Aliases for SRM Gene
External Ids for SRM Gene
Previous HGNC Symbols for SRM Gene
Previous GeneCards Identifiers for SRM Gene
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
GeneCards Summary for SRM Gene
SRM (Spermidine Synthase) is a Protein Coding gene. Diseases associated with SRM include Sleeping Sickness and Leishmaniasis. Among its related pathways are Urea cycle and metabolism of amino groups and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and spermidine synthase activity. An important paralog of this gene is SMS.
UniProtKB/Swiss-Prot Summary for SRM Gene
Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.