Aliases for SRD5A1 Gene
External Ids for SRD5A1 Gene
Previous GeneCards Identifiers for SRD5A1 Gene
Steroid 5-alpha-reductase (EC 188.8.131.52) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
GeneCards Summary for SRD5A1 Gene
SRD5A1 (Steroid 5 Alpha-Reductase 1) is a Protein Coding gene. Diseases associated with SRD5A1 include Prostatic Adenoma and Androgen Insensitivity Syndrome. Among its related pathways are Metabolism and Translation Non-genomic (rapid) action of Androgen Receptor. Gene Ontology (GO) annotations related to this gene include electron transfer activity and 3-oxo-5-alpha-steroid 4-dehydrogenase activity. An important paralog of this gene is SRD5A2.
UniProtKB/Swiss-Prot Summary for SRD5A1 Gene
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.