Aliases for SRP19 Gene

Aliases for SRP19 Gene

  • Signal Recognition Particle 19 2 3 5
  • Signal Recognition Particle 19 KDa Protein 3 4
  • Signal Recognition Particle 19kDa 2 3
  • Signal Recognition Particle 19kD 3

External Ids for SRP19 Gene

Previous GeneCards Identifiers for SRP19 Gene

  • GC05P111793
  • GC05P112644
  • GC05P112227
  • GC05P112273
  • GC05P112224
  • GC05P112196
  • GC05P107376

Summaries for SRP19 Gene

GeneCards Summary for SRP19 Gene

SRP19 (Signal Recognition Particle 19) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include 7S RNA binding.

UniProtKB/Swiss-Prot Summary for SRP19 Gene

  • Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

Additional gene information for SRP19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRP19 Gene

Genomics for SRP19 Gene

GeneHancer (GH) Regulatory Elements for SRP19 Gene

Promoters and enhancers for SRP19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J112860 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 535.4 +0.7 713 3 ZBTB40 ZNF217 EP300 NRF1 TCF12 POLR2G USF1 SP1 GTF2E2 PHF8 SRP19 REEP5 APC YTHDC2 RF00017-4820 ENSG00000258864
GH05J112920 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20 +61.6 61579 5.5 ZNF217 EP300 CTCF NRF1 TCF12 POLR2G GTF2E2 PHF8 ZFX ZIC2 REEP5 LOC105379123 SRP19 ENSG00000251187 RF00017-4821
GH05J112878 Enhancer 1 Ensembl ENCODE 35.8 +17.4 17413 3.2 ZSCAN5C JUND ZNF740 MYC RUNX1 CTBP1 JUN ZEB1 OSR2 HDAC3 SRP19 REEP5 APC lnc-APC-3 XBP1P1 piR-35729-049
GH05J112706 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.1 -152.6 -152627 4.1 ZNF217 EP300 NRF1 TCF12 POLR2G GTF2E2 PHF8 ZFX ZIC2 POLR2A APC NONHSAG041256.2 YTHDC2 SRP19 REEP5 CBX3P3 RNU6-482P ZRSR2P1
GH05J112882 Enhancer 0.7 FANTOM5 35.8 +22.1 22090 0.6 HES1 PBX2 NFE2 TAL1 MNT RCOR1 NR2F1 HDAC2 HDAC1 TCF12 XBP1P1 lnc-APC-3 SRP19 REEP5 APC piR-35729-049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRP19 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRP19

Top Transcription factor binding sites by QIAGEN in the SRP19 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HSF2
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SEF-1 (1)
  • SREBP-1c

Genomic Locations for SRP19 Gene

Genomic Locations for SRP19 Gene
chr5:112,861,188-112,898,371
(GRCh38/hg38)
Size:
37,184 bases
Orientation:
Plus strand
chr5:112,196,885-112,228,776
(GRCh37/hg19)
Size:
31,892 bases
Orientation:
Plus strand

Genomic View for SRP19 Gene

Genes around SRP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP19 Gene

Proteins for SRP19 Gene

  • Protein details for SRP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09132-SRP19_HUMAN
    Recommended name:
    Signal recognition particle 19 kDa protein
    Protein Accession:
    P09132
    Secondary Accessions:
    • B2R4E9
    • D6RCQ5
    • Q05D77
    • Q96FG6

    Protein attributes for SRP19 Gene

    Size:
    144 amino acids
    Molecular mass:
    16156 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP19 Gene

    Alternative splice isoforms for SRP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRP19 Gene

Post-translational modifications for SRP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRP19 Gene

Domains & Families for SRP19 Gene

Gene Families for SRP19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SRP19 Gene

Blocks:
  • Ribonucleoprotein complex SRP, Srp19 component
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRP19 Gene

GenScript: Design optimal peptide antigens:
  • SRP19 protein (Q05D77_HUMAN)
  • Signal recognition particle 19 kDa protein (SRP19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09132

UniProtKB/Swiss-Prot:

SRP19_HUMAN :
  • Belongs to the SRP19 family.
Family:
  • Belongs to the SRP19 family.
genes like me logo Genes that share domains with SRP19: view

Function for SRP19 Gene

Molecular function for SRP19 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
GENATLAS Biochemistry:
signal recognition particle,ribosomal (19kDa)

Phenotypes From GWAS Catalog for SRP19 Gene

Gene Ontology (GO) - Molecular Function for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 24700861
GO:0008312 7S RNA binding IDA,IEA 17434535
GO:0043022 contributes_to ribosome binding IDA 27899666
genes like me logo Genes that share ontologies with SRP19: view
genes like me logo Genes that share phenotypes with SRP19: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP19 Gene

Localization for SRP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP19 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 10618370
GO:0005737 cytoplasm IEA --
GO:0005786 signal recognition particle, endoplasmic reticulum targeting TAS,IDA 18089836
GO:0005829 cytosol TAS --
GO:0048500 signal recognition particle IDA,IEA 27899666
genes like me logo Genes that share ontologies with SRP19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRP19 Gene

Pathways & Interactions for SRP19 Gene

genes like me logo Genes that share pathways with SRP19: view

Pathways by source for SRP19 Gene

Gene Ontology (GO) - Biological Process for SRP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 1678319
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA,TAS --
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA 21873635
GO:0042493 response to drug IDA 18089836
genes like me logo Genes that share ontologies with SRP19: view

No data available for SIGNOR curated interactions for SRP19 Gene

Drugs & Compounds for SRP19 Gene

(4) Drugs for SRP19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 582
Fluoxetine Approved, Vet_approved Pharma Channel blocker, Antagonist, Inhibition, Inhibitor 272
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 252
Sertraline Approved Pharma Inhibition, Inhibitor 332
genes like me logo Genes that share compounds with SRP19: view

Transcripts for SRP19 Gene

mRNA/cDNA for SRP19 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRP19 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: -

Relevant External Links for SRP19 Gene

GeneLoc Exon Structure for
SRP19

Expression for SRP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRP19 Gene

Protein differential expression in normal tissues from HIPED for SRP19 Gene

This gene is overexpressed in Bone (11.8), Pancreas (6.9), Peripheral blood mononuclear cells (6.8), and Lung (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRP19 Gene



Protein tissue co-expression partners for SRP19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRP19

SOURCE GeneReport for Unigene cluster for SRP19 Gene:

Hs.637001

Evidence on tissue expression from TISSUES for SRP19 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with SRP19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRP19 Gene

Orthologs for SRP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRP19 31 30
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SRP19 31 30
  • 94.81 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SRP19 31 30
  • 90.74 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Srp19 17 31 30
  • 89.38 (n)
rat
(Rattus norvegicus)
Mammalia Srp19 30
  • 89.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 85 (a)
OneToMany
SRP19 30
  • 76.54 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srp19 30
  • 65.89 (n)
Str.11353 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2367 30
zebrafish
(Danio rerio)
Actinopterygii srp19 31 30
  • 65.35 (n)
OneToMany
wufj65h05 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8854 30
fruit fly
(Drosophila melanogaster)
Insecta Srp19 31 30
  • 53.87 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009948 30
  • 49.25 (n)
worm
(Caenorhabditis elegans)
Secernentea F37F2.2 31 30
  • 52.99 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC65 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G48160 30
  • 51.28 (n)
rice
(Oryza sativa)
Liliopsida Os06g0342100 30
  • 47.12 (n)
Species where no ortholog for SRP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRP19 Gene

ENSEMBL:
Gene Tree for SRP19 (if available)
TreeFam:
Gene Tree for SRP19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRP19: view image

Paralogs for SRP19 Gene

Pseudogenes.org Pseudogenes for SRP19 Gene

genes like me logo Genes that share paralogs with SRP19: view

No data available for Paralogs for SRP19 Gene

Variants for SRP19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRP19 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs17855423 - p.Ala4Thr

Additional dbSNP identifiers (rs#s) for SRP19 Gene

Structural Variations from Database of Genomic Variants (DGV) for SRP19 Gene

Variant ID Type Subtype PubMed ID
esv2667456 CNV deletion 23128226
esv26872 CNV loss 19812545
esv2730601 CNV deletion 23290073
esv3566464 CNV deletion 23714750
esv3606302 CNV loss 21293372
nsv4960 CNV deletion 18451855
nsv599394 CNV gain 21841781
nsv968976 CNV duplication 23825009

Variation tolerance for SRP19 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP19 Gene

Disorders for SRP19 Gene

Additional Disease Information for SRP19

No disorders were found for SRP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRP19 Gene

Publications for SRP19 Gene

  1. Structural insights into the assembly of the human and archaeal signal recognition particles. (PMID: 20179341) Wild K … Sinning I (Acta crystallographica. Section D, Biological crystallography 2010) 3 4 23 54
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A … Nagai K (Nature structural biology 2002) 3 4 23 54
  3. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. (PMID: 11641499) Wild K … Cusack S (Science (New York, N.Y.) 2001) 3 4 23 54
  4. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. (PMID: 2460823) Lingelbach K … Dobberstein B (Nucleic acids research 1988) 2 3 4 54
  5. A threefold RNA-protein interface in the signal recognition particle gates native complex assembly. (PMID: 17434535) Maity TS … Weeks KM (Journal of molecular biology 2007) 3 23 54

Products for SRP19 Gene

Sources for SRP19 Gene