Aliases for SRCIN1 Gene
Aliases for SRCIN1 Gene
External Ids for SRCIN1 Gene
- HGNC: 29506
- Entrez Gene: 80725
- Ensembl: ENSG00000277363
- OMIM: 610786
- UniProtKB: Q9C0H9
Previous GeneCards Identifiers for SRCIN1 Gene
- GC17M033943
- GC17M036686
- GC17M032482
Summaries for SRCIN1 Gene
GeneCards Summary for SRCIN1 Gene
SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include Sclerosing Keratitis and Anterior Scleritis. Among its related pathways are Cytoskeletal Signaling and Neuroscience. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.
UniProtKB/Swiss-Prot for SRCIN1 Gene
-
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Additional gene information for SRCIN1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCIN1 Gene
Genomics for SRCIN1 Gene
GeneHancer (GH) Regulatory Elements for SRCIN1 Gene
Promoters and enhancers for SRCIN1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17I038604 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | -0.4 | -357 | 2.6 | FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 | SRCIN1 GC17P038603 GC17M038621 | |
| GH17I038550 | Enhancer | 0.6 | dbSUPER | 17.7 | +53.7 | 53720 | 3.4 | PKNOX1 RFX1 ZNF449 BHLHE40 NRF1 DPF2 ZKSCAN1 ZFHX2 GLIS2 NFE2 | SRCIN1 ARL5C LOC105371761 GC17P038534 GC17P038504 | |
| GH17I038600 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 4.6 | +4.0 | 3954 | 3.2 | ARID4B SIN3A ZNF2 GLIS2 ZNF143 KLF7 SP3 SP5 NFIL3 ZNF610 | GC17P038603 ENSG00000274996 LOC105371762 CDK12 MED1 RPL19 SRCIN1 PIP4K2B SOCS7 GPR179 | |
| GH17I038671 | Enhancer | 0.5 | ENCODE | 11.7 | -66.1 | -66063 | 0.1 | PAF1 CTCF ZNF366 NR2F1 NR2F6 ZNF48 EZH2 | GC17M038673 SRCIN1 CISD3 EPOP GC17M038636 | |
| GH17I038553 | Enhancer | 0.3 | dbSUPER | 18.7 | +50.8 | 50752 | 2.4 | ZNF248 | SRCIN1 LOC105371761 GC17P038534 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SRCIN1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SRCIN1 Gene
Genomic Locations for SRCIN1 Gene
- chr17:38,530,016-38,605,930
- (GRCh38/hg38)
- Size:
- 75,915 bases
- Orientation:
- Minus strand
- chr17:36,686,251-36,762,183
- (GRCh37/hg19)
Genomic View for SRCIN1 Gene
Genes around SRCIN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
SRCIN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCIN1 Gene
Proteins for SRCIN1 Gene
-
Protein details for SRCIN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0H9-SRCN1_HUMAN
- Recommended name:
- SRC kinase signaling inhibitor 1
- Protein Accession:
- Q9C0H9
- Q75T46
- Q8N4W8
Protein attributes for SRCIN1 Gene
- Size:
- 1055 amino acids
- Molecular mass:
- 112453 Da
- Quaternary structure:
-
- Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3.
Protein Expression for SRCIN1 Gene
Post-translational modifications for SRCIN1 Gene
- Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SRCIN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SRCIN1
- Novus Biologicals Antibodies for SRCIN1
-
Abcam antibodies for SRCIN1
- Invitrogen Antibodies for SRCIN1
- Search GeneTex for Antibodies for SRCIN1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCIN1
- Origene Custom Protein Services for SRCIN1
- Novus Biologicals proteins for SRCIN1
- antibodies-online: Search results for 3 available SRCIN1 Proteins ranked by validation data
- Compare Top SRCIN1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SRCIN1
-
Abcam proteins for SRCIN1
Assay Products
- antibodies-online: Search results for 2 available SRCIN1 Elisa Kits ranked by validation data
- Compare Top SRCIN1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SRCIN1 Gene
Domains & Families for SRCIN1 Gene
Gene Families for SRCIN1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for SRCIN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9C0H9- Family:
-
- Belongs to the SRCIN1 family.
Function for SRCIN1 Gene
Molecular function for SRCIN1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14657239 |
| GO:0019901 | protein kinase binding | IDA | 17525734 |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for SRCIN1 Gene
- MGI mutant phenotypes for SRCIN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SRCIN1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCIN1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCIN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCIN1 gene
- Search ViGene Biosciences for SRCIN1
CRISPR Products
-
OriGene CRISPR knockouts for SRCIN1
- genomics-online: gRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- Applied Biological Materials CRISPR for SRCIN1
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCIN1
- GenScript: Design CRISPR guide RNA sequences for SRCIN1
miRNA for SRCIN1 Gene
- miRTarBase miRNAs that target SRCIN1
-
- hsa-mir-542-5p (MIRT006067)
- hsa-mir-374a-5p (MIRT054263)
- hsa-mir-150-5p (MIRT054852)
- hsa-mir-6848-5p (MIRT490731)
- hsa-mir-6846-5p (MIRT490732)
- hsa-mir-4283 (MIRT490733)
- hsa-mir-3191-3p (MIRT490734)
- hsa-mir-4437 (MIRT490735)
- hsa-mir-4726-5p (MIRT490736)
- hsa-mir-4640-5p (MIRT490737)
- hsa-mir-92b-5p (MIRT490738)
- hsa-mir-24-3p (MIRT490739)
- hsa-mir-3934-3p (MIRT490740)
- hsa-mir-4749-5p (MIRT490741)
- hsa-mir-4706 (MIRT490742)
- hsa-mir-3664-3p (MIRT490743)
- hsa-mir-6895-5p (MIRT490744)
- hsa-mir-873-5p (MIRT490745)
- hsa-mir-4781-5p (MIRT490746)
- hsa-mir-6834-5p (MIRT490747)
- hsa-mir-486-3p (MIRT490748)
- hsa-mir-6883-5p (MIRT490749)
- hsa-mir-6785-5p (MIRT490750)
- hsa-mir-4728-5p (MIRT490751)
- hsa-mir-149-3p (MIRT490752)
- hsa-mir-6787-5p (MIRT490753)
- hsa-mir-663a (MIRT490754)
- hsa-mir-1908-5p (MIRT490755)
- hsa-mir-744-5p (MIRT490756)
- hsa-mir-6133 (MIRT490757)
- hsa-mir-6130 (MIRT490758)
- hsa-mir-6129 (MIRT490759)
- hsa-mir-6127 (MIRT490760)
- hsa-mir-4510 (MIRT490761)
- hsa-mir-6875-5p (MIRT490762)
- hsa-mir-4419a (MIRT490763)
- hsa-mir-3126-5p (MIRT490764)
- hsa-mir-6775-5p (MIRT490765)
- hsa-mir-5090 (MIRT490766)
- hsa-mir-3937 (MIRT490767)
- hsa-mir-6794-5p (MIRT490768)
- hsa-mir-4716-3p (MIRT490769)
- hsa-mir-4756-5p (MIRT490770)
- hsa-mir-4739 (MIRT490771)
- hsa-mir-1321 (MIRT490772)
- hsa-mir-6837-5p (MIRT622092)
- hsa-mir-4685-5p (MIRT622093)
- hsa-mir-7113-5p (MIRT622094)
- hsa-mir-665 (MIRT622095)
- hsa-mir-6823-5p (MIRT622096)
- hsa-mir-4459 (MIRT622097)
- hsa-mir-4779 (MIRT622098)
- hsa-mir-6797-5p (MIRT626783)
- hsa-mir-1249-5p (MIRT626784)
- hsa-mir-1238-3p (MIRT666121)
- hsa-mir-670-3p (MIRT666122)
- hsa-mir-3180-5p (MIRT666123)
- hsa-mir-6881-3p (MIRT666124)
- hsa-mir-6780a-3p (MIRT666125)
- hsa-mir-1290 (MIRT666126)
- hsa-mir-877-3p (MIRT666127)
- hsa-mir-4713-5p (MIRT719518)
- hsa-mir-3156-3p (MIRT719519)
- hsa-mir-6731-5p (MIRT719520)
- hsa-mir-8085 (MIRT719521)
- hsa-mir-6738-5p (MIRT719522)
- hsa-mir-5194 (MIRT719523)
- hsa-mir-2116-3p (MIRT719524)
- hsa-mir-1914-3p (MIRT719525)
- hsa-mir-532-3p (MIRT719526)
- hsa-mir-6746-5p (MIRT719527)
- hsa-mir-4301 (MIRT719528)
- hsa-mir-1273g-3p (MIRT719529)
- hsa-mir-346 (MIRT732707)
miRNA Products
- Search ViGene Biosciences for SRCIN1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SRCIN1
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- genomics-online: shRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCIN1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SRCIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCIN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SRCIN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SRCIN1
-
ViGene Biosciences adenoviral particle packaged cDNA for SRCIN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SRCIN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCIN1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRCIN1 Gene
Localization for SRCIN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCIN1 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytosol | 2 |
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 19146815 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | NOT focal adhesion | IDA | 14657239 |
| GO:0014069 | postsynaptic density | ISS | -- |
Pathways & Interactions for SRCIN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adhesion |
-
|
|
| 2 | Cytoskeletal Signaling | ||
| 3 | Neuroscience | ||
Pathways by source for SRCIN1 Gene
3 Cell Signaling Technology pathways for SRCIN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006887 | exocytosis | IEA | -- |
| GO:0030334 | regulation of cell migration | IEA,IMP | 17525734 |
| GO:0034446 | substrate adhesion-dependent cell spreading | IMP,IEA | 17525734 |
| GO:0050709 | negative regulation of protein secretion | IEA | -- |
| GO:0061001 | regulation of dendritic spine morphogenesis | IEA,IMP | 19146815 |
Drugs & Compounds for SRCIN1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
Transcripts for SRCIN1 Gene
mRNA/cDNA for SRCIN1 Gene
- (7) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (72) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SRCIN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SRCIN1
- genomics-online: gRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- Applied Biological Materials CRISPR for SRCIN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCIN1
- GenScript: Design CRISPR guide RNA sequences for SRCIN1
miRNA Products
- Search ViGene Biosciences for SRCIN1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SRCIN1
- Browse OriGene Inhibitory RNA Products For SRCIN1
- genomics-online: shRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SRCIN1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SRCIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCIN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SRCIN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SRCIN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SRCIN1 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2), Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), and Brain - Substantia nigra (x4.4).
This gene is overexpressed in Frontal cortex (25.5), Brain (23.6), and Fetal Brain (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCIN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SRCIN1 Gene:
SRCIN1SOURCE GeneReport for Unigene cluster for SRCIN1 Gene:
Hs.448872mRNA Expression by UniProt/SwissProt for SRCIN1 Gene:
Q9C0H9-SRCN1_HUMAN
Tissue specificity:
Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
Evidence on tissue expression from TISSUES for SRCIN1 Gene
- Nervous system(4.7)
- Eye(4.4)
- Liver(4.3)
- Skin(2.8)
Primer Products
-
OriGene qPCR primer pairs for SRCIN1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCIN1 Gene
Orthologs for SRCIN1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SRCIN1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | SRCIN1 33 |
|
||
| dog (Canis familiaris) |
Mammalia | SRCIN1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Srcin1 33 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Srcin1 33 |
|
||
| chicken (Gallus gallus) |
Aves | SRCIN1 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | srcin1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC565863 33 |
|
- Species where no ortholog for SRCIN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SRCIN1 Gene
(1) SIMAP similar genes for SRCIN1 Gene using alignment to 4 proteins:
Variants for SRCIN1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000079066 | -- | 38,556,794(-) | C/A | intron_variant | |
| rs1000101647 | -- | 38,546,266(-) | G/T | intron_variant | |
| rs1000123512 | -- | 38,589,195(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000139137 | -- | 38,595,272(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000180410 | -- | 38,569,758(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1006872 | CNV | loss | 20482838 |
| esv2758688 | CNV | gain+loss | 17122850 |
| esv27695 | CNV | gain | 19812545 |
| esv3310352 | CNV | mobile element insertion | 20981092 |
| esv3442833 | CNV | insertion | 20981092 |
| nsv1112705 | CNV | deletion | 24896259 |
| nsv1144799 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2042 | CNV | insertion | 18451855 |
| nsv2044 | CNV | insertion | 18451855 |
| nsv428341 | CNV | gain+loss | 18775914 |
| nsv469701 | CNV | loss | 16826518 |
| nsv827980 | CNV | gain | 20364138 |
| nsv827981 | CNV | gain | 20364138 |
| nsv833436 | CNV | loss | 17160897 |
| nsv833438 | CNV | loss | 17160897 |
| nsv953893 | CNV | deletion | 24416366 |
| nsv9549 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.09;
60.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRCIN1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCIN1 Gene
Disorders for SRCIN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sclerosing keratitis |
|
|
| anterior scleritis |
|
|
| punctate epithelial keratoconjunctivitis |
|
|
| deep keratitis |
|
|
| loiasis |
|
|
Search SRCIN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SRCIN1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SRCIN1 Gene
Publications for SRCIN1 Gene
- P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. (PMID: 14657239) Di Stefano P … Defilippi P (Molecular biology of the cell 2004) 3 4 22 58
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PMID: 19146815) Jaworski J … Hoogenraad CC (Neuron 2009) 3 4 58
- SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. (PMID: 18475297) Kennedy S … O'Driscoll L (British journal of cancer 2008) 3 4 58
- Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. (PMID: 18662323) Ito H … Nagata K (Journal of neurochemistry 2008) 3 4 58
Products for SRCIN1 Gene
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- Browse OriGene Inhibitory RNA Products For SRCIN1
- OriGene qPCR primer pairs for SRCIN1
- OriGene CRISPR knockouts for SRCIN1
- OriGene ORF clones in human for SRCIN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SRCIN1
- GenScript: Next-day shipping of latest version cDNA ORF clones for SRCIN1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SRCIN1
- GenScript Custom Assay Services for SRCIN1
- GenScript Custom overexpressing Cell Line Services for SRCIN1
- GenScript: Design CRISPR guide RNA sequences for SRCIN1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SRCIN1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SRCIN1
- Novus Biologicals proteins for SRCIN1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SRCIN1
- Abcam proteins for SRCIN1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCIN1
- VectorBuilder custom plasmid, inducible vectors for SRCIN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SRCIN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available SRCIN1 Antibodies ranked by validation data
- Compare Top SRCIN1 Antibodies
- antibodies-online: Search results for 2 available SRCIN1 Elisa Kits ranked by validation data
- Compare Top SRCIN1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available SRCIN1 Proteins ranked by validation data
- Compare Top SRCIN1 Proteins
- Quality Products:
- Search GeneTex for Antibodies for SRCIN1
- Search GeneTex for Proteins for SRCIN1
- ViGene Biosciences adenoviral particle packaged cDNA for SRCIN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SRCIN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SRCIN1 gene
- Search ViGene Biosciences for SRCIN1
- Horizon Cell Lines for SRCIN1
- genomics-online: cdna clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- orf clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- genomics-online: gRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- genomics-online: primer clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
- genomics-online: shRNA clones - Search results for 64 available SRCIN1 gene related products
- Overview of 64 available SRCIN1 gene related products
Sources for SRCIN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
