SRP68 Gene (Protein Coding)

Signal Recognition Particle 68

GC17M076038
GIFtS:
38
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for ... See more...

Aliases for SRP68 Gene

Aliases for SRP68 Gene

  • Signal Recognition Particle 68 2 3 5
  • Signal Recognition Particle 68 KDa Protein 3 4
  • Signal Recognition Particle Subunit SRP68 3 4
  • Signal Recognition Particle 68kDa 2 3
  • Signal Recognition Particle 68kD 2 3
  • SRP68 5

External Ids for SRP68 Gene

Previous GeneCards Identifiers for SRP68 Gene

  • GC17P073853
  • GC17M077061
  • GC17M074499
  • GC17M074632
  • GC17M071546
  • GC17M074035
  • GC17M069460

Summaries for SRP68 Gene

Entrez Gene Summary for SRP68 Gene

  • This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

GeneCards Summary for SRP68 Gene

SRP68 (Signal Recognition Particle 68) is a Protein Coding gene. Diseases associated with SRP68 include Smith-Magenis Syndrome and Coffin-Siris Syndrome 1. Among its related pathways are Metabolism of proteins and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include signal recognition particle binding.

UniProtKB/Swiss-Prot Summary for SRP68 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Additional gene information for SRP68 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRP68 Gene

Genomics for SRP68 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SRP68 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRP68 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRP68

Top Transcription factor binding sites by QIAGEN in the SRP68 gene promoter:
  • FAC1
  • MyoD
  • RREB-1
  • USF-1
  • USF1
  • YY1

Genomic Locations for SRP68 Gene

Latest Assembly
chr17:76,038,775-76,072,517
(GRCh38/hg38)
Size:
33,743 bases
Orientation:
Minus strand

Previous Assembly
chr17:74,034,866-74,068,598
(GRCh37/hg19 by Entrez Gene)
Size:
33,733 bases
Orientation:
Minus strand

chr17:74,035,184-74,068,734
(GRCh37/hg19 by Ensembl)
Size:
33,551 bases
Orientation:
Minus strand

Genomic View for SRP68 Gene

Genes around SRP68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP68 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SRP68 Gene

Proteins for SRP68 Gene

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  • Protein details for SRP68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB9-SRP68_HUMAN
    Recommended name:
    Signal recognition particle subunit SRP68
    Protein Accession:
    Q9UHB9
    Secondary Accessions:
    • B3KUU5
    • B3KWY7
    • G3V1U4
    • Q8NCJ4
    • Q8WUK2

    Protein attributes for SRP68 Gene

    Size:
    627 amino acids
    Molecular mass:
    70730 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP68 Gene

    Alternative splice isoforms for SRP68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP68 Gene

Protein Expression for SRP68 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SRP68 Gene

  • Ubiquitination at Lys142, Lys504, Lys205, Lys220, and Lys277
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP68 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for SRP68

No data available for DME Specific Peptides for SRP68 Gene

Domains & Families for SRP68 Gene

Gene Families for SRP68 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SRP68 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRP68 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ40643 fis, clone THYMU2017099, highly similar to SIGNAL RECOGNITION PARTICLE 68 kDa PROTEIN (B3KUU5_HUMAN)
  • cDNA FLJ14414 fis, clone HEMBA1004847, highly similar to SIGNAL RECOGNITION PARTICLE 68 KD PROTEIN (Q96K98_HUMAN)
  • Signal recognition particle 68 kDa protein (SRP68_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHB9

UniProtKB/Swiss-Prot:

SRP68_HUMAN :
  • The RNA-binding domain is located near the N-terminus.
  • Belongs to the SRP68 family.
Domain:
  • The RNA-binding domain is located near the N-terminus.
Family:
  • Belongs to the SRP68 family.
genes like me logo Genes that share domains with SRP68: view

Function for SRP68 Gene

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  6. Cell Lines for research

Molecular function for SRP68 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Phenotypes From GWAS Catalog for SRP68 Gene

Gene Ontology (GO) - Molecular Function for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005047 signal recognition particle binding IBA,IPI 17254600
GO:0005515 protein binding IPI 24700861
GO:0008312 7S RNA binding IMP 27899666
GO:0019904 protein domain specific binding IPI 27899666
genes like me logo Genes that share ontologies with SRP68: view
genes like me logo Genes that share phenotypes with SRP68: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRP68

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP68 Gene

Localization for SRP68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP68 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP68 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus TAS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum TAS 10618370
GO:0005786 signal recognition particle, endoplasmic reticulum targeting TAS,IDA 18089836
genes like me logo Genes that share ontologies with SRP68: view

Pathways & Interactions for SRP68 Gene

genes like me logo Genes that share pathways with SRP68: view

Pathways by source for SRP68 Gene

1 KEGG pathway for SRP68 Gene

SIGNOR curated interactions for SRP68 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SRP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0042493 response to drug IDA 18089836
genes like me logo Genes that share ontologies with SRP68: view

Drugs & Compounds for SRP68 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SRP68 Gene

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mRNA/cDNA for SRP68 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRP68

Alternative Splicing Database (ASD) splice patterns (SP) for SRP68 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -
SP7:
SP8:

Relevant External Links for SRP68 Gene

GeneLoc Exon Structure for
SRP68

Expression for SRP68 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRP68 Gene

mRNA expression in normal human tissues for SRP68 Gene
mRNA expression by GTEx for SRP68 GenemRNA expression by BioGPS for SRP68 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRP68 Gene

This gene is overexpressed in Brain (19.7) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRP68 Gene



Protein tissue co-expression partners for SRP68 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRP68

SOURCE GeneReport for Unigene cluster for SRP68 Gene:

Hs.514495

Evidence on tissue expression from TISSUES for SRP68 Gene

  • Skin(4.7)
  • Liver(4.5)
  • Blood(4.3)
  • Nervous system(4.1)
  • Lung(2.9)
  • Intestine(2.3)
  • Muscle(2.3)
  • Thyroid gland(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SRP68: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRP68 Gene

Orthologs for SRP68 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP68 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SRP68 30 31
  • 99.03 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SRP68 31
  • 92 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SRP68 30 31
  • 91.77 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SRP68 30 31
  • 89.03 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Srp68 30
  • 87.68 (n)
Mouse
(Mus musculus)
 Mammalia Srp68 30 17 31
  • 87.52 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SRP68 31
  • 78 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SRP68 30 31
  • 79.29 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SRP68 31
  • 70 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia srp68 30
  • 75.19 (n)
Str.6140 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.1915 30
Zebrafish
(Danio rerio)
 Actinopterygii srp68 30 31
  • 71.56 (n)
 OneToOne
Dr.29692 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Srp68 30 31
  • 51.92 (n)
 OneToOne
CG5064 32
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002183 30
  • 50.79 (n)
Worm
(Caenorhabditis elegans)
 Secernentea CELE_F55C5.8 30
  • 46.16 (n)
F55C5.8 32
  • 31 (a)
srpa-68 31
  • 30 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SRP68 33
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G61970 30
  • 47.26 (n)
Rice
(Oryza sativa)
 Liliopsida Os08g0323000 30
  • 45.79 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 43 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1809 30
Species where no ortholog for SRP68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SRP68 Gene

ENSEMBL:
Gene Tree for SRP68 (if available)
TreeFam:
Gene Tree for SRP68 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRP68: view image

Paralogs for SRP68 Gene

Pseudogenes.org Pseudogenes for SRP68 Gene

genes like me logo Genes that share paralogs with SRP68: view

No data available for Paralogs for SRP68 Gene

Variants for SRP68 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRP68 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRP68 Gene

Variant ID Type Subtype PubMed ID
esv2588678 CNV insertion 19546169
nsv1120114 OTHER inversion 24896259
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897
nsv960531 CNV duplication 23825009

Variation tolerance for SRP68 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRP68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP68

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRP68 Gene

Disorders for SRP68 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRP68 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • sms
coffin-siris syndrome 1
  • css1
- elite association - COSMIC cancer census association via MalaCards
Search SRP68 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRP68

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SRP68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRP68 Gene

Publications for SRP68 Gene

  1. Signal recognition particle components in the nucleolus. (PMID: 10618370) Politz JC … Pederson T (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4
  2. Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle. (PMID: 18564060) Maity TS … Weeks KM (The Biochemical journal 2008) 3 23
  3. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. (PMID: 16672232) Iakhiaeva E … Zwieb C (Protein science : a publication of the Protein Society 2006) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for SRP68 gene in Mastermind

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