss-Prot Summary for SRSF3 Gene

  • Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).

Gene Wiki entry for SRSF3 Gene

Additional gene information for SRSF3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF3 Gene

Genomics for SRSF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRSF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRSF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF3

Genomic Locations for SRSF3 Gene

Genomic Locations for SRSF3 Gene
chr6:36,594,313-36,605,600
(GRCh38/hg38)
Size:
11,288 bases
Orientation:
Plus strand
chr6:36,562,090-36,573,377
(GRCh37/hg19)
Size:
11,288 bases
Orientation:
Plus strand

Genomic View for SRSF3 Gene

Genes around SRSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF3 Gene

Proteins for SRSF3 Gene

  • Protein details for SRSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84103-SRSF3_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 3
    Protein Accession:
    P84103
    Secondary Accessions:
    • B4E241
    • O08831
    • P23152
    • Q5R3K0

    Protein attributes for SRSF3 Gene

    Size:
    164 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    • Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937, PubMed:28984244).

    Three dimensional structures from OCA and Proteopedia for SRSF3 Gene

    Alternative splice isoforms for SRSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF3 Gene

Post-translational modifications for SRSF3 Gene

  • Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys23 and Lys85
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF3 Gene

No data available for DME Specific Peptides for SRSF3 Gene

Domains & Families for SRSF3 Gene

Gene Families for SRSF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRSF3 Gene

Suggested Antigen Peptide Sequences for SRSF3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92926, Homo sapiens splicing factor, arginine/serine-rich 3 (SFRS3), mRNA (B2R6F3_HUMAN)
  • cDNA FLJ52832, highly similar to Splicing factor, arginine/serine-rich 3 (B4E241_HUMAN)
  • Splicing factor, arginine/serine-rich 3 (SRSF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P84103

UniProtKB/Swiss-Prot:

SRSF3_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF3: view

Function for SRSF3 Gene

Molecular function for SRSF3 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). RNA-binding is semi-sequence specific (PubMed:17036044).

Phenotypes From GWAS Catalog for SRSF3 Gene

Gene Ontology (GO) - Molecular Function for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,IDA 26876937
GO:0005515 protein binding IPI 14559993
GO:0043274 phospholipase binding IEA --
GO:1990825 sequence-specific mRNA binding IEA --
genes like me logo Genes that share ontologies with SRSF3: view
genes like me logo Genes that share phenotypes with SRSF3: view

Animal Models for SRSF3 Gene

MGI Knock Outs for SRSF3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF3 Gene

Localization for SRSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF3 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000269 PubMed:26876937}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IBA,IDA 26876937
genes like me logo Genes that share ontologies with SRSF3: view

Pathways & Interactions for SRSF3 Gene

genes like me logo Genes that share pathways with SRSF3: view

Pathways by source for SRSF3 Gene

SIGNOR curated interactions for SRSF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA 21873635
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF3: view

Drugs & Compounds for SRSF3 Gene

(2) Drugs for SRSF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SRSF3: view

Transcripts for SRSF3 Gene

mRNA/cDNA for SRSF3 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF3

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - -
SP11:
SP12: - -

ExUns: 13f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SRSF3 Gene

GeneLoc Exon Structure for
SRSF3

Expression for SRSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF3 Gene



Protein tissue co-expression partners for SRSF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF3

SOURCE GeneReport for Unigene cluster for SRSF3 Gene:

Hs.405144

Evidence on tissue expression from TISSUES for SRSF3 Gene

  • Nervous system(5)
  • Lung(4.5)
  • Kidney(4.2)
  • Liver(4.2)
  • Pancreas(4.1)
  • Skin(4)
  • Intestine(3.9)
  • Blood(3.7)
  • Eye(3.3)
  • Heart(3)
  • Muscle(2.9)
  • Bone marrow(2.8)
  • Stomach(2.7)
  • Lymph node(2.6)
  • Thyroid gland(2.6)
  • Bone(2.5)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with SRSF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF3 Gene

Orthologs for SRSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF3 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia SRSF3 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia SRSF3 30 31
  • 99.59 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SRSF3 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm12355 31
  • 96 (a)
OneToOne
Srsf3 30 17
  • 91.87 (n)
Cow
(Bos Taurus)
Mammalia SRSF3 30 31
  • 94.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SRSF3 30 31
  • 94.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Srsf3 30
  • 93.5 (n)
Chicken
(Gallus gallus)
Aves SRSF3 30 31
  • 83.54 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SRSF3 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia srsf3 30
  • 80.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia sfrs3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii srsf3b 31
  • 94 (a)
OneToMany
srsf3a 31
  • 85 (a)
OneToMany
sfrs3 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11030 30
Worm
(Caenorhabditis elegans)
Secernentea rsp-6 31
  • 48 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9083 31
  • 58 (a)
OneToOne
Species where no ortholog for SRSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SRSF3 Gene

ENSEMBL:
Gene Tree for SRSF3 (if available)
TreeFam:
Gene Tree for SRSF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRSF3: view image

Paralogs for SRSF3 Gene

Paralogs for SRSF3 Gene

(7) SIMAP similar genes for SRSF3 Gene using alignment to 1 proteins:

  • SRSF3_HUMAN
genes like me logo Genes that share paralogs with SRSF3: view

Variants for SRSF3 Gene

Additional dbSNP identifiers (rs#s) for SRSF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRSF3 Gene

Variant ID Type Subtype PubMed ID
esv3608706 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv1131956 CNV deletion 24896259
nsv969391 CNV duplication 23825009

Variation tolerance for SRSF3 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF3 Gene

Disorders for SRSF3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SRSF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ocular hypertension
  • hypertension, ocular
paralytic poliomyelitis
  • poliomyelitis, paralytic
spinal muscular atrophy
  • progressive muscular atrophy
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards
Search SRSF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRSF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SRSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF3 Gene

Publications for SRSF3 Gene

  1. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PMID: 17036044) Hargous Y … Allain FH (The EMBO journal 2006) 3 4 23
  2. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. (PMID: 11336712) Huang Y … Steitz JA (Molecular cell 2001) 3 4 23
  3. SR proteins: a conserved family of pre-mRNA splicing factors. (PMID: 1577277) Zahler AM … Roth MB (Genes & development 1992) 2 3 4
  4. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. (PMID: 28984244) Roundtree IA … He C (eLife 2017) 3 4
  5. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. (PMID: 26876937) Xiao W … Yang YG (Molecular cell 2016) 3 4

Products for SRSF3 Gene

  • Signalway ELISA kits for SRSF3
  • Signalway Proteins for SRSF3

Sources for SRSF3 Gene