Aliases for SRP14 Gene

Aliases for SRP14 Gene

  • Signal Recognition Particle 14 2 3 5
  • Signal Recognition Particle 14 KDa Protein 3 4
  • Homologous Alu RNA Binding Protein 2 3
  • 18 KDa Alu RNA-Binding Protein 3 4
  • ALURBP 2 3
  • Signal Recognition Particle 14kD (Homologous Alu RNA-Binding Protein) 2
  • MGC14326 2
  • SRP14 5

External Ids for SRP14 Gene

Previous GeneCards Identifiers for SRP14 Gene

  • GC15M035695
  • GC15M033223
  • GC15M037907
  • GC15M038044
  • GC15M038115
  • GC15M040327
  • GC15M017172

Summaries for SRP14 Gene

GeneCards Summary for SRP14 Gene

SRP14 (Signal Recognition Particle 14) is a Protein Coding gene. Diseases associated with SRP14 include Coffin-Siris Syndrome 1. Among its related pathways are Viral mRNA Translation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include 7S RNA binding.

UniProtKB/Swiss-Prot Summary for SRP14 Gene

  • Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRP14 Gene

Genomics for SRP14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRP14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRP14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRP14

Top Transcription factor binding sites by QIAGEN in the SRP14 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • C/EBPbeta
  • HNF-1
  • HNF-1A
  • ITF-2
  • Tal-1beta

Genomic Locations for SRP14 Gene

Latest Assembly
chr15:40,035,690-40,039,202
(GRCh38/hg38)
Size:
3,513 bases
Orientation:
Minus strand

Previous Assembly
chr15:40,327,891-40,331,403
(GRCh37/hg19 by Entrez Gene)
Size:
3,513 bases
Orientation:
Minus strand

chr15:40,327,940-40,331,389
(GRCh37/hg19 by Ensembl)
Size:
3,450 bases
Orientation:
Minus strand

Genomic View for SRP14 Gene

Genes around SRP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRP14 Gene

Proteins for SRP14 Gene

  • Protein details for SRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37108-SRP14_HUMAN
    Recommended name:
    Signal recognition particle 14 kDa protein
    Protein Accession:
    P37108
    Secondary Accessions:
    • B5BUF5
    • Q6B0K5
    • Q96Q14

    Protein attributes for SRP14 Gene

    Size:
    136 amino acids
    Molecular mass:
    14570 Da
    Quaternary structure:
    • Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Three dimensional structures from OCA and Proteopedia for SRP14 Gene

neXtProt entry for SRP14 Gene

Post-translational modifications for SRP14 Gene

  • Ubiquitination at Lys43, Lys55, Lys74, and Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for SRP14 Gene

No data available for DME Specific Peptides for SRP14 Gene

Domains & Families for SRP14 Gene

Gene Families for SRP14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SRP14 Gene

InterPro:
Blocks:
  • Signal recognition particle, 14 kDa protein

Suggested Antigen Peptide Sequences for SRP14 Gene

GenScript: Design optimal peptide antigens:
  • 18 kDa Alu RNA-binding protein (SRP14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P37108

UniProtKB/Swiss-Prot:

SRP14_HUMAN :
  • Belongs to the SRP14 family.
Family:
  • Belongs to the SRP14 family.
genes like me logo Genes that share domains with SRP14: view

Function for SRP14 Gene

Molecular function for SRP14 Gene

UniProtKB/Swiss-Prot Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
GENATLAS Biochemistry:
signal recognition particle (14kDa),binding the Alu homologous region of 7SL RNA,with five or more CAG repeats

Phenotypes From GWAS Catalog for SRP14 Gene

Gene Ontology (GO) - Molecular Function for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22658674
GO:0005515 protein binding IPI 11089964
GO:0008312 7S RNA binding IEA --
GO:0030942 endoplasmic reticulum signal peptide binding IEA --
genes like me logo Genes that share ontologies with SRP14: view
genes like me logo Genes that share phenotypes with SRP14: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRP14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRP14 Gene

Localization for SRP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRP14 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 22720776
GO:0005737 cytoplasm IEA,TAS 8196634
GO:0005786 signal recognition particle, endoplasmic reticulum targeting IEA,IDA 18089836
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRP14: view

Pathways & Interactions for SRP14 Gene

genes like me logo Genes that share pathways with SRP14: view

Pathways by source for SRP14 Gene

1 KEGG pathway for SRP14 Gene

Gene Ontology (GO) - Biological Process for SRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 2557625
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA,TAS --
GO:0043312 neutrophil degranulation TAS --
GO:0045047 protein targeting to ER IBA,IMP 18089836
genes like me logo Genes that share ontologies with SRP14: view

No data available for SIGNOR curated interactions for SRP14 Gene

Drugs & Compounds for SRP14 Gene

(1) Drugs for SRP14 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Experimental, Investigational Pharma Target, ligand 123
genes like me logo Genes that share compounds with SRP14: view

Transcripts for SRP14 Gene

mRNA/cDNA for SRP14 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRP14

Alternative Splicing Database (ASD) splice patterns (SP) for SRP14 Gene

No ASD Table

Relevant External Links for SRP14 Gene

GeneLoc Exon Structure for
SRP14

Expression for SRP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRP14 Gene



Protein tissue co-expression partners for SRP14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRP14

SOURCE GeneReport for Unigene cluster for SRP14 Gene:

Hs.533732

Evidence on tissue expression from TISSUES for SRP14 Gene

  • Liver(4.8)
  • Nervous system(4.2)
  • Lung(3.8)
  • Skin(3.8)
  • Eye(3.2)
  • Muscle(2.8)
  • Heart(2.7)
  • Kidney(2.7)
  • Blood(2.6)
  • Intestine(2.5)
  • Spleen(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Lymph node(2.1)
  • Bone marrow(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SRP14: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRP14 Gene

Orthologs for SRP14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRP14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SRP14 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SRP14 29 30
  • 90.43 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SRP14 30
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SRP14 29 30
  • 89.72 (n)
OneToMany
-- 30
  • 89 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Srp14 29
  • 87.79 (n)
Mouse
(Mus musculus)
Mammalia Srp14 29 16 30
  • 87.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SRP14 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SRP14 29 30
  • 81.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SRP14 30
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia srp14 29
  • 74.59 (n)
Str.6625 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.33043 29
Zebrafish
(Danio rerio)
Actinopterygii srp14 29 30
  • 72.28 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Srp14 30
  • 38 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F25G6.8 30
  • 41 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1955 29
Species where no ortholog for SRP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SRP14 Gene

ENSEMBL:
Gene Tree for SRP14 (if available)
TreeFam:
Gene Tree for SRP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRP14: view image
Alliance of Genome Resources:
Additional Orthologs for SRP14

Paralogs for SRP14 Gene

genes like me logo Genes that share paralogs with SRP14: view

No data available for Paralogs for SRP14 Gene

Variants for SRP14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRP14 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs7535 Benign: not specified 40,036,374(-) G/Cp.Pro124Ala
NM_003134.6(SRP14):c.370C>G (p.Pro124Ala)
MISSENSE
rs8208 Benign: not specified 40,036,464(-) G/A
NM_003134.6(SRP14):c.280C>T (p.Leu94=)
SYNONYMOUS
rs16924521 -- p.Ala127Thr
rs1802600 -- p.Ser68Ile
rs1802601 -- p.Pro51Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRP14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRP14 Gene

Variant ID Type Subtype PubMed ID
dgv1193n106 CNV deletion 24896259
esv2749592 CNV deletion 23290073
esv2749593 CNV deletion 23290073
esv2749594 CNV deletion 23290073
esv2749595 CNV deletion 23290073
nsv958007 CNV deletion 24416366
nsv974561 CNV duplication 23825009

Variation tolerance for SRP14 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRP14
Leiden Open Variation Database (LOVD)
SRP14

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRP14 Gene

Disorders for SRP14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRP14 Gene - From: COP

Disorder Aliases PubMed IDs
coffin-siris syndrome 1
  • css1
- elite association - COSMIC cancer census association via MalaCards
Search SRP14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRP14

genes like me logo Genes that share disorders with SRP14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRP14 Gene

Publications for SRP14 Gene

  1. Structure and assembly of the Alu domain of the mammalian signal recognition particle. (PMID: 11089964) Weichenrieder O … Cusack S (Nature 2000) 3 4 22
  2. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. (PMID: 8196634) Chang DY … Maraia RJ (Molecular and cellular biology 1994) 2 3 4
  3. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PMID: 22327514) Postel-Vinay S … Delattre O (Nature genetics 2012) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. (PMID: 7542942) Bovia F … Strub K (Molecular biology of the cell 1995) 3 4

Products for SRP14 Gene

Sources for SRP14 Gene