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Aliases for SRPK3 Gene

Aliases for SRPK3 Gene

  • SRSF Protein Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase 23 3 4
  • Muscle-Specific Serine Kinase 1 3 4
  • SR-Protein-Specific Kinase 3 3 4
  • Serine/Threonine Kinase 23 2 3
  • SFRS Protein Kinase 3 2 3
  • EC 2.7.11.1 4 56
  • MSSK-1 3 4
  • STK23 3 4
  • MSSK1 3 4
  • Serine Arginine Rich Protein-Specific Kinase 3 3
  • Serine/Arginine-Rich Protein-Specific Kinase 3 4
  • Serine/Threonine-Protein Kinase SRPK3 3

External Ids for SRPK3 Gene

Previous HGNC Symbols for SRPK3 Gene

  • STK23

Previous GeneCards Identifiers for SRPK3 Gene

  • GC0XP152699
  • GC0XP153041
  • GC0XP141703

Summaries for SRPK3 Gene

Entrez Gene Summary for SRPK3 Gene

  • This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for SRPK3 Gene

SRPK3 (SRSF Protein Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SRPK2.

UniProtKB/Swiss-Prot for SRPK3 Gene

  • Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

Additional gene information for SRPK3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRPK3 Gene

Genomics for SRPK3 Gene

GeneHancer (GH) Regulatory Elements for SRPK3 Gene

Promoters and enhancers for SRPK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI153780 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 562.3 +5.2 5179 2.5 HDGF CTCF KLF1 ZNF449 ZIC2 RAD21 BCL11B ZFHX2 GLIS2 PATZ1 SRPK3 PLXNB3 SSR4
GH0XI153884 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 13.2 +109.7 109693 3 CTCF KLF1 MAX KLF17 ZIC2 RAD21 HIC1 ZFHX2 GATA3 GLIS2 L1CAM RENBP TMEM187 PDZD4 IDH3G SSR4 SRPK3 PLXNB3 ARHGAP4 NAA10
GH0XI153702 Enhancer 0.8 FANTOM5 ENCODE 32.2 -71.3 -71347 4.6 CTCF KLF1 ZBTB48 HLF KLF17 ZBTB33 SRPK3 PNCK SLC6A8 IKBKG AVPR2 BCAP31
GH0XI153792 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.6 +18.0 17967 3.3 PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF143 FOS SP3 SSR4 IDH3G PLXNB3 SRPK3
GH0XI153844 Enhancer 0.6 ENCODE 13.7 +69.3 69267 1.8 MEIS2 BACH1 MAFG SP1 ZNF316 ZNF143 EMSY MAFK SSR4 IDH3G SRPK3 PLXNB3 L1CAM ABCD1 BCAP31 FAM3A CYCSP45 GC0XM153869
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRPK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRPK3 gene promoter:

Genomic Locations for SRPK3 Gene

Genomic Locations for SRPK3 Gene
chrX:153,776,412-153,785,732
(GRCh38/hg38)
Size:
9,321 bases
Orientation:
Plus strand
chrX:153,041,867-153,051,187
(GRCh37/hg19)

Genomic View for SRPK3 Gene

Genes around SRPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRPK3 Gene

Proteins for SRPK3 Gene

  • Protein details for SRPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPE1-SRPK3_HUMAN
    Recommended name:
    SRSF protein kinase 3
    Protein Accession:
    Q9UPE1
    Secondary Accessions:
    • Q13583
    • Q4F970
    • Q562F5
    • Q9UM62

    Protein attributes for SRPK3 Gene

    Size:
    567 amino acids
    Molecular mass:
    62014 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SRPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRPK3 Gene

Selected DME Specific Peptides for SRPK3 Gene

Q9UPE1:
  • DIQTRQYR
  • AAEATEWQ
  • FNRRGELR
  • KLGWGHFSTVWL
  • DLGNACW
  • ACMAFELATGD
  • RDEDHIA
  • LGSDDEEQEDP
  • DYCKGGY
  • FNGRYHV
  • YSRDEDH

Post-translational modifications for SRPK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SRPK3
  • Cloud-Clone Corp. Antibodies for SRPK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for SRPK3

Domains & Families for SRPK3 Gene

Gene Families for SRPK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SRPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPE1

UniProtKB/Swiss-Prot:

SRPK3_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SRPK3: view

Function for SRPK3 Gene

Molecular function for SRPK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).

Enzyme Numbers (IUBMB) for SRPK3 Gene

Gene Ontology (GO) - Molecular Function for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 23602568
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with SRPK3: view
genes like me logo Genes that share phenotypes with SRPK3: view

Animal Models for SRPK3 Gene

MGI Knock Outs for SRPK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SRPK3

CRISPR Products

miRNA for SRPK3 Gene

miRTarBase miRNAs that target SRPK3

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRPK3 Gene

Localization for SRPK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRPK3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SRPK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SRPK3 Gene

Pathways & Interactions for SRPK3 Gene

SuperPathways for SRPK3 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with SRPK3: view

Pathways by source for SRPK3 Gene

1 Qiagen pathway for SRPK3 Gene

Gene Ontology (GO) - Biological Process for SRPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0006468 protein phosphorylation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with SRPK3: view

No data available for SIGNOR curated interactions for SRPK3 Gene

Drugs & Compounds for SRPK3 Gene

(1) Drugs for SRPK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for SRPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with SRPK3: view

Transcripts for SRPK3 Gene

Unigene Clusters for SRPK3 Gene

SRSF protein kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRPK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for SRPK3 Gene

GeneLoc Exon Structure for
SRPK3
ECgene alternative splicing isoforms for
SRPK3

Expression for SRPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRPK3 Gene

This gene is overexpressed in Muscle - Skeletal (x15.3), Heart - Left Ventricle (x5.7), and Heart - Atrial Appendage (x5.3).

Protein differential expression in normal tissues from HIPED for SRPK3 Gene

This gene is overexpressed in Liver (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRPK3 Gene



Protein tissue co-expression partners for SRPK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRPK3 Gene:

SRPK3

SOURCE GeneReport for Unigene cluster for SRPK3 Gene:

Hs.104865

mRNA Expression by UniProt/SwissProt for SRPK3 Gene:

Q9UPE1-SRPK3_HUMAN
Tissue specificity: Exclusively expressed in skeletal and heart muscle.

Evidence on tissue expression from TISSUES for SRPK3 Gene

  • Muscle(4.5)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SRPK3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRPK3 Gene

Orthologs for SRPK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRPK3 33 34
  • 97.04 (n)
dog
(Canis familiaris)
Mammalia SRPK3 33 34
  • 91.48 (n)
cow
(Bos Taurus)
Mammalia SRPK3 33 34
  • 90 (n)
mouse
(Mus musculus)
Mammalia Srpk3 33 16 34
  • 86.79 (n)
rat
(Rattus norvegicus)
Mammalia Srpk3 33
  • 86.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRPK3 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRPK3 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRPK3 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srpk2 33
  • 70.31 (n)
zebrafish
(Danio rerio)
Actinopterygii srpk3 33 34
  • 68.85 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11303 33
fruit fly
(Drosophila melanogaster)
Insecta SRPK 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spk-1 33 34
  • 53.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKY1 34 36
  • 29 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.9557 33
rice
(Oryza sativa)
Liliopsida Os.26432 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for SRPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRPK3 Gene

ENSEMBL:
Gene Tree for SRPK3 (if available)
TreeFam:
Gene Tree for SRPK3 (if available)

Paralogs for SRPK3 Gene

Paralogs for SRPK3 Gene

(5) SIMAP similar genes for SRPK3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SRPK3: view

Variants for SRPK3 Gene

Sequence variations from dbSNP and Humsavar for SRPK3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000061564 -- 153,786,012(+) G/A downstream_transcript_variant
rs1000114958 -- 153,785,760(+) G/A downstream_transcript_variant
rs1001521011 -- 153,779,417(+) T/G upstream_transcript_variant
rs1001671484 -- 153,784,829(+) C/T coding_sequence_variant, missense_variant
rs1001805336 -- 153,784,620(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRPK3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407

Variation tolerance for SRPK3 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRPK3 Gene

Human Gene Mutation Database (HGMD)
SRPK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRPK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRPK3 Gene

Disorders for SRPK3 Gene

Additional Disease Information for SRPK3

No disorders were found for SRPK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRPK3 Gene

Publications for SRPK3 Gene

  1. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. (PMID: 16140986) Nakagawa O … Olson EN (Genes & development 2005) 2 3 58
  2. Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. (PMID: 11063724) Grunau C … Rosenthal A (Human molecular genetics 2000) 3 4 58
  3. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells. (PMID: 25404735) Zhang M … Davie J (The Journal of biological chemistry 2015) 3 58

Products for SRPK3 Gene

  • Addgene plasmids for SRPK3

Sources for SRPK3 Gene

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