Aliases for SRI Gene
External Ids for SRI Gene
Previous GeneCards Identifiers for SRI Gene
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for SRI Gene
SRI (Sorcin) is a Protein Coding gene. Diseases associated with SRI include Interstitial Myocarditis and Apical Myocardial Infarction. Among its related pathways are Cardiac conduction and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding and receptor binding. An important paralog of this gene is GCA.
UniProtKB/Swiss-Prot for SRI Gene
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.