Aliases for SRGAP1 Gene
External Ids for SRGAP1 Gene
Previous GeneCards Identifiers for SRGAP1 Gene
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
GeneCards Summary for SRGAP1 Gene
SRGAP1 (SLIT-ROBO Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with SRGAP1 include Thyroid Cancer, Nonmedullary, 2 and Familial Hypocalciuric Hypercalcemia. Among its related pathways are Development Slit-Robo signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP3.
UniProtKB/Swiss-Prot for SRGAP1 Gene
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.