Aliases for SRD5A3 Gene
External Ids for SRD5A3 Gene
Previous GeneCards Identifiers for SRD5A3 Gene
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
GeneCards Summary for SRD5A3 Gene
SRD5A3 (Steroid 5 Alpha-Reductase 3) is a Protein Coding gene. Diseases associated with SRD5A3 include Kahrizi Syndrome and Congenital Disorder Of Glycosylation, Type Iq. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and 3-oxo-5-alpha-steroid 4-dehydrogenase activity.
UniProtKB/Swiss-Prot for SRD5A3 Gene
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).