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SRCIN1 (SRC Kinase Signaling Inhibitor 1) is a Protein Coding gene. Diseases associated with SRCIN1 include Sclerosing Keratitis and Deep Keratitis. Among its related pathways are Neuroscience and Adhesion. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is KIAA1217.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14657239 |
GO:0019901 | protein kinase binding | IDA | 17525734 |
GO:0019904 | protein domain specific binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IDA | 19146815 |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005925 | NOT focal adhesion | IDA | 14657239 |
GO:0014069 | postsynaptic density | ISS | -- |
GO:0015629 | actin cytoskeleton | IEA,IDA | 14657239 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Adhesion |
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2 | Cytoskeletal Signaling | ||
3 | Neuroscience |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006887 | exocytosis | IEA | -- |
GO:0030334 | regulation of cell migration | IEA,IMP | 17525734 |
GO:0034446 | substrate adhesion-dependent cell spreading | IEA,IMP | 17525734 |
GO:0050709 | negative regulation of protein secretion | IEA | -- |
GO:0061001 | regulation of dendritic spine morphogenesis | IEA,IMP | 19146815 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | SRCIN1 30 |
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Cow (Bos Taurus) |
Mammalia | SRCIN1 30 |
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Dog (Canis familiaris) |
Mammalia | SRCIN1 30 |
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Mouse (Mus musculus) |
Mammalia | Srcin1 30 17 |
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Rat (Rattus norvegicus) |
Mammalia | Srcin1 30 |
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Chicken (Gallus gallus) |
Aves | SRCIN1 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | srcin1 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC565863 30 |
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SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
682222 | Likely Benign: not provided | 38,559,642(-) | G/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1006872 | CNV | loss | 20482838 |
esv2758688 | CNV | gain+loss | 17122850 |
esv27695 | CNV | gain | 19812545 |
esv3310352 | CNV | mobile element insertion | 20981092 |
esv3442833 | CNV | insertion | 20981092 |
nsv1112705 | CNV | deletion | 24896259 |
nsv1144799 | CNV | deletion | 24896259 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv2042 | CNV | insertion | 18451855 |
nsv2044 | CNV | insertion | 18451855 |
nsv428341 | CNV | gain+loss | 18775914 |
nsv469701 | CNV | loss | 16826518 |
nsv827980 | CNV | gain | 20364138 |
nsv827981 | CNV | gain | 20364138 |
nsv833436 | CNV | loss | 17160897 |
nsv833438 | CNV | loss | 17160897 |
nsv953893 | CNV | deletion | 24416366 |
nsv9549 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
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sclerosing keratitis |
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deep keratitis |
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punctate epithelial keratoconjunctivitis |
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loiasis |
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chronic dacryocystitis |
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