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This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014] See more...
Aliases for SRSF1 Gene
Aliases for SRSF1 Gene
External Ids for SRSF1 Gene
- HGNC: 10780
- Entrez Gene: 6426
- Ensembl: ENSG00000136450
- OMIM: 600812
- UniProtKB: Q07955
Previous HGNC Symbols for SRSF1 Gene
- SFRS1
Previous GeneCards Identifiers for SRSF1 Gene
- GC17M056079
- GC17M051439
Summaries for SRSF1 Gene
-
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]
GeneCards Summary for SRSF1 Gene
SRSF1 (Serine And Arginine Rich Splicing Factor 1) is a Protein Coding gene. Diseases associated with SRSF1 include Retinitis Pigmentosa 4 and Homocystinuria. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and mRNA Splicing - Minor Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ENSG00000266086.
UniProtKB/Swiss-Prot Summary for SRSF1 Gene
-
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.
Additional gene information for SRSF1 Gene
- HGNC(10780)
- Entrez Gene(6426)
- Ensembl(ENSG00000136450)
- OMIM(600812)
- UniProtKB(Q07955)
- Open Targets Platform(ENSG00000136450)
- Monarch Initiative
- Search for SRSF1 at DataMed
- Search for SRSF1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRSF1 Gene
Genomics for SRSF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SRSF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SRSF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRSF1
Genomic Locations for SRSF1 Gene
Genomic Locations for SRSF1 Gene
- chr17:58,000,919-58,007,346
- (GRCh38/hg38)
- Size:
- 6,428 bases
- Orientation:
- Minus strand
- chr17:56,078,280-56,084,707
- (GRCh37/hg19)
- Size:
- 6,428 bases
- Orientation:
- Minus strand
Genomic View for SRSF1 Gene
Genes around SRSF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
SRSF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRSF1 Gene
Proteins for SRSF1 Gene
-
Protein details for SRSF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07955-SRSF1_HUMAN
- Recommended name:
- Serine/arginine-rich splicing factor 1
- Protein Accession:
- Q07955
- B2R6Z7
- D3DTZ3
- Q13809
Protein attributes for SRSF1 Gene
- Size:
- 248 amino acids
- Molecular mass:
- 27745 Da
- Quaternary structure:
-
- Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its sequential and processive phosphorylation by SRPK1. Interacts with NXF1. Interacts with CCNL1, CCNL2 and CDK11B (PubMed:18216018). Interacts with RRP1B (PubMed:23604122). Interacts (when phosphorylated in its RS domain) with TNPO3; promoting nuclear import (PubMed:24449914).
- Miscellaneous:
-
- [Isoform ASF-3]: May be due to intron retention.
Three dimensional structures from OCA and Proteopedia for SRSF1 Gene
Protein Expression for SRSF1 Gene
Post-translational modifications for SRSF1 Gene
- Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed.
- Asymmetrically dimethylated at arginines, probably by PRMT1, methylation promotes localization to nuclear speckles.
-
Ubiquitination at Lys30, Lys38, Lys138, Lys174, and Lys179
- NX_Q07955 (NX_Q07955-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SRSF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SRSF1 / SF2 Monoclonal Antibody (LS-B2340) and SRSF1 / SF2 Monoclonal Antibody (LS-B3263)
- G Biosciences Immunotag™ SFRS1 Antibody
- NSJ Bioreagents SF2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SRSF1
- Novus Biologicals Antibodies for SRSF1
-
Abcam antibodies for SRSF1
- Invitrogen Antibodies for SRSF1 (AFLGC-SRSF1)
-
Biorbyt antibodies for SRSF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SRSF1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SRSF1
- Origene Custom Protein Services for SRSF1
- ProSpec Recombinant Proteins for SRSF1
-
Abcam proteins for SRSF1
Assay Products
- antibodies-online: Show 11 available SRSF1 Elisa Kits ranked by validation data
- Compare Top SRSF1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for SRSF1
No data available for DME Specific Peptides for SRSF1 Gene
Domains & Families for SRSF1 Gene
Gene Families for SRSF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SRSF1 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for SRSF1 Gene
- GenScript: Design optimal peptide antigens:
-
- pre-mRNA-splicing factor SF2, P33 subunit (SRSF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07955UniProtKB/Swiss-Prot:
SRSF1_HUMAN :- The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling.
- Belongs to the splicing factor SR family.
- Domain:
-
- The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for nucleocytoplasmic shuttling.
- Family:
-
- Belongs to the splicing factor SR family.
Function for SRSF1 Gene
Molecular function for SRSF1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.
Phenotypes From GWAS Catalog for SRSF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IPI | 20797886 |
| GO:0003729 | mRNA binding | IDA | 21984414 |
| GO:0005515 | protein binding | IPI | 9237760 |
| GO:0044547 | DNA topoisomerase binding | IPI | 9611241 |
Phenotypes for SRSF1 Gene
- MGI mutant phenotypes for SRSF1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SRSF1:
-
- Increased Salmonella proliferation
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with Ras
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Strongly decreased CFP-tsO45G cell surface transport
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in colon lineage
- Synthetic lethal with imatinib mesylate
- Downregulation of RLR pathway after Sendai virus (SeV) infection
- Decreased Aire reporter expression
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), many micronuclei (grape)
Animal Models for SRSF1 Gene
- MGI Knock Outs for SRSF1:
-
- Srsf1 Srsf1<tm1.1Xdfu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRSF1 - Select products 50% OFF >
- * SRSF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRSF1
miRNA for SRSF1 Gene
- miRTarBase miRNAs that target SRSF1
-
- hsa-miR-7-5p (MIRT004497)
- mmu-miR-28a-5p (MIRT004720)
- mmu-miR-505-3p (MIRT004721)
- hsa-miR-10a-5p (MIRT006536)
- hsa-miR-10b-5p (MIRT006539)
- mmu-miR-362-5p (MIRT009085)
- mmu-miR-190a-5p (MIRT013690)
- mmu-miR-24-3p (MIRT013967)
- hsa-miR-505-3p (MIRT016250)
- hsa-miR-103a-3p (MIRT027043)
- hsa-miR-16-5p (MIRT031783)
- hsa-miR-744-5p (MIRT037540)
- hsa-miR-193b-3p (MIRT041396)
- hsa-miR-423-3p (MIRT042557)
- hsa-miR-149-5p (MIRT045599)
- hsa-miR-335-3p (MIRT078186)
- hsa-miR-5692c (MIRT288447)
- hsa-miR-5692b (MIRT288448)
- hsa-miR-607 (MIRT345408)
- hsa-miR-1305 (MIRT345435)
- hsa-miR-4709-3p (MIRT345453)
- hsa-miR-155-5p (MIRT439655)
- hsa-miR-6516-5p (MIRT467020)
- hsa-miR-455-3p (MIRT467021)
- hsa-miR-7847-3p (MIRT467022)
- hsa-miR-6880-5p (MIRT467023)
- hsa-miR-6745 (MIRT467024)
- hsa-miR-363-5p (MIRT467025)
- hsa-miR-608 (MIRT467026)
- hsa-miR-4651 (MIRT467027)
- hsa-miR-6851-5p (MIRT467028)
- hsa-miR-3689d (MIRT467029)
- hsa-miR-6499-3p (MIRT467030)
- hsa-miR-6086 (MIRT467031)
- hsa-miR-6823-3p (MIRT467032)
- hsa-miR-377-5p (MIRT467033)
- hsa-miR-2114-3p (MIRT467034)
- hsa-miR-7113-5p (MIRT467035)
- hsa-miR-4762-5p (MIRT467036)
- hsa-miR-6782-5p (MIRT467037)
- hsa-miR-6837-5p (MIRT467038)
- hsa-miR-4685-5p (MIRT467039)
- hsa-miR-6715a-3p (MIRT467040)
- hsa-miR-7843-5p (MIRT467041)
- hsa-miR-6879-5p (MIRT467042)
- hsa-miR-6735-5p (MIRT467043)
- hsa-miR-4632-5p (MIRT467044)
- hsa-miR-4436b-3p (MIRT467045)
- hsa-miR-6753-5p (MIRT467046)
- hsa-miR-377-3p (MIRT467047)
- hsa-miR-466 (MIRT467048)
- hsa-miR-4672 (MIRT467049)
- hsa-miR-3941 (MIRT467050)
- hsa-miR-4653-3p (MIRT467051)
- hsa-miR-4424 (MIRT467052)
- hsa-miR-622 (MIRT467053)
- hsa-miR-6514-5p (MIRT467054)
- hsa-miR-4802-5p (MIRT467055)
- hsa-miR-4801 (MIRT467056)
- hsa-miR-4731-3p (MIRT467057)
- hsa-miR-338-5p (MIRT467058)
- hsa-miR-5583-5p (MIRT467059)
- hsa-miR-3129-3p (MIRT467060)
- hsa-miR-216a-3p (MIRT467061)
- hsa-miR-128-3p (MIRT467062)
- hsa-miR-27a-3p (MIRT467063)
- hsa-miR-27b-3p (MIRT467064)
- hsa-miR-3681-3p (MIRT467065)
- hsa-miR-552-5p (MIRT505497)
- hsa-miR-6792-5p (MIRT505498)
- hsa-miR-107 (MIRT505499)
- hsa-miR-6838-5p (MIRT505500)
- hsa-miR-497-5p (MIRT505501)
- hsa-miR-424-5p (MIRT505502)
- hsa-miR-195-5p (MIRT505503)
- hsa-miR-15b-5p (MIRT505504)
- hsa-miR-15a-5p (MIRT505505)
- hsa-miR-1255b-2-3p (MIRT505506)
- hsa-miR-6776-3p (MIRT505507)
- hsa-miR-33a-3p (MIRT565468)
- hsa-miR-4452 (MIRT565469)
- hsa-miR-183-3p (MIRT565470)
- hsa-miR-508-3p (MIRT565471)
- hsa-miR-4724-5p (MIRT565472)
- hsa-miR-6734-3p (MIRT653105)
- hsa-miR-3667-3p (MIRT653106)
- hsa-miR-34c-3p (MIRT653107)
- hsa-miR-500a-5p (MIRT653108)
- hsa-miR-34b-3p (MIRT653109)
- hsa-miR-4668-3p (MIRT653110)
- hsa-miR-548c-3p (MIRT653111)
- hsa-miR-9-5p (MIRT734622)
- hsa-miR-1227-3p (MIRT736158)
- hsa-miR-25-5p (MIRT739394)
- hsa-miR-4252 (MIRT743343)
- hsa-miR-4459 (MIRT744849)
- hsa-miR-4537 (MIRT746112)
- hsa-miR-508-5p (MIRT749622)
- hsa-miR-550b-2-5p (MIRT750868)
- hsa-miR-6087 (MIRT751924)
- hsa-miR-658 (MIRT753525)
- hsa-miR-766-3p (MIRT759620)
- hsa-miR-5186 (MIRT773520)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF1
- Browse OriGene Inhibitory RNA Products For SRSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF1
Clone Products
- Applied Biological Materials (abm): Clones for SRSF1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203152
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- MR203152
- MR203152L1
- MR203152L2
- MR203152L3
- MR203152L4
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- MR226387L3
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- RC201636
- RC201636L1
- RC201636L2
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- RR207824L3
- RR207824L4
- MR203152L1V
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- MR203152L3V
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- RR207824L3V
- RR207824L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SRSF1
- Addgene plasmids for SRSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRSF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF1 Gene
Localization for SRSF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRSF1 Gene
- Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:9420331, PubMed:24449914). Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914). {ECO:0000269 PubMed:12215544, ECO:0000269 PubMed:20308322, ECO:0000269 PubMed:24449914, ECO:0000269 PubMed:9420331}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 21984414 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 24449914 |
| GO:0016607 | nuclear speck | IDA | 20797886 |
Pathways & Interactions for SRSF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
| 2 | Cleavage of Growing Transcript in the Termination Region | ||
| 3 | Transport of Mature Transcript to Cytoplasm | ||
| 4 | Translational Control | ||
| 5 | Herpes simplex virus 1 infection | ||
Pathways by source for SRSF1 Gene
1 Sino Biological pathway for SRSF1 Gene
1 BioSystems pathway for SRSF1 Gene
11 Reactome pathways for SRSF1 Gene
3 KEGG pathways for SRSF1 Gene
1 Cell Signaling Technology pathway for SRSF1 Gene
Interacting Proteins for SRSF1 Gene
Selected Interacting proteins:
Q07955-SRSF1_HUMAN
ENSP00000258962
for SRSF1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SRSF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000380 | alternative mRNA splicing, via spliceosome | IDA | 8940107 |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IBA | 21873635 |
| GO:0000395 | mRNA 5'-splice site recognition | IDA | 8940107 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006376 | mRNA splice site selection | TAS | 1830244 |
Drugs & Compounds for SRSF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 |
Transcripts for SRSF1 Gene
mRNA/cDNA for SRSF1 Gene
- 2 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258962 5343 nts (view in UCSC)
- ENST00000578430 689 nts (view in UCSC)
- ENST00000581497 438 nts (view in UCSC)
- ENST00000581979 1720 nts (view in UCSC)
- ENST00000582730 3117 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRSF1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRSF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF1
- Browse OriGene Inhibitory RNA Products For SRSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRSF1
Clone Products
- Applied Biological Materials (abm): Clones for SRSF1 - Select products 50% OFF >
- * SRSF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203152
- MG226387
- MR203152
- MR203152L1
- MR203152L2
- MR203152L3
- MR203152L4
- MR226387
- MR226387L3
- MR226387L4
- RC201636
- RC201636L1
- RC201636L2
- RC201636L3
- RC201636L4
- RC213304
- RC213304L1
- RC213304L2
- RC213304L3
- RC213304L4
- RG201636
- RG213304
- RR207824
- RR207824L3
- RR207824L4
- MR203152L1V
- MR203152L2V
- MR203152L3V
- MR203152L4V
- MR226387L3V
- MR226387L4V
- RC201636L1V
- RC201636L2V
- RC201636L3V
- RC201636L4V
- RC213304L1V
- RC213304L2V
- RC213304L3V
- RC213304L4V
- RR207824L3V
- RR207824L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SRSF1
- Addgene plasmids for SRSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRSF1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Relevant External Links for SRSF1 Gene
- GeneLoc Exon Structure for
- SRSF1
Expression for SRSF1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (8.3) and Nasal epithelium (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRSF1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRSF1
SOURCE GeneReport for Unigene cluster for SRSF1 Gene:
Hs.68714Evidence on tissue expression from TISSUES for SRSF1 Gene
- Nervous system(5)
- Liver(4.7)
- Kidney(4)
- Skin(3.9)
- Intestine(3.8)
- Lung(3.5)
- Muscle(3.4)
- Heart(3.4)
- Pancreas(3.2)
- Lymph node(3.2)
- Thyroid gland(3.1)
- Bone marrow(3.1)
- Blood(3.1)
- Spleen(3.1)
- Adrenal gland(2.8)
- Eye(2.8)
- Stomach(2.7)
- Gall bladder(2.4)
Primer Products
-
OriGene qPCR primer pairs for SRSF1
-
OriGene qPCR primer pairs and template standards for SRSF1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF1 Gene
Orthologs for SRSF1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SRSF1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SRSF1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SRSF1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Srsf1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Srsf1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SRSF1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SRSF1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SRSF1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SRSF1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | srsf1 30 |
|
||
| Str.6578 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | srsf1b 31 |
|
OneToMany | |
| srsf1a 30 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010496 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | SF2 30 31 |
|
ManyToMany | |
| Rsf1 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | rsp-3 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NPL3 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G02430 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.560 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5260 31 |
|
ManyToMany | |
| CSA.1451 31 |
|
ManyToMany |
- Species where no ortholog for SRSF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SRSF1 Gene
- ENSEMBL:
- Gene Tree for SRSF1 (if available)
- TreeFam:
- Gene Tree for SRSF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SRSF1: view image
Paralogs for SRSF1 Gene
Paralogs for SRSF1 Gene
(11) SIMAP similar genes for SRSF1 Gene using alignment to 5 proteins:
- SRSF1_HUMAN
- J3KSR8_HUMAN
- J3KSW7_HUMAN
- J3KTL2_HUMAN
- J3QQV5_HUMAN
Pseudogenes.org Pseudogenes for SRSF1 Gene
Variants for SRSF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRSF1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1555575855 | Uncertain Significance: not provided | 58,006,433(-) | G/A | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT | |
| VAR_035488 | A breast cancer sample | p.Pro89Ser |
Residual Variation Intolerance Score:
45.3% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRSF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SRSF1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF1 Gene
Disorders for SRSF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 4 |
|
|
| homocystinuria |
|
|
| congenital myasthenic syndrome |
|
|
| endometrial stromal tumor |
|
|
| rothmund-thomson syndrome, type 2 |
|
|
Search SRSF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SRSF1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF1 Gene
Publications for SRSF1 Gene
- Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PMID: 8530103) Bermingham JR … Rosenfeld MG (Genomics 1995) 2 3 23
- Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. (PMID: 1855257) Ge H … Manley JL (Cell 1991) 3 4 23
- RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. (PMID: 23604122) Lee M … Crawford NP (Oncogene 2014) 3 4
- Structural basis for nuclear import of splicing factors by human Transportin 3. (PMID: 24449914) Maertens GN … Cherepanov P (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4
- NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. (PMID: 21296756) Kim YD … Jun CD (Nucleic acids research 2011) 3 4
ExternalLinks
Products for SRSF1 Gene
- Custom Antibody ServicesOriGene Antibodies for SRSF1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SRSF1
- Origene Custom Protein Services for SRSF1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRSF1
- Browse OriGene Inhibitory RNA Products For SRSF1
- OriGene qPCR primer pairs for SRSF1
- OriGene qPCR primer pairs and template standards for SRSF1
- OriGene CRISPR knockouts for SRSF1
- MG203152
- MG226387
- MR203152
- MR203152L1
- MR203152L2
- MR203152L3
- MR203152L4
- MR226387
- MR226387L3
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- RC201636
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- RC213304
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- RG201636
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- RR207824
- RR207824L3
- RR207824L4
- MR203152L1V
- MR203152L2V
- MR203152L3V
- MR203152L4V
- MR226387L3V
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- RC201636L1V
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- RC213304L1V
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- RC213304L4V
- RR207824L3V
- RR207824L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SRSF1
- Sino Biological Human cDNA Clone for SRSF1