Aliases for SRCIN1 Gene

Aliases for SRCIN1 Gene

  • SRC Kinase Signaling Inhibitor 1 2 3 4 5
  • SNAP-25-Interacting Protein 2 3 4
  • P130Cas-Associated Protein 2 3 4
  • P140Cap 2 3 4
  • SNIP 2 3 4
  • KIAA1684 2 4
  • P140 3 4
  • SNAP25-Interacting Protein 3
  • SRCIN1 5

External Ids for SRCIN1 Gene

Previous GeneCards Identifiers for SRCIN1 Gene

  • GC17M033943
  • GC17M036686
  • GC17M032482

Summaries for SRCIN1 Gene

GeneCards Summary for SRCIN1 Gene

SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include Kohlschutter-Tonz Syndrome and Coffin-Siris Syndrome 3. Among its related pathways are Cytoskeletal Signaling and Adhesion. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.

UniProtKB/Swiss-Prot Summary for SRCIN1 Gene

  • Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRCIN1 Gene

Genomics for SRCIN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SRCIN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038557 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.3 +48.4 48400 2.9 ZNF654 MYC IKZF1 ZNF600 KLF9 CEBPA BRCA1 NFIC ZIC2 ZBTB10 SRCIN1 LOC105371762 CDK12 MED1 RPL19 LOC105371761 lnc-EPOP-1 ARHGAP23
GH17J038605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.2 1173 3.2 MYC ZNF580 ZMYM3 KLF9 ZNF223 BRCA1 POLR2A ZIC2 CHD4 ZBTB10 SRCIN1 CDK12 LOC105371762 SNORA21 MED1 RPL23 RPL19 ENSG00000274996 ARHGAP23
GH17J038550 Enhancer 0.7 Ensembl dbSUPER 12.2 +56.2 56206 0.9 BHLHE40 NFE2 NRF1 RFX1 EGR2 PKNOX1 ZKSCAN1 ZFHX2 DPF2 SRCIN1 ARL5C lnc-EPOP-1 LOC105371761 ARHGAP23
GH17J038553 Enhancer 0.4 Ensembl dbSUPER 18.2 +52.6 52565 0.8 ZNF248 SRCIN1 lnc-EPOP-1 LOC105371761 ARHGAP23
GH17J038600 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 +5.0 4992 3.7 ZNF600 IKZF1 ZSCAN16 NFIC ZBTB10 ZNF639 ZNF341 KLF7 SIN3A KLF9 ENSG00000274996 CDK12 MED1 LOC105371762 SNORA21 RPL19 SRCIN1 PIP4K2B SOCS7 GPR179
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SRCIN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRCIN1

Genomic Locations for SRCIN1 Gene

Latest Assembly
77,152 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
75,940 bases
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):2,565,332-2,641,271 (-)

Genomic View for SRCIN1 Gene

Genes around SRCIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRCIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRCIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRCIN1 Gene

Proteins for SRCIN1 Gene

  • Protein details for SRCIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SRC kinase signaling inhibitor 1
    Protein Accession:
    Secondary Accessions:
    • Q75T46
    • Q8N4W8

    Protein attributes for SRCIN1 Gene

    1183 amino acids
    Molecular mass:
    127105 Da
    Quaternary structure:
    • Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.

    Alternative splice isoforms for SRCIN1 Gene


neXtProt entry for SRCIN1 Gene

Post-translational modifications for SRCIN1 Gene

  • Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRCIN1 Gene

Domains & Families for SRCIN1 Gene

Gene Families for SRCIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRCIN1 Gene


Suggested Antigen Peptide Sequences for SRCIN1 Gene

GenScript: Design optimal peptide antigens:
  • p140Cap (SRCN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SRCIN1 family.
  • Belongs to the SRCIN1 family.
genes like me logo Genes that share domains with SRCIN1: view

Function for SRCIN1 Gene

Molecular function for SRCIN1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.

Phenotypes From GWAS Catalog for SRCIN1 Gene

Gene Ontology (GO) - Molecular Function for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14657239
GO:0019901 protein kinase binding IDA 17525734
GO:0019904 protein domain specific binding IEA --
GO:0030234 enzyme regulator activity IBA 21873635
genes like me logo Genes that share ontologies with SRCIN1: view
genes like me logo Genes that share phenotypes with SRCIN1: view

Animal Models for SRCIN1 Gene

MGI Knock Outs for SRCIN1:

miRNA for SRCIN1 Gene

miRTarBase miRNAs that target SRCIN1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCIN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRCIN1 Gene

Localization for SRCIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRCIN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250 UniProtKB:Q9QXY2}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRCIN1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 19146815
GO:0005856 cytoskeleton IEA --
GO:0005925 NOT focal adhesion IDA 14657239
GO:0014069 postsynaptic density IEA,ISS --
GO:0015629 actin cytoskeleton IEA,IDA 14657239
genes like me logo Genes that share ontologies with SRCIN1: view

Pathways & Interactions for SRCIN1 Gene

PathCards logo

SuperPathways for SRCIN1 Gene

genes like me logo Genes that share pathways with SRCIN1: view

Pathways by source for SRCIN1 Gene

3 Cell Signaling Technology pathways for SRCIN1 Gene

SIGNOR curated interactions for SRCIN1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SRCIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0030334 regulation of cell migration IEA,IMP 17525734
GO:0034446 substrate adhesion-dependent cell spreading IEA,IMP 17525734
GO:0050709 negative regulation of protein secretion IEA --
GO:0061001 regulation of dendritic spine morphogenesis IEA,IMP 19146815
genes like me logo Genes that share ontologies with SRCIN1: view

Drugs & Compounds for SRCIN1 Gene

(1) Drugs for SRCIN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6959
genes like me logo Genes that share compounds with SRCIN1: view

Transcripts for SRCIN1 Gene

mRNA/cDNA for SRCIN1 Gene

10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCIN1

Alternative Splicing Database (ASD) splice patterns (SP) for SRCIN1 Gene

No ASD Table

Relevant External Links for SRCIN1 Gene

GeneLoc Exon Structure for

Expression for SRCIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRCIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRCIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2), Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), and Brain - Substantia nigra (x4.4).

Protein differential expression in normal tissues from HIPED for SRCIN1 Gene

This gene is overexpressed in Frontal cortex (25.5), Brain (23.6), and Fetal Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCIN1 Gene

Protein tissue co-expression partners for SRCIN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRCIN1

SOURCE GeneReport for Unigene cluster for SRCIN1 Gene:


mRNA Expression by UniProt/SwissProt for SRCIN1 Gene:

Tissue specificity: Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.

Evidence on tissue expression from TISSUES for SRCIN1 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with SRCIN1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCIN1 Gene

Orthologs for SRCIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SRCIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRCIN1 29
  • 99.01 (n)
(Bos Taurus)
Mammalia SRCIN1 29
  • 92.41 (n)
(Canis familiaris)
Mammalia SRCIN1 29
  • 91.82 (n)
(Mus musculus)
Mammalia Srcin1 29 16
  • 89.03 (n)
(Rattus norvegicus)
Mammalia Srcin1 29
  • 88.48 (n)
(Gallus gallus)
Aves SRCIN1 29
  • 76.72 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia srcin1 29
  • 69.05 (n)
(Danio rerio)
Actinopterygii LOC565863 29
  • 67.63 (n)
Species where no ortholog for SRCIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SRCIN1 Gene

Gene Tree for SRCIN1 (if available)
Gene Tree for SRCIN1 (if available)
Evolutionary constrained regions (ECRs) for SRCIN1: view image
Alliance of Genome Resources:
Additional Orthologs for SRCIN1

Paralogs for SRCIN1 Gene

Paralogs for SRCIN1 Gene

(1) SIMAP similar genes for SRCIN1 Gene using alignment to 4 proteins:

  • F5H376_HUMAN
  • J3KT41_HUMAN
genes like me logo Genes that share paralogs with SRCIN1: view

Variants for SRCIN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRCIN1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs763475410 Likely Benign: not provided 38,559,642(-) G/T
NM_025248.3(SRCIN1):c.1968C>A (p.Gly656=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SRCIN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SRCIN1 Gene

Variant ID Type Subtype PubMed ID
esv1006872 CNV loss 20482838
esv2758688 CNV gain+loss 17122850
esv27695 CNV gain 19812545
esv3310352 CNV mobile element insertion 20981092
esv3442833 CNV insertion 20981092
nsv1112705 CNV deletion 24896259
nsv1144799 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv2042 CNV insertion 18451855
nsv2044 CNV insertion 18451855
nsv428341 CNV gain+loss 18775914
nsv469701 CNV loss 16826518
nsv827980 CNV gain 20364138
nsv827981 CNV gain 20364138
nsv833436 CNV loss 17160897
nsv833438 CNV loss 17160897
nsv953893 CNV deletion 24416366
nsv9549 CNV gain 18304495

Variation tolerance for SRCIN1 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRCIN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCIN1 Gene

Disorders for SRCIN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRCIN1 Gene - From: COP

Disorder Aliases PubMed IDs
kohlschutter-tonz syndrome
  • ktzs
coffin-siris syndrome 3
  • css3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SRCIN1

genes like me logo Genes that share disorders with SRCIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRCIN1 Gene

Publications for SRCIN1 Gene

  1. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PMID: 14657239) Di Stefano P … Defilippi P (Molecular biology of the cell 2004) 3 4 22
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  3. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PMID: 19146815) Jaworski J … Hoogenraad CC (Neuron 2009) 3 4
  4. SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. (PMID: 18475297) Kennedy S … O'Driscoll L (British journal of cancer 2008) 3 4
  5. Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. (PMID: 18662323) Ito H … Nagata K (Journal of neurochemistry 2008) 3 4

Products for SRCIN1 Gene

Sources for SRCIN1 Gene