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Aliases for SRCIN1 Gene
Aliases for SRCIN1 Gene
External Ids for SRCIN1 Gene
- HGNC: 29506
- NCBI Entrez Gene: 80725
- Ensembl: ENSG00000277363
- OMIM®: 610786
- UniProtKB/Swiss-Prot: Q9C0H9
Previous GeneCards Identifiers for SRCIN1 Gene
- GC17M033943
- GC17M036686
- GC17M032482
Summaries for SRCIN1 Gene
GeneCards Summary for SRCIN1 Gene
SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include Kohlschutter-Tonz Syndrome and Coffin-Siris Syndrome 3. Among its related pathways are Cytoskeletal Signaling and Adhesion. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.
UniProtKB/Swiss-Prot Summary for SRCIN1 Gene
-
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Additional gene information for SRCIN1 Gene
- HGNC (29506)
- NCBI Entrez Gene (80725)
- Ensembl (ENSG00000277363)
- OMIM® (610786)
- UniProtKB/Swiss-Prot (Q9C0H9)
- Open Targets Platform(ENSG00000277363)
- Alliance of Genome Resources
- Search for SRCIN1 at DataMed
- Search for SRCIN1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRCIN1 Gene
Genomics for SRCIN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SRCIN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SRCIN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRCIN1
Genomic Locations for SRCIN1 Gene
Latest Assembly
- chr17:38,530,015-38,607,166
- (GRCh38/hg38)
- Size:
- 77,152 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:36,686,266-36,762,205
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 75,940 bases
- Orientation:
- Minus strand
Alternative Locations (GRCh38/hg38)
- chr17(ALT_REF_LOCI_1):2,565,332-2,641,271 (-)
Genomic View for SRCIN1 Gene
Genes around SRCIN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
SRCIN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCIN1 Gene
Proteins for SRCIN1 Gene
-
Protein details for SRCIN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0H9-SRCN1_HUMAN
- Recommended name:
- SRC kinase signaling inhibitor 1
- Protein Accession:
- Q9C0H9
- Q75T46
- Q8N4W8
Protein attributes for SRCIN1 Gene
- Size:
- 1183 amino acids
- Molecular mass:
- 127105 Da
- Quaternary structure:
-
- Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.
Protein Expression for SRCIN1 Gene
Post-translational modifications for SRCIN1 Gene
- Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SRCIN1 Gene
Antibodies for research
- G Biosciences Immunotag™ SNIP Antibody
- NSJ Bioreagents SRCIN1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SRCIN1
- Novus Biologicals Antibodies for SRCIN1
-
Abcam antibodies for SRCIN1
- Invitrogen Antibodies for SRCIN1 (AFLGC-SRCIN1)
- Sino Biological Antibodies for SRCIN1
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCIN1
- Origene Custom Protein Services for SRCIN1
- Novus Biologicals proteins for SRCIN1
- antibodies-online: Show 3 available SRCIN1 Proteins ranked by validation data
- Compare Top SRCIN1 Proteins
-
Quality Products:
-
Abcam proteins for SRCIN1
Assay products for research
- antibodies-online: Show 5 available SRCIN1 Elisa Kits ranked by validation data
- Compare Top SRCIN1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SRCIN1 Gene
Domains & Families for SRCIN1 Gene
Gene Families for SRCIN1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SRCIN1 Gene
- InterPro:
Suggested Antigen Peptide Sequences for SRCIN1 Gene
- GenScript: Design optimal peptide antigens:
-
- p140Cap (SRCN1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9C0H9- Family:
-
- Belongs to the SRCIN1 family.
Function for SRCIN1 Gene
Molecular function for SRCIN1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Phenotypes From GWAS Catalog for SRCIN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14657239 |
| GO:0019901 | protein kinase binding | IDA | 17525734 |
| GO:0019904 | protein domain specific binding | IEA | -- |
| GO:0030234 | enzyme regulator activity | IBA | 21873635 |
Phenotypes for SRCIN1 Gene
- MGI mutant phenotypes for SRCIN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SRCIN1:
Animal Models for SRCIN1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SRCIN1 - Starting at $85 >
- * SRCIN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SRCIN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCIN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCIN1
miRNA for SRCIN1 Gene
- miRTarBase miRNAs that target SRCIN1
-
- hsa-miR-542-5p (MIRT006067)
- mmu-miR-541-5p (MIRT008174)
- mmu-miR-17-5p (MIRT009891)
- mmu-miR-26a-5p (MIRT011087)
- mmu-let-7b-5p (MIRT011997)
- mmu-miR-34b-5p (MIRT012620)
- mmu-miR-9-5p (MIRT015116)
- hsa-miR-374a-5p (MIRT054263)
- hsa-miR-150-5p (MIRT054852)
- hsa-miR-6848-5p (MIRT490731)
- hsa-miR-6846-5p (MIRT490732)
- hsa-miR-4283 (MIRT490733)
- hsa-miR-3191-3p (MIRT490734)
- hsa-miR-4437 (MIRT490735)
- hsa-miR-4726-5p (MIRT490736)
- hsa-miR-4640-5p (MIRT490737)
- hsa-miR-92b-5p (MIRT490738)
- hsa-miR-24-3p (MIRT490739)
- hsa-miR-3934-3p (MIRT490740)
- hsa-miR-4749-5p (MIRT490741)
- hsa-miR-4706 (MIRT490742)
- hsa-miR-3664-3p (MIRT490743)
- hsa-miR-6895-5p (MIRT490744)
- hsa-miR-873-5p (MIRT490745)
- hsa-miR-4781-5p (MIRT490746)
- hsa-miR-6834-5p (MIRT490747)
- hsa-miR-486-3p (MIRT490748)
- hsa-miR-6883-5p (MIRT490749)
- hsa-miR-6785-5p (MIRT490750)
- hsa-miR-4728-5p (MIRT490751)
- hsa-miR-149-3p (MIRT490752)
- hsa-miR-6787-5p (MIRT490753)
- hsa-miR-663a (MIRT490754)
- hsa-miR-1908-5p (MIRT490755)
- hsa-miR-744-5p (MIRT490756)
- hsa-miR-6133 (MIRT490757)
- hsa-miR-6130 (MIRT490758)
- hsa-miR-6129 (MIRT490759)
- hsa-miR-6127 (MIRT490760)
- hsa-miR-4510 (MIRT490761)
- hsa-miR-6875-5p (MIRT490762)
- hsa-miR-4419a (MIRT490763)
- hsa-miR-3126-5p (MIRT490764)
- hsa-miR-6775-5p (MIRT490765)
- hsa-miR-5090 (MIRT490766)
- hsa-miR-3937 (MIRT490767)
- hsa-miR-6794-5p (MIRT490768)
- hsa-miR-4716-3p (MIRT490769)
- hsa-miR-4756-5p (MIRT490770)
- hsa-miR-4739 (MIRT490771)
- hsa-miR-1321 (MIRT490772)
- hsa-miR-6837-5p (MIRT622092)
- hsa-miR-4685-5p (MIRT622093)
- hsa-miR-7113-5p (MIRT622094)
- hsa-miR-665 (MIRT622095)
- hsa-miR-6823-5p (MIRT622096)
- hsa-miR-4459 (MIRT622097)
- hsa-miR-4779 (MIRT622098)
- hsa-miR-6797-5p (MIRT626783)
- hsa-miR-1249-5p (MIRT626784)
- hsa-miR-1238-3p (MIRT666121)
- hsa-miR-670-3p (MIRT666122)
- hsa-miR-3180-5p (MIRT666123)
- hsa-miR-6881-3p (MIRT666124)
- hsa-miR-6780a-3p (MIRT666125)
- hsa-miR-1290 (MIRT666126)
- hsa-miR-877-3p (MIRT666127)
- hsa-miR-4713-5p (MIRT719518)
- hsa-miR-3156-3p (MIRT719519)
- hsa-miR-6731-5p (MIRT719520)
- hsa-miR-8085 (MIRT719521)
- hsa-miR-6738-5p (MIRT719522)
- hsa-miR-5194 (MIRT719523)
- hsa-miR-2116-3p (MIRT719524)
- hsa-miR-1914-3p (MIRT719525)
- hsa-miR-532-3p (MIRT719526)
- hsa-miR-6746-5p (MIRT719527)
- hsa-miR-4301 (MIRT719528)
- hsa-miR-1273g-3p (MIRT719529)
- hsa-miR-346 (MIRT732707)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRCIN1
- Browse OriGene Inhibitory RNA Products For SRCIN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCIN1
Clone products for research
- Applied Biological Materials (abm): Clones for SRCIN1 - Starting at $45 >
- * SRCIN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SRCIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCIN1
Cell Lines for research
-
Horizon Cell Lines for SRCIN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRCIN1 Gene
Localization for SRCIN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCIN1 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250 UniProtKB:Q9QXY2}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 19146815 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | NOT focal adhesion | IDA | 14657239 |
| GO:0014069 | postsynaptic density | IEA,ISS | -- |
| GO:0015629 | actin cytoskeleton | IEA,IDA | 14657239 |
Pathways & Interactions for SRCIN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adhesion |
-
|
|
| 2 | Cytoskeletal Signaling | ||
| 3 | Neuroscience | ||
Pathways by source for SRCIN1 Gene
3 Cell Signaling Technology pathways for SRCIN1 Gene
Interacting Proteins for SRCIN1 Gene
Selected Interacting proteins:
Q9C0H9-SRCN1_HUMAN
ENSP00000484715
for SRCIN1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SRCIN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006887 | exocytosis | IEA | -- |
| GO:0030334 | regulation of cell migration | IEA,IMP | 17525734 |
| GO:0034446 | substrate adhesion-dependent cell spreading | IEA,IMP | 17525734 |
| GO:0050709 | negative regulation of protein secretion | IEA | -- |
| GO:0061001 | regulation of dendritic spine morphogenesis | IEA,IMP | 19146815 |
Drugs & Compounds for SRCIN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Nutra | 6959 |
Transcripts for SRCIN1 Gene
mRNA/cDNA for SRCIN1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000612208 1316 nts (view in UCSC)
- ENST00000612431 1431 nts (view in UCSC)
- ENST00000613927 1150 nts (view in UCSC)
- ENST00000617146 7065 nts (view in UCSC)
- ENST00000621275 453 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SRCIN1 - Starting at $85 >
- * SRCIN1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SRCIN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCIN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCIN1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRCIN1
- Browse OriGene Inhibitory RNA Products For SRCIN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCIN1
Clone products for research
- Applied Biological Materials (abm): Clones for SRCIN1 - Starting at $45 >
- * SRCIN1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SRCIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCIN1
Relevant External Links for SRCIN1 Gene
- GeneLoc Exon Structure for
- SRCIN1
Expression for SRCIN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SRCIN1 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2), Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), and Brain - Substantia nigra (x4.4).
This gene is overexpressed in Frontal cortex (25.5), Brain (23.6), and Fetal Brain (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCIN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRCIN1
SOURCE GeneReport for Unigene cluster for SRCIN1 Gene:
Hs.448872mRNA Expression by UniProt/SwissProt for SRCIN1 Gene:
Q9C0H9-SRCN1_HUMAN
Tissue specificity:
Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
Evidence on tissue expression from TISSUES for SRCIN1 Gene
- Nervous system(4.7)
- Liver(4.2)
- Eye(4.2)
Primer products for research
-
OriGene qPCR primer pairs for SRCIN1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCIN1 Gene
Orthologs for SRCIN1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SRCIN1 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | SRCIN1 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | SRCIN1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Srcin1 29 16 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Srcin1 29 |
|
||
| Chicken (Gallus gallus) |
Aves | SRCIN1 29 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | srcin1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC565863 29 |
|
- Species where no ortholog for SRCIN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SRCIN1 Gene
- ENSEMBL:
- Gene Tree for SRCIN1 (if available)
- TreeFam:
- Gene Tree for SRCIN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SRCIN1: view image
- Alliance of Genome Resources:
- Additional Orthologs for SRCIN1
Paralogs for SRCIN1 Gene
Variants for SRCIN1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRCIN1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs763475410 | Likely Benign: not provided | 38,559,642(-) |
G/T NM_025248.3(SRCIN1):c.1968C>A (p.Gly656=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1006872 | CNV | loss | 20482838 |
| esv2758688 | CNV | gain+loss | 17122850 |
| esv27695 | CNV | gain | 19812545 |
| esv3310352 | CNV | mobile element insertion | 20981092 |
| esv3442833 | CNV | insertion | 20981092 |
| nsv1112705 | CNV | deletion | 24896259 |
| nsv1144799 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2042 | CNV | insertion | 18451855 |
| nsv2044 | CNV | insertion | 18451855 |
| nsv428341 | CNV | gain+loss | 18775914 |
| nsv469701 | CNV | loss | 16826518 |
| nsv827980 | CNV | gain | 20364138 |
| nsv827981 | CNV | gain | 20364138 |
| nsv833436 | CNV | loss | 17160897 |
| nsv833438 | CNV | loss | 17160897 |
| nsv953893 | CNV | deletion | 24416366 |
| nsv9549 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.09;
60.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRCIN1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCIN1 Gene
Disorders for SRCIN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kohlschutter-tonz syndrome |
|
|
| coffin-siris syndrome 3 |
|
|
Search SRCIN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SRCIN1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SRCIN1 Gene
Publications for SRCIN1 Gene
- P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PMID: 14657239) Di Stefano P … Defilippi P (Molecular biology of the cell 2004) 3 4 22
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
- Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PMID: 19146815) Jaworski J … Hoogenraad CC (Neuron 2009) 3 4
- SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. (PMID: 18475297) Kennedy S … O'Driscoll L (British journal of cancer 2008) 3 4
- Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. (PMID: 18662323) Ito H … Nagata K (Journal of neurochemistry 2008) 3 4
ExternalLinks
Products for SRCIN1 Gene
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse Proteins and Peptides
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SRCIN1 (AFLGC-SRCIN1)
- VectorBuilder Custom and pre-made DNA vectors for SRCIN1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SRCIN1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SRCIN1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SRCIN1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SRCIN1
- antibodies-online: Show 5 available SRCIN1 Antibodies ranked by validation data
- Compare Top SRCIN1 Antibodies
- antibodies-online: Show 5 available SRCIN1 Elisa Kits ranked by validation data
- Compare Top SRCIN1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available SRCIN1 Proteins ranked by validation data
- Compare Top SRCIN1 Proteins
- Quality Products:
- Horizon Cell Lines for SRCIN1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCIN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SRCIN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCIN1
Sources for SRCIN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources