This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which... See more...

Aliases for SRGN Gene

Aliases for SRGN Gene

  • Serglycin 2 3 4 5
  • Secretory Granule Proteoglycan Core Protein 3 4
  • Hematopoietic Proteoglycan Core Protein 3 4
  • Platelet Proteoglycan Core Protein 3 4
  • Proteoglycan 1, Secretory Granule 2 3
  • Serglycin Proteoglycan 2 3
  • PRG1 3 4
  • P.PG 3 4
  • PPG 2 3
  • PRG 3 4
  • Proteoglycan Protein Core For Mast Cell Secretory Granule 3
  • Secretory Granule Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Peptide 3
  • Hematopoetic Proteoglycan Core Protein 3
  • SRGN 5

External Ids for SRGN Gene

Previous HGNC Symbols for SRGN Gene

  • PRG
  • PRG1

Previous GeneCards Identifiers for SRGN Gene

  • GC10P070518
  • GC10P070847
  • GC10P064847

Summaries for SRGN Gene

Entrez Gene Summary for SRGN Gene

  • This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for SRGN Gene

SRGN (Serglycin) is a Protein Coding gene. Diseases associated with SRGN include Mucinoses and Central Corneal Ulcer. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include collagen binding.

UniProtKB/Swiss-Prot Summary for SRGN Gene

  • Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Gene Wiki entry for SRGN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRGN Gene

Genomics for SRGN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J069085 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 261.8 +32.6 32593 9 BCLAF1 SP1 ZNF207 MYC NCOR1 ZNF654 IKZF1 ZNF592 ZMYM3 POLR2A SRGN DDX21 SUPV3L1 HKDC1 PBLD LOC101928994 TACR2 VPS26A NONHSAG006100.2 lnc-TACR2-5
GH10J069055 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 263.2 -0.3 -333 3.3 SP1 ZNF592 BCL11A NR2C1 GABPA RXRA ZNF511 IRF4 ETV4 RARA SRGN lnc-KIF1BP-2 KIFBP DDX21
GH10J069043 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 19.2 -10.7 -10722 6.3 BCLAF1 SP1 ZNF207 IKZF1 POLR2A BCL11A CTCF TRIM22 BHLHE40 IRF4 lnc-TACR2-7 lnc-KIF1BP-1 SRGN VPS26A KIFBP HKDC1 DDX21 HK1 HSALNG0078556 LOC105378342
GH10J069060 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 16.5 +4.3 4311 3 MYC IKZF1 ZNF592 CEBPA CEBPB TRIM22 HES1 MNT MAX EP300 CCAR1 HNRNPH3 SRGN HERC4 DDX50 VPS26A DDX21 lnc-TACR2-10 lnc-KIF1BP-2
GH10J069100 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 12.7 +44.5 44453 2.9 CEBPA CEBPB MAX POLR2A ZNF384 ZMYM3 KDM1A ATF3 BCOR ZNF121 SRGN KIFBP MED28P1 VPS26A SUPV3L1 ENSG00000274008 lnc-TACR2-9 NONHSAG006100.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRGN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRGN

Top Transcription factor binding sites by QIAGEN in the SRGN gene promoter:
  • c-Ets-1
  • CP2
  • E2F
  • E2F-1
  • FAC1
  • HNF-3beta
  • STAT1
  • TBP
  • TFIID

Genomic Locations for SRGN Gene

Latest Assembly
chr10:69,057,533-69,104,811
(GRCh38/hg38)
Size:
47,279 bases
Orientation:
Plus strand

Previous Assembly
chr10:70,847,359-70,864,567
(GRCh37/hg19 by Entrez Gene)
Size:
17,209 bases
Orientation:
Plus strand

chr10:70,847,862-70,864,567
(GRCh37/hg19 by Ensembl)
Size:
16,706 bases
Orientation:
Plus strand

Genomic View for SRGN Gene

Genes around SRGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGN Gene

Proteins for SRGN Gene

  • Protein details for SRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10124-SRGN_HUMAN
    Recommended name:
    Serglycin
    Protein Accession:
    P10124
    Secondary Accessions:
    • B2R4L7
    • Q5VW06

    Protein attributes for SRGN Gene

    Size:
    158 amino acids
    Molecular mass:
    17652 Da
    Quaternary structure:
    • Binds to activated CD44 and to GZMB.

neXtProt entry for SRGN Gene

Post-translational modifications for SRGN Gene

  • O-glycosylated; contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at Ser94, Ser96, Ser100, Ser102, Ser104, Ser106, Ser108, and Ser110

Other Protein References for SRGN Gene

Antibodies for research

  • Boster Bio Antibodies for SRGN

Protein products for research

No data available for DME Specific Peptides for SRGN Gene

Domains & Families for SRGN Gene

Gene Families for SRGN Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRGN Gene

InterPro:
Blocks:
  • Serglycin

Suggested Antigen Peptide Sequences for SRGN Gene

GenScript: Design optimal peptide antigens:
  • Secretory granule proteoglycan core protein (SRGN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10124

UniProtKB/Swiss-Prot:

SRGN_HUMAN :
  • Belongs to the serglycin family.
Family:
  • Belongs to the serglycin family.
genes like me logo Genes that share domains with SRGN: view

Function for SRGN Gene

Molecular function for SRGN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Phenotypes From GWAS Catalog for SRGN Gene

Gene Ontology (GO) - Molecular Function for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11911826
genes like me logo Genes that share ontologies with SRGN: view
genes like me logo Genes that share phenotypes with SRGN: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SRGN

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRGN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRGN Gene

Localization for SRGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRGN Gene

Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). {ECO:0000250 UniProtKB:P13609, ECO:0000269 PubMed:11154222, ECO:0000269 PubMed:15136585}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRGN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 4
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 11154222
GO:0005794 Golgi apparatus IEA,IDA 15136585
GO:0030141 secretory granule IBA 21873635
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with SRGN: view

Pathways & Interactions for SRGN Gene

genes like me logo Genes that share pathways with SRGN: view

Gene Ontology (GO) - Biological Process for SRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA,ISS --
GO:0002576 platelet degranulation TAS --
GO:0006915 apoptotic process IEA --
GO:0016485 protein processing IEA,ISS --
GO:0030502 negative regulation of bone mineralization IBA,IDA 16870619
genes like me logo Genes that share ontologies with SRGN: view

No data available for SIGNOR curated interactions for SRGN Gene

Drugs & Compounds for SRGN Gene

(5) Drugs for SRGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SRGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRGN: view

Transcripts for SRGN Gene

mRNA/cDNA for SRGN Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRGN

Alternative Splicing Database (ASD) splice patterns (SP) for SRGN Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: -

Relevant External Links for SRGN Gene

GeneLoc Exon Structure for
SRGN

Expression for SRGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRGN Gene

mRNA differential expression in normal tissues according to GTEx for SRGN Gene

This gene is overexpressed in Whole Blood (x25.9).

Protein differential expression in normal tissues from HIPED for SRGN Gene

This gene is overexpressed in Serum (41.3), Peripheral blood mononuclear cells (13.8), and Platelet (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRGN Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRGN

SOURCE GeneReport for Unigene cluster for SRGN Gene:

Hs.1908

Evidence on tissue expression from TISSUES for SRGN Gene

  • Lung(4.8)
  • Blood(4.3)
  • Bone marrow(3.7)
  • Intestine(3.4)
  • Nervous system(3.2)
  • Spleen(3.1)
  • Lymph node(3.1)
  • Liver(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Muscle(2.3)
  • Stomach(2.3)
  • Gall bladder(2.3)
  • Skin(2.1)
  • Eye(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SRGN: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRGN Gene

Orthologs for SRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRGN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SRGN 29 30
  • 96.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SRGN 29 30
  • 78.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SRGN 29 30
  • 76.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Srgn 30
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SRGN 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SRGN 30
  • 31 (a)
OneToOne
Species where no ortholog for SRGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SRGN Gene

ENSEMBL:
Gene Tree for SRGN (if available)
TreeFam:
Gene Tree for SRGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SRGN: view image
Alliance of Genome Resources:
Additional Orthologs for SRGN

Paralogs for SRGN Gene

Pseudogenes.org Pseudogenes for SRGN Gene

genes like me logo Genes that share paralogs with SRGN: view

No data available for Paralogs for SRGN Gene

Variants for SRGN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRGN Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs138154045 Benign: not provided 69,103,949(+) C/T
NM_002727.4(SRGN):c.306C>T (p.Ser102=)
SYNONYMOUS
rs146830092 Benign: not provided 69,103,942(+) C/T
NM_002727.4(SRGN):c.299C>T (p.Ser100Phe)
MISSENSE
rs67852477 Benign: not provided 69,097,207(+) C/G
NM_002727.4(SRGN):c.203C>G (p.Pro68Arg)
MISSENSE_VARIANT,INTRON
rs2229498 -- p.Arg31Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRGN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRGN Gene

Variant ID Type Subtype PubMed ID
nsv1145466 CNV deletion 24896259
nsv7010 CNV deletion 18451855

Variation tolerance for SRGN Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRGN
Leiden Open Variation Database (LOVD)
SRGN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRGN Gene

Disorders for SRGN Gene

MalaCards: The human disease database

(4) MalaCards diseases for SRGN Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mucinoses
central corneal ulcer
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
coffin-siris syndrome 1
  • css1
- elite association - COSMIC cancer census association via MalaCards
Search SRGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SRGN

genes like me logo Genes that share disorders with SRGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRGN Gene

Publications for SRGN Gene

  1. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. (PMID: 16870619) Theocharis AD … Hjerpe A (The Journal of biological chemistry 2006) 3 4 22
  2. Localization of serglycin in human neutrophil granulocytes and their precursors. (PMID: 15136585) Niemann CU … Borregaard N (Journal of leukocyte biology 2004) 3 4 22
  3. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. (PMID: 12388539) Raja SM … Froelich CJ (The Journal of biological chemistry 2002) 3 4 22
  4. Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. (PMID: 11154222) Schick BP … San Antonio JD (Blood 2001) 3 4 22
  5. The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. (PMID: 1377686) Humphries DE … Stevens RL (The Journal of biological chemistry 1992) 3 4 22

Products for SRGN Gene

Sources for SRGN Gene