The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 20... See more...

Aliases for SRPRA Gene

Aliases for SRPRA Gene

  • SRP Receptor Subunit Alpha 2 3 5
  • Signal Recognition Particle Receptor (Docking Protein) 2 3
  • Signal Recognition Particle Receptor Subunit Alpha 3 4
  • Docking Protein Alpha 3 4
  • DP-Alpha 3 4
  • SR-Alpha 3 4
  • SRPR 3 4
  • SRP Receptor Alpha Subunit 3
  • SRP-Alpha 3
  • Sralpha 3
  • DP 3

External Ids for SRPRA Gene

Previous HGNC Symbols for SRPRA Gene

  • SRPR

Summaries for SRPRA Gene

Entrez Gene Summary for SRPRA Gene

  • The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for SRPRA Gene

SRPRA (SRP Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with SRPRA include Pyrimidine Metabolic Disorder and Orotic Aciduria. Among its related pathways are Gene Expression and Viral mRNA Translation. An important paralog of this gene is SRP54.

UniProtKB/Swiss-Prot Summary for SRPRA Gene

  • Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Additional gene information for SRPRA Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRPRA Gene

Genomics for SRPRA Gene

GeneHancer (GH) Regulatory Elements for SRPRA Gene

Promoters and enhancers for SRPRA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J126266 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.5 492 3.5 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G USF1 SP1 GTF2E2 PHF8 FOXRED1 SRPRA FAM118B lnc-FOXRED1-2 RN7SL351P
GH11J126270 Promoter 0.3 Ensembl 500.7 -1.6 -1557 0.2 FOXRED1 SRPRA HSALNG0088018
GH11J126210 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.8 +57.2 57181 3.1 ZNF217 EP300 ZSCAN5C SIN3A NRF1 MYC POLR2G USF1 SP1 PHF8 FAM118B RPUSD4 lnc-SRPRA-6 FOXRED1 SRPRA RF00015-015 RNU4-86P lnc-RPUSD4-1
GH11J126317 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.4 -49.6 -49643 3.2 JUND REST MXI1 RBM25 CBFB MAFK IKZF1 FOXP2 ATF2 GLIS1 FOXRED1 ST3GAL4 TIRAP ENSG00000254694 SRPRA DCPS FAM118B HYLS1 lnc-ST3GAL4-2 ENSG00000255062
GH11J126480 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 9.5 -211.8 -211757 1.2 ZBTB40 CTCF MYC REST POLR2A GABPA RUNX1 RAD21 TRIM22 SMC3 ENSG00000255062 ENSG00000254905 TIRAP DCPS KIRREL3 FOXRED1 SRPRA lnc-ST3GAL4-1 lnc-ST3GAL4-3 ST3GAL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRPRA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRPRA

Genomic Locations for SRPRA Gene

Genomic Locations for SRPRA Gene
chr11:126,262,919-126,269,144
(GRCh38/hg38)
Size:
6,226 bases
Orientation:
Minus strand
chr11:126,132,814-126,139,039
(GRCh37/hg19)
Size:
6,226 bases
Orientation:
Minus strand

Genomic View for SRPRA Gene

Genes around SRPRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPRA Gene

Proteins for SRPRA Gene

  • Protein details for SRPRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08240-SRPRA_HUMAN
    Recommended name:
    Signal recognition particle receptor subunit alpha
    Protein Accession:
    P08240
    Secondary Accessions:
    • A6NIB3
    • B2R5Z8
    • B4E0H3
    • E9PJS4
    • Q9BVJ4

    Protein attributes for SRPRA Gene

    Size:
    638 amino acids
    Molecular mass:
    69811 Da
    Quaternary structure:
    • Heterodimer with SRPRB.

    Three dimensional structures from OCA and Proteopedia for SRPRA Gene

    Alternative splice isoforms for SRPRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPRA Gene

Post-translational modifications for SRPRA Gene

  • Ubiquitination at Lys492
  • Modification sites at PhosphoSitePlus

Other Protein References for SRPRA Gene

No data available for DME Specific Peptides for SRPRA Gene

Domains & Families for SRPRA Gene

Gene Families for SRPRA Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRPRA Gene

Blocks:
  • GTP-binding signal recognition particle (SRP54) G-domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRPRA Gene

GenScript: Design optimal peptide antigens:
  • SRPR protein (Q6IAX9_HUMAN)
  • Docking protein alpha (SRPR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08240

UniProtKB/Swiss-Prot:

SRPRA_HUMAN :
  • Belongs to the GTP-binding SRP family.
Family:
  • Belongs to the GTP-binding SRP family.
genes like me logo Genes that share domains with SRPRA: view

Function for SRPRA Gene

Molecular function for SRPRA Gene

UniProtKB/Swiss-Prot Function:
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Phenotypes From GWAS Catalog for SRPRA Gene

Gene Ontology (GO) - Molecular Function for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003924 GTPase activity IBA 21873635
GO:0005047 signal recognition particle binding IBA 21873635
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SRPRA: view
genes like me logo Genes that share phenotypes with SRPRA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRPRA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRPRA Gene

Localization for SRPRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRPRA Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRPRA gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005785 signal recognition particle receptor complex IEA --
GO:0005789 endoplasmic reticulum membrane IBA,TAS 2827661
GO:0016020 membrane IDA 22375059
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with SRPRA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRPRA Gene

Pathways & Interactions for SRPRA Gene

genes like me logo Genes that share pathways with SRPRA: view

Pathways by source for SRPRA Gene

Gene Ontology (GO) - Biological Process for SRPRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IBA 21873635
GO:0006613 cotranslational protein targeting to membrane TAS 2827661
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA --
GO:0006886 intracellular protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SRPRA: view

No data available for SIGNOR curated interactions for SRPRA Gene

Drugs & Compounds for SRPRA Gene

(1) Drugs for SRPRA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for SRPRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRPRA: view

Transcripts for SRPRA Gene

mRNA/cDNA for SRPRA Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRPRA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPRA Gene

No ASD Table

Relevant External Links for SRPRA Gene

GeneLoc Exon Structure for
SRPRA

Expression for SRPRA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRPRA

Evidence on tissue expression from TISSUES for SRPRA Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.5)
  • Muscle(4.5)
  • Skin(3.3)
  • Pancreas(3.2)
  • Intestine(3.1)
  • Kidney(3.1)
  • Spleen(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPRA Gene

Orthologs for SRPRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPR 31 30
  • 99.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srpr 30
  • 92.14 (n)
mouse
(Mus musculus)
Mammalia Srpr 17 31 30
  • 91.72 (n)
dog
(Canis familiaris)
Mammalia SRPR 31 30
  • 91.07 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SRPR 31 30
  • 90.39 (n)
OneToOne
chicken
(Gallus gallus)
Aves SRPR 31 30
  • 74.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPR 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpr 30
  • 69.6 (n)
Str.11928 30
zebrafish
(Danio rerio)
Actinopterygii srpr 31 30
  • 67.57 (n)
OneToOne
idibd1064 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010894 30
  • 60.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gtp-bp 31 30
  • 58.8 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F38A1.8 30
  • 53.84 (n)
F38A1.8 31
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP101 33 31
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30600 30
  • 52.74 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6715 30
soybean
(Glycine max)
eudicotyledons Gma.17407 30
rice
(Oryza sativa)
Liliopsida Os08g0480100 30
  • 53.49 (n)
Os.4838 30
barley
(Hordeum vulgare)
Liliopsida Hv.296 30
corn
(Zea mays)
Liliopsida Zm.3583 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToOne
Cin.1732 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC3B9.03 30
  • 48.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11187 30
  • 48.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1732 30
Species where no ortholog for SRPRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPRA Gene

ENSEMBL:
Gene Tree for SRPRA (if available)
TreeFam:
Gene Tree for SRPRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRPRA: view image

Paralogs for SRPRA Gene

Paralogs for SRPRA Gene

genes like me logo Genes that share paralogs with SRPRA: view

Variants for SRPRA Gene

Additional dbSNP identifiers (rs#s) for SRPRA Gene

Structural Variations from Database of Genomic Variants (DGV) for SRPRA Gene

Variant ID Type Subtype PubMed ID
nsv556529 CNV loss 21841781
nsv556530 CNV loss 21841781

Variation tolerance for SRPRA Gene

Residual Variation Intolerance Score: 8.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRPRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRPRA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRPRA Gene

Disorders for SRPRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRPRA Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyrimidine metabolic disorder
  • disorder of pyrimidine metabolism
orotic aciduria
  • orotic aciduria i
- elite association - COSMIC cancer census association via MalaCards
Search SRPRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRPRA

genes like me logo Genes that share disorders with SRPRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRPRA Gene

Publications for SRPRA Gene

  1. Complete cDNA sequence coding for human docking protein. (PMID: 3340536) Hortsch M … Meyer DI (Nucleic acids research 1988) 2 3 4 54
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. PCR-assisted localization of the human SRPR gene. (PMID: 1312991) Janin N … Lipinski M (Human genetics 1992) 2 3 54
  5. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion. (PMID: 31678930) Méant A … Roux PP (Molecular & cellular proteomics : MCP 2020) 3 54

Products for SRPRA Gene

Sources for SRPRA Gene