Aliases for SRMS Gene

Aliases for SRMS Gene

  • Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites 2 3 5
  • Tyrosine-Protein Kinase Srms 3 4
  • EC 2.7.10.2 4 50
  • DJ697K14.1 2 3
  • C20orf148 3 4
  • PTK70 2 3
  • SRM 2 3
  • Chromosome 20 Open Reading Frame 148 2
  • EC 2.7.10 50
  • SRMS 5

External Ids for SRMS Gene

Previous HGNC Symbols for SRMS Gene

  • C20orf148

Previous GeneCards Identifiers for SRMS Gene

  • GC00U990353
  • GC20M062009
  • GC20M062851
  • GC20M062899
  • GC20M062900
  • GC20M061642
  • GC20M062172
  • GC20M058902

Summaries for SRMS Gene

GeneCards Summary for SRMS Gene

SRMS (Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites) is a Protein Coding gene. Diseases associated with SRMS include Lung Sarcoma. Among its related pathways are Signaling by GPCR and Signaling by PTK6. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PTK6.

UniProtKB/Swiss-Prot Summary for SRMS Gene

  • Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRMS Gene

Genomics for SRMS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRMS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J063547 Promoter/Enhancer 1 EPDnew Ensembl 250.7 -1.4 -1352 3.8 ZIC2 BHLHE40 ZNF623 ZFP91 CTCF ZBTB33 HNRNPL KLF1 HDGF ZNF24 FNDC11 HSALNG0131648 SRMS PTK6 PPDPF piR-39322 HELZ2
GH20J063893 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -348.8 -348800 5.1 SP1 NCOR1 IKZF1 ZNF600 ZNF10 BRCA1 POLR2A ZIC2 YY1 MXD4 DNAJC5 lnc-DNAJC5-1 RGS19 OPRL1 ZBTB46 C20orf181 FNDC11 SRMS ZBTB46-AS1 ENSG00000229299
GH20J063544 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.9 +2.3 2348 2.4 ZNF10 MXD4 MAX ZNF217 MBD2 ELF1 KDM6A CTBP1 SP2 SMAD4 ENSG00000275812 PPDPF SRMS PTK6
GH20J063541 Enhancer 0.9 ENCODE dbSUPER 24.3 +5.1 5143 1.4 SP1 ZIC2 BHLHE40 MAX EBF1 BATF IKZF1 NRF1 NR2F1 ATF2 ENSG00000275812 HSALNG0131647 SRMS PTK6
GH20J063680 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -137.6 -137585 9.3 IKZF1 ZNF600 SSRP1 JUND ZNF10 ZIC2 ZNF217 DEK BHLHE40 ZNF639 HSALNG0131670 LIME1 RTEL1 ZGPAT SLC2A4RG ENSG00000229299 SRMS FNDC11 STMN3 HSALNG0131669
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRMS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRMS

Top Transcription factor binding sites by QIAGEN in the SRMS gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • Egr-3
  • HTF
  • NF-1
  • p53
  • S8

Genomic Locations for SRMS Gene

Latest Assembly
chr20:63,538,489-63,547,749
(GRCh38/hg38)
Size:
9,261 bases
Orientation:
Minus strand

Previous Assembly
chr20:62,169,842-62,179,102
(GRCh37/hg19 by Entrez Gene)
Size:
9,261 bases
Orientation:
Minus strand

chr20:62,172,163-62,178,857
(GRCh37/hg19 by Ensembl)
Size:
6,695 bases
Orientation:
Minus strand

Genomic View for SRMS Gene

Genes around SRMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRMS Gene

Proteins for SRMS Gene

  • Protein details for SRMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3Y6-SRMS_HUMAN
    Recommended name:
    Tyrosine-protein kinase Srms
    Protein Accession:
    Q9H3Y6

    Protein attributes for SRMS Gene

    Size:
    488 amino acids
    Molecular mass:
    54507 Da
    Quaternary structure:
    • Interacts (via the SH2 and SH3 domains) with DOK1 (PubMed:23822091). Interacts with KHDRBS1/SAM68 and VIM (PubMed:29496907).

neXtProt entry for SRMS Gene

Selected DME Specific Peptides for SRMS Gene

Q9H3Y6:
  • RDLAARN
  • KWTAPEA
  • AARNVLV
  • KSDVWSFG

Post-translational modifications for SRMS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRMS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for SRMS

Domains & Families for SRMS Gene

Gene Families for SRMS Gene

Protein Domains for SRMS Gene

Suggested Antigen Peptide Sequences for SRMS Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein kinase Srms (SRMS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H3Y6

UniProtKB/Swiss-Prot:

SRMS_HUMAN :
  • The N-terminal region regulates its kinase activity.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • The N-terminal region regulates its kinase activity.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with SRMS: view

Function for SRMS Gene

Molecular function for SRMS Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907};.

Enzyme Numbers (IUBMB) for SRMS Gene

Phenotypes From GWAS Catalog for SRMS Gene

Gene Ontology (GO) - Molecular Function for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity EXP,IDA 23822091
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA 21873635
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with SRMS: view
genes like me logo Genes that share phenotypes with SRMS: view

Animal Models for SRMS Gene

MGI Knock Outs for SRMS:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRMS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRMS Gene

Localization for SRMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRMS Gene

Cytoplasm. Note=Localizes to punctate cytoplasmic structures. {ECO:0000269 PubMed:23822091, ECO:0000269 PubMed:29496907}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRMS gene
Compartment Confidence
cytosol 4
plasma membrane 3
mitochondrion 2
cytoskeleton 1
peroxisome 1
nucleus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 23822091
GO:0005829 cytosol TAS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with SRMS: view

Pathways & Interactions for SRMS Gene

genes like me logo Genes that share pathways with SRMS: view

Gene Ontology (GO) - Biological Process for SRMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0009968 negative regulation of signal transduction TAS --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IDA 29496907
genes like me logo Genes that share ontologies with SRMS: view

No data available for SIGNOR curated interactions for SRMS Gene

Drugs & Compounds for SRMS Gene

(2) Drugs for SRMS Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra 0

(1) Additional Compounds for SRMS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with SRMS: view

Transcripts for SRMS Gene

mRNA/cDNA for SRMS Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRMS

Alternative Splicing Database (ASD) splice patterns (SP) for SRMS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for SRMS Gene

GeneLoc Exon Structure for
SRMS

Expression for SRMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRMS Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2).

Protein differential expression in normal tissues from HIPED for SRMS Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRMS Gene



Protein tissue co-expression partners for SRMS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRMS

SOURCE GeneReport for Unigene cluster for SRMS Gene:

Hs.411061

mRNA Expression by UniProt/SwissProt for SRMS Gene:

Q9H3Y6-SRMS_HUMAN
Tissue specificity: Highly expressed in most breast cancers (at protein level).

Evidence on tissue expression from TISSUES for SRMS Gene

  • Intestine(2.7)
  • Bone marrow(2.3)
  • Gall bladder(2.3)
  • Lung(2.3)
  • Spleen(2.3)
  • Nervous system(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SRMS: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRMS Gene

Orthologs for SRMS Gene

This gene was present in the common ancestor of animals.

Orthologs for SRMS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SRMS 29 30
  • 99.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SRMS 29 30
  • 83.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SRMS 29 30
  • 82.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Srms 29
  • 80.58 (n)
Mouse
(Mus musculus)
Mammalia Srms 29 16 30
  • 80.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SRMS 30
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SRMS 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SRMS 29 30
  • 69.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SRMS 30
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100491303 29
  • 57.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:194282 29
  • 54.17 (n)
SRMS 30
  • 44 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Src64B 30
  • 34 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea src-1 30
  • 34 (a)
ManyToMany
Species where no ortholog for SRMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SRMS Gene

ENSEMBL:
Gene Tree for SRMS (if available)
TreeFam:
Gene Tree for SRMS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRMS: view image
Alliance of Genome Resources:
Additional Orthologs for SRMS

Paralogs for SRMS Gene

Variants for SRMS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRMS Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
994223 Uncertain Significance: none provided 63,541,331(-) G/A
NC_000020.10:g.62172684G>A
MISSENSE
994345 Uncertain Significance: none provided 63,542,188(-) C/G
NC_000020.10:g.62173541C>G
MISSENSE
rs113866891 Benign: not provided 63,543,395(-) G/A
NM_080823.3(SRMS):c.564C>T (p.Pro188=)
SYNONYMOUS
rs310654 -- p.Val457Leu
rs310655 -- p.Ala453Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRMS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRMS Gene

Variant ID Type Subtype PubMed ID
dgv35n64 CNV loss 17921354
dgv521n27 CNV loss 19166990
dgv522n27 CNV loss 19166990
dgv7667n54 CNV loss 21841781
dgv7668n54 CNV loss 21841781
esv2758806 CNV gain+loss 17122850
nsv1136564 CNV deletion 24896259
nsv180256 CNV insertion 16902084
nsv470563 CNV loss 18288195
nsv517702 CNV loss 19592680
nsv521734 CNV loss 19592680
nsv586569 CNV loss 21841781
nsv586571 CNV loss 21841781
nsv586573 CNV loss 21841781
nsv586574 CNV loss 21841781
nsv834033 CNV gain 17160897
nsv834034 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for SRMS Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.55; 94.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRMS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRMS
Leiden Open Variation Database (LOVD)
SRMS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRMS Gene

Disorders for SRMS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRMS Gene - From: COP

Disorder Aliases PubMed IDs
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search SRMS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRMS

genes like me logo Genes that share disorders with SRMS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRMS Gene

Publications for SRMS Gene

  1. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. (PMID: 23822091) Goel RK … Lukong KE (The FEBS journal 2013) 2 3 4
  2. Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS). (PMID: 29496907) Goel RK … Lukong KE (Molecular & cellular proteomics : MCP 2018) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PMID: 7935409) Kohmura N … Aizawa S (Molecular and cellular biology 1994) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SRMS Gene

Sources for SRMS Gene