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Aliases for SRPX Gene

Aliases for SRPX Gene

  • Sushi Repeat Containing Protein, X-Linked 2 3 5
  • Sushi-Repeat-Containing Protein, X Chromosome 2 3
  • ETX1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 83p 3
  • Sushi-Repeat-Containing Protein, X-Linked 2
  • Sushi Repeat-Containing Protein SRPX 3
  • HEL-S-83p 3
  • SRPX1 3
  • DRS 3

External Ids for SRPX Gene

Previous GeneCards Identifiers for SRPX Gene

  • GC0XM036113
  • GC0XM036296
  • GC0XM036853
  • GC0XM037039
  • GC0XM037764
  • GC0XM037893
  • GC0XM038009
  • GC0XM035753

Summaries for SRPX Gene

GeneCards Summary for SRPX Gene

SRPX (Sushi Repeat Containing Protein, X-Linked) is a Protein Coding gene. Diseases associated with SRPX include Retinitis Pigmentosa 3 and Retinitis Pigmentosa. An important paralog of this gene is SRPX2.

UniProtKB/Swiss-Prot for SRPX Gene

  • May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.

Gene Wiki entry for SRPX Gene

Additional gene information for SRPX Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPX Gene

Genomics for SRPX Gene

GeneHancer (GH) Regulatory Elements for SRPX Gene

Promoters and enhancers for SRPX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI038219 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 559.1 +0.3 282 1.7 CTCF KLF1 KLF17 ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 SCRT2 SRPX ENSG00000226679 GC0XM038216 GC0XM038061 ENSG00000250349
GH0XI038271 Enhancer 0.8 FANTOM5 12.8 -50.5 -50519 0.3 BACH1 BMI1 BATF IRF4 RELA ZNF316 ATF7 BCLAF1 IKZF2 RUNX3 RPGR ENSG00000226679 SRPX CYBB GC0XM038216 ENSG00000252050 ENSG00000250349
GH0XI038278 Enhancer 0.6 ENCODE 12.2 -57.9 -57938 2.5 GATAD2A FOXA2 SP5 FOXA3 KLF17 JUNB ATF2 THRB RARA FOXA1 ENSG00000226679 SRPX RPGR ENSG00000252050 GC0XM038216 ENSG00000250349
GH0XI038350 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 5.5 -134.0 -133981 8.3 TAF1 HLF MAX ATF2 ZNF664 JUND HNF4G HNF4A ATF7 OTC RPGR SRPX TDGF1P1
GH0XI038213 Enhancer 0.5 Ensembl ENCODE 10.4 +5.8 5764 2.4 JUND SRPX GC0XM038216 GC0XM038061 ENSG00000250349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRPX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRPX gene promoter:

Genomic Locations for SRPX Gene

Genomic Locations for SRPX Gene
71,590 bases
Minus strand

Genomic View for SRPX Gene

Genes around SRPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPX Gene

Proteins for SRPX Gene

  • Protein details for SRPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sushi repeat-containing protein SRPX
    Protein Accession:
    Secondary Accessions:
    • A8K065
    • B3KWP8
    • B4DDB8
    • B4DQH5
    • F5H4D7
    • G3V1L0
    • Q4VX66
    • Q99652
    • Q99913

    Protein attributes for SRPX Gene

    464 amino acids
    Molecular mass:
    51572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SRPX Gene


neXtProt entry for SRPX Gene

Post-translational modifications for SRPX Gene

  • Glycosylation at isoforms=2, 3, 4, 5240 and posLast=328328

No data available for DME Specific Peptides for SRPX Gene

Domains & Families for SRPX Gene

Gene Families for SRPX Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SRPX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRPX: view

No data available for UniProtKB/Swiss-Prot for SRPX Gene

Function for SRPX Gene

Molecular function for SRPX Gene

GENATLAS Biochemistry:
short consensus repeat protein 1,X chromosome,abundantly expressed in retina,deleted in patients with retinitis pigmentosa (RP3)
UniProtKB/Swiss-Prot Function:
May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.

Phenotypes From GWAS Catalog for SRPX Gene

genes like me logo Genes that share phenotypes with SRPX: view

Animal Models for SRPX Gene

MGI Knock Outs for SRPX:

Animal Model Products

CRISPR Products

miRNA for SRPX Gene

miRTarBase miRNAs that target SRPX

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRPX Gene

Localization for SRPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPX Gene

Cell surface. Note=Possibly surface of photoreceptor cell.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRPX gene
Compartment Confidence
plasma membrane 3
extracellular 3
endoplasmic reticulum 3
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 8634708
genes like me logo Genes that share ontologies with SRPX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRPX Gene

Pathways & Interactions for SRPX Gene

No Data Available

Interacting Proteins for SRPX Gene

Gene Ontology (GO) - Biological Process for SRPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001845 phagolysosome assembly IEA --
GO:0006914 autophagy IEA --
GO:0007155 cell adhesion IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:0060244 negative regulation of cell proliferation involved in contact inhibition IEA --
genes like me logo Genes that share ontologies with SRPX: view

No data available for Pathways by source and SIGNOR curated interactions for SRPX Gene

Drugs & Compounds for SRPX Gene

No Compound Related Data Available

Transcripts for SRPX Gene

Unigene Clusters for SRPX Gene

Sushi-repeat containing protein, X-linked:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP2: -
SP3: -

Relevant External Links for SRPX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.4).

Protein differential expression in normal tissues from HIPED for SRPX Gene

This gene is overexpressed in Gallbladder (23.2) and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SRPX Gene

Protein tissue co-expression partners for SRPX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRPX Gene:


SOURCE GeneReport for Unigene cluster for SRPX Gene:


mRNA Expression by UniProt/SwissProt for SRPX Gene:

Tissue specificity: Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain.

Evidence on tissue expression from TISSUES for SRPX Gene

  • Liver(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with SRPX: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPX Gene

Orthologs for SRPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRPX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRPX 33 34
  • 99.05 (n)
(Canis familiaris)
Mammalia RPGR 34
  • 97 (a)
  • 91.36 (n)
(Bos Taurus)
Mammalia SRPX 33 34
  • 89.93 (n)
(Mus musculus)
Mammalia Srpx 33 16 34
  • 88 (n)
(Rattus norvegicus)
Mammalia Srpx 33
  • 87.5 (n)
(Ornithorhynchus anatinus)
Mammalia SRPX 34
  • 86 (a)
(Monodelphis domestica)
Mammalia SRPX 34
  • 85 (a)
(Gallus gallus)
Aves SRPX 33
  • 75.31 (n)
(Anolis carolinensis)
Reptilia SRPX 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494595 33
  • 68.65 (n)
(Danio rerio)
Actinopterygii srpx 33 34
  • 63.34 (n)
Dr.14621 33
Species where no ortholog for SRPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRPX Gene

Gene Tree for SRPX (if available)
Gene Tree for SRPX (if available)

Paralogs for SRPX Gene

Paralogs for SRPX Gene

(1) SIMAP similar genes for SRPX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRPX: view

Variants for SRPX Gene

Sequence variations from dbSNP and Humsavar for SRPX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000025865 -- 38,199,222(-) C/T intron_variant
rs1000052271 -- 38,166,622(-) TTTT/TT intron_variant
rs1000107513 -- 38,217,320(-) C/T intron_variant
rs1000128605 -- 38,183,696(-) T/C intron_variant
rs1000221508 -- 38,162,308(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRPX Gene

Variant ID Type Subtype PubMed ID
nsv6866 CNV deletion 18451855
nsv525751 CNV gain 19592680

Variation tolerance for SRPX Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRPX Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPX Gene

Disorders for SRPX Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRPX Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 3
  • rp3
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards
Search SRPX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRPX

genes like me logo Genes that share disorders with SRPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRPX Gene

Publications for SRPX Gene

  1. A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. (PMID: 8634708) Meindl A … Meitinger T (Human molecular genetics 1995) 2 3 4 22 58
  2. Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3). (PMID: 8634709) Dry KL … Thomson K (Human molecular genetics 1995) 2 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Down-regulation of drs mRNA in colorectal neoplasms. (PMID: 12716466) Mukaisho K … Hattori T (Japanese journal of cancer research : Gann 2002) 3 22 58

Products for SRPX Gene

Sources for SRPX Gene

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