Aliases for SRRM3 Gene

Aliases for SRRM3 Gene

  • Serine/Arginine Repetitive Matrix 3 2 3 5
  • Serine/Arginine Repetitive Matrix Protein 3 3 4
  • SRRM2-Like Protein 3

External Ids for SRRM3 Gene

Previous GeneCards Identifiers for SRRM3 Gene

  • GC07P075752
  • GC07P075831
  • GC07P070917
  • GC07P076201

Summaries for SRRM3 Gene

GeneCards Summary for SRRM3 Gene

SRRM3 (Serine/Arginine Repetitive Matrix 3) is a Protein Coding gene. Diseases associated with SRRM3 include Breast Cancer.

UniProtKB/Swiss-Prot Summary for SRRM3 Gene

  • May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911).

Additional gene information for SRRM3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRRM3 Gene

Genomics for SRRM3 Gene

GeneHancer (GH) Regulatory Elements for SRRM3 Gene

Promoters and enhancers for SRRM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRRM3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRRM3 Gene

Genomic Locations for SRRM3 Gene
chr7:76,166,675-76,287,292
(GRCh38/hg38)
Size:
120,618 bases
Orientation:
Plus strand
chr7:75,831,216-75,916,605
(GRCh37/hg19)
Size:
85,390 bases
Orientation:
Plus strand

Genomic View for SRRM3 Gene

Genes around SRRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM3 Gene

Proteins for SRRM3 Gene

  • Protein details for SRRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNA2-SRRM3_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 3
    Protein Accession:
    A6NNA2
    Secondary Accessions:
    • A6ND75

    Protein attributes for SRRM3 Gene

    Size:
    597 amino acids
    Molecular mass:
    65249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRM3 Gene

Post-translational modifications for SRRM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRM3 Gene

Domains & Families for SRRM3 Gene

Gene Families for SRRM3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRRM3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRRM3 Gene

GenScript: Design optimal peptide antigens:
  • Serine/arginine repetitive matrix protein 3 (SRRM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NNA2

UniProtKB/Swiss-Prot:

SRRM3_HUMAN :
  • Belongs to the CWC21 family.
Family:
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM3: view

Function for SRRM3 Gene

Molecular function for SRRM3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911).

Phenotypes From GWAS Catalog for SRRM3 Gene

Gene Ontology (GO) - Molecular Function for SRRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA 21873635
genes like me logo Genes that share ontologies with SRRM3: view
genes like me logo Genes that share phenotypes with SRRM3: view

Animal Model Products

CRISPR Products

miRNA for SRRM3 Gene

miRTarBase miRNAs that target SRRM3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM3 Gene

Localization for SRRM3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM3 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Microtubules (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRM3 Gene

Pathways & Interactions for SRRM3 Gene

PathCards logo

SuperPathways for SRRM3 Gene

No Data Available

Interacting Proteins for SRRM3 Gene

Gene Ontology (GO) - Biological Process for SRRM3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SRRM3 Gene

Drugs & Compounds for SRRM3 Gene

No Compound Related Data Available

Transcripts for SRRM3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM3 Gene

No ASD Table

Relevant External Links for SRRM3 Gene

GeneLoc Exon Structure for
SRRM3
ECgene alternative splicing isoforms for
SRRM3

Expression for SRRM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRM3 Gene

mRNA differential expression in normal tissues according to GTEx for SRRM3 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7) and Brain - Cerebellar Hemisphere (x10.7).

Protein differential expression in normal tissues from HIPED for SRRM3 Gene

This gene is overexpressed in Liver, secretome (38.5), Adipocyte (12.8), Saliva (10.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRRM3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SRRM3 Gene:

SRRM3

SOURCE GeneReport for Unigene cluster for SRRM3 Gene:

Hs.511025

mRNA Expression by UniProt/SwissProt for SRRM3 Gene:

A6NNA2-SRRM3_HUMAN
Tissue specificity: Expressed in breast cancer cell lines.
genes like me logo Genes that share expression patterns with SRRM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRM3 Gene

Orthologs for SRRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM3 33 32
  • 99.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Srrm3 33
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM3 33
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM3 33
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM3 33
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM3 33
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRRM3 33
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM3 33
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii srrm2 33
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 33
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 33
  • 21 (a)
OneToMany
Species where no ortholog for SRRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRM3 Gene

ENSEMBL:
Gene Tree for SRRM3 (if available)
TreeFam:
Gene Tree for SRRM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRRM3: view image

Paralogs for SRRM3 Gene

(1) SIMAP similar genes for SRRM3 Gene using alignment to 3 proteins:

  • SRRM3_HUMAN
  • F5GYC8_HUMAN
  • H7C383_HUMAN
genes like me logo Genes that share paralogs with SRRM3: view

No data available for Paralogs for SRRM3 Gene

Variants for SRRM3 Gene

Sequence variations from dbSNP and Humsavar for SRRM3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000103910 -- 76,220,092(+) C/G/T intron_variant
rs1000136274 -- 76,261,183(+) C/A intron_variant
rs1000159894 -- 76,228,999(+) C/A/T intron_variant
rs1000201692 -- 76,203,631(+) C/A intron_variant
rs1000254084 -- 76,203,865(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM3 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv3597n106 CNV deletion 24896259
esv2422494 CNV duplication 17116639
esv2734682 CNV deletion 23290073
esv2734684 CNV deletion 23290073
nsv1074520 CNV deletion 25765185
nsv1075974 CNV deletion 25765185
nsv1126797 CNV deletion 24896259
nsv519194 CNV loss 19592680
nsv528969 CNV gain 19592680
nsv955984 CNV deletion 24416366

Variation tolerance for SRRM3 Gene

Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRRM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM3 Gene

Disorders for SRRM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRRM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search SRRM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRRM3

genes like me logo Genes that share disorders with SRRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRRM3 Gene

Publications for SRRM3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 56
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  4. RING1 and YY1 binding protein suppresses breast cancer growth and metastasis. (PMID: 27748911) Zhou H … Wang S (International journal of oncology 2016) 4 56
  5. Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness. (PMID: 26053433) Lee NS … Chow RH (Scientific reports 2015) 4 56

Products for SRRM3 Gene

Sources for SRRM3 Gene