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Aliases for SRGAP3 Gene

Aliases for SRGAP3 Gene

  • SLIT-ROBO Rho GTPase Activating Protein 3 2 3 5
  • SLIT-ROBO Rho GTPase Activating Protein 2 2 3
  • Rho GTPase-Activating Protein 14 3 4
  • Mental Disorder-Associated GAP 3 4
  • ARHGAP14 3 4
  • SrGAP2 3 4
  • MEGAP 3 4
  • WRP 3 4
  • WAVE-Associated Rac GTPase Activating Protein 3
  • WAVE-Associated Rac GTPase-Activating Protein 4
  • SLIT-ROBO Rho GTPase-Activating Protein 3 3
  • KIAA0411 4
  • KIAA1156 4
  • SRGAP3 4

External Ids for SRGAP3 Gene

Previous HGNC Symbols for SRGAP3 Gene

  • SRGAP2

Summaries for SRGAP3 Gene

GeneCards Summary for SRGAP3 Gene

SRGAP3 (SLIT-ROBO Rho GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with SRGAP3 include Pilocytic Astrocytoma and Chromosome 3Pter-P25 Deletion Syndrome. Among its related pathways are Developmental Biology and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP1.

UniProtKB/Swiss-Prot for SRGAP3 Gene

  • GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Gene Wiki entry for SRGAP3 Gene

Additional gene information for SRGAP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRGAP3 Gene

Genomics for SRGAP3 Gene

GeneHancer (GH) Regulatory Elements for SRGAP3 Gene

Promoters and enhancers for SRGAP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I009362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.4 -0.1 -149 2.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRGAP3 THUMPD3 GC03M009360 ENSG00000254485 THUMPD3-AS1 RAD18 BRPF1 SETD5 TTLL3 FANCD2
GH03I009247 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.1 +113.9 113914 3.9 HDGF PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZNF121 ZNF766 ZNF143 ATF7 SRGAP3-AS4 SRGAP3 EMC3-AS1 GC03P009233
GH03I009394 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21 -35.9 -35938 9.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SETD5 THUMPD3-AS1 GC03P009403 BRPF1 RAD18 GHRLOS TTLL3 FANCD2 JAGN1 SEC13
GH03I009420 Enhancer 1.5 Ensembl ENCODE dbSUPER 19 -60.1 -60102 5.8 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SRGAP3 THUMPD3-AS1 GC03M009409 GC03P009403 SETD5
GH03I009409 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -47.3 -47332 1.7 HDAC1 ATF1 ARNT ZBTB40 ATF7 CEBPB ZEB2 ZNF592 ATF4 GMEB1 SRGAP3 SETD5 THUMPD3-AS1 MTMR14 GC03P009403 GC03M009409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRGAP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SRGAP3 gene promoter:

Genomic Locations for SRGAP3 Gene

Genomic Locations for SRGAP3 Gene
382,463 bases
Minus strand

Genomic View for SRGAP3 Gene

Genes around SRGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRGAP3 Gene

Proteins for SRGAP3 Gene

  • Protein details for SRGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT-ROBO Rho GTPase-activating protein 3
    Protein Accession:
    Secondary Accessions:
    • Q8IX13
    • Q8IZV8

    Protein attributes for SRGAP3 Gene

    1099 amino acids
    Molecular mass:
    124504 Da
    Quaternary structure:
    • Homodimer (Probable). Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG.

    Alternative splice isoforms for SRGAP3 Gene


neXtProt entry for SRGAP3 Gene

Post-translational modifications for SRGAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRGAP3 Gene

Domains & Families for SRGAP3 Gene

Gene Families for SRGAP3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SRGAP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions.
  • The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions.
genes like me logo Genes that share domains with SRGAP3: view

Function for SRGAP3 Gene

Molecular function for SRGAP3 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Phenotypes From GWAS Catalog for SRGAP3 Gene

Gene Ontology (GO) - Molecular Function for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 17500595
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with SRGAP3: view
genes like me logo Genes that share phenotypes with SRGAP3: view

Animal Models for SRGAP3 Gene

MGI Knock Outs for SRGAP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SRGAP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRGAP3 Gene

Localization for SRGAP3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRGAP3 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SRGAP3 Gene

Pathways & Interactions for SRGAP3 Gene

genes like me logo Genes that share pathways with SRGAP3: view

Pathways by source for SRGAP3 Gene

1 KEGG pathway for SRGAP3 Gene
1 GeneGo (Thomson Reuters) pathway for SRGAP3 Gene
2 Qiagen pathways for SRGAP3 Gene

SIGNOR curated interactions for SRGAP3 Gene


Gene Ontology (GO) - Biological Process for SRGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030336 negative regulation of cell migration IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SRGAP3: view

Drugs & Compounds for SRGAP3 Gene

No Compound Related Data Available

Transcripts for SRGAP3 Gene

Unigene Clusters for SRGAP3 Gene

SLIT-ROBO Rho GTPase activating protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRGAP3 Gene

No ASD Table

Relevant External Links for SRGAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRGAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRGAP3 Gene

This gene is overexpressed in Brain - Cerebellum (x6.4) and Brain - Cerebellar Hemisphere (x6.1).

Protein differential expression in normal tissues from HIPED for SRGAP3 Gene

This gene is overexpressed in Brain (20.6), Fetal Brain (17.7), Frontal cortex (10.4), and Liver, secretome (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRGAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRGAP3 Gene:


SOURCE GeneReport for Unigene cluster for SRGAP3 Gene:


mRNA Expression by UniProt/SwissProt for SRGAP3 Gene:

Tissue specificity: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.

Evidence on tissue expression from TISSUES for SRGAP3 Gene

  • Nervous system(4.9)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with SRGAP3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRGAP3 Gene

Orthologs for SRGAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRGAP3 33 34
  • 99.51 (n)
(Monodelphis domestica)
Mammalia SRGAP3 34
  • 95 (a)
(Canis familiaris)
Mammalia SRGAP3 33 34
  • 93.99 (n)
(Bos Taurus)
Mammalia SRGAP3 33 34
  • 93.54 (n)
(Mus musculus)
Mammalia Srgap3 33 16 34
  • 92.36 (n)
(Rattus norvegicus)
Mammalia Srgap3 33
  • 92.36 (n)
(Ornithorhynchus anatinus)
Mammalia SRGAP3 34
  • 92 (a)
(Gallus gallus)
Aves SRGAP3 33 34
  • 85.62 (n)
(Anolis carolinensis)
Reptilia SRGAP3 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srgap3 33
  • 78.87 (n)
(Danio rerio)
Actinopterygii srgap3 33 34
  • 77.93 (n)
(Caenorhabditis elegans)
Secernentea F12F6.5 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for SRGAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRGAP3 Gene

Gene Tree for SRGAP3 (if available)
Gene Tree for SRGAP3 (if available)

Paralogs for SRGAP3 Gene

(8) SIMAP similar genes for SRGAP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SRGAP3: view

Variants for SRGAP3 Gene

Sequence variations from dbSNP and Humsavar for SRGAP3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_035550 A breast cancer sample p.Leu623Ile
rs1000007243 -- 9,203,769(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000010347 -- 9,029,096(-) C/T intron_variant
rs1000019080 -- 9,108,349(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000022374 -- 9,315,698(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRGAP3 Gene

Variant ID Type Subtype PubMed ID
dgv276n21 CNV loss 19592680
esv2122831 CNV deletion 18987734
esv25936 CNV loss 19812545
esv3561447 CNV deletion 23714750
esv3568606 CNV loss 25503493
esv3595233 CNV loss 21293372
esv3595234 CNV loss 21293372
nsv1072238 CNV deletion 25765185
nsv1125769 CNV tandem duplication 24896259
nsv1139085 CNV deletion 24896259
nsv3689 CNV deletion 18451855
nsv3690 CNV insertion 18451855
nsv472849 CNV novel sequence insertion 20440878
nsv518352 CNV loss 19592680
nsv521065 CNV loss 19592680
nsv955313 CNV deletion 24416366

Variation tolerance for SRGAP3 Gene

Residual Variation Intolerance Score: 3.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRGAP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRGAP3 Gene

Disorders for SRGAP3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SRGAP3 Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
pilocytic astrocytoma
  • grade i astrocytic tumor
chromosome 3pter-p25 deletion syndrome
  • 3p- syndrome
obstructive hydrocephalus
van der woude syndrome 1
  • vws1
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014). {ECO:0000269 PubMed:12195014}.

Additional Disease Information for SRGAP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SRGAP3: view

No data available for Genatlas for SRGAP3 Gene

Publications for SRGAP3 Gene

  1. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. (PMID: 12195014) Endris V … Rappold GA (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4 58
  4. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. (PMID: 20035503) Elstner M … Turnbull DM (Annals of neurology 2009) 3 44 58
  5. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. (PMID: 16730001) Yang Y … Rappold G (Experimental cell research 2006) 3 22 58

Products for SRGAP3 Gene

Sources for SRGAP3 Gene

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