Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRRM5 Gene

Aliases for SRRM5 Gene

  • Serine/Arginine Repetitive Matrix 5 2 3 5
  • ZNF576 3 4
  • Serine/Arginine Repetitive Matrix Protein 5 3
  • Zinc Finger Protein 576 3

External Ids for SRRM5 Gene

Previous GeneCards Identifiers for SRRM5 Gene

  • GC19P044116
  • GC19P040547

Summaries for SRRM5 Gene

GeneCards Summary for SRRM5 Gene

SRRM5 (Serine/Arginine Repetitive Matrix 5) is a Protein Coding gene.

Additional gene information for SRRM5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM5 Gene

Genomics for SRRM5 Gene

GeneHancer (GH) Regulatory Elements for SRRM5 Gene

Promoters and enhancers for SRRM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043594 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -222 4.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 ZNF576 IRGQ SRRM5 ZNF45 ZNF180 ZNF112 ZNF283 ZNF224 ZNF225 MRPS15P2
GH19I043612 Promoter 0.7 EPDnew 550.4 +15.5 15470 0.1 ZBTB21 ZNF280C SRRM5 ZNF180 ZNF225 ZNF45 XRCC1 ZNF227 LOC105372411 ZNF428
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15 +183.3 183285 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044050 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 14.9 +455.4 455442 3.4 PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF213 ZNF223 ZNF45 ZNF112 ZNF180 MRPS15P2 ZNF283 ZNF225 ZNF155 ZNF284 ZNF224
GH19I043462 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.9 -132.1 -132085 3.6 HDGF PKNOX1 SIN3A YY1 ZNF416 FOS KLF13 SP3 ZHX2 SMARCB1 LYPD3 ZNF223 ZNF225 ZNF235 ZNF226 ZNF227 ZNF45 ZNF284 PINLYP ZNF576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRRM5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRRM5 Gene

Genomic Locations for SRRM5 Gene
chr19:43,596,617-43,614,498
(GRCh38/hg38)
Size:
17,882 bases
Orientation:
Plus strand
chr19:44,100,769-44,118,650
(GRCh37/hg19)

Genomic View for SRRM5 Gene

Genes around SRRM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM5 Gene

Proteins for SRRM5 Gene

  • Protein details for SRRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B3KS81-SRRM5_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 5
    Protein Accession:
    B3KS81
    Secondary Accessions:
    • B4DNF0

    Protein attributes for SRRM5 Gene

    Size:
    715 amino acids
    Molecular mass:
    80355 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG60212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SRRM5 Gene

Post-translational modifications for SRRM5 Gene

No Post-translational modifications

Other Protein References for SRRM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRM5 Gene

Domains & Families for SRRM5 Gene

Gene Families for SRRM5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRRM5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SRRM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRRM5: view

No data available for UniProtKB/Swiss-Prot for SRRM5 Gene

Function for SRRM5 Gene

Phenotypes From GWAS Catalog for SRRM5 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SRRM5 Gene

Localization for SRRM5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM5 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SRRM5 Gene

Pathways & Interactions for SRRM5 Gene

SuperPathways for SRRM5 Gene

No Data Available

Interacting Proteins for SRRM5 Gene

Gene Ontology (GO) - Biological Process for SRRM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SRRM5 Gene

Drugs & Compounds for SRRM5 Gene

No Compound Related Data Available

Transcripts for SRRM5 Gene

mRNA/cDNA for SRRM5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRRM5 Gene

Serine/arginine repetitive matrix 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM5 Gene

No ASD Table

Relevant External Links for SRRM5 Gene

GeneLoc Exon Structure for
SRRM5
ECgene alternative splicing isoforms for
SRRM5

Expression for SRRM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRM5 Gene

mRNA expression in normal human tissues for SRRM5 Gene

Protein differential expression in normal tissues from HIPED for SRRM5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRRM5 Gene



Protein tissue co-expression partners for SRRM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRRM5 Gene:

SRRM5

SOURCE GeneReport for Unigene cluster for SRRM5 Gene:

Hs.722032
genes like me logo Genes that share expression patterns with SRRM5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRM5 Gene

Orthologs for SRRM5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SRRM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF576 33
  • 98.43 (n)
SRRM5 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM5 33
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia SRRM5 34
  • 57 (a)
OneToOne
Species where no ortholog for SRRM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRRM5 Gene

ENSEMBL:
Gene Tree for SRRM5 (if available)
TreeFam:
Gene Tree for SRRM5 (if available)

Paralogs for SRRM5 Gene

(1) SIMAP similar genes for SRRM5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SRRM5: view

No data available for Paralogs for SRRM5 Gene

Variants for SRRM5 Gene

Sequence variations from dbSNP and Humsavar for SRRM5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000401373 -- 43,613,417(+) C/A coding_sequence_variant, missense_variant
rs1001004165 -- 43,612,530(+) A/G coding_sequence_variant, missense_variant
rs1001050277 -- 43,612,736(+) G/T coding_sequence_variant, synonymous_variant
rs1001206258 -- 43,610,254(+) C/T upstream_transcript_variant
rs1001843306 -- 43,612,821(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM5 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for SRRM5 Gene

Gene Damage Index Score: 8.74; 86.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRRM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM5 Gene

Disorders for SRRM5 Gene

Additional Disease Information for SRRM5

No disorders were found for SRRM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM5 Gene

Publications for SRRM5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for SRRM5 Gene

Sources for SRRM5 Gene

Content
Loading form....