This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins.... See more...

Aliases for SRSF11 Gene

Aliases for SRSF11 Gene

  • Serine And Arginine Rich Splicing Factor 11 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 11 2 3 4
  • Serine/Arginine-Rich Splicing Factor 11 2 3 4
  • Arginine-Rich 54 KDa Nuclear Protein 3 4
  • SR Splicing Factor 11 2 3
  • SFRS11 3 4
  • P54 3 4
  • Splicing Factor P54 3
  • DJ677H15.2 3
  • NET2 3

External Ids for SRSF11 Gene

Previous HGNC Symbols for SRSF11 Gene

  • SFRS11

Previous GeneCards Identifiers for SRSF11 Gene

  • GC01P070672
  • GC01P068782

Summaries for SRSF11 Gene

Entrez Gene Summary for SRSF11 Gene

  • This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF11 Gene

SRSF11 (Serine And Arginine Rich Splicing Factor 11) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SREK1.

UniProtKB/Swiss-Prot Summary for SRSF11 Gene

Gene Wiki entry for SRSF11 Gene

Additional gene information for SRSF11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF11 Gene

Genomics for SRSF11 Gene

GeneHancer (GH) Regulatory Elements for SRSF11 Gene

Promoters and enhancers for SRSF11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J070219 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.4 +16.2 16183 4.3 HNRNPK EP300 ZSCAN5C NRF1 POLR2G GTF2E2 PHF8 ZFX ZNF10 ZIC2 ENSG00000228988 NONHSAG001792.2-001 SRSF11 LRRC40 lnc-LRRC7-5
GH01J070203 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.2 198 4.3 ZBTB40 ZNF217 EP300 TCF12 SIN3A MYC NRF1 POLR2G SP1 NCOR1 LRRC40 SRSF11 piR-34911-001
GH01J070409 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.9 +206.3 206267 4.9 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 PHF8 TEAD4 ZNF639 ZNF10 CTH lnc-ANKRD13C-4 HHLA3 ZRANB2 ANKRD13C SRSF11 ENSG00000278636
GH01J070352 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15.9 +148.3 148319 4.8 ZBTB40 ZNF217 EP300 TCF12 SIN3A NRF1 POLR2G GTF2E2 PHF8 TEAD4 HHLA3 ANKRD13C SRSF11 ZRANB2 MIR186 LRRC40 HHLA3-AS1 lnc-LRRC40-5
GH01J071044 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 16.2 +841.0 840967 3.5 NRF1 ZIC2 ZNF423 ZBTB26 TARDBP MYC TOE1 CTBP1 JUN PRPF4 PTGER3 ZRANB2-AS1 SRSF11 ZRANB2 ENSG00000269933
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRSF11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF11

Genomic Locations for SRSF11 Gene

Genomic Locations for SRSF11 Gene
chr1:70,205,682-70,253,052
(GRCh38/hg38)
Size:
47,371 bases
Orientation:
Plus strand
chr1:70,671,365-70,718,735
(GRCh37/hg19)
Size:
47,371 bases
Orientation:
Plus strand

Genomic View for SRSF11 Gene

Genes around SRSF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF11 Gene

Proteins for SRSF11 Gene

  • Protein details for SRSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05519-SRS11_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 11
    Protein Accession:
    Q05519
    Secondary Accessions:
    • Q5T758
    • Q8IWE6

    Protein attributes for SRSF11 Gene

    Size:
    484 amino acids
    Molecular mass:
    53542 Da
    Quaternary structure:
    • Interacts with PUF60.

    Alternative splice isoforms for SRSF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF11 Gene

Post-translational modifications for SRSF11 Gene

  • Ubiquitination at Lys58, Lys82, and Lys197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRSF11 Gene

Domains & Families for SRSF11 Gene

Gene Families for SRSF11 Gene

Protein Domains for SRSF11 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRSF11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58939, highly similar to Splicing factor arginine/serine-rich 11 (B4DTC1_HUMAN)
  • cDNA FLJ52287, highly similar to Splicing factor arginine/serine-rich 11 (B4DWT1_HUMAN)
  • SFRS11 protein (Q05BU6_HUMAN)
  • SFRS11 protein (Q6PJB9_HUMAN)
  • SFRS11 protein (Q6PJY9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05519

UniProtKB/Swiss-Prot:

SRS11_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF11: view

Function for SRSF11 Gene

Molecular function for SRSF11 Gene

UniProtKB/Swiss-Prot Function:
May function in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with SRSF11: view
genes like me logo Genes that share phenotypes with SRSF11: view

Animal Models for SRSF11 Gene

MGI Knock Outs for SRSF11:
  • Srsf11 Srsf11<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF11 Gene

Localization for SRSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF11 Gene

Nucleus. Note=Colocalizes with spliceosome components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF11 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1896467
GO:0005654 nucleoplasm IBA,TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with SRSF11: view

Pathways & Interactions for SRSF11 Gene

genes like me logo Genes that share pathways with SRSF11: view

Gene Ontology (GO) - Biological Process for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 1896467
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing IEA,TAS 1896467
genes like me logo Genes that share ontologies with SRSF11: view

No data available for SIGNOR curated interactions for SRSF11 Gene

Drugs & Compounds for SRSF11 Gene

No Compound Related Data Available

Transcripts for SRSF11 Gene

mRNA/cDNA for SRSF11 Gene

14 REFSEQ mRNAs :
35 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - -
SP17: - - -
SP18: -
SP19: - - - -
SP20: - -
SP21:
SP22:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SRSF11 Gene

GeneLoc Exon Structure for
SRSF11

Expression for SRSF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF11 Gene

Protein differential expression in normal tissues from HIPED for SRSF11 Gene

This gene is overexpressed in Lymph node (11.0) and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF11 Gene



Protein tissue co-expression partners for SRSF11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF11

SOURCE GeneReport for Unigene cluster for SRSF11 Gene:

Hs.479693

Evidence on tissue expression from TISSUES for SRSF11 Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Lung(3.8)
  • Bone marrow(2.1)
  • Spleen(2.1)
  • Intestine(2)
  • Kidney(2)
  • Lymph node(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with SRSF11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF11 Gene

Orthologs for SRSF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF11 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS11 31
  • 98 (a)
OneToOne
SRSF11 30
  • 94.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF11 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF11 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf11 17 31 30
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Srsf11 30
  • 87.61 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF11 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF11 31
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF11 31
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34822 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2497 30
zebrafish
(Danio rerio)
Actinopterygii srsf11 31
  • 70 (a)
OneToOne
wufb37g02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6523 30
fruit fly
(Drosophila melanogaster)
Insecta Srp54 31
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-7 31
  • 30 (a)
OneToMany
Species where no ortholog for SRSF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF11 Gene

ENSEMBL:
Gene Tree for SRSF11 (if available)
TreeFam:
Gene Tree for SRSF11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRSF11: view image

Paralogs for SRSF11 Gene

Paralogs for SRSF11 Gene

(6) SIMAP similar genes for SRSF11 Gene using alignment to 6 proteins:

  • SRS11_HUMAN
  • B4DTC1_HUMAN
  • B4DWT1_HUMAN
  • Q5T757_HUMAN
  • Q5T760_HUMAN
  • S4R3C4_HUMAN

Pseudogenes.org Pseudogenes for SRSF11 Gene

genes like me logo Genes that share paralogs with SRSF11: view

Variants for SRSF11 Gene

Additional dbSNP identifiers (rs#s) for SRSF11 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRSF11 Gene

Variant ID Type Subtype PubMed ID
esv2671094 CNV deletion 23128226
esv3586351 CNV loss 21293372
nsv1014292 CNV gain 25217958
nsv1076523 CNV deletion 25765185
nsv1343 CNV insertion 18451855
nsv950171 CNV duplication 24416366

Variation tolerance for SRSF11 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF11 Gene

Human Gene Mutation Database (HGMD)
SRSF11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF11 Gene

Disorders for SRSF11 Gene

Additional Disease Information for SRSF11

No disorders were found for SRSF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF11 Gene

Publications for SRSF11 Gene

  1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PMID: 1896467) Chaudhary N … Blobel G (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23 54
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E … Mayeda A (Molecular and cellular biology 2004) 3 23 54
  5. PUF60: a novel U2AF65-related splicing activity. (PMID: 10606266) Page-McCaw PS … Sharp PA (RNA (New York, N.Y.) 1999) 3 4 54

Products for SRSF11 Gene

Sources for SRSF11 Gene