Aliases for SRCAP Gene
Aliases for SRCAP Gene
- Snf2 Related CREBBP Activator Protein 2 3 5
- Domino Homolog 2 3 4
- Helicase SRCAP 3 4
- Swi2/Snf2-Related ATPase Homolog, Domino Homolog 1 3
- Swi2/Snf2-Related ATPase Homolog (S. Cerevisiae) 2
- Snf2-Related CREBBP Activator Protein 2
- Snf2-Related CBP Activator Protein 3
- Domino Homolog 1 (Drosophila) 2
- Snf2-Related CBP Activator 4
External Ids for SRCAP Gene
- HGNC: 16974
- Entrez Gene: 10847
- Ensembl: ENSG00000080603
- OMIM: 611421
- UniProtKB: Q6ZRS2
Previous GeneCards Identifiers for SRCAP Gene
- GC16P030002
- GC16P031203
- GC16P030715
- GC16P030754
- GC16P030748
- GC16P030622
- GC16P030710
- GC16P028273
Summaries for SRCAP Gene
-
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Chromosome 16P13.3 Deletion Syndrome, Proximal. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.
UniProtKB/Swiss-Prot for SRCAP Gene
-
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Additional gene information for SRCAP Gene
- Monarch Initiative
- Search for SRCAP at DataMed
- Search for SRCAP at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRCAP Gene
Genomics for SRCAP Gene
GeneHancer (GH) Regulatory Elements for SRCAP Gene
Promoters and enhancers for SRCAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SRCAP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SRCAP gene promoter:
-
- AhR
- AML1a
- ATF
- c-Myb
- C/EBPalpha
- CREB
- deltaCREB
- HEN1
- Pax-4a
- Zic1
Genomic Locations for SRCAP Gene
Genomic Locations for SRCAP Gene
- chr16:30,698,209-30,741,409
- (GRCh38/hg38)
- Size:
- 43,201 bases
- Orientation:
- Plus strand
- chr16:30,709,530-30,755,602
- (GRCh37/hg19)
- Size:
- 46,073 bases
- Orientation:
- Plus strand
Genomic View for SRCAP Gene
Genes around SRCAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
SRCAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCAP Gene
Proteins for SRCAP Gene
-
Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRS2-SRCAP_HUMAN
- Recommended name:
- Helicase SRCAP
- Protein Accession:
- Q6ZRS2
- B0JZA6
- O15026
- Q7Z744
- Q9Y5L9
Protein attributes for SRCAP Gene
- Size:
- 3230 amino acids
- Molecular mass:
- 343555 Da
- Quaternary structure:
-
- Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
- (Microbial infection) Interacts with hepatitis C virus (HCV) NS5A.
- (Microbial infection) Interacts with human adenovirus 2 DBP.
- SequenceCaution:
-
- Sequence=AAI59100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SRCAP Gene
Selected DME Specific Peptides for SRCAP Gene
- Q6ZRS2:
-
- DEMGLGKT
- NLTGADTV
- RKVCNHP
- TGTPLQN
- HRIGQTRDVHIYR
- GHRVLIF
- MGLGKTIQ
- FYDSDWNP
- HLIIVPTSV
- RCHRIGQ
- NGILADE
- LHKVLRP
Post-translational modifications for SRCAP Gene
Other Protein References for SRCAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-SRCAP Antibody
-
Custom Antibody ServicesOriGene Antibodies for SRCAP
- Novus Biologicals Antibodies for SRCAP
-
Abcam antibodies for SRCAP
- Invitrogen Antibodies for SRCAP (AFLGC-SRCAP)
Protein Products
- Atlas Antibodies PrEST Antigen SRCAP
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Novus Biologicals proteins for SRCAP
Domains & Families for SRCAP Gene
Gene Families for SRCAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for SRCAP Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SRCAP Gene
- GenScript: Design optimal peptide antigens:
-
- SRCAP protein (Q6P4A2_HUMAN)
- Snf2-related CBP activator (SRCAP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZRS2- Family:
-
- Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Function for SRCAP Gene
Molecular function for SRCAP Gene
- UniProtKB/Swiss-Prot Function:
- Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=66 uM for ATP {ECO:0000269 PubMed:10347196};
Enzyme Numbers (IUBMB) for SRCAP Gene
Phenotypes From GWAS Catalog for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10347196 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0004402 | histone acetyltransferase activity | TAS | 10347196 |
| GO:0005515 | protein binding | IPI | 10702287 |
Phenotypes for SRCAP Gene
- GenomeRNAi human phenotypes for SRCAP:
-
- Decreased BBC3 mRNA expression
- Increased shRNA abundance (Z-score > 2)
- Decreased CDKN1A mRNA expression
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased Nanog expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased gamma-H2AX phosphorylation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- shRNA abundance <= 50%
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCAP
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRCAP - Now 50% OFF >
- * SRCAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SRCAP CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for SRCAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
- genomics-online: gRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
miRNA for SRCAP Gene
- miRTarBase miRNAs that target SRCAP
-
- hsa-mir-1229-3p (MIRT036303)
- hsa-mir-877-3p (MIRT036817)
- hsa-mir-744-5p (MIRT037418)
- hsa-mir-130b-5p (MIRT038290)
- hsa-mir-296-3p (MIRT038471)
- hsa-mir-615-3p (MIRT040165)
- hsa-mir-484 (MIRT041967)
- hsa-mir-320a (MIRT044623)
- hsa-mir-194-5p (MIRT044873)
- hsa-mir-27b-3p (MIRT046182)
- hsa-mir-197-3p (MIRT048104)
- hsa-mir-17-3p (MIRT050747)
- hsa-let-7c-5p (MIRT051752)
- hsa-let-7b-5p (MIRT051910)
- hsa-mir-450a-2-3p (MIRT498904)
- hsa-mir-6857-5p (MIRT498905)
- hsa-mir-6763-5p (MIRT498906)
- hsa-mir-3150a-3p (MIRT498907)
- hsa-mir-2110 (MIRT498908)
- hsa-mir-6810-5p (MIRT498909)
- hsa-mir-6825-5p (MIRT498910)
- hsa-mir-939-5p (MIRT498911)
- hsa-mir-1343-5p (MIRT498912)
- hsa-mir-3175 (MIRT498913)
- hsa-mir-7106-5p (MIRT498914)
- hsa-mir-765 (MIRT498915)
- hsa-mir-4644 (MIRT498916)
- hsa-mir-4306 (MIRT498917)
- hsa-mir-185-5p (MIRT498918)
- hsa-mir-3188 (MIRT498919)
- hsa-mir-4784 (MIRT498920)
- hsa-mir-3150b-3p (MIRT498921)
- hsa-mir-4259 (MIRT498922)
- hsa-mir-6758-5p (MIRT498923)
- hsa-mir-6856-5p (MIRT498924)
- hsa-mir-4311 (MIRT498925)
- hsa-mir-539-3p (MIRT613120)
- hsa-mir-485-3p (MIRT613121)
- hsa-mir-3941 (MIRT613122)
- hsa-mir-93-3p (MIRT613123)
- hsa-mir-6893-3p (MIRT613124)
- hsa-mir-370-3p (MIRT613125)
- hsa-mir-3620-3p (MIRT613126)
- hsa-mir-603 (MIRT613127)
- hsa-mir-362-3p (MIRT613128)
- hsa-mir-329-3p (MIRT613129)
- hsa-mir-8485 (MIRT613130)
- hsa-mir-3671 (MIRT642115)
- hsa-mir-372-5p (MIRT642116)
- hsa-mir-371a-5p (MIRT642117)
- hsa-mir-616-5p (MIRT642118)
- hsa-mir-373-5p (MIRT642119)
- hsa-mir-371b-5p (MIRT642120)
- hsa-mir-6849-3p (MIRT642121)
- hsa-mir-6877-3p (MIRT642122)
- hsa-mir-6819-3p (MIRT642123)
- hsa-mir-4446-5p (MIRT658823)
- hsa-mir-5006-3p (MIRT658824)
- hsa-mir-4755-5p (MIRT658825)
- hsa-mir-211-5p (MIRT658826)
- hsa-mir-204-5p (MIRT658827)
- hsa-mir-623 (MIRT658828)
- hsa-mir-3140-3p (MIRT658829)
- hsa-mir-4645-3p (MIRT658830)
- hsa-mir-6832-3p (MIRT658831)
- hsa-mir-6752-3p (MIRT658832)
- hsa-mir-2114-5p (MIRT658833)
- hsa-mir-378a-5p (MIRT678717)
- hsa-mir-6778-3p (MIRT678718)
- hsa-mir-6821-3p (MIRT678719)
- hsa-mir-6790-3p (MIRT678720)
- hsa-mir-18a-3p (MIRT678721)
- hsa-mir-324-3p (MIRT678722)
- hsa-mir-1913 (MIRT678723)
- hsa-mir-3653-5p (MIRT678724)
- hsa-mir-150-5p (MIRT678725)
- hsa-mir-7107-5p (MIRT678726)
- hsa-mir-1234-3p (MIRT678727)
- hsa-mir-1224-3p (MIRT678728)
- hsa-mir-186-3p (MIRT678729)
- hsa-mir-6513-3p (MIRT678730)
- hsa-mir-520h (MIRT678731)
- hsa-mir-520g-3p (MIRT678732)
- hsa-mir-512-3p (MIRT678733)
- hsa-mir-8079 (MIRT678734)
- hsa-mir-1245a (MIRT678735)
- hsa-mir-520e (MIRT678736)
- hsa-mir-520d-3p (MIRT678737)
- hsa-mir-520c-3p (MIRT678738)
- hsa-mir-520b (MIRT678739)
- hsa-mir-520a-3p (MIRT678740)
- hsa-mir-373-3p (MIRT678741)
- hsa-mir-372-3p (MIRT678742)
- hsa-mir-302e (MIRT678743)
- hsa-mir-302d-3p (MIRT678744)
- hsa-mir-302c-3p (MIRT678745)
- hsa-mir-302b-3p (MIRT678746)
- hsa-mir-302a-3p (MIRT678747)
- hsa-mir-93-5p (MIRT678748)
- hsa-mir-526b-3p (MIRT678749)
- hsa-mir-519d-3p (MIRT678750)
- hsa-mir-20b-5p (MIRT678751)
- hsa-mir-20a-5p (MIRT678752)
- hsa-mir-17-5p (MIRT678753)
- hsa-mir-106b-5p (MIRT678754)
- hsa-mir-106a-5p (MIRT678755)
- hsa-mir-6515-5p (MIRT704059)
- hsa-mir-2113 (MIRT704060)
- hsa-mir-9-3p (MIRT704061)
- hsa-mir-6797-5p (MIRT704062)
- hsa-mir-1249-5p (MIRT704063)
- hsa-mir-3135b (MIRT704064)
- hsa-mir-2467-3p (MIRT704065)
- hsa-mir-3616-3p (MIRT704066)
- hsa-mir-7843-5p (MIRT704067)
- hsa-mir-6879-5p (MIRT704068)
- hsa-mir-6735-5p (MIRT704069)
- hsa-mir-4632-5p (MIRT704070)
- hsa-mir-4436b-3p (MIRT704071)
- hsa-mir-320e (MIRT704072)
- hsa-mir-6776-3p (MIRT704073)
- hsa-mir-4429 (MIRT704074)
- hsa-mir-320d (MIRT704075)
- hsa-mir-320c (MIRT704076)
- hsa-mir-320b (MIRT704077)
- hsa-mir-1251-3p (MIRT783212)
- hsa-mir-129-5p (MIRT783604)
- hsa-mir-3672 (MIRT785161)
- hsa-mir-431-5p (MIRT785739)
- hsa-mir-4524a-3p (MIRT786138)
- hsa-mir-4797-5p (MIRT786843)
- hsa-mir-5007-5p (MIRT786964)
- hsa-mir-6864-3p (MIRT789166)
- hsa-mir-8055 (MIRT789733)
- hsa-mir-924 (MIRT789951)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
- genomics-online: shRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SRCAP - Now 50% OFF >
- * SRCAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SRCAP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SRCAP Gene
Localization for SRCAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 4 |
| cytosol | 0 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000812 | Swr1 complex | IBA | 21873635 |
| GO:0005634 | nucleus | IDA | 10702287 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for SRCAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Pathways Affected in Adenoid Cystic Carcinoma | ||
Pathways by source for SRCAP Gene
1 BioSystems pathway for SRCAP Gene
Interacting Proteins for SRCAP Gene
GPS-Prot Interaction Network for SRCAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | IBA | 21873635 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10347196 |
| GO:0016032 | viral process | IEA | -- |
| GO:0016458 | gene silencing | IBA | 21873635 |
Drugs & Compounds for SRCAP Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen SRCAP
Transcripts for SRCAP Gene
mRNA/cDNA for SRCAP Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (526) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000395059 9126 bps (ENST00000395059.6)
- ENST00000474008 730 bps (ENST00000474008.1)
- ENST00000483083 5937 bps (ENST00000483083.3)
- ENST00000262518 11724 bps (ENST00000262518.8)
- ENST00000411466 836 bps (ENST00000411466.6)
Unigene Clusters for SRCAP Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRCAP - Now 50% OFF >
- * SRCAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * SRCAP CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for SRCAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
- genomics-online: gRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
- genomics-online: shRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SRCAP - Now 50% OFF >
- * SRCAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * SRCAP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for SRCAP Gene
This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCAP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SRCAP Gene:
SRCAPSOURCE GeneReport for Unigene cluster for SRCAP Gene:
Hs.620916Evidence on tissue expression from TISSUES for SRCAP Gene
- Nervous system(4.7)
- Eye(3.1)
- Intestine(2.5)
- Lung(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCAP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- scalp
- skull
- vocal cord
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
Pelvis:
- pelvis
- rectum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for SRCAP
- genomics-online: primer clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene
Orthologs for SRCAP Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SRCAP 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SRCAP 35 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Srcap 17 35 35 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SRCAP 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Srcap 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SRCAP 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SRCAP 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15109 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.15976 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | srcap 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | dom 35 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y111B2A.23 36 |
|
|
|
| ssl-1 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWR1 37 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| Cin.10052 34 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10052 34 |
|
- Species where no ortholog for SRCAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SRCAP Gene
- ENSEMBL:
- Gene Tree for SRCAP (if available)
- TreeFam:
- Gene Tree for SRCAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SRCAP: view image
Paralogs for SRCAP Gene
Paralogs for SRCAP Gene
- ENSG00000282034 5
- EP400 5
- INO80 5
- CHD8 5
- CHD6 5
- CHD9 5
- CHD7 5
- CHD1 5
- SMARCA1 5
- SMARCA2 5
- SMARCA5 5
- CHD2 5
- CHD4 5
- SMARCA4 5
- CHD5 5
- CHD3 5
- ENSG00000285238 5
- SMARCAD1 5
- PGBD3 5
- CHD1L 5
- BTAF1 5
- ATRX 5
- HELLS 5
- RAD54L2 5
- ERCC6L 5
- ERCC6L2 5
- RAD54B 5
- TTF2 5
- RAD54L 5
- FSBP 5
- SHPRH 5
- HLTF 5
- SMARCAL1 5
- ZRANB3 5
- ENSG00000279765 5
(3) SIMAP similar genes for SRCAP Gene using alignment to 4 proteins:
- SRCAP_HUMAN
- C9J4U4_HUMAN
- G1UI29_HUMAN
- Q6P4A2_HUMAN
Variants for SRCAP Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117480926 | benign, likely-benign, not specified, Floating-Harbor syndrome | 30,729,012(+) | A/G | coding_sequence_variant, missense_variant | |
| rs117804715 | likely-benign, benign-likely-benign, Floating-Harbor syndrome, not specified, not provided | 30,724,027(+) | C/A/G/T | coding_sequence_variant, missense_variant | |
| rs138333984 | likely-benign, Floating-Harbor syndrome | 30,704,076(+) | G/A | coding_sequence_variant, missense_variant | |
| rs138541811 | likely-benign, benign, Floating-Harbor syndrome, not specified | 30,723,987(+) | T/A/C | coding_sequence_variant, synonymous_variant | |
| rs139339184 | benign, likely-benign, not specified, Floating-Harbor syndrome, not provided | 30,711,901(+) | G/A | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
0.229% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRCAP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCAP Gene
Disorders for SRCAP Gene
(2) MalaCards diseases for SRCAP Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| floating-harbor syndrome |
|
|
| chromosome 16p13.3 deletion syndrome, proximal |
|
|
Search SRCAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SRCAP_HUMAN- Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269 PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SRCAP
No data available for Genatlas for SRCAP Gene
Publications for SRCAP Gene
- Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PMID: 10347196) Johnston H … Chrivia J (The Journal of biological chemistry 1999) 2 3 4 23 58
- SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PMID: 14500758) Monroy MA … Chrivia JC (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 23 58
- Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PMID: 11581372) Xu X … Yaciuk P (Journal of virology 2001) 3 4 23 58
- The human SRCAP chromatin remodeling complex promotes DNA-end resection. (PMID: 25176633) Dong S … Huang J (Current biology : CB 2014) 2 3 58
- Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. (PMID: 22265015) Hood RL … Boycott KM (American journal of human genetics 2012) 3 4 58
ExternalLinks
Products for SRCAP Gene
- Custom Antibody ServicesOriGene Antibodies for SRCAP
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Origene sirna, shrna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- OriGene qPCR primer pairs for SRCAP
- OriGene CRISPR knockouts for SRCAP
- OriGene ORF clones in human for SRCAP
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- Browse OriGene miRNA Products For SRCAP
- Browse Sino Biological cDNA Clones
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- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SRCAP
- Novus Biologicals proteins for SRCAP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SRCAP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SRCAP (AFLGC-SRCAP)
- Cyagen custom Knockout/knockin (KOKI) mouse models for SRCAP
- antibodies-online: Search results for 23 available SRCAP Antibodies ranked by validation data
- Compare Top SRCAP Antibodies
- antibodies-online: Search results for available SRCAP related products ranked by validation data
- antibodies-online: Search results for available SRCAP related products ranked by validation data
- genomics-online: cdna clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
- orf clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
- genomics-online: gRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
- genomics-online: primer clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
- genomics-online: shRNA clones - Search results for 24 available SRCAP gene related products
- Overview of 24 available SRCAP gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
Sources for SRCAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27)