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This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Flo... See more...
Aliases for SRCAP Gene
Aliases for SRCAP Gene
External Ids for SRCAP Gene
- HGNC: 16974
- Entrez Gene: 10847
- Ensembl: ENSG00000080603
- OMIM: 611421
- UniProtKB: Q6ZRS2
Previous GeneCards Identifiers for SRCAP Gene
- GC16P030002
- GC16P031203
- GC16P030715
- GC16P030754
- GC16P030748
- GC16P030622
- GC16P030710
- GC16P028273
Summaries for SRCAP Gene
-
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Expressive Language Disorder. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.
UniProtKB/Swiss-Prot Summary for SRCAP Gene
-
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
Additional gene information for SRCAP Gene
- HGNC(16974)
- Entrez Gene(10847)
- Ensembl(ENSG00000080603)
- OMIM(611421)
- UniProtKB(Q6ZRS2)
- Open Targets Platform(ENSG00000080603)
- Monarch Initiative
- Search for SRCAP at DataMed
- Search for SRCAP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SRCAP Gene
Genomics for SRCAP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SRCAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SRCAP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SRCAP
- Top Transcription factor binding sites by QIAGEN in the SRCAP gene promoter:
-
- AhR
- AML1a
- ATF
- c-Myb
- C/EBPalpha
- CREB
- deltaCREB
- HEN1
- Pax-4a
- Zic1
Genomic Locations for SRCAP Gene
Genomic Locations for SRCAP Gene
- chr16:30,698,209-30,741,409
- (GRCh38/hg38)
- Size:
- 43,201 bases
- Orientation:
- Plus strand
- chr16:30,709,530-30,755,602
- (GRCh37/hg19)
- Size:
- 46,073 bases
- Orientation:
- Plus strand
Genomic View for SRCAP Gene
Genes around SRCAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
SRCAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SRCAP Gene
Proteins for SRCAP Gene
-
Protein details for SRCAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRS2-SRCAP_HUMAN
- Recommended name:
- Helicase SRCAP
- Protein Accession:
- Q6ZRS2
- B0JZA6
- O15026
- Q7Z744
- Q9Y5L9
Protein attributes for SRCAP Gene
- Size:
- 3230 amino acids
- Molecular mass:
- 343555 Da
- Quaternary structure:
-
- Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
- (Microbial infection) Interacts with hepatitis C virus (HCV) NS5A.
- (Microbial infection) Interacts with human adenovirus 2 DBP.
- SequenceCaution:
-
- Sequence=AAI59100.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for SRCAP Gene
Selected DME Specific Peptides for SRCAP Gene
- Q6ZRS2:
-
- DEMGLGKT
- NLTGADTV
- RKVCNHP
- TGTPLQN
- HRIGQTRDVHIYR
- GHRVLIF
- MGLGKTIQ
- FYDSDWNP
- HLIIVPTSV
- RCHRIGQ
- NGILADE
- LHKVLRP
Post-translational modifications for SRCAP Gene
Other Protein References for SRCAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SWR1 / SRCAP Antibody
-
Custom Antibody ServicesOriGene Antibodies for SRCAP
- Novus Biologicals Antibodies for SRCAP
-
Abcam antibodies for SRCAP
- Invitrogen Antibodies for SRCAP (AFLGC-SRCAP)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Novus Biologicals proteins for SRCAP
Domains & Families for SRCAP Gene
Gene Families for SRCAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for SRCAP Gene
- InterPro:
- Blocks:
-
- SNF2 related domain
- HSA
- ProtoNet:
Suggested Antigen Peptide Sequences for SRCAP Gene
- GenScript: Design optimal peptide antigens:
-
- SRCAP protein (Q6P4A2_HUMAN)
- Snf2-related CBP activator (SRCAP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZRS2- Family:
-
- Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Function for SRCAP Gene
Molecular function for SRCAP Gene
- UniProtKB/Swiss-Prot Function:
- Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=66 uM for ATP {ECO:0000269|PubMed:10347196};
Enzyme Numbers (IUBMB) for SRCAP Gene
Phenotypes From GWAS Catalog for SRCAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | TAS | 10347196 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0004402 | histone acetyltransferase activity | TAS | 10347196 |
Phenotypes for SRCAP Gene
- MGI mutant phenotypes for SRCAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SRCAP:
-
- no effect
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Increased Nanog expression
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Increased CDKN1A mRNA expression
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
- Increased BBC3 mRNA expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRCAP - Select products 50% OFF >
- * SRCAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRCAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
miRNA for SRCAP Gene
- miRTarBase miRNAs that target SRCAP
-
- hsa-miR-1229-3p (MIRT036303)
- hsa-miR-877-3p (MIRT036817)
- hsa-miR-744-5p (MIRT037418)
- hsa-miR-130b-5p (MIRT038290)
- hsa-miR-296-3p (MIRT038471)
- hsa-miR-615-3p (MIRT040165)
- hsa-miR-484 (MIRT041967)
- hsa-miR-320a (MIRT044623)
- hsa-miR-194-5p (MIRT044873)
- hsa-miR-27b-3p (MIRT046182)
- hsa-miR-197-3p (MIRT048104)
- hsa-miR-17-3p (MIRT050747)
- hsa-let-7c-5p (MIRT051752)
- hsa-let-7b-5p (MIRT051910)
- hsa-miR-450a-2-3p (MIRT498904)
- hsa-miR-6857-5p (MIRT498905)
- hsa-miR-6763-5p (MIRT498906)
- hsa-miR-3150a-3p (MIRT498907)
- hsa-miR-2110 (MIRT498908)
- hsa-miR-6810-5p (MIRT498909)
- hsa-miR-6825-5p (MIRT498910)
- hsa-miR-939-5p (MIRT498911)
- hsa-miR-1343-5p (MIRT498912)
- hsa-miR-3175 (MIRT498913)
- hsa-miR-7106-5p (MIRT498914)
- hsa-miR-765 (MIRT498915)
- hsa-miR-4644 (MIRT498916)
- hsa-miR-4306 (MIRT498917)
- hsa-miR-185-5p (MIRT498918)
- hsa-miR-3188 (MIRT498919)
- hsa-miR-4784 (MIRT498920)
- hsa-miR-3150b-3p (MIRT498921)
- hsa-miR-4259 (MIRT498922)
- hsa-miR-6758-5p (MIRT498923)
- hsa-miR-6856-5p (MIRT498924)
- hsa-miR-4311 (MIRT498925)
- hsa-miR-539-3p (MIRT613120)
- hsa-miR-485-3p (MIRT613121)
- hsa-miR-3941 (MIRT613122)
- hsa-miR-93-3p (MIRT613123)
- hsa-miR-6893-3p (MIRT613124)
- hsa-miR-370-3p (MIRT613125)
- hsa-miR-3620-3p (MIRT613126)
- hsa-miR-603 (MIRT613127)
- hsa-miR-362-3p (MIRT613128)
- hsa-miR-329-3p (MIRT613129)
- hsa-miR-8485 (MIRT613130)
- hsa-miR-3671 (MIRT642115)
- hsa-miR-372-5p (MIRT642116)
- hsa-miR-371a-5p (MIRT642117)
- hsa-miR-616-5p (MIRT642118)
- hsa-miR-373-5p (MIRT642119)
- hsa-miR-371b-5p (MIRT642120)
- hsa-miR-6849-3p (MIRT642121)
- hsa-miR-6877-3p (MIRT642122)
- hsa-miR-6819-3p (MIRT642123)
- hsa-miR-4446-5p (MIRT658823)
- hsa-miR-5006-3p (MIRT658824)
- hsa-miR-4755-5p (MIRT658825)
- hsa-miR-211-5p (MIRT658826)
- hsa-miR-204-5p (MIRT658827)
- hsa-miR-623 (MIRT658828)
- hsa-miR-3140-3p (MIRT658829)
- hsa-miR-4645-3p (MIRT658830)
- hsa-miR-6832-3p (MIRT658831)
- hsa-miR-6752-3p (MIRT658832)
- hsa-miR-2114-5p (MIRT658833)
- hsa-miR-378a-5p (MIRT678717)
- hsa-miR-6778-3p (MIRT678718)
- hsa-miR-6821-3p (MIRT678719)
- hsa-miR-6790-3p (MIRT678720)
- hsa-miR-18a-3p (MIRT678721)
- hsa-miR-324-3p (MIRT678722)
- hsa-miR-1913 (MIRT678723)
- hsa-miR-3653-5p (MIRT678724)
- hsa-miR-150-5p (MIRT678725)
- hsa-miR-7107-5p (MIRT678726)
- hsa-miR-1234-3p (MIRT678727)
- hsa-miR-1224-3p (MIRT678728)
- hsa-miR-186-3p (MIRT678729)
- hsa-miR-6513-3p (MIRT678730)
- hsa-miR-520h (MIRT678731)
- hsa-miR-520g-3p (MIRT678732)
- hsa-miR-512-3p (MIRT678733)
- hsa-miR-8079 (MIRT678734)
- hsa-miR-1245a (MIRT678735)
- hsa-miR-520e (MIRT678736)
- hsa-miR-520d-3p (MIRT678737)
- hsa-miR-520c-3p (MIRT678738)
- hsa-miR-520b (MIRT678739)
- hsa-miR-520a-3p (MIRT678740)
- hsa-miR-373-3p (MIRT678741)
- hsa-miR-372-3p (MIRT678742)
- hsa-miR-302e (MIRT678743)
- hsa-miR-302d-3p (MIRT678744)
- hsa-miR-302c-3p (MIRT678745)
- hsa-miR-302b-3p (MIRT678746)
- hsa-miR-302a-3p (MIRT678747)
- hsa-miR-93-5p (MIRT678748)
- hsa-miR-526b-3p (MIRT678749)
- hsa-miR-519d-3p (MIRT678750)
- hsa-miR-20b-5p (MIRT678751)
- hsa-miR-20a-5p (MIRT678752)
- hsa-miR-17-5p (MIRT678753)
- hsa-miR-106b-5p (MIRT678754)
- hsa-miR-106a-5p (MIRT678755)
- hsa-miR-6515-5p (MIRT704059)
- hsa-miR-2113 (MIRT704060)
- hsa-miR-9-3p (MIRT704061)
- hsa-miR-6797-5p (MIRT704062)
- hsa-miR-1249-5p (MIRT704063)
- hsa-miR-3135b (MIRT704064)
- hsa-miR-2467-3p (MIRT704065)
- hsa-miR-3616-3p (MIRT704066)
- hsa-miR-7843-5p (MIRT704067)
- hsa-miR-6879-5p (MIRT704068)
- hsa-miR-6735-5p (MIRT704069)
- hsa-miR-4632-5p (MIRT704070)
- hsa-miR-4436b-3p (MIRT704071)
- hsa-miR-320e (MIRT704072)
- hsa-miR-6776-3p (MIRT704073)
- hsa-miR-4429 (MIRT704074)
- hsa-miR-320d (MIRT704075)
- hsa-miR-320c (MIRT704076)
- hsa-miR-320b (MIRT704077)
- hsa-miR-1251-3p (MIRT783212)
- hsa-miR-129-5p (MIRT783604)
- hsa-miR-3672 (MIRT785161)
- hsa-miR-431-5p (MIRT785739)
- hsa-miR-4524a-3p (MIRT786138)
- hsa-miR-4797-5p (MIRT786843)
- hsa-miR-5007-5p (MIRT786964)
- hsa-miR-6864-3p (MIRT789166)
- hsa-miR-8055 (MIRT789733)
- hsa-miR-924 (MIRT789951)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
Clone Products
- Applied Biological Materials (abm): Clones for SRCAP - Select products 50% OFF >
- * SRCAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SRCAP Gene
Localization for SRCAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SRCAP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 0 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000812 | Swr1 complex | IBA | 21873635 |
| GO:0005634 | nucleus | IDA | 10702287 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for SRCAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Pathways Affected in Adenoid Cystic Carcinoma | ||
Pathways by source for SRCAP Gene
1 BioSystems pathway for SRCAP Gene
Interacting Proteins for SRCAP Gene
Selected Interacting proteins:
Q6ZRS2-SRCAP_HUMAN
ENSP00000262518
for SRCAP Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SRCAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | IBA | 21873635 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10347196 |
| GO:0016032 | viral process | IEA | -- |
| GO:0016458 | gene silencing | IBA | 21873635 |
Transcripts for SRCAP Gene
mRNA/cDNA for SRCAP Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262518 11724 nts (view in UCSC)
- ENST00000395059 9126 nts (view in UCSC)
- ENST00000411466 836 nts (view in UCSC)
- ENST00000474008 730 nts (view in UCSC)
- ENST00000483083 5937 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SRCAP - Select products 50% OFF >
- * SRCAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SRCAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for SRCAP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
Clone Products
- Applied Biological Materials (abm): Clones for SRCAP - Select products 50% OFF >
- * SRCAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for SRCAP Gene
- GeneLoc Exon Structure for
- SRCAP
Expression for SRCAP Gene
This gene is overexpressed in Ovary (16.3), Peripheral blood mononuclear cells (13.9), Blymphocyte (8.5), and Lung (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRCAP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SRCAP
SOURCE GeneReport for Unigene cluster for SRCAP Gene:
Hs.620916Evidence on tissue expression from TISSUES for SRCAP Gene
- Nervous system(4.8)
- Eye(3.1)
- Intestine(3)
- Muscle(2.6)
- Blood(2.6)
- Lung(2.4)
- Kidney(2.3)
- Skin(2.2)
- Liver(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SRCAP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- scalp
- skull
- vocal cord
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
Pelvis:
- pelvis
- rectum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for SRCAP
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRCAP Gene
Orthologs for SRCAP Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SRCAP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SRCAP 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Srcap 30 17 31 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | SRCAP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Srcap 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | SRCAP 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SRCAP 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15109 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.15976 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | srcap 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | dom 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y111B2A.23 32 |
|
|
|
| ssl-1 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWR1 31 33 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10052 30 |
|
- Species where no ortholog for SRCAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SRCAP Gene
- ENSEMBL:
- Gene Tree for SRCAP (if available)
- TreeFam:
- Gene Tree for SRCAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SRCAP: view image
Paralogs for SRCAP Gene
Paralogs for SRCAP Gene
- ENSG00000282034 5
- EP400 5
- SMARCA4 5
- SMARCA2 5
- INO80 5
- CHD7 5
- CHD6 5
- CHD8 5
- CHD9 5
- CHD2 5
- CHD1 5
- CHD3 5
- CHD5 5
- ERCC6 5
- CHD4 5
- ENSG00000285238 5
- BTAF1 5
- ATRX 5
- SMARCA5 5
- RAD54L2 5
- SMARCA1 5
- SMARCAD1 5
- HELLS 5
- CHD1L 5
- RAD54B 5
- ERCC6L 5
- RAD54L 5
- TTF2 5
- ZRANB3 5
- SHPRH 5
- ERCC6L2 5
- HLTF 5
- SMARCAL1 5
- ENSG00000279765 5
(3) SIMAP similar genes for SRCAP Gene using alignment to 4 proteins:
- SRCAP_HUMAN
- C9J4U4_HUMAN
- G1UI29_HUMAN
- Q6P4A2_HUMAN
Variants for SRCAP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SRCAP Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 689791 | Pathogenic: Floating-Harbor syndrome | 30,737,327(+) | C/A | NONSENSE | |
| 708332 | Benign: not provided | 30,738,933(+) | C/T | MISSENSE_VARIANT | |
| 710396 | Benign: not provided | 30,711,827(+) | C/A | INTRON_VARIANT | |
| 711163 | Benign: not provided | 30,724,020(+) | A/C | SYNONYMOUS_VARIANT | |
| 711649 | Benign: not provided | 30,739,152(+) | T/C | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
0.229% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SRCAP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRCAP Gene
Disorders for SRCAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| floating-harbor syndrome |
|
|
| expressive language disorder |
|
|
| chromosome 16p13.3 deletion syndrome, proximal |
|
|
| glass syndrome |
|
|
| autism spectrum disorder |
|
|
Search SRCAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SRCAP_HUMAN- Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269 PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SRCAP
No data available for Genatlas for SRCAP Gene
Publications for SRCAP Gene
- Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. (PMID: 10347196) Johnston H … Chrivia J (The Journal of biological chemistry 1999) 2 3 4 23
- SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. (PMID: 14500758) Monroy MA … Chrivia JC (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 23
- Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription. (PMID: 11581372) Xu X … Yaciuk P (Journal of virology 2001) 3 4 23
- The human SRCAP chromatin remodeling complex promotes DNA-end resection. (PMID: 25176633) Dong S … Huang J (Current biology : CB 2014) 2 3
- Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. (PMID: 22265015) Hood RL … Boycott KM (American journal of human genetics 2012) 3 4
ExternalLinks
Products for SRCAP Gene
- Custom Antibody ServicesOriGene Antibodies for SRCAP
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SRCAP
- Origene Custom Protein Services for SRCAP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SRCAP
- Browse OriGene Inhibitory RNA Products For SRCAP
- OriGene qPCR primer pairs for SRCAP
- OriGene CRISPR knockouts for SRCAP
- OriGene ORF clones in human for SRCAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SRCAP
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SRCAP
- Novus Biologicals proteins for SRCAP
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for SRCAP
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SRCAP (AFLGC-SRCAP)
- VectorBuilder Custom and pre-made DNA vectors for SRCAP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SRCAP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SRCAP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SRCAP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SRCAP
- antibodies-online: Show 4 available SRCAP Antibodies ranked by validation data
- Compare Top SRCAP Antibodies
- antibodies-online: Search results for available SRCAP related products ranked by validation data
- antibodies-online: Search results for available SRCAP related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SRCAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SRCAP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SRCAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SRCAP
Sources for SRCAP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82)