Aliases for SRCAP Gene
External Ids for SRCAP Gene
Previous GeneCards Identifiers for SRCAP Gene
This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
GeneCards Summary for SRCAP Gene
SRCAP (Snf2 Related CREBBP Activator Protein) is a Protein Coding gene. Diseases associated with SRCAP include Floating-Harbor Syndrome and Expressive Language Disorder. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity. An important paralog of this gene is ENSG00000282034.
UniProtKB/Swiss-Prot Summary for SRCAP Gene
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.