Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins.... See more...
Aliases for SRSF11 Gene
Aliases for SRSF11 Gene
External Ids for SRSF11 Gene
- HGNC: 10782
- Entrez Gene: 9295
- Ensembl: ENSG00000116754
- OMIM: 602010
- UniProtKB: Q05519
Previous HGNC Symbols for SRSF11 Gene
- SFRS11
Previous GeneCards Identifiers for SRSF11 Gene
- GC01P070672
- GC01P068782
Summaries for SRSF11 Gene
-
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
GeneCards Summary for SRSF11 Gene
SRSF11 (Serine And Arginine Rich Splicing Factor 11) is a Protein Coding gene. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SREK1.
UniProtKB/Swiss-Prot Summary for SRSF11 Gene
-
May function in pre-mRNA splicing.
Additional gene information for SRSF11 Gene
- HGNC(10782)
- Entrez Gene(9295)
- Ensembl(ENSG00000116754)
- OMIM(602010)
- UniProtKB(Q05519)
- Open Targets Platform(ENSG00000116754)
- Search for SRSF11 at DataMed
- Search for SRSF11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF11 Gene
Genomics for SRSF11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SRSF11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SRSF11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF11
Genomic Locations for SRSF11 Gene
Genomic Locations for SRSF11 Gene
- chr1:70,205,682-70,253,052
- (GRCh38/hg38)
- Size:
- 47,371 bases
- Orientation:
- Plus strand
- chr1:70,671,365-70,718,735
- (GRCh37/hg19)
- Size:
- 47,371 bases
- Orientation:
- Plus strand
Genomic View for SRSF11 Gene
Genes around SRSF11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by HGNC
- 1p31.1 by Entrez Gene
- 1p31.1 by Ensembl
SRSF11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRSF11 Gene
Proteins for SRSF11 Gene
-
Protein details for SRSF11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q05519-SRS11_HUMAN
- Recommended name:
- Serine/arginine-rich splicing factor 11
- Protein Accession:
- Q05519
- Q5T758
- Q8IWE6
Protein attributes for SRSF11 Gene
- Size:
- 484 amino acids
- Molecular mass:
- 53542 Da
- Quaternary structure:
-
- Interacts with PUF60.
Protein Expression for SRSF11 Gene
Post-translational modifications for SRSF11 Gene
Other Protein References for SRSF11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005271395.1
- XP_011540730.1
- XP_011540733.1
- XP_016858304.1
- XP_016858306.1
- XP_016858308.1
- XP_016858309.1
- XP_016858314.1
- XP_016858320.1
- XP_024306673.1
- XP_024306674.1
- XP_024306676.1
- XP_024306680.1
- XP_024306683.1
- XP_024306684.1
- XP_024306685.1
- XP_024306689.1
- XP_024306690.1
- XP_024306691.1
- XP_024306693.1
- XP_024306695.1
- NP_001177916.1
- NP_001337534.1
- NP_001337535.1
- NP_001337536.1
- NP_001337537.1
- NP_001337538.1
- NP_001337539.1
- NP_001337540.1
- NP_001337541.1
- NP_001337542.1
- NP_001337543.1
- NP_001337544.1
- NP_001337545.1
- NP_004759.1
Antibody Products
- G Biosciences Immunotag™ SFRS11 Antibody and Immunotag™ SFRS11 Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for SRSF11
- Novus Biologicals Antibodies for SRSF11
-
Abcam antibodies for SRSF11
- Invitrogen Antibodies for SRSF11 (AFLGC-SRSF11)
Protein Products
-
OriGene Purified Proteins for SRSF11
- Search Origene for MassSpec and Protein Over-expression Lysates for SRSF11
- Origene Custom Protein Services for SRSF11
No data available for DME Specific Peptides for SRSF11 Gene
Domains & Families for SRSF11 Gene
Gene Families for SRSF11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SRSF11 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for SRSF11 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58939, highly similar to Splicing factor arginine/serine-rich 11 (B4DTC1_HUMAN)
- cDNA FLJ52287, highly similar to Splicing factor arginine/serine-rich 11 (B4DWT1_HUMAN)
- SFRS11 protein (Q05BU6_HUMAN)
- SFRS11 protein (Q6PJB9_HUMAN)
- SFRS11 protein (Q6PJY9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q05519- Family:
-
- Belongs to the splicing factor SR family.
Function for SRSF11 Gene
Molecular function for SRSF11 Gene
- UniProtKB/Swiss-Prot Function:
- May function in pre-mRNA splicing.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 20195357 |
Phenotypes for SRSF11 Gene
- MGI mutant phenotypes for SRSF11:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SRSF11:
Animal Models for SRSF11 Gene
- MGI Knock Outs for SRSF11:
-
- Srsf11 Srsf11<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRSF11 - Select products 50% OFF >
- * SRSF11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRSF11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRSF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRSF11
miRNA for SRSF11 Gene
- miRTarBase miRNAs that target SRSF11
-
- hsa-miR-376a-5p (MIRT004025)
- mmu-miR-340-5p (MIRT010274)
- mmu-miR-24-3p (MIRT013761)
- hsa-miR-376a-3p (MIRT019666)
- hsa-miR-21-5p (MIRT030735)
- hsa-miR-423-5p (MIRT038024)
- hsa-miR-186-5p (MIRT045297)
- hsa-miR-126-5p (MIRT195903)
- hsa-miR-576-3p (MIRT195904)
- hsa-miR-944 (MIRT195905)
- hsa-miR-3190-3p (MIRT195906)
- hsa-miR-3668 (MIRT195907)
- hsa-miR-4491 (MIRT195908)
- hsa-miR-4657 (MIRT195910)
- hsa-miR-6505-5p (MIRT195911)
- hsa-miR-6833-5p (MIRT195912)
- hsa-miR-493-3p (MIRT285709)
- hsa-miR-3974 (MIRT285713)
- hsa-miR-4999-3p (MIRT285714)
- hsa-miR-5195-5p (MIRT285715)
- hsa-miR-6832-3p (MIRT285719)
- hsa-miR-4738-3p (MIRT285723)
- hsa-miR-376a-2-5p (MIRT344215)
- hsa-miR-3935 (MIRT344221)
- hsa-miR-548t-5p (MIRT344224)
- hsa-miR-3609 (MIRT344225)
- hsa-miR-548ah-5p (MIRT344226)
- hsa-miR-548az-5p (MIRT344227)
- hsa-miR-510-3p (MIRT445829)
- hsa-miR-127-5p (MIRT445830)
- hsa-miR-6806-3p (MIRT445831)
- hsa-miR-3928-5p (MIRT445832)
- hsa-miR-6807-3p (MIRT445833)
- hsa-miR-217 (MIRT445834)
- hsa-miR-509-5p (MIRT445835)
- hsa-miR-4418 (MIRT445836)
- hsa-miR-509-3-5p (MIRT445837)
- hsa-miR-100-3p (MIRT445838)
- hsa-miR-653-3p (MIRT544208)
- hsa-miR-4420 (MIRT544209)
- hsa-miR-181b-3p (MIRT544210)
- hsa-miR-181b-2-3p (MIRT544211)
- hsa-miR-556-3p (MIRT544212)
- hsa-miR-3682-5p (MIRT544213)
- hsa-miR-3171 (MIRT544214)
- hsa-miR-3662 (MIRT574415)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF11
- Browse OriGene Inhibitory RNA Products For SRSF11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF11
Clone Products
- Applied Biological Materials (abm): Clones for SRSF11 - Select products 50% OFF >
- * SRSF11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226399
- MG226400
- MG226401
- MR226399
- MR226399L3
- MR226399L4
- MR226400
- MR226400L3
- MR226400L4
- MR226401
- MR226401L3
- MR226401L4
- RC208055
- RC208055L3
- RC208055L4
- RC230840
- RC230840L3
- RC230840L4
- RG208055
- RG230840
- RR201466
- RR201466L3
- RR201466L4
- MR226399L3V
- MR226399L4V
- MR226400L3V
- MR226400L4V
- MR226401L3V
- MR226401L4V
- RC208055L3V
- RC208055L4V
- RC230840L3V
- RC230840L4V
- RR201466L3V
- RR201466L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SRSF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRSF11
Cell Line Products
-
Horizon Cell Lines for SRSF11
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF11 Gene
Localization for SRSF11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRSF11 Gene
- Nucleus. Note=Colocalizes with spliceosome components.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 1896467 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for SRSF11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cleavage of Growing Transcript in the Termination Region | ||
| 2 | mRNA Splicing - Major Pathway |
.79
|
|
| 3 | Transport of Mature Transcript to Cytoplasm | ||
| 4 | Gene Expression |
.48
|
|
| 5 | HIV Transcription Elongation | ||
Pathways by source for SRSF11 Gene
10 Reactome pathways for SRSF11 Gene
Interacting Proteins for SRSF11 Gene
Selected Interacting proteins:
Q05519-SRS11_HUMAN
ENSP00000359988
for SRSF11 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SRSF11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | TAS | 1896467 |
| GO:0006405 | RNA export from nucleus | TAS | -- |
| GO:0006406 | mRNA export from nucleus | TAS | -- |
| GO:0008380 | RNA splicing | IEA,TAS | 1896467 |
No data available for SIGNOR curated interactions for SRSF11 Gene
Transcripts for SRSF11 Gene
mRNA/cDNA for SRSF11 Gene
- 14 REFSEQ mRNAs :
- 35 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370949 3034 nts (view in UCSC)
- ENST00000370950 3784 nts (view in UCSC)
- ENST00000370951 2385 nts (view in UCSC)
- ENST00000395136 1408 nts (view in UCSC)
- ENST00000460795 528 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRSF11 - Select products 50% OFF >
- * SRSF11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRSF11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRSF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRSF11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF11
- Browse OriGene Inhibitory RNA Products For SRSF11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF11
Clone Products
- Applied Biological Materials (abm): Clones for SRSF11 - Select products 50% OFF >
- * SRSF11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226399
- MG226400
- MG226401
- MR226399
- MR226399L3
- MR226399L4
- MR226400
- MR226400L3
- MR226400L4
- MR226401
- MR226401L3
- MR226401L4
- RC208055
- RC208055L3
- RC208055L4
- RC230840
- RC230840L3
- RC230840L4
- RG208055
- RG230840
- RR201466
- RR201466L3
- RR201466L4
- MR226399L3V
- MR226399L4V
- MR226400L3V
- MR226400L4V
- MR226401L3V
- MR226401L4V
- RC208055L3V
- RC208055L4V
- RC230840L3V
- RC230840L4V
- RR201466L3V
- RR201466L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SRSF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRSF11
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: | |||||||||||
| SP19: | |||||||||||
| SP20: | |||||||||||
| SP21: | |||||||||||
| SP22: |
Relevant External Links for SRSF11 Gene
- GeneLoc Exon Structure for
- SRSF11
Expression for SRSF11 Gene
This gene is overexpressed in Lymph node (11.0) and Testis (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF11 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF11
SOURCE GeneReport for Unigene cluster for SRSF11 Gene:
Hs.479693Evidence on tissue expression from TISSUES for SRSF11 Gene
- Liver(4.6)
- Nervous system(4.5)
- Lung(3.8)
- Skin(2.7)
- Kidney(2.6)
- Heart(2.4)
- Muscle(2.3)
- Thyroid gland(2.1)
- Bone marrow(2.1)
- Spleen(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for SRSF11
-
OriGene qPCR primer pairs and template standards for SRSF11
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF11 Gene
Orthologs for SRSF11 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SRSF11 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SFRS11 31 |
|
OneToOne | |
| SRSF11 30 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SRSF11 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SRSF11 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Srsf11 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Srsf11 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SRSF11 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SRSF11 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SRSF11 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.34822 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.2497 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | srsf11 31 |
|
OneToOne | |
| wufb37g02 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6523 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Srp54 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rsp-7 31 |
|
OneToMany |
- Species where no ortholog for SRSF11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SRSF11 Gene
- ENSEMBL:
- Gene Tree for SRSF11 (if available)
- TreeFam:
- Gene Tree for SRSF11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SRSF11: view image
Paralogs for SRSF11 Gene
(6) SIMAP similar genes for SRSF11 Gene using alignment to 6 proteins:
- SRS11_HUMAN
- B4DTC1_HUMAN
- B4DWT1_HUMAN
- Q5T757_HUMAN
- Q5T760_HUMAN
- S4R3C4_HUMAN
Pseudogenes.org Pseudogenes for SRSF11 Gene
Variants for SRSF11 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2671094 | CNV | deletion | 23128226 |
| esv3586351 | CNV | loss | 21293372 |
| nsv1014292 | CNV | gain | 25217958 |
| nsv1076523 | CNV | deletion | 25765185 |
| nsv1343 | CNV | insertion | 18451855 |
| nsv950171 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.23;
5.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRSF11 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF11 Gene
Disorders for SRSF11 Gene
Additional Disease Information for SRSF11
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for SRSF11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF11 Gene
Publications for SRSF11 Gene
- Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PMID: 1896467) Chaudhary N … Blobel G (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23
- A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
- Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E … Mayeda A (Molecular and cellular biology 2004) 3 23
- PUF60: a novel U2AF65-related splicing activity. (PMID: 10606266) Page-McCaw PS … Sharp PA (RNA (New York, N.Y.) 1999) 3 4
ExternalLinks
Products for SRSF11 Gene
- Custom Antibody ServicesOriGene Antibodies for SRSF11
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SRSF11
- Search Origene for MassSpec and Protein Over-expression Lysates for SRSF11
- Origene Custom Protein Services for SRSF11
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF11
- Browse OriGene Inhibitory RNA Products For SRSF11
- OriGene qPCR primer pairs for SRSF11
- OriGene qPCR primer pairs and template standards for SRSF11
- OriGene CRISPR knockouts for SRSF11
- MG226399
- MG226400
- MG226401
- MR226399
- MR226399L3
- MR226399L4
- MR226400
- MR226400L3
- MR226400L4
- MR226401
- MR226401L3
- MR226401L4
- RC208055
- RC208055L3
- RC208055L4
- RC230840
- RC230840L3
- RC230840L4
- RG208055
- RG230840
- RR201466
- RR201466L3
- RR201466L4
- MR226399L3V
- MR226399L4V
- MR226400L3V
- MR226400L4V
- MR226401L3V
- MR226401L4V
- RC208055L3V
- RC208055L4V
- RC230840L3V
- RC230840L4V
- RR201466L3V
- RR201466L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SRSF11
- Sino Biological Human cDNA Clone for SRSF11
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SRSF11
- Novus Biologicals proteins and lysates for SRSF11
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SRSF11
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SRSF11 (AFLGC-SRSF11)
- VectorBuilder Custom and pre-made DNA vectors for SRSF11 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SRSF11 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SRSF11 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SRSF11 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SRSF11
- antibodies-online: Show 16 available SRSF11 Antibodies ranked by validation data
- Compare Top SRSF11 Antibodies
- antibodies-online: Search results for available SRSF11 related products ranked by validation data
- antibodies-online: Search results for available SRSF11 related products ranked by validation data
- Horizon Cell Lines for SRSF11
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRSF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRSF11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SRSF11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF11
Sources for SRSF11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB