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Aliases for SRRT Gene

Aliases for SRRT Gene

  • Serrate, RNA Effector Molecule 2 3 5
  • Arsenite-Resistance Protein 2 3 4
  • Arsenite Resistance Protein 2 3
  • ARS2 3 4
  • ASR2 3 4
  • Serrate RNA Effector Molecule Homolog (Arabidopsis) 2
  • Serrate RNA Effector Molecule Homolog 3
  • Arsenate Resistance Protein ARS2 3
  • Arsenate Resistance Protein 2 3
  • Serrate 3

External Ids for SRRT Gene

Previous GeneCards Identifiers for SRRT Gene

  • GC07P100311
  • GC07P100472
  • GC07P095103

Summaries for SRRT Gene

GeneCards Summary for SRRT Gene

SRRT (Serrate, RNA Effector Molecule) is a Protein Coding gene. Diseases associated with SRRT include Alagille Syndrome 1. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for SRRT Gene

  • Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Wiki entry for SRRT Gene

Additional gene information for SRRT Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRT Gene

Genomics for SRRT Gene

GeneHancer (GH) Regulatory Elements for SRRT Gene

Promoters and enhancers for SRRT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100873 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 599.9 +0.3 335 2.9 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D SRRT PIR40651 TRIM4 ZNF3 GIGYF1 PPP1R35 STAG3L5P PCOLCE PILRB ENSG00000242798
GH07I100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 94.6 -397.2 -397216 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 GIGYF1 ZNF3 ENSG00000242798 STAG3L5P PILRA
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 76 -441.8 -441772 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
GH07I100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 64.8 -198.0 -197979 8.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 GNB2 GC07P100676 TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798
GH07I100704 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 58 -168.7 -168731 2.9 CLOCK MLX DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 ZNF610 POP7 ZSCAN21 SRRT STAG3L5P GIGYF1 ENSG00000242798 ZNF3 AP4M1 TRIM4 PILRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRRT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRRT gene promoter:

Genomic Locations for SRRT Gene

Genomic Locations for SRRT Gene
chr7:100,874,971-100,888,664
(GRCh38/hg38)
Size:
13,694 bases
Orientation:
Plus strand
chr7:100,472,701-100,486,285
(GRCh37/hg19)

Genomic View for SRRT Gene

Genes around SRRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRT Gene

Proteins for SRRT Gene

  • Protein details for SRRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXP5-SRRT_HUMAN
    Recommended name:
    Serrate RNA effector molecule homolog
    Protein Accession:
    Q9BXP5
    Secondary Accessions:
    • A4D2E5
    • A4D2E6
    • A6NK22
    • B4DJL4
    • B4DZA6
    • O95808
    • Q32MI4
    • Q6NT74
    • Q8TDQ5
    • Q9BWP6
    • Q9BXP4
    • Q9Y4S4

    Protein attributes for SRRT Gene

    Size:
    876 amino acids
    Molecular mass:
    100666 Da
    Quaternary structure:
    • Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM00189.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305}; Sequence=BAG58876.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23816.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRT Gene

Post-translational modifications for SRRT Gene

  • Ubiquitination at posLast=153153, posLast=476476, and isoforms=2, 3, 4, 5758
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRRT Gene

Domains & Families for SRRT Gene

Gene Families for SRRT Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRRT Gene

Suggested Antigen Peptide Sequences for SRRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXP5

UniProtKB/Swiss-Prot:

SRRT_HUMAN :
  • Belongs to the ARS2 family.
Family:
  • Belongs to the ARS2 family.
genes like me logo Genes that share domains with SRRT: view

Function for SRRT Gene

Molecular function for SRRT Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Phenotypes From GWAS Catalog for SRRT Gene

Gene Ontology (GO) - Molecular Function for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,ISS --
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with SRRT: view
genes like me logo Genes that share phenotypes with SRRT: view

Animal Models for SRRT Gene

MGI Knock Outs for SRRT:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRRT Gene

Localization for SRRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRT Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRT gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm ISS --
GO:0043234 protein complex IDA 23793891
genes like me logo Genes that share ontologies with SRRT: view

Pathways & Interactions for SRRT Gene

genes like me logo Genes that share pathways with SRRT: view

Gene Ontology (GO) - Biological Process for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0008283 cell proliferation IEA,ISS --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with SRRT: view

No data available for SIGNOR curated interactions for SRRT Gene

Drugs & Compounds for SRRT Gene

No Compound Related Data Available

Transcripts for SRRT Gene

Unigene Clusters for SRRT Gene

Serrate RNA effector molecule homolog (Arabidopsis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18: -
SP19: -
SP20:

Relevant External Links for SRRT Gene

GeneLoc Exon Structure for
SRRT
ECgene alternative splicing isoforms for
SRRT

Expression for SRRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRT Gene

This gene is overexpressed in Lymph node (15.8) and Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRRT Gene



Protein tissue co-expression partners for SRRT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRRT Gene:

SRRT

SOURCE GeneReport for Unigene cluster for SRRT Gene:

Hs.111801

mRNA Expression by UniProt/SwissProt for SRRT Gene:

Q9BXP5-SRRT_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SRRT Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Kidney(4.3)
  • Lung(3.1)
  • Skin(2.3)
  • Bone marrow(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with SRRT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRT Gene

Orthologs for SRRT Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRT 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia SRRT 33 34
  • 90.52 (n)
cow
(Bos Taurus)
Mammalia SRRT 33 34
  • 90.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SRRT 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrt 33 16 34
  • 87.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRRT 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRT 34
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398542 33
zebrafish
(Danio rerio)
Actinopterygii srrt 34
  • 70 (a)
OneToOne
ars2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10964 33
fruit fly
(Drosophila melanogaster)
Insecta Ars2 33 34
  • 55.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta SRRT_ANOGA 33
  • 52.85 (n)
worm
(Caenorhabditis elegans)
Secernentea E01A2.2 33 34
  • 52.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.208 34
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2711 33
Species where no ortholog for SRRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRT Gene

ENSEMBL:
Gene Tree for SRRT (if available)
TreeFam:
Gene Tree for SRRT (if available)

Paralogs for SRRT Gene

No data available for Paralogs for SRRT Gene

Variants for SRRT Gene

Sequence variations from dbSNP and Humsavar for SRRT Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000487700 -- 100,879,015(+) C/T intron_variant
rs1000793942 -- 100,876,624(+) C/G/T intron_variant
rs1001214408 -- 100,885,554(+) T/C intron_variant
rs1001462526 -- 100,888,308(+) CCCC/CCCCC coding_sequence_variant, frameshift
rs1001618762 -- 100,875,302(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SRRT Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
nsv1020837 CNV loss 25217958
nsv5870 CNV insertion 18451855
nsv607965 CNV loss 21841781
nsv607966 CNV loss 21841781
nsv607967 CNV loss 21841781
nsv607968 CNV loss 21841781
nsv831073 CNV loss 17160897

Variation tolerance for SRRT Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRRT Gene

Human Gene Mutation Database (HGMD)
SRRT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRT Gene

Disorders for SRRT Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRRT Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
alagille syndrome 1
  • algs1
- elite association - COSMIC cancer census association via MalaCards
Search SRRT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRRT

genes like me logo Genes that share disorders with SRRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRRT Gene

Publications for SRRT Gene

  1. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PMID: 19546234) Kiriyama M … Yonehara S (Molecular and cellular biology 2009) 3 4 22 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson MD … Koop BF (Nucleic acids research 2001) 2 3 4 58
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N … Wilson SA (Nucleic acids research 2015) 3 4 58
  5. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. (PMID: 26382858) Gebhardt A … Pichlmair A (Nature communications 2015) 3 4 58

Products for SRRT Gene

Sources for SRRT Gene