Aliases for SRR Gene

Aliases for SRR Gene

  • Serine Racemase 2 3 4 5
  • D-Serine Ammonia-Lyase 3 4
  • L-Serine Ammonia-Lyase 3 4
  • D-Serine Dehydratase 3 4
  • L-Serine Dehydratase 3 4
  • EC 5.1.1.18 4 54
  • EC 4.3.1.18 4
  • EC 4.3.1.17 4
  • ILV1 3
  • ISO1 3

External Ids for SRR Gene

Previous GeneCards Identifiers for SRR Gene

  • GC17P002513
  • GC17P002158
  • GC17P002413
  • GC17P002153
  • GC17P002102
  • GC17P002212

Summaries for SRR Gene

GeneCards Summary for SRR Gene

SRR (Serine Racemase) is a Protein Coding gene. Diseases associated with SRR include Streptococcal Meningitis and Vitamin E, Familial Isolated Deficiency Of. Among its related pathways are Glycine, serine and threonine metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is SDSL.

UniProtKB/Swiss-Prot Summary for SRR Gene

  • Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.

Additional gene information for SRR Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRR Gene

Genomics for SRR Gene

GeneHancer (GH) Regulatory Elements for SRR Gene

Promoters and enhancers for SRR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRR gene promoter:
  • AML1a
  • ATF-2
  • c-Fos
  • Cart-1
  • E47
  • Egr-2
  • GATA-1
  • MZF-1
  • Tal-1beta
  • YY1

Genomic Locations for SRR Gene

Genomic Locations for SRR Gene
chr17:2,303,371-2,325,264
(GRCh38/hg38)
Size:
21,894 bases
Orientation:
Plus strand
chr17:2,206,677-2,228,554
(GRCh37/hg19)
Size:
21,878 bases
Orientation:
Plus strand

Genomic View for SRR Gene

Genes around SRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRR Gene

Proteins for SRR Gene

  • Protein details for SRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT4-SRR_HUMAN
    Recommended name:
    Serine racemase
    Protein Accession:
    Q9GZT4
    Secondary Accessions:
    • D3DTI5
    • Q6IA55

    Protein attributes for SRR Gene

    Size:
    340 amino acids
    Molecular mass:
    36566 Da
    Cofactor:
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SRR Gene

neXtProt entry for SRR Gene

Selected DME Specific Peptides for SRR Gene

Q9GZT4:
  • PSVKVYAAEP
  • LVWERMK
  • HSSGNHGQAL
  • RMKLLIEPTAGV
  • LEGIPAY
  • QKTGSFK

Post-translational modifications for SRR Gene

  • S-nitrosylated, leading to decrease the enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for SRR Gene

Gene Families for SRR Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SRR Gene

GenScript: Design optimal peptide antigens:
  • L-serine dehydratase (SRR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZT4

UniProtKB/Swiss-Prot:

SRR_HUMAN :
  • Belongs to the serine/threonine dehydratase family.
Family:
  • Belongs to the serine/threonine dehydratase family.
genes like me logo Genes that share domains with SRR: view

Function for SRR Gene

Molecular function for SRR Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-serine = D-serine; Xref=Rhea:RHEA:10980, ChEBI:CHEBI:33384, ChEBI:CHEBI:35247; EC=5.1.1.18; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169, ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.5 mM for L-serine {ECO:0000269 PubMed:20106978};

Enzyme Numbers (IUBMB) for SRR Gene

Phenotypes From GWAS Catalog for SRR Gene

Gene Ontology (GO) - Molecular Function for SRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA,IDA 20106978
GO:0003824 catalytic activity IEA --
GO:0003941 L-serine ammonia-lyase activity IBA,IDA 18812225
GO:0005509 calcium ion binding IEA,ISS --
GO:0005524 ATP binding IBA,ISS --
genes like me logo Genes that share ontologies with SRR: view
genes like me logo Genes that share phenotypes with SRR: view

Animal Models for SRR Gene

MGI Knock Outs for SRR:
  • Srr Srr<tm1(cre/PGR)Himo>
  • Srr Srr<tm1.2Jtc>

Animal Model Products

  • Taconic Biosciences Mouse Models for SRR

CRISPR Products

miRNA for SRR Gene

miRTarBase miRNAs that target SRR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRR

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRR Gene

Localization for SRR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRR gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 1
nucleus 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 16314870
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0043025 neuronal cell body IDA 17880399
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with SRR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SRR Gene

Pathways & Interactions for SRR Gene

genes like me logo Genes that share pathways with SRR: view

Pathways by source for SRR Gene

1 BioSystems pathway for SRR Gene
1 Cell Signaling Technology pathway for SRR Gene

Gene Ontology (GO) - Biological Process for SRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006563 L-serine metabolic process IBA,IDA 11054547
GO:0006564 L-serine biosynthetic process TAS --
GO:0007420 brain development IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with SRR: view

No data available for SIGNOR curated interactions for SRR Gene

Drugs & Compounds for SRR Gene

(10) Drugs for SRR Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Serine Approved Nutra Full agonist, Agonist, Target Weak endogenous glycine receptor agonist 1317
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 22
Ammonia Approved Pharma 0
D-serine Approved, Experimental Pharma Agonist 0
Pyruvic acid Approved, Investigational Nutra 0

(2) Additional Compounds for SRR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRR: view

Transcripts for SRR Gene

mRNA/cDNA for SRR Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRR Gene

No ASD Table

Relevant External Links for SRR Gene

GeneLoc Exon Structure for
SRR
ECgene alternative splicing isoforms for
SRR

Expression for SRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRR Gene

This gene is overexpressed in Heart (23.2) and Fetal Brain (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRR Gene



Protein tissue co-expression partners for SRR Gene

NURSA nuclear receptor signaling pathways regulating expression of SRR Gene:

SRR

SOURCE GeneReport for Unigene cluster for SRR Gene:

Hs.461954

mRNA Expression by UniProt/SwissProt for SRR Gene:

Q9GZT4-SRR_HUMAN
Tissue specificity: Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.

Evidence on tissue expression from TISSUES for SRR Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SRR: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRR Gene

Orthologs for SRR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRR 33 32
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 91 (a)
OneToMany
-- 33
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Srr 32
  • 88.96 (n)
cow
(Bos Taurus)
Mammalia SRR 33 32
  • 88.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Srr 17 33 32
  • 88.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRR 33
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRR 33
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRR 33 32
  • 67.39 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srr 32
  • 66.56 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-263o4.3 32
  • 47.37 (n)
SRR (1 of 2) 33
  • 29 (a)
OneToMany
SRR (2 of 2) 33
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T01H8.2 33 34
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRY1 35 33 32
  • 50.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SR 32
  • 54.88 (n)
rice
(Oryza sativa)
Liliopsida Os04g0555900 32
  • 51.75 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.14 32
  • 52.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 30 (a)
OneToMany
-- 33
  • 29 (a)
OneToMany
Species where no ortholog for SRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRR Gene

ENSEMBL:
Gene Tree for SRR (if available)
TreeFam:
Gene Tree for SRR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRR: view image

Paralogs for SRR Gene

Paralogs for SRR Gene

(1) SIMAP similar genes for SRR Gene using alignment to 7 proteins:

  • SRR_HUMAN
  • I3L3N0_HUMAN
  • I3L4B4_HUMAN
  • I3L4L3_HUMAN
  • I3L4W4_HUMAN
  • Q3ZK31_HUMAN
  • V9GYE8_HUMAN
genes like me logo Genes that share paralogs with SRR: view

Variants for SRR Gene

Sequence variations from dbSNP and Humsavar for SRR Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000166151 -- 2,307,520(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000180220 -- 2,317,729(+) A/G intron_variant
rs1000210601 -- 2,322,272(+) TT/TTT intron_variant
rs1000424070 -- 2,318,084(+) G/A intron_variant
rs1000447548 -- 2,320,059(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRR Gene

Variant ID Type Subtype PubMed ID
esv1317366 CNV insertion 17803354
nsv1067416 CNV loss 25217958
nsv469765 CNV loss 16826518
nsv574224 CNV gain 21841781
nsv833336 CNV loss 17160897
nsv960041 CNV duplication 23825009

Variation tolerance for SRR Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRR Gene

Human Gene Mutation Database (HGMD)
SRR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRR Gene

Disorders for SRR Gene

MalaCards: The human disease database

(5) MalaCards diseases for SRR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SRR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SRR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRR Gene

Publications for SRR Gene

  1. A genetic variant of the serine racemase gene is associated with schizophrenia. (PMID: 17067558) Morita Y … Kuroda S (Biological psychiatry 2007) 2 3 23 43 56
  2. Characterization and localization of a human serine racemase. (PMID: 15193426) Xia M … Connolly TM (Brain research. Molecular brain research 2004) 2 3 4 23 56
  3. Human serine racemase: moleular cloning, genomic organization and functional analysis. (PMID: 11054547) De Miranda J … Wolosker H (Gene 2000) 2 3 4 23 56
  4. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. (PMID: 20174558) Tsai FJ … Wu JY (PLoS genetics 2010) 3 23 43 56
  5. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. (PMID: 20106978) Smith MA … Barker J (The Journal of biological chemistry 2010) 3 4 23 56

Products for SRR Gene

Sources for SRR Gene