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Aliases for SRSF10 Gene

Aliases for SRSF10 Gene

  • Serine And Arginine Rich Splicing Factor 10 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 13A 2 3 4
  • FUS-Interacting Protein (Serine-Arginine Rich) 2 2 3
  • Protein Phosphatase 1, Regulatory Subunit 149 2 3
  • TLS-Associated Protein With Ser-Arg Repeats 3 4
  • Splicing Factor, Arginine/Serine-Rich 13 2 3
  • Serine/Arginine-Rich Splicing Factor 10 2 3
  • TLS-Associated Protein With SR Repeats 3 4
  • 40 KDa SR-Repressor Protein 3 4
  • Neural-Salient SR Protein 2 3
  • TLS-Associated SR Protein 3 4
  • SR Splicing Factor 10 2 3
  • Splicing Factor SRp38 3 4
  • SFRS13A 3 4
  • FUSIP1 3 4
  • FUSIP2 3 4
  • SRrp40 3 4
  • TASR 3 4
  • FUS Interacting Protein (Serine/Arginine-Rich) 1 2
  • FUS Interacting Protein (Serine-Arginine Rich) 1 3
  • FUS-Interacting Serine-Arginine-Rich Protein 1 4
  • Serine-Arginine Repressor Protein (40 KDa) 3
  • TLS-Associated Serine-Arginine Protein 1 3
  • TLS-Associated Serine-Arginine Protein 2 3
  • TLS-Associated Serine-Arginine Protein 4
  • TLS-Associated Protein TASR 3
  • PPP1R149 3
  • SFRS13 3
  • SRp38 3
  • TASR1 3
  • TASR2 3
  • NSSR 3

External Ids for SRSF10 Gene

Previous HGNC Symbols for SRSF10 Gene

  • FUSIP2
  • FUSIP1
  • SFRS13A

Previous GeneCards Identifiers for SRSF10 Gene

  • GC01M024293

Summaries for SRSF10 Gene

Entrez Gene Summary for SRSF10 Gene

  • This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for SRSF10 Gene

SRSF10 (Serine And Arginine Rich Splicing Factor 10) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF12.

UniProtKB/Swiss-Prot for SRSF10 Gene

  • Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).

Gene Wiki entry for SRSF10 Gene

Additional gene information for SRSF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF10 Gene

Genomics for SRSF10 Gene

GeneHancer (GH) Regulatory Elements for SRSF10 Gene

Promoters and enhancers for SRSF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023975 Promoter/Enhancer 2.9 UCNEbase EPDnew Ensembl ENCODE dbSUPER 615.2 +2.1 2090 6.4 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRSF10 ELOA SRRM1 LINC01355 KDM1A RPL11 ZNF436-AS1 PNRC2 CNR2 RUNX3
GH01I023691 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 87.6 +288.3 288304 3.1 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 RPL11 SRSF10 SRRM1 LINC01355 PNRC2 HNRNPR KDM1A ELOA ASAP3 GC01M023708
GH01I023553 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.6 +421.7 421706 12.2 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ID3 GC01M023559 GC01M023560 LOC105376859 PIR53087 SRSF10 LINC01355 RPL11 MDS2 E2F2
GH01I023521 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.7 +452.2 452243 13.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 E2F2 GC01P023526 SRSF10 LINC01355 ASAP3 ID3 ZNF436 KDM1A ELOA TCEA3
GH01I024641 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 35.2 -662.5 -662477 4.1 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 SRRM1 SRSF10 ENSG00000261349 ELOA NCMAP SYF2 RPL11 PNRC2 FUCA1 MAN1C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRSF10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRSF10 Gene

Genomic Locations for SRSF10 Gene
chr1:23,964,347-23,980,927
(GRCh38/hg38)
Size:
16,581 bases
Orientation:
Minus strand
chr1:24,291,294-24,307,417
(GRCh37/hg19)

Genomic View for SRSF10 Gene

Genes around SRSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF10 Gene

Proteins for SRSF10 Gene

  • Protein details for SRSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75494-SRS10_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 10
    Protein Accession:
    O75494
    Secondary Accessions:
    • A6NFM6
    • A6NI42
    • A6NIU7
    • B4DJP9
    • O60572
    • Q5JRH9
    • Q5JRI0
    • Q5JRI2
    • Q5JRI3
    • Q5JRI4
    • Q96G09
    • Q96P17

    Protein attributes for SRSF10 Gene

    Size:
    262 amino acids
    Molecular mass:
    31301 Da
    Quaternary structure:
    • The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10 (PubMed:14765198). The dephosphorylated form interacts with SNRNP70 (PubMed:14765198). Isoform 1 interacts with FUS C-terminus (PubMed:9774382). Isoform 3 interacts with FUS C-terminus (PubMed:9774382). Interacts with YTHDC1, leading to inhibit RNA-binding activity of SRSF10 (PubMed:26876937).

    Alternative splice isoforms for SRSF10 Gene

neXtProt entry for SRSF10 Gene

Post-translational modifications for SRSF10 Gene

  • Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.

No data available for DME Specific Peptides for SRSF10 Gene

Domains & Families for SRSF10 Gene

Protein Domains for SRSF10 Gene

Graphical View of Domain Structure for InterPro Entry

O75494

UniProtKB/Swiss-Prot:

SRS10_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF10: view

Function for SRSF10 Gene

Molecular function for SRSF10 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).

Phenotypes From GWAS Catalog for SRSF10 Gene

Gene Ontology (GO) - Molecular Function for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,NAS 9774382
GO:0005515 protein binding IPI 9774382
GO:0050733 RS domain binding NAS 11684676
GO:0051082 unfolded protein binding NAS 11684676
genes like me logo Genes that share ontologies with SRSF10: view
genes like me logo Genes that share phenotypes with SRSF10: view

Animal Models for SRSF10 Gene

MGI Knock Outs for SRSF10:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF10 Gene

Localization for SRSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF10 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF10 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 9774382
GO:0005654 nucleoplasm IDA,IEA 11684676
GO:0005737 cytoplasm NAS 11684676
GO:0005829 cytosol IEA --
GO:0016607 nuclear speck IEA,IDA 26876937
genes like me logo Genes that share ontologies with SRSF10: view

Pathways & Interactions for SRSF10 Gene

genes like me logo Genes that share pathways with SRSF10: view

Pathways by source for SRSF10 Gene

1 KEGG pathway for SRSF10 Gene

Gene Ontology (GO) - Biological Process for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000375 RNA splicing, via transesterification reactions IEA,IDA 9774382
GO:0000398 mRNA splicing, via spliceosome IDA 9774382
GO:0006355 regulation of transcription, DNA-templated NAS 9774382
GO:0006376 mRNA splice site selection IDA 9774382
genes like me logo Genes that share ontologies with SRSF10: view

No data available for SIGNOR curated interactions for SRSF10 Gene

Drugs & Compounds for SRSF10 Gene

No Compound Related Data Available

Transcripts for SRSF10 Gene

Unigene Clusters for SRSF10 Gene

Serine/arginine-rich splicing factor 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - - - -
SP14:
SP15: -
SP16: - - - - - - -
SP17: -
SP18: -
SP19:
SP20:

ExUns: 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1:
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9:
SP10:
SP11: - - - - -
SP12:
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SRSF10 Gene

GeneLoc Exon Structure for
SRSF10
ECgene alternative splicing isoforms for
SRSF10

Expression for SRSF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), Nasal epithelium (7.5), and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF10 Gene



Protein tissue co-expression partners for SRSF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF10 Gene:

SRSF10

SOURCE GeneReport for Unigene cluster for SRSF10 Gene:

Hs.3530

mRNA Expression by UniProt/SwissProt for SRSF10 Gene:

O75494-SRS10_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SRSF10 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with SRSF10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF10 Gene

Orthologs for SRSF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRS13A 33 34
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SRSF10 33
  • 96.82 (n)
-- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srsf10 33 16 34
  • 94.53 (n)
cow
(Bos Taurus)
Mammalia FUSIP1 34
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves GGA.8379 34
  • 98 (a)
OneToMany
SRSF10 33
  • 90.08 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf10 33
  • 71.45 (n)
Str.1085 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53149 33
zebrafish
(Danio rerio)
Actinopterygii zgc:65772 34
  • 60 (a)
ManyToMany
si:ch211-135d14.5 34
  • 58 (a)
ManyToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta SC35 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 34
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 34
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11150 33
Species where no ortholog for SRSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF10 Gene

ENSEMBL:
Gene Tree for SRSF10 (if available)
TreeFam:
Gene Tree for SRSF10 (if available)

Paralogs for SRSF10 Gene

Paralogs for SRSF10 Gene

(15) SIMAP similar genes for SRSF10 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF10 Gene

genes like me logo Genes that share paralogs with SRSF10: view

Variants for SRSF10 Gene

Sequence variations from dbSNP and Humsavar for SRSF10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000291060 -- 23,971,102(-) A/C 3_prime_UTR_variant, intron_variant
rs1000327592 -- 23,977,741(-) A/G 5_prime_UTR_variant, intron_variant
rs1000378615 -- 23,977,409(-) T/C 5_prime_UTR_variant, intron_variant
rs1000385755 -- 23,968,608(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000997775 -- 23,973,004(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF10 Gene

Variant ID Type Subtype PubMed ID
nsv950285 CNV duplication 24416366
nsv945827 CNV duplication 23825009
nsv1075339 CNV deletion 25765185
esv2676255 CNV deletion 23128226
esv2662136 CNV deletion 23128226
dgv60n106 CNV deletion 24896259

Additional Variant Information for SRSF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SRSF10 Gene

Disorders for SRSF10 Gene

Additional Disease Information for SRSF10

No disorders were found for SRSF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF10 Gene

Publications for SRSF10 Gene

  1. Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. (PMID: 11891055) Clinton JM … Yang L (Gene 2002) 2 3 4 22 58
  2. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper AE … Screaton GR (The Journal of biological chemistry 2001) 3 4 22 58
  3. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. (PMID: 10779324) Yang L … Hickstein DD (Molecular and cellular biology 2000) 3 4 22 58
  4. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PMID: 9774382) Yang L … Hickstein DD (The Journal of biological chemistry 1998) 3 4 22 58
  5. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. (PMID: 26876937) Xiao W … Yang YG (Molecular cell 2016) 3 4 58

Products for SRSF10 Gene

Sources for SRSF10 Gene

  • (80)